{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,13]],"date-time":"2026-01-13T03:18:48Z","timestamp":1768274328132,"version":"3.49.0"},"reference-count":34,"publisher":"Elsevier BV","issue":"17-18","license":[{"start":{"date-parts":[[2011,12,1]],"date-time":"2011-12-01T00:00:00Z","timestamp":1322697600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2011,12,1]],"date-time":"2011-12-01T00:00:00Z","timestamp":1322697600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Clinical Biochemistry"],"published-print":{"date-parts":[[2011,12]]},"DOI":"10.1016\/j.clinbiochem.2011.09.015","type":"journal-article","created":{"date-parts":[[2011,10,3]],"date-time":"2011-10-03T08:28:48Z","timestamp":1317630528000},"page":"1380-1384","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":8,"title":["Association of pregnancy-associated plasma protein A polymorphism with preeclampsia \u2014 A pilot study"],"prefix":"10.1016","volume":"44","author":[{"given":"Alexandra","family":"Muravsk\u00e1","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anna","family":"Germanov\u00e1","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marie","family":"J\u00e1chymov\u00e1","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zden\u011bk","family":"H\u00e1jek","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jana","family":"\u0160varcov\u00e1","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tom\u00e1\u0161","family":"Zima","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marta","family":"Kalousov\u00e1","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.clinbiochem.2011.09.015_bb0005","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1016\/0002-9378(74)90553-5","article-title":"Characterization of four pregnancy-associated plasma proteins","volume":"118","author":"Lin","year":"1974","journal-title":"Am. J. Obstet. Gynecol."},{"key":"10.1016\/j.clinbiochem.2011.09.015_bb0010","doi-asserted-by":"crossref","first-page":"808","DOI":"10.1016\/0002-9378(77)90725-6","article-title":"Plasma concentrations of four pregnancy proteins in complications of pregnancy","volume":"128","author":"Lin","year":"1977","journal-title":"Am. J. Obstet. Gynecol."},{"key":"10.1016\/j.clinbiochem.2011.09.015_bb0015","series-title":"Pregnancy proteins","first-page":"333","article-title":"Biological and clinical aspect of PAPP-A","author":"Klopper","year":"1982"},{"key":"10.1016\/j.clinbiochem.2011.09.015_bb0020","series-title":"The embryo: normal and abnormal development and growth","first-page":"181","article-title":"Ultrasound and biochemical assessment of first trimester of pregnancy","author":"Brambati","year":"1990"},{"key":"10.1016\/j.clinbiochem.2011.09.015_bb0025","doi-asserted-by":"crossref","first-page":"1022","DOI":"10.1056\/NEJMoa003147","article-title":"Pregnancy-associated plasma protein A as a marker of acute coronary syndromes","volume":"345","author":"Bayes-Genis","year":"2001","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.clinbiochem.2011.09.015_bb0030","doi-asserted-by":"crossref","first-page":"2577","DOI":"10.1093\/ndt\/gfg404","article-title":"Glycoxidation and inflammation in chronic haemodialysis patients","volume":"18","author":"Kalousova","year":"2003","journal-title":"Nephrol. Dial. Transplant."},{"key":"10.1016\/j.clinbiochem.2011.09.015_bb0035","doi-asserted-by":"crossref","first-page":"298","DOI":"10.1159\/000078701","article-title":"Increased levels of pregnancy-associated plasma protein A are associated with mortality in hemodialysis patients: preliminary results","volume":"22","author":"Kalousov\u00e1","year":"2004","journal-title":"Blood Purif."},{"key":"10.1016\/j.clinbiochem.2011.09.015_bb0040","doi-asserted-by":"crossref","first-page":"134","DOI":"10.1016\/0014-5793(93)80312-I","article-title":"Astacins, serralysins, snake venom and matrix metalloproteinases exhibit zinc-binding environments and topologies and should be grouped into a common family the \u201cmetzins\u201d","volume":"331","author":"Bode","year":"1993","journal-title":"FEBS Lett."},{"key":"10.1016\/j.clinbiochem.2011.09.015_bb0175","doi-asserted-by":"crossref","first-page":"2106","DOI":"10.1074\/jbc.M208777200","article-title":"Complex of pregnancy-associated plasma protein-A and the proform of eosinophil major basic protein. Disulfide structure and carbohydrate attachment","volume":"278","author":"Overgaard","year":"2003","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.clinbiochem.2011.09.015_bb0050","doi-asserted-by":"crossref","first-page":"3149","DOI":"10.1073\/pnas.96.6.3149","article-title":"The insulin-like growth factor (IGF)-dependent IGF binding protein-4 protease secreted by human fibroblasts is pregnancy-associated plasma protein-A","volume":"96","author":"Lawrence","year":"1999","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.clinbiochem.2011.09.015_bb0055","doi-asserted-by":"crossref","first-page":"1083","DOI":"10.1095\/biolreprod61.4.1083","article-title":"Messenger ribonucleic acid levels of pregnancy-associated plasma protein-A and the proform of eosinophil major basic protein: expression in human reproductive and nonreproductive tissues","volume":"61","author":"Overgaard","year":"1999","journal-title":"Biol. Reprod."},{"key":"10.1016\/j.clinbiochem.2011.09.015_bb0060","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1515\/JPM.2008.004","article-title":"Genes and preeclampsia syndrome","volume":"36","author":"M\u00fctze","year":"2008","journal-title":"J. Perinat. Med."},{"key":"10.1016\/j.clinbiochem.2011.09.015_bb0180","doi-asserted-by":"crossref","first-page":"445.e1","DOI":"10.1016\/j.ajog.2010.01.040","article-title":"Allelic variations in angiogenic pathway genes are associated with preeclampsia","volume":"202","author":"Srinivas","year":"2010","journal-title":"Am. J. Obstet. Gynecol."},{"key":"10.1016\/j.clinbiochem.2011.09.015_bb0070","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1016\/0092-8674(92)90275-H","article-title":"Molecular basis of human hypertension: role of angiotensinogen","volume":"71","author":"Jeunemaitre","year":"1992","journal-title":"Cell"},{"key":"10.1016\/j.clinbiochem.2011.09.015_bb0075","doi-asserted-by":"crossref","first-page":"308","DOI":"10.1161\/01.HYP.0000049762.77830.89","article-title":"Haplotype analysis of the human renin gene and essential hypertension","volume":"41","author":"Hasimu","year":"2003","journal-title":"Hypertension"},{"key":"10.1016\/j.clinbiochem.2011.09.015_bb0080","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1161\/01.HYP.32.1.3","article-title":"Endothelial nitric oxide synthase gene is positively associated with essential hypertension","volume":"32","author":"Miyamoto","year":"1998","journal-title":"Hypertension"},{"key":"10.1016\/j.clinbiochem.2011.09.015_bb0085","doi-asserted-by":"crossref","first-page":"426","DOI":"10.1006\/bbrc.2001.5007","article-title":"Association of the Glu298Asp polymorphis in the endothelial nitric oxide synthase gene with essential hypertension to conventional therapy","volume":"284","author":"J\u00e1chymov\u00e1","year":"2001","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.clinbiochem.2011.09.015_bb0090","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1203\/PDR.0b013e31818912e7","article-title":"Genetic contributions to disparities in preterm birth","volume":"65","author":"Anum","year":"2009","journal-title":"Pediatr. Res."},{"key":"10.1016\/j.clinbiochem.2011.09.015_bb0185","first-page":"1215","article-title":"A simple salting out procedure for extracting DNA from human nucleated cells","volume":"11","author":"Miller","year":"1998","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.clinbiochem.2011.09.015_bb0100","doi-asserted-by":"crossref","first-page":"82","DOI":"10.14712\/fb2011057020082","article-title":"Pregnancy-associated plasma protein A polymorphisms in patients with risk pregnancies","volume":"57","author":"Germanov\u00e1","year":"2011","journal-title":"Folia Biol. (Praha)"},{"key":"10.1016\/j.clinbiochem.2011.09.015_bb0105","doi-asserted-by":"crossref","first-page":"417","DOI":"10.1097\/MCA.0b013e328241d967","article-title":"Genetic polymorphism in the pregnancy-associated plasma protein-A associated with acute myocardial infarction","volume":"18","author":"Park","year":"2007","journal-title":"Coron. Artery Dis."},{"key":"10.1016\/j.clinbiochem.2011.09.015_bb0110","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1016\/j.jri.2005.11.004","article-title":"Pregnancy-associated plasma protein-A polymorphism and the risk of recurrent pregnancy loss","volume":"70","author":"Suzuki","year":"2006","journal-title":"J. Reprod. Immunol."},{"key":"10.1016\/j.clinbiochem.2011.09.015_bb0190","doi-asserted-by":"crossref","DOI":"10.1016\/j.ejogrb.2011.03.004","article-title":"Decreased PAPP-A is associated with preeclampsia, premature delivery and small for gestational age infants but not with placental abruption","author":"Ranta","year":"2011","journal-title":"Eur. J. Obstet. Gynecol."},{"key":"10.1016\/j.clinbiochem.2011.09.015_bb0120","doi-asserted-by":"crossref","first-page":"1265","DOI":"10.1111\/j.1471-0528.2000.tb11618.x","article-title":"First trimester maternal serum free beta human chorionic gonadotrophin and pregnancy associated plasma protein A as predictors of pregnancy complications","volume":"107","author":"Ong","year":"2000","journal-title":"BJOG"},{"key":"10.1016\/j.clinbiochem.2011.09.015_bb0125","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1002\/pd.2452","article-title":"Association of first-trimester low PAPP-A levels with preterm birth","volume":"30","author":"Goetzinger","year":"2010","journal-title":"Prenat. Diagn."},{"key":"10.1016\/j.clinbiochem.2011.09.015_bb0130","doi-asserted-by":"crossref","first-page":"1762","DOI":"10.1210\/jcem.87.4.8430","article-title":"Early pregnancy levels of pregnancy-associated plasma protein a and the risk of intrauterine growth restriction, premature birth, preeclampsia, and stillbirth","volume":"87","author":"Smith","year":"2002","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"10.1016\/j.clinbiochem.2011.09.015_bb0135","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1111\/j.1600-0412.2004.00277.x","article-title":"Second- and third-trimester serum levels of placental proteins in preeclampsia and small-for-gestational age pregnancies","volume":"83","author":"Bersinger","year":"2004","journal-title":"Acta Obstet. Gynecol. Scand."},{"key":"10.1016\/j.clinbiochem.2011.09.015_bb0140","doi-asserted-by":"crossref","first-page":"94","DOI":"10.1111\/j.1447-0756.2008.00835.x","article-title":"Pregnancy-associated plasma protein-A and C-reactive protein levels in pre-eclamptic and normotensive pregnant women at third trimester","volume":"35","author":"Deveci","year":"2009","journal-title":"J. Obstet. Gynaecol. Res."},{"key":"10.1016\/j.clinbiochem.2011.09.015_bb0145","doi-asserted-by":"crossref","first-page":"1230","DOI":"10.1111\/j.1471-0528.1984.tb04742.x","article-title":"Placental protein measurements in complicated pregnancies. III. Premature labour","volume":"91","author":"Westergaard","year":"1984","journal-title":"Br. J. Obstet. Gynaecol."},{"key":"10.1016\/j.clinbiochem.2011.09.015_bb0150","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1159\/000076390","article-title":"Relationship of pregnancy-associated plasma protein-A to renal function and dialysis modalities","volume":"27","author":"Fialov\u00e1","year":"2004","journal-title":"Kidney Blood Press. Res."},{"key":"10.1016\/j.clinbiochem.2011.09.015_bb0155","doi-asserted-by":"crossref","first-page":"1441","DOI":"10.1097\/01.tp.0000185199.67531.1a","article-title":"Pretransplant pregnancy-associated plasma protein-A as a predictor of chronic allograft nephropathy and posttransplant cardiovascular events","volume":"80","author":"Lauzurica","year":"2005","journal-title":"Transplantation"},{"key":"10.1016\/j.clinbiochem.2011.09.015_bb0160","doi-asserted-by":"crossref","first-page":"3072","DOI":"10.1016\/j.transproceed.2007.08.111","article-title":"Pregnancy-associated plasma protein-A: evaluation of a new biomarker in renal transplant patients","volume":"39","author":"Coskun","year":"2007","journal-title":"Transplant. Proc."},{"key":"10.1016\/j.clinbiochem.2011.09.015_bb0165","doi-asserted-by":"crossref","first-page":"176","DOI":"10.1097\/00006250-199102000-00002","article-title":"C-reactive protein in normal pregnancy","volume":"77","author":"Watts","year":"1991","journal-title":"Obstet. Gynecol."},{"key":"10.1016\/j.clinbiochem.2011.09.015_bb0170","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1016\/0028-2243(90)90138-Q","article-title":"C-reactive protein during normal pregnancy","volume":"35","author":"Nielsen","year":"1990","journal-title":"Eur. J. Obstet. Gynecol. Reprod. Biol."}],"container-title":["Clinical Biochemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0009912011026555?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0009912011026555?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,14]],"date-time":"2025-09-14T15:35:53Z","timestamp":1757864153000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0009912011026555"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011,12]]},"references-count":34,"journal-issue":{"issue":"17-18","published-print":{"date-parts":[[2011,12]]}},"alternative-id":["S0009912011026555"],"URL":"https:\/\/doi.org\/10.1016\/j.clinbiochem.2011.09.015","relation":{},"ISSN":["0009-9120"],"issn-type":[{"value":"0009-9120","type":"print"}],"subject":[],"published":{"date-parts":[[2011,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Association of pregnancy-associated plasma protein A polymorphism with preeclampsia \u2014 A pilot study","name":"articletitle","label":"Article Title"},{"value":"Clinical Biochemistry","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.clinbiochem.2011.09.015","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2011 The Canadian Society of Clinical Chemists. Published by Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}