{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,15]],"date-time":"2026-03-15T11:13:44Z","timestamp":1773573224004,"version":"3.50.1"},"reference-count":26,"publisher":"Elsevier BV","issue":"10-11","license":[{"start":{"date-parts":[[2012,7,1]],"date-time":"2012-07-01T00:00:00Z","timestamp":1341100800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2012,7,1]],"date-time":"2012-07-01T00:00:00Z","timestamp":1341100800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Clinical Biochemistry"],"published-print":{"date-parts":[[2012,7]]},"DOI":"10.1016\/j.clinbiochem.2012.03.028","type":"journal-article","created":{"date-parts":[[2012,4,4]],"date-time":"2012-04-04T00:12:46Z","timestamp":1333498366000},"page":"758-765","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":23,"title":["Platelet proteome and clopidogrel response in patients with stable angina undergoing percutaneous coronary intervention"],"prefix":"10.1016","volume":"45","author":[{"given":"Elisabetta","family":"Volpi","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Laura","family":"Giusti","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Federica","family":"Ciregia","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ylenia","family":"Da Valle","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gino","family":"Giannaccini","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sergio","family":"Berti","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Aldo","family":"Clerico","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Antonio","family":"Lucacchini","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.clinbiochem.2012.03.028_bb0005","doi-asserted-by":"crossref","first-page":"2271","DOI":"10.1161\/CIRCULATIONAHA.109.192663","volume":"120","author":"Kushner","year":"2009","journal-title":"Circulation"},{"key":"10.1016\/j.clinbiochem.2012.03.028_bb0010","doi-asserted-by":"crossref","first-page":"2411","DOI":"10.1001\/jama.288.19.2411","article-title":"Early and sustained dual oral antiplatelet therapy following percutaneous coronary intervention: a randomized controlled trial","volume":"288","author":"Steinhubl","year":"2002","journal-title":"JAMA"},{"key":"10.1016\/j.clinbiochem.2012.03.028_bb0015","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1136\/heart.85.1.92","article-title":"Effect of a high loading dose of clopidogrel on platelet function in patients undergoing coronary stent placement","volume":"85","author":"M\u00fcller","year":"2001","journal-title":"Heart"},{"key":"10.1016\/j.clinbiochem.2012.03.028_bb0020","doi-asserted-by":"crossref","first-page":"2099","DOI":"10.1161\/01.CIR.0000161383.06692.D4","volume":"111","author":"Patti","year":"2005","journal-title":"Circulation"},{"key":"10.1016\/j.clinbiochem.2012.03.028_bb0025","doi-asserted-by":"crossref","first-page":"20A","DOI":"10.1016\/j.amjcard.2008.11.019","article-title":"Methods for the measurement of platelet function","volume":"103","author":"Michelson","year":"2009","journal-title":"Am J Cardiol"},{"key":"10.1016\/j.clinbiochem.2012.03.028_bb0030","doi-asserted-by":"crossref","first-page":"341","DOI":"10.1016\/j.exphem.2010.03.001","article-title":"Proteome of platelets in patients with coronary artery disease","volume":"38","author":"Banfi","year":"2010","journal-title":"Exp Hematol"},{"key":"10.1016\/j.clinbiochem.2012.03.028_bb0035","doi-asserted-by":"crossref","first-page":"e13404","DOI":"10.1371\/journal.pone.0013404","article-title":"Proteins involved in platelet signaling are differentially regulated in acute coronary syndrome: a proteomic study","volume":"5","author":"Pargui\u00f1a","year":"2010","journal-title":"PLoS One"},{"key":"10.1016\/j.clinbiochem.2012.03.028_bb0040","doi-asserted-by":"crossref","first-page":"1634","DOI":"10.1002\/pmic.200600783","article-title":"Proteome analysis of whole saliva: a new tool for rheumatic diseases\u2013the example of Sj\u00f6gren's syndrome","volume":"7","author":"Giusti","year":"2007","journal-title":"Proteomics"},{"key":"10.1016\/j.clinbiochem.2012.03.028_bb0045","doi-asserted-by":"crossref","first-page":"412","DOI":"10.1016\/0003-2697(88)90208-4","article-title":"Development of polyacrylamide gels that improve the separation of proteins and their detection by silver staining","volume":"173","author":"Hochstrasser","year":"1988","journal-title":"Anal Biochem"},{"key":"10.1016\/j.clinbiochem.2012.03.028_bb0050","doi-asserted-by":"crossref","first-page":"1327","DOI":"10.1002\/elps.200305844","article-title":"Blue silver: a very sensitive colloidal Coomassie G-250 staining for proteome analysis","volume":"25","author":"Candiano","year":"2004","journal-title":"Electrophoresis"},{"key":"10.1016\/j.clinbiochem.2012.03.028_bb0055","doi-asserted-by":"crossref","first-page":"687","DOI":"10.1039\/C0MB00191K","article-title":"A proteomic approach to study parathyroid glands","volume":"7","author":"Giusti","year":"2011","journal-title":"Mol Biosyst"},{"key":"10.1016\/j.clinbiochem.2012.03.028_bb0060","doi-asserted-by":"crossref","first-page":"5383","DOI":"10.1021\/ac025747h","article-title":"Empirical statistical model to estimate the accuracy of peptide identifications made by MS\/MS and database search","volume":"74","author":"Keller","year":"2002","journal-title":"Anal Chem"},{"key":"10.1016\/j.clinbiochem.2012.03.028_bb0065","doi-asserted-by":"crossref","first-page":"4646","DOI":"10.1021\/ac0341261","article-title":"A statistical model for identifying proteins by tandem mass spectrometry","volume":"75","author":"Nesvizhskii","year":"2003","journal-title":"Anal Chem"},{"key":"10.1016\/j.clinbiochem.2012.03.028_bb0070","doi-asserted-by":"crossref","first-page":"2096","DOI":"10.1182\/blood-2003-08-2804","article-title":"Characterization of the proteins released from activated platelets leads to localization of novel platelet proteins in human atherosclerotic lesions","volume":"103","author":"Coppinger","year":"2004","journal-title":"Blood"},{"key":"10.1016\/j.clinbiochem.2012.03.028_bb0075","doi-asserted-by":"crossref","first-page":"3370","DOI":"10.1172\/JCI26885","article-title":"Platelet genomics and proteomics in human health and disease","volume":"115","author":"Macaulay","year":"2005","journal-title":"J Clin Invest"},{"key":"10.1016\/j.clinbiochem.2012.03.028_bb0080","doi-asserted-by":"crossref","first-page":"36321","DOI":"10.1074\/jbc.274.51.36321","article-title":"Inhibition of calpain blocks platelet secretion, aggregation, and spreading","volume":"274","author":"Croce","year":"1999","journal-title":"J Biol Chem"},{"key":"10.1016\/j.clinbiochem.2012.03.028_bb0085","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1080\/09537100050057620","article-title":"Calpain regulation of integrin alpha IIb beta 3 signaling in human platelets","volume":"11","author":"Schoenwaelder","year":"2000","journal-title":"Platelets"},{"key":"10.1016\/j.clinbiochem.2012.03.028_bb0090","doi-asserted-by":"crossref","first-page":"1492","DOI":"10.1182\/blood-2006-11-055772","article-title":"SNAP-23 and syntaxin-2 localize to the extracellular surface of the platelet plasma membrane","volume":"110","author":"Flaumenhaft","year":"2007","journal-title":"Blood"},{"key":"10.1016\/j.clinbiochem.2012.03.028_bb0095","doi-asserted-by":"crossref","first-page":"37009","DOI":"10.1074\/jbc.M204526200","article-title":"SNAP-23 is a target for calpain cleavage in activated platelets","volume":"277","author":"Rutledge","year":"2002","journal-title":"J Biol Chem"},{"key":"10.1016\/j.clinbiochem.2012.03.028_bb0100","first-page":"131","article-title":"The profile of profilins","volume":"159","author":"Jockusch","year":"2007","journal-title":"Rev Physiol Biochem Pharmacol"},{"key":"10.1016\/j.clinbiochem.2012.03.028_bb0105","doi-asserted-by":"crossref","first-page":"461","DOI":"10.1016\/j.tcb.2004.07.003","article-title":"The role of profilin complexes in cell motility and other cellular processes","volume":"14","author":"Witke","year":"2004","journal-title":"Trends Cell Biol"},{"key":"10.1016\/j.clinbiochem.2012.03.028_bb0110","doi-asserted-by":"crossref","first-page":"589","DOI":"10.1016\/j.cellsig.2003.10.001","article-title":"Phosphorylation of profilin regulates its interaction with actin and poly (L-proline)","volume":"16","author":"Sathish","year":"2004","journal-title":"Cell Signal"},{"key":"10.1016\/j.clinbiochem.2012.03.028_bb0115","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1016\/0014-5793(88)80575-1","article-title":"The primary structure of human platelet profilin: reinvestigation of the calf spleen profilin sequence","volume":"228","author":"Ampe","year":"1988","journal-title":"FEBS Lett"},{"key":"10.1016\/j.clinbiochem.2012.03.028_bb0120","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1111\/j.1538-7836.2004.01063.x","article-title":"Flow cytometric analysis of intraplatelet VASP phosphorilation for the detection of clopidogrel resistance in patients with ischemic cardiovascular diseases","volume":"3","author":"Aleil","year":"2005","journal-title":"J Thromb Haemost"},{"key":"10.1016\/j.clinbiochem.2012.03.028_bb0125","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1080\/09537100400005634","article-title":"Inhibitory effects of P2Y12 receptor antagonists on TRAP-induced platelet aggregation, procoagulant activity, microparticle formation and intracellular calcium responses in patients with acute coronary syndromes","volume":"2","author":"Behan","year":"2005","journal-title":"Platelets"},{"key":"10.1016\/j.clinbiochem.2012.03.028_bb0130","doi-asserted-by":"crossref","first-page":"30933","DOI":"10.1074\/jbc.M801472200","article-title":"Agonist-selective, receptor-specific interaction of human P2Y receptors with beta-arrestin-1 and -2","volume":"283","author":"Hoffmann","year":"2008","journal-title":"J Biol Chem"}],"container-title":["Clinical Biochemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0009912012001592?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0009912012001592?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,14]],"date-time":"2025-09-14T15:36:59Z","timestamp":1757864219000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0009912012001592"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,7]]},"references-count":26,"journal-issue":{"issue":"10-11","published-print":{"date-parts":[[2012,7]]}},"alternative-id":["S0009912012001592"],"URL":"https:\/\/doi.org\/10.1016\/j.clinbiochem.2012.03.028","relation":{},"ISSN":["0009-9120"],"issn-type":[{"value":"0009-9120","type":"print"}],"subject":[],"published":{"date-parts":[[2012,7]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Platelet proteome and clopidogrel response in patients with stable angina undergoing percutaneous coronary intervention","name":"articletitle","label":"Article Title"},{"value":"Clinical Biochemistry","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.clinbiochem.2012.03.028","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2012 The Canadian Society of Clinical Chemists. Published by Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}