{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,27]],"date-time":"2025-10-27T15:22:17Z","timestamp":1761578537502,"version":"3.44.0"},"reference-count":48,"publisher":"Elsevier BV","issue":"16-17","license":[{"start":{"date-parts":[[2009,11,1]],"date-time":"2009-11-01T00:00:00Z","timestamp":1257033600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2009,11,1]],"date-time":"2009-11-01T00:00:00Z","timestamp":1257033600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Clinical Biochemistry"],"published-print":{"date-parts":[[2009,11]]},"DOI":"10.1016\/j.clinbiochem.2009.08.014","type":"journal-article","created":{"date-parts":[[2009,9,3]],"date-time":"2009-09-03T07:22:28Z","timestamp":1251962548000},"page":"1713-1718","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":28,"title":["C-reactive protein but not soluble CD40 ligand and homocysteine is associated to common atherosclerotic risk factors in a cohort of coronary artery disease patients"],"prefix":"10.1016","volume":"42","author":[{"given":"Nicoletta","family":"Vivona","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Giulia","family":"Bivona","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Davide","family":"Noto","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bruna Lo","family":"Sasso","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Angelo B.","family":"Cefal\u00f9","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gaia","family":"Chiarello","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Angelo","family":"Falletta","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marcello","family":"Ciaccio","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maurizio R.","family":"Averna","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.clinbiochem.2009.08.014_bib1","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1161\/01.CIR.101.1.111","article-title":"Prevention conference V: beyond secondary prevention: identifying the high-risk patient for primary prevention","volume":"101","author":"Smith","year":"2000","journal-title":"Circulation"},{"key":"10.1016\/j.clinbiochem.2009.08.014_bib2","doi-asserted-by":"crossref","first-page":"363","DOI":"10.7326\/0003-4819-131-5-199909070-00008","article-title":"Homocyst(e)ine and cardiovascular disease: a critical review of the epidemiologic evidence","volume":"131","author":"Eikelboom","year":"1999","journal-title":"Ann. Intern. Med."},{"issue":"5 Pt 2","key":"10.1016\/j.clinbiochem.2009.08.014_bib3","doi-asserted-by":"crossref","first-page":"S419","DOI":"10.1016\/S0002-8703(99)70266-8","article-title":"Atherosclerosis is an inflammatory disease","volume":"138","author":"Ross","year":"1999","journal-title":"Am. Heart J."},{"issue":"6","key":"10.1016\/j.clinbiochem.2009.08.014_bib4","doi-asserted-by":"crossref","first-page":"537","DOI":"10.1093\/oxfordjournals.aje.a008963","article-title":"Relation of C-reactive protein and coronary heart disease in the MRFIT nested case-control study. Multiple Risk Factor Intervention Trial","volume":"144","author":"Kuller","year":"1996","journal-title":"Am. J. Epidemiol."},{"key":"10.1016\/j.clinbiochem.2009.08.014_bib5","doi-asserted-by":"crossref","first-page":"704","DOI":"10.1093\/ije\/24.4.704","article-title":"Serum total homocysteine and coronary heart disease","volume":"24","author":"Arnesen","year":"1995","journal-title":"Int. J. Epidemiol."},{"key":"10.1016\/j.clinbiochem.2009.08.014_bib6","doi-asserted-by":"crossref","first-page":"387","DOI":"10.7326\/0003-4819-131-5-199909070-00010","article-title":"Homocysteine in health and disease","volume":"131","author":"Graham","year":"1999","journal-title":"Ann. Intern. Med."},{"issue":"suppl 2","key":"10.1016\/j.clinbiochem.2009.08.014_bib7","doi-asserted-by":"crossref","first-page":"S50","DOI":"10.1007\/PL00014304","article-title":"Biochemistry and molecular genetics of cystathionine beta-synthase deficiency","volume":"157","author":"Kraus","year":"1998","journal-title":"Eur. J. Pediatr."},{"key":"10.1016\/j.clinbiochem.2009.08.014_bib8","first-page":"1","article-title":"The natural history of homocystinuria due to cystathionine beta-synthase deficiency","volume":"37","author":"Mudd","year":"1985","journal-title":"Am. J. Hum. Genet"},{"key":"10.1016\/j.clinbiochem.2009.08.014_bib9","series-title":"Atherosclerotic cardiovascular disease, hemostasis, and endothelial function","first-page":"183","article-title":"Plasma homocysteine and cardiovascular disease","author":"Ueland","year":"1992"},{"key":"10.1016\/j.clinbiochem.2009.08.014_bib10","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1111\/j.1753-4887.1995.tb01478.x","article-title":"Prospective studies of homocysteine and cardiovascular disease","volume":"53","author":"Verhoef","year":"1995","journal-title":"Nutr. Rev."},{"key":"10.1016\/j.clinbiochem.2009.08.014_bib11","doi-asserted-by":"crossref","first-page":"1205","DOI":"10.1016\/S0024-3205(97)00392-5","article-title":"Homocysteine and vascular dysfunction","volume":"61","author":"Lentz","year":"1997","journal-title":"Life Sci."},{"key":"10.1016\/j.clinbiochem.2009.08.014_bib12","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1111\/j.1753-4887.1996.tb03770.x","article-title":"Biological chemistry of thiols in the vasculature and in vascular related disease","volume":"54","author":"Stamler","year":"1996","journal-title":"Nutr. Rev."},{"key":"10.1016\/j.clinbiochem.2009.08.014_bib13","doi-asserted-by":"crossref","first-page":"836","DOI":"10.1056\/NEJM200003233421202","article-title":"C-reactive protein and other markers of inflammation in the prediction of cardiovascular disease in women","volume":"342","author":"Ridker","year":"2000","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.clinbiochem.2009.08.014_bib14","doi-asserted-by":"crossref","first-page":"973","DOI":"10.1056\/NEJM199704033361401","article-title":"Inflammation, aspirin, and the risk of cardiovascular disease in apparently healthy men","volume":"336","author":"Ridker","year":"1997","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.clinbiochem.2009.08.014_bib15","doi-asserted-by":"crossref","first-page":"731","DOI":"10.1161\/01.CIR.98.8.731","article-title":"Prospective study of C-reactive protein and the risk of future cardiovascular events among apparently healthy women","volume":"98","author":"Ridker","year":"1998","journal-title":"Circulation"},{"key":"10.1016\/j.clinbiochem.2009.08.014_bib16","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1161\/01.CIR.99.2.237","volume":"99","author":"Koenig","year":"1999","journal-title":"Circulation"},{"issue":"7","key":"10.1016\/j.clinbiochem.2009.08.014_bib17","doi-asserted-by":"crossref","first-page":"417","DOI":"10.1056\/NEJM199408183310701","article-title":"The prognostic value of C-reactive protein and serum amyloid a protein in severe unstable angina","volume":"331","author":"Liuzzo","year":"1994","journal-title":"N. Engl. J. Med"},{"issue":"7","key":"10.1016\/j.clinbiochem.2009.08.014_bib18","doi-asserted-by":"crossref","first-page":"855","DOI":"10.1161\/01.CIR.99.7.855","article-title":"Elevated levels of C-reactive protein at discharge in patients with unstable angina predict recurrent instability","volume":"99","author":"Biasucci","year":"1999","journal-title":"Circulation"},{"issue":"9050","key":"10.1016\/j.clinbiochem.2009.08.014_bib19","doi-asserted-by":"crossref","first-page":"462","DOI":"10.1016\/S0140-6736(96)07591-5","article-title":"Production of C-reactive protein and risk of coronary events in stable and unstable angina. European Concerted Action on Thrombosis and Disabilities Angina Pectoris Study Group","volume":"349","author":"Haverkate","year":"1997","journal-title":"Lancet"},{"key":"10.1016\/j.clinbiochem.2009.08.014_bib20","doi-asserted-by":"crossref","first-page":"1092","DOI":"10.1161\/hh2401.101272","article-title":"CD40 signalling and plaque instability","volume":"89","author":"Schonbeck","year":"2001","journal-title":"Circ. Res."},{"key":"10.1016\/j.clinbiochem.2009.08.014_bib21","doi-asserted-by":"crossref","first-page":"578","DOI":"10.1160\/TH04-09-0586","article-title":"Soluble CD40L in peripheral artery disease. Relationship with disease severity, platelet markers and the effects of angioplasty","volume":"93","author":"Blann","year":"2005","journal-title":"Thromb. Haemost."},{"issue":"12","key":"10.1016\/j.clinbiochem.2009.08.014_bib22","doi-asserted-by":"crossref","first-page":"1104","DOI":"10.1056\/NEJMoa022600","article-title":"Soluble CD40 ligand in acute coronary syndromes","volume":"348","author":"Heeschen","year":"2003","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.clinbiochem.2009.08.014_bib23","doi-asserted-by":"crossref","first-page":"413","DOI":"10.1093\/ije\/dyh405","article-title":"Prediction of coronary events in a low incidence population. Assessing accuracy of the CUORE Cohort Study prediction equation","volume":"34","author":"Ferrario","year":"2005","journal-title":"Int. J. Epidemiol."},{"issue":"6","key":"10.1016\/j.clinbiochem.2009.08.014_bib24","doi-asserted-by":"crossref","first-page":"614","DOI":"10.1161\/01.CIR.100.6.614","article-title":"Enhanced levels of soluble and membrane-bound CD40 ligand in patients with unstable angina. Possible reflection of T lymphocyte and platelet involvement in the pathogenesis of acute coronary syndromes","volume":"100","author":"Aukrust","year":"1999","journal-title":"Circulation"},{"issue":"1","key":"10.1016\/j.clinbiochem.2009.08.014_bib25","doi-asserted-by":"crossref","first-page":"e11","DOI":"10.1161\/01.ATV.0000050143.22910.62","article-title":"Soluble CD40 ligand levels indicate lipid accumulation in carotid atheroma: an in vivo study with high-resolution MRI","volume":"23","author":"Blake","year":"2003","journal-title":"Arterioscler. Thromb. Vasc. Biol."},{"issue":"2","key":"10.1016\/j.clinbiochem.2009.08.014_bib26","doi-asserted-by":"crossref","first-page":"361","DOI":"10.1016\/j.atherosclerosis.2005.02.019","article-title":"The relationship between soluble CD40 ligand levels and Framingham coronary heart disease risk score in healthy volunteers","volume":"182","author":"Verma","year":"2005","journal-title":"Atherosclerosis"},{"issue":"10","key":"10.1016\/j.clinbiochem.2009.08.014_bib27","doi-asserted-by":"crossref","first-page":"2192","DOI":"10.1161\/01.ATV.0000182904.08513.60","article-title":"Associations between soluble CD40 ligand, atherosclerosis risk factors, and subclinical atherosclerosis: results from the Dallas Heart Study","volume":"25","author":"de Lemos","year":"2005","journal-title":"Arterioscler. Thromb. Vasc. Biol."},{"issue":"1","key":"10.1016\/j.clinbiochem.2009.08.014_bib28","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1016\/j.ahj.2005.10.006","article-title":"Effect of atorvastatin on circulating proinflammatory T-lymphocyte subsets and soluble CD40 ligand in patients with stable coronary artery disease\u2014a randomized, placebo-controlled study","volume":"151","author":"Alber","year":"2006","journal-title":"Am. Heart J."},{"issue":"111","key":"10.1016\/j.clinbiochem.2009.08.014_bib29","doi-asserted-by":"crossref","first-page":"S60","DOI":"10.1038\/ki.2008.514","article-title":"Atorvastatin decreases elevated soluble CD40L in subjects at high cardiovascular risk. Atorvastatin on inflammatory markers study: a substudy of ACTFAST","author":"Blanco-Colio","year":"2008","journal-title":"Kidney Int. Suppl."},{"issue":"2","key":"10.1016\/j.clinbiochem.2009.08.014_bib30","doi-asserted-by":"crossref","first-page":"521.e1","DOI":"10.1016\/j.ahj.2005.10.021","article-title":"Effects of clopidogrel on soluble CD40 ligand and on high-sensitivity C-reactive protein in patients with stable coronary artery disease","volume":"151","author":"Azar","year":"2006","journal-title":"Am. Heart J."},{"issue":"21","key":"10.1016\/j.clinbiochem.2009.08.014_bib31","doi-asserted-by":"crossref","first-page":"2664","DOI":"10.1161\/01.CIR.0000074043.46437.44","article-title":"Elevated plasma levels of the atherogenic mediator soluble CD40 ligand in diabetic patients: a novel target of thiazolidinediones","volume":"107","author":"Varo","year":"2003","journal-title":"Circulation"},{"issue":"2","key":"10.1016\/j.clinbiochem.2009.08.014_bib32","doi-asserted-by":"crossref","first-page":"321","DOI":"10.1016\/j.atherosclerosis.2004.05.008","article-title":"Increased CD40 ligand and platelet\u2013monocyte aggregates in patients with type 1 diabetes mellitus","volume":"176","author":"Harding","year":"2004","journal-title":"Atherosclerosis"},{"issue":"1\u20132","key":"10.1016\/j.clinbiochem.2009.08.014_bib33","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1016\/j.cccn.2003.09.007","article-title":"Upregulation of CD40\u2013CD40 ligand system in patients with diabetes mellitus","volume":"339","author":"Jinchuan","year":"2004","journal-title":"Clin. Chim. Acta."},{"issue":"25","key":"10.1016\/j.clinbiochem.2009.08.014_bib34","doi-asserted-by":"crossref","first-page":"2599","DOI":"10.1056\/NEJMoa040967","article-title":"Inflammatory markers and the risk of coronary heart disease in men and women","volume":"351","author":"Pai","year":"2004","journal-title":"N. Engl. J. Med."},{"issue":"1","key":"10.1016\/j.clinbiochem.2009.08.014_bib35","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1016\/j.atherosclerosis.2008.08.009","article-title":"Predictive value of coronary artery stenoses and C-reactive protein levels in patients with stable coronary artery disease","volume":"204","author":"Arroyo-Espliguero","year":"2009","journal-title":"Atherosclerosis"},{"key":"10.1016\/j.clinbiochem.2009.08.014_bib36","doi-asserted-by":"crossref","first-page":"1557","DOI":"10.1056\/NEJMoa021993","article-title":"Comparison of C-reactive protein and low-density lipoprotein cholesterol levels in the prediction of first cardiovascular events","volume":"347","author":"Ridker","year":"2002","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.clinbiochem.2009.08.014_bib37","doi-asserted-by":"crossref","first-page":"2007","DOI":"10.1161\/01.CIR.97.20.2007","article-title":"C-reactive protein adds to the predictive value of total and HDL cholesterol in determining risk of first myocardial infarction","volume":"97","author":"Ridker","year":"1998","journal-title":"Circulation"},{"key":"10.1016\/j.clinbiochem.2009.08.014_bib38","doi-asserted-by":"crossref","first-page":"1813","DOI":"10.1161\/01.CIR.103.13.1813","article-title":"High-sensitive C-reactive protein: potential adjunct for global risk assessment in the primary prevention of cardiovascular disease","volume":"103","author":"Ridker","year":"2001","journal-title":"Circulation"},{"key":"10.1016\/j.clinbiochem.2009.08.014_bib39","doi-asserted-by":"crossref","first-page":"1387","DOI":"10.1056\/NEJMoa032804","article-title":"C-reactive protein and other circulating markers of inflammation in the prediction of coronary heart disease","volume":"350","author":"Danesh","year":"2004","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.clinbiochem.2009.08.014_bib40","doi-asserted-by":"crossref","first-page":"1229","DOI":"10.1161\/01.STR.0000260090.90508.3e","article-title":"High-sensitivity C-reactive protein and soluble CD40 ligand as indices of inflammation and platelet activation in 880 patients with nonvalvular atrial fibrillation","author":"Lip","year":"2007","journal-title":"Stroke"},{"issue":"12","key":"10.1016\/j.clinbiochem.2009.08.014_bib41","doi-asserted-by":"crossref","first-page":"1834","DOI":"10.1001\/archinte.160.12.1834","article-title":"Serum homocysteine concentration as an indicator of survival in patients with acute coronary syndromes","volume":"160","author":"Omland","year":"2000","journal-title":"Arch. Intern. Med."},{"issue":"6","key":"10.1016\/j.clinbiochem.2009.08.014_bib42","doi-asserted-by":"crossref","first-page":"605","DOI":"10.1161\/01.CIR.102.6.605","article-title":"Effect of plasma homocysteine concentration on early and late events in patients with acute coronary syndromes","volume":"102","author":"Stubbs","year":"2000","journal-title":"Circulation"},{"issue":"16","key":"10.1016\/j.clinbiochem.2009.08.014_bib43","doi-asserted-by":"crossref","first-page":"1933","DOI":"10.1001\/archinte.163.16.1933","article-title":"Association of elevated homocysteine levels with a higher risk of recurrent coronary events and mortality in patients with acute myocardial infarction","volume":"163","author":"Matetzky","year":"2003","journal-title":"Arch. Intern. Med."},{"issue":"4","key":"10.1016\/j.clinbiochem.2009.08.014_bib44","doi-asserted-by":"crossref","first-page":"230","DOI":"10.1056\/NEJM199707243370403","article-title":"Plasma homocysteine levels and mortality in patients with coronary artery disease","volume":"337","author":"Nyg\u00e5rd","year":"1997","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.clinbiochem.2009.08.014_bib45","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1016\/j.ijcard.2004.09.001","article-title":"Early determination of homocysteine levels in acute coronary syndromes, is it an independent prognostic factor?","volume":"100","author":"F\u00e1cila","year":"2005","journal-title":"Int. J. Cardiol."},{"key":"10.1016\/j.clinbiochem.2009.08.014_bib46","doi-asserted-by":"crossref","first-page":"312","DOI":"10.1016\/j.ijcard.2007.02.011","article-title":"The impact of circulating total homocysteine levels on long-term cardiovascular mortality in patients with acute coronary syndrome","volume":"124","author":"Foussas","year":"2008","journal-title":"Int. J. Cardiol."},{"key":"10.1016\/j.clinbiochem.2009.08.014_bib47","doi-asserted-by":"crossref","first-page":"888","DOI":"10.1373\/clinchem.2005.062083","article-title":"Influence of sample type and storage conditions on soluble CD40 ligand assessment","volume":"52","author":"Weber","year":"2006","journal-title":"Clin. Chem."},{"key":"10.1016\/j.clinbiochem.2009.08.014_bib48","doi-asserted-by":"crossref","first-page":"811","DOI":"10.1016\/j.thromres.2007.01.014","article-title":"Influence of sample type on soluble CD40 ligand assessment in patients with acute coronary syndromes","volume":"120","author":"Weber","year":"2007","journal-title":"Thromb. Res."}],"container-title":["Clinical Biochemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0009912009003671?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0009912009003671?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,14]],"date-time":"2025-09-14T15:30:17Z","timestamp":1757863817000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0009912009003671"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2009,11]]},"references-count":48,"journal-issue":{"issue":"16-17","published-print":{"date-parts":[[2009,11]]}},"alternative-id":["S0009912009003671"],"URL":"https:\/\/doi.org\/10.1016\/j.clinbiochem.2009.08.014","relation":{},"ISSN":["0009-9120"],"issn-type":[{"type":"print","value":"0009-9120"}],"subject":[],"published":{"date-parts":[[2009,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"C-reactive protein but not soluble CD40 ligand and homocysteine is associated to common atherosclerotic risk factors in a cohort of coronary artery disease patients","name":"articletitle","label":"Article Title"},{"value":"Clinical Biochemistry","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.clinbiochem.2009.08.014","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2009 Published by Elsevier Inc.","name":"copyright","label":"Copyright"}]}}