{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T21:06:02Z","timestamp":1792789562790,"version":"4.5.0"},"reference-count":10,"publisher":"Elsevier BV","issue":"15","license":[{"start":{"date-parts":[[2009,10,1]],"date-time":"2009-10-01T00:00:00Z","timestamp":1254355200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2009,10,1]],"date-time":"2009-10-01T00:00:00Z","timestamp":1254355200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Clinical Biochemistry"],"published-print":{"date-parts":[[2009,10]]},"DOI":"10.1016\/j.clinbiochem.2009.07.010","type":"journal-article","created":{"date-parts":[[2009,7,18]],"date-time":"2009-07-18T05:00:30Z","timestamp":1247893230000},"page":"1572-1576","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":13,"title":["Advantages of the high resolution melting in the detection of BRCA1 or BRCA2 mutation carriers"],"prefix":"10.1016","volume":"42","author":[{"given":"Inmaculada de Juan","family":"Jim\u00e9nez","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eva Esteban","family":"Carde\u00f1osa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sarai Palanca","family":"Suela","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eva Barrag\u00e1n","family":"Gonz\u00e1lez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pascual Bolufer","family":"Gilabert","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.clinbiochem.2009.07.010_bib1","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1016\/j.yexmp.2008.03.012","article-title":"High resolution melting applications for clinical laboratory medicine","volume":"85","author":"Erali","year":"2008","journal-title":"Exp Mol Pathol"},{"key":"10.1016\/j.clinbiochem.2009.07.010_bib2","doi-asserted-by":"crossref","first-page":"982","DOI":"10.1373\/clinchem.2007.098764","article-title":"Rapid and sensitive detection of BRCA1\/2 mutations in a diagnostic setting: Comparison of Two High-Resolution Melting Platforms","volume":"54","author":"De Leeneer","year":"2008","journal-title":"Clin Chem"},{"key":"10.1016\/j.clinbiochem.2009.07.010_bib3","doi-asserted-by":"crossref","first-page":"2211","DOI":"10.1373\/clinchem.2007.093781","article-title":"Detection of factor VIII gene mutations by high-resolution melting analysis","volume":"53","author":"Laurie","year":"2007","journal-title":"Clin Chem"},{"key":"10.1016\/j.clinbiochem.2009.07.010_bib4","doi-asserted-by":"crossref","first-page":"1748","DOI":"10.1373\/clinchem.2003.029751","article-title":"Sensitivity and specificity of single-nucleotide polymorphism scanning by high-resolution melting analysis","volume":"50","author":"Reed","year":"2004","journal-title":"Clin Chem"},{"key":"10.1016\/j.clinbiochem.2009.07.010_bib5","doi-asserted-by":"crossref","first-page":"1295","DOI":"10.1373\/clinchem.2005.051516","article-title":"Distinguishing different DNA heterozygotes by high-resolution melting","volume":"51","author":"Graham","year":"2005","journal-title":"Clin Chem"},{"key":"10.1016\/j.clinbiochem.2009.07.010_bib6","doi-asserted-by":"crossref","first-page":"676","DOI":"10.1086\/301749","article-title":"Genetic heterogeneity and penetrance analysis of the BRCA1 and BRCA2 genes in breast cancer families: the Breast Cancer Linkage Consortium","volume":"62","author":"Ford","year":"1998","journal-title":"Am J Hum Genet"},{"key":"10.1016\/j.clinbiochem.2009.07.010_bib7","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1157\/13115767","article-title":"BRCA1 and BRCA2 mutations in families studied in the program of genetic counselling in cancer of the Valencia Community (Spain)","volume":"130","author":"Esteban Carde\u00f1osa","year":"2008","journal-title":"Med Clin (Barc)"},{"key":"10.1016\/j.clinbiochem.2009.07.010_bib8","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1007\/s10549-007-9818-y","article-title":"Twenty-three novel BRCA1 and BRCA2 sequence alterations in breast and\/or ovarian cancer families of Eastern Spain","volume":"112","author":"Esteban","year":"2007","journal-title":"Breast Cancer Res Treat"},{"key":"10.1016\/j.clinbiochem.2009.07.010_bib9","doi-asserted-by":"crossref","first-page":"405","DOI":"10.1007\/s10549-008-0073-7","article-title":"High-resolution melting analysis for rapid screening of BRCA1 and BRCA2 Spanish mutations","volume":"115","author":"De Juan","year":"2009","journal-title":"Breast Cancer Res Treat"},{"key":"10.1016\/j.clinbiochem.2009.07.010_bib10","doi-asserted-by":"crossref","first-page":"2760","DOI":"10.1093\/nar\/22.14.2760","article-title":"Thermal denaturation of double-stranded nucleic acids: prediction of temperatures critical for gradient gel electrophoresis and polymerase chain reaction","volume":"22","author":"Steger","year":"1994","journal-title":"Nucleic Acids Res"}],"container-title":["Clinical Biochemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S000991200900304X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S000991200900304X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,14]],"date-time":"2025-09-14T15:29:59Z","timestamp":1757863799000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S000991200900304X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2009,10]]},"references-count":10,"journal-issue":{"issue":"15","published-print":{"date-parts":[[2009,10]]}},"alternative-id":["S000991200900304X"],"URL":"https:\/\/doi.org\/10.1016\/j.clinbiochem.2009.07.010","relation":{},"ISSN":["0009-9120"],"issn-type":[{"value":"0009-9120","type":"print"}],"subject":[],"published":{"date-parts":[[2009,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Advantages of the high resolution melting in the detection of BRCA1 or BRCA2 mutation carriers","name":"articletitle","label":"Article Title"},{"value":"Clinical Biochemistry","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.clinbiochem.2009.07.010","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2009 The Canadian Society of Clinical Chemists. Published by Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}