{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T17:55:56Z","timestamp":1788285356352,"version":"build-2803163510"},"reference-count":129,"publisher":"Elsevier BV","issue":"16-17","license":[{"start":{"date-parts":[[2012,11,1]],"date-time":"2012-11-01T00:00:00Z","timestamp":1351728000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2012,11,1]],"date-time":"2012-11-01T00:00:00Z","timestamp":1351728000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/501100001868","name":"National Science Council of Taiwan","doi-asserted-by":"crossref","award":["100-2314-B-016-027"],"award-info":[{"award-number":["100-2314-B-016-027"]}],"id":[{"id":"10.13039\/501100001868","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100010425","name":"Tri-Service General Hospital","doi-asserted-by":"crossref","award":["TSGH-C101-009-S04"],"award-info":[{"award-number":["TSGH-C101-009-S04"]}],"id":[{"id":"10.13039\/501100010425","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Clinical Biochemistry"],"published-print":{"date-parts":[[2012,11]]},"DOI":"10.1016\/j.clinbiochem.2012.05.031","type":"journal-article","created":{"date-parts":[[2012,6,6]],"date-time":"2012-06-06T08:08:31Z","timestamp":1338970111000},"page":"1286-1294","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":48,"title":["Role of homocysteine in end-stage renal disease"],"prefix":"10.1016","volume":"45","author":[{"given":"Chia-Chao","family":"Wu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cai-Mei","family":"Zheng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuh-Feng","family":"Lin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lan","family":"Lo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Min-Tser","family":"Liao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kuo-Cheng","family":"Lu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.clinbiochem.2012.05.031_bb0005","doi-asserted-by":"crossref","first-page":"1782","DOI":"10.1001\/jama.2009.1488","article-title":"Cardiovascular and noncardiovascular mortality among patients starting dialysis","volume":"302","author":"de Jager","year":"2009","journal-title":"JAMA"},{"key":"10.1016\/j.clinbiochem.2012.05.031_bb0010","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1001\/jama.1994.03510250050033","article-title":"Effect of age and diagnosis on survival of older patients beginning chronic dialysis","volume":"271","author":"Byrne","year":"1994","journal-title":"JAMA"},{"key":"10.1016\/j.clinbiochem.2012.05.031_bb0015","first-page":"455","article-title":"Biomarkers for the prediction of mortality and morbidity in patients with renal replacement therapy","volume":"57","author":"Chaykovska","year":"2011","journal-title":"Clin Lab"},{"key":"10.1016\/j.clinbiochem.2012.05.031_bb0020","first-page":"672","article-title":"Nontraditional risk factors for cardiovascular disease in patients with chronic kidney disease. Nature clinical practice","volume":"4","author":"Kendrick","year":"2008","journal-title":"Nephrology"},{"key":"10.1016\/j.clinbiochem.2012.05.031_bb0025","doi-asserted-by":"crossref","first-page":"1763","DOI":"10.1161\/CIRCULATIONAHA.110.000588","article-title":"Homocysteine-lowering and cardiovascular disease outcomes in kidney transplant recipients: primary results from the Folic Acid for Vascular Outcome Reduction in Transplantation trial","volume":"123","author":"Bostom","year":"2011","journal-title":"Circulation"},{"key":"10.1016\/j.clinbiochem.2012.05.031_bb0030","doi-asserted-by":"crossref","first-page":"1379","DOI":"10.1161\/CIR.0b013e3181daa7c9","article-title":"Homocysteine lowering in end-stage renal disease: is there any cardiovascular benefit?","volume":"121","author":"de Koning","year":"2010","journal-title":"Circulation"},{"key":"10.1016\/j.clinbiochem.2012.05.031_bb0035","doi-asserted-by":"crossref","first-page":"1390","DOI":"10.1016\/j.metabol.2007.05.010","article-title":"Correlations between homocysteine levels and atherosclerosis in Japanese type 2 diabetic patients","volume":"56","author":"Anan","year":"2007","journal-title":"Metabolism"},{"key":"10.1016\/j.clinbiochem.2012.05.031_bb0040","doi-asserted-by":"crossref","first-page":"656","DOI":"10.1016\/j.metabol.2005.12.007","article-title":"Hyperhomocysteinemia is a significant risk factor for silent cerebral infarction in patients with chronic renal failure undergoing hemodialysis","volume":"55","author":"Anan","year":"2006","journal-title":"Metabolism"},{"key":"10.1016\/j.clinbiochem.2012.05.031_bb0045","doi-asserted-by":"crossref","first-page":"645","DOI":"10.1038\/labinvest.3780275","article-title":"Impaired homocysteine metabolism and atherothrombotic disease","volume":"81","author":"Durand","year":"2001","journal-title":"Lab Invest"},{"key":"10.1016\/j.clinbiochem.2012.05.031_bb0050","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1530\/EJE-07-0388","article-title":"Correlations of high-sensitivity C-reactive protein and atherosclerosis in Japanese type 2 diabetic patients","volume":"157","author":"Anan","year":"2007","journal-title":"Eur J Endocrinol"},{"key":"10.1016\/j.clinbiochem.2012.05.031_bb0055","doi-asserted-by":"crossref","first-page":"600","DOI":"10.1111\/j.1365-2362.1994.tb01111.x","article-title":"Plasma homocysteine in relation to serum cobalamin and blood folate in a psychogeriatric population","volume":"24","author":"Nilsson","year":"1994","journal-title":"Eur J Clin Invest"},{"key":"10.1016\/j.clinbiochem.2012.05.031_bb0060","first-page":"473","article-title":"Plasma homocysteine, a risk factor for vascular disease: plasma levels in health, disease, and drug therapy","volume":"114","author":"Ueland","year":"1989","journal-title":"J Lab Clin Med"},{"key":"10.1016\/j.clinbiochem.2012.05.031_bb0065","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1016\/0021-9150(95)05720-X","article-title":"Enhanced platelet thromboxane synthesis and reduced macrophage-dependent fibrinolytic activity related to oxidative stress in oral contraceptive-treated female rats","volume":"121","author":"Durand","year":"1996","journal-title":"Atherosclerosis"},{"key":"10.1016\/j.clinbiochem.2012.05.031_bb0070","doi-asserted-by":"crossref","first-page":"1281S","DOI":"10.1093\/jn\/126.suppl_4.1281S","article-title":"Reduced, oxidized and protein-bound forms of homocysteine and other aminothiols in plasma comprise the redox thiol status\u2014a possible element of the extracellular antioxidant defense system","volume":"126","author":"Ueland","year":"1996","journal-title":"J Nutr"},{"key":"10.1016\/j.clinbiochem.2012.05.031_bb0075","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1016\/0021-9150(95)05522-X","article-title":"Net uptake of plasma homocysteine by the rat kidney in vivo","volume":"116","author":"Bostom","year":"1995","journal-title":"Atherosclerosis"},{"key":"10.1016\/j.clinbiochem.2012.05.031_bb0080","doi-asserted-by":"crossref","first-page":"2497","DOI":"10.1172\/JCI116485","article-title":"Enzymatic methyl esterification of erythrocyte membrane proteins is impaired in chronic renal failure. Evidence for high levels of the natural inhibitor S-adenosylhomocysteine","volume":"91","author":"Perna","year":"1993","journal-title":"J Clin Invest"},{"key":"10.1016\/j.clinbiochem.2012.05.031_bb0085","doi-asserted-by":"crossref","first-page":"488","DOI":"10.1111\/j.1365-2796.2007.01777.x","article-title":"Impact of inflammation on epigenetic DNA methylation\u2014a novel risk factor for cardiovascular disease?","volume":"261","author":"Stenvinkel","year":"2007","journal-title":"J Intern Med"},{"key":"10.1016\/j.clinbiochem.2012.05.031_bb0090","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1055\/s-2005-872405","article-title":"Homocysteine and methionine metabolism in renal failure","volume":"5","author":"van Guldener","year":"2005","journal-title":"Semin Vasc Med"},{"key":"10.1016\/j.clinbiochem.2012.05.031_bb0095","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1016\/0167-4889(95)00094-9","article-title":"Metabolism of homocysteine, its relation to the other cellular thiols and its mechanism of cell damage in a cell culture line (human histiocytic cell line U-937)","volume":"1269","author":"Hultberg","year":"1995","journal-title":"Biochim Biophys Acta"},{"key":"10.1016\/j.clinbiochem.2012.05.031_bb0100","doi-asserted-by":"crossref","first-page":"2414","DOI":"10.1681\/ASN.V7112414","article-title":"Homocysteine and folate concentrations in blood from patients treated with hemodialysis","volume":"7","author":"Tamura","year":"1996","journal-title":"J Am Soc Nephrol"},{"key":"10.1016\/j.clinbiochem.2012.05.031_bb0105","doi-asserted-by":"crossref","first-page":"143","DOI":"10.3132\/dvdr.2007.033","article-title":"Homocysteine and cardiovascular disease: a review of the evidence","volume":"4","author":"Wierzbicki","year":"2007","journal-title":"Diab Vasc Dis Res"},{"key":"10.1016\/j.clinbiochem.2012.05.031_bb0110","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1373\/clinchem.2005.056119","article-title":"Effects of folic acid before and after vitamin B12 on plasma homocysteine concentrations in hemodialysis patients with known MTHFR genotypes","volume":"52","author":"Pastore","year":"2006","journal-title":"Clin Chem"},{"key":"10.1016\/j.clinbiochem.2012.05.031_bb0115","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1152\/physiolgenomics.00039.2010","article-title":"Lack of carotid stiffening associated with MTHFR 677TT genotype in cardiorespiratory fit adults","volume":"42","author":"Iemitsu","year":"2010","journal-title":"Physiol Genomics"},{"key":"10.1016\/j.clinbiochem.2012.05.031_bb0120","doi-asserted-by":"crossref","first-page":"993","DOI":"10.1053\/j.ajkd.2005.08.027","article-title":"Are homocysteine and MTHFR genotype polymorphism associated with arteriovenous fistula patency?","volume":"46","author":"Tai","year":"2005","journal-title":"Am J Kidney Dis"},{"key":"10.1016\/j.clinbiochem.2012.05.031_bb0125","doi-asserted-by":"crossref","first-page":"565","DOI":"10.1001\/jama.291.5.565","article-title":"Lowering homocysteine in patients with ischemic stroke to prevent recurrent stroke, myocardial infarction, and death: the Vitamin Intervention for Stroke Prevention (VISP) randomized controlled trial","volume":"291","author":"Toole","year":"2004","journal-title":"JAMA"},{"key":"10.1016\/j.clinbiochem.2012.05.031_bb0130","doi-asserted-by":"crossref","first-page":"1053","DOI":"10.1136\/bmj.38611.658947.55","article-title":"Meta-analysis of MTHFR 677C->T polymorphism and coronary heart disease: does totality of evidence support causal role for homocysteine and preventive potential of folate?","volume":"331","author":"Lewis","year":"2005","journal-title":"BMJ"},{"key":"10.1016\/j.clinbiochem.2012.05.031_bb0135","doi-asserted-by":"crossref","first-page":"382","DOI":"10.1093\/ndt\/gfh620","article-title":"The C677T methylenetetrahydrofolate reductase gene mutation does not influence cardiovascular risk in the dialysis population: results of a multicentre prospective study","volume":"20","author":"Aucella","year":"2005","journal-title":"Nephrol Dial Transplant"},{"key":"10.1016\/j.clinbiochem.2012.05.031_bb0140","first-page":"111","article-title":"Vascular pathology of homocysteinemia: implications for the pathogenesis of arteriosclerosis","volume":"56","author":"McCully","year":"1969","journal-title":"Am J Pathol"},{"key":"10.1016\/j.clinbiochem.2012.05.031_bb0145","doi-asserted-by":"crossref","first-page":"S131","DOI":"10.1046\/j.1523-1755.63.s84.7.x","article-title":"Homocysteine, renal function, and risk of cardiovascular disease","author":"Clarke","year":"2003","journal-title":"Kidney Int Suppl"},{"key":"10.1016\/j.clinbiochem.2012.05.031_bb0150","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1111\/j.1440-1797.2003.00210.x","article-title":"Homocysteine and cardiovascular disease in renal disease","volume":"8","author":"Austen","year":"2003","journal-title":"Nephrology (Carlton)"},{"key":"10.1016\/j.clinbiochem.2012.05.031_bb0155","doi-asserted-by":"crossref","first-page":"557","DOI":"10.1016\/j.atherosclerosis.2008.05.031","article-title":"Role of homocysteine in aortic calcification and osteogenic cell differentiation","volume":"202","author":"Van Campenhout","year":"2009","journal-title":"Atherosclerosis"},{"key":"10.1016\/j.clinbiochem.2012.05.031_bb0160","doi-asserted-by":"crossref","first-page":"1042","DOI":"10.1056\/NEJM199804093381507","article-title":"Homocysteine and atherothrombosis","volume":"338","author":"Welch","year":"1998","journal-title":"N Engl J Med"},{"key":"10.1016\/j.clinbiochem.2012.05.031_bb0165","doi-asserted-by":"crossref","first-page":"967","DOI":"10.1053\/euhj.1999.1914","article-title":"Homocysteine and atherothrombosis\u2014mechanisms for injury","volume":"21","author":"Thambyrajah","year":"2000","journal-title":"Eur Heart J"},{"key":"10.1016\/j.clinbiochem.2012.05.031_bb0170","doi-asserted-by":"crossref","first-page":"30","DOI":"10.2174\/157488410790410551","article-title":"Hyperhomocysteinemia and cardiovascular risk: effect of vitamin supplementation in risk reduction","volume":"5","author":"Ciaccio","year":"2010","journal-title":"Curr Clin Pharmacol"},{"key":"10.1016\/j.clinbiochem.2012.05.031_bb0175","first-page":"455","article-title":"Biomarkers for the prediction of mortality and morbidity in patients with renal replacement therapy","volume":"57","author":"Chaykovska","year":"2011","journal-title":"Clin Lab"},{"key":"10.1016\/j.clinbiochem.2012.05.031_bb0180","doi-asserted-by":"crossref","first-page":"1207","DOI":"10.1097\/00004872-200018090-00006","article-title":"Inflammation is associated with carotid atherosclerosis in dialysis patients. Creed Investigators. Cardiovascular Risk Extended Evaluation in Dialysis Patients","volume":"18","author":"Zoccali","year":"2000","journal-title":"J Hypertens"},{"key":"10.1016\/j.clinbiochem.2012.05.031_bb0185","doi-asserted-by":"crossref","first-page":"442","DOI":"10.1097\/01.ASN.0000107564.60018.51","article-title":"A low, rather than a high, total plasma homocysteine is an indicator of poor outcome in hemodialysis patients","volume":"15","author":"Kalantar-Zadeh","year":"2004","journal-title":"J Am Soc Nephrol"},{"key":"10.1016\/j.clinbiochem.2012.05.031_bb0190","first-page":"707","article-title":"Homocysteine lowering and cardiovascular disease risk: lost in translation","volume":"23","author":"Marcus","year":"2007","journal-title":"Can J Cardiol"},{"issue":"Suppl. 11","key":"10.1016\/j.clinbiochem.2012.05.031_bb0195","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1093\/ndt\/17.suppl_11.28","article-title":"The malnutrition, inflammation, and atherosclerosis (MIA) syndrome\u2014the heart of the matter","volume":"17","author":"Pecoits-Filho","year":"2002","journal-title":"Nephrol Dial Transplant"},{"key":"10.1016\/j.clinbiochem.2012.05.031_bb0200","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1111\/j.1749-6632.2010.05726.x","article-title":"Role of inflammation in cognitive impairment: results of observational epidemiological studies and clinical trials","volume":"1207","author":"Gorelick","year":"2010","journal-title":"Ann N Y Acad Sci"},{"key":"10.1016\/j.clinbiochem.2012.05.031_bb0205","doi-asserted-by":"crossref","first-page":"73635","DOI":"10.1155\/2007\/73635","article-title":"Evaluation of C-reactive protein, endothelin-1, adhesion molecule(s), and lipids as inflammatory markers in type 2 diabetes mellitus patients","volume":"2007","author":"el-Mesallamy","year":"2007","journal-title":"Mediators Inflamm"},{"key":"10.1016\/j.clinbiochem.2012.05.031_bb0210","doi-asserted-by":"crossref","first-page":"120","DOI":"10.1016\/S1056-8727(02)00204-0","article-title":"Associations between inflammatory markers, traditional risk factors, and complications in patients with type 2 diabetes mellitus","volume":"17","author":"Streja","year":"2003","journal-title":"J Diabetes Complications"},{"key":"10.1016\/j.clinbiochem.2012.05.031_bb0215","doi-asserted-by":"crossref","first-page":"1039","DOI":"10.1515\/CCLM.2005.182","article-title":"Hyperhomocysteinemia and response of methionine cycle intermediates to vitamin treatment in renal patients","volume":"43","author":"Herrmann","year":"2005","journal-title":"Clin Chem Lab Med"},{"key":"10.1016\/j.clinbiochem.2012.05.031_bb0220","doi-asserted-by":"crossref","first-page":"1175","DOI":"10.1042\/BST0351175","article-title":"Homocysteine metabolism in diabetes","volume":"35","author":"Wijekoon","year":"2007","journal-title":"Biochem Soc Trans"},{"key":"10.1016\/j.clinbiochem.2012.05.031_bb0225","doi-asserted-by":"crossref","first-page":"1234","DOI":"10.1016\/j.cca.2011.03.020","article-title":"Influence of diabetes on homocysteine-lowering therapy in chronic hemodialysis patients","volume":"412","author":"Lu","year":"2011","journal-title":"Clin Chim Acta"},{"key":"10.1016\/j.clinbiochem.2012.05.031_bb0230","doi-asserted-by":"crossref","first-page":"891","DOI":"10.1373\/clinchem.2004.044453","article-title":"Disturbed homocysteine and methionine cycle intermediates S-adenosylhomocysteine and S-adenosylmethionine are related to degree of renal insufficiency in type 2 diabetes","volume":"51","author":"Herrmann","year":"2005","journal-title":"Clin Chem"},{"key":"10.1016\/j.clinbiochem.2012.05.031_bb0235","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1186\/1475-2891-2-6","article-title":"Distribution of serum total homocysteine and its association with diabetes and cardiovascular risk factors of the insulin resistance syndrome in Mexican American men: the Third National Health and Nutrition Examination Survey","volume":"2","author":"Gillum","year":"2003","journal-title":"Nutr J"},{"key":"10.1016\/j.clinbiochem.2012.05.031_bb0240","doi-asserted-by":"crossref","first-page":"1967","DOI":"10.2337\/diabetes.47.12.1967","article-title":"Effects of streptozotocin-induced diabetes and of insulin treatment on homocysteine metabolism in the rat","volume":"47","author":"Jacobs","year":"1998","journal-title":"Diabetes"},{"key":"10.1016\/j.clinbiochem.2012.05.031_bb0245","first-page":"1","volume":"34","year":"2011","journal-title":"J Inherit Metab Dis"},{"key":"10.1016\/j.clinbiochem.2012.05.031_bb0250","doi-asserted-by":"crossref","first-page":"338","DOI":"10.1016\/j.cbpb.2008.04.002","article-title":"Hyperglycemia-induced membrane lipid peroxidation and elevated homocysteine levels are poorly attenuated by exogenous folate in embryonic chick brains","volume":"150","author":"Cole","year":"2008","journal-title":"Comp Biochem Physiol B Biochem Mol Biol"},{"key":"10.1016\/j.clinbiochem.2012.05.031_bb0255","doi-asserted-by":"crossref","first-page":"93","DOI":"10.33549\/physiolres.930135","article-title":"Unexpected inverse relationship between insulin resistance and serum homocysteine in healthy subjects","volume":"51","author":"Rosolova","year":"2002","journal-title":"Physiol Res"},{"key":"10.1016\/j.clinbiochem.2012.05.031_bb0260","doi-asserted-by":"crossref","first-page":"148","DOI":"10.1007\/s12199-008-0024-2","article-title":"Factors associated with serum total homocysteine level in type 2 diabetes","volume":"13","author":"Masuda","year":"2008","journal-title":"Environ Health Prev Med"},{"key":"10.1016\/j.clinbiochem.2012.05.031_bb0265","first-page":"175","article-title":"Metabolic consequences of peritoneal dialysis treatment","volume":"51","author":"Gallieni","year":"2009","journal-title":"Panminerva Med"},{"key":"10.1016\/j.clinbiochem.2012.05.031_bb0270","doi-asserted-by":"crossref","first-page":"1079","DOI":"10.1172\/JCI108350","article-title":"The pathogenesis of coronary artery disease. A possible role for methionine metabolism","volume":"57","author":"Wilcken","year":"1976","journal-title":"J Clin Invest"},{"key":"10.1016\/j.clinbiochem.2012.05.031_bb0275","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1097\/01.mnh.0000165896.98372.f4","article-title":"Folic acid supplementation to prevent adverse events in individuals with chronic kidney disease and end stage renal disease","volume":"14","author":"Gonin","year":"2005","journal-title":"Curr Opin Nephrol Hypertens"},{"key":"10.1016\/j.clinbiochem.2012.05.031_bb0280","doi-asserted-by":"crossref","first-page":"478","DOI":"10.1053\/j.ajkd.2009.01.266","article-title":"Homocysteine as a risk factor for cardiovascular disease in patients treated by dialysis: a meta-analysis","volume":"54","author":"Heinz","year":"2009","journal-title":"Am J Kidney Dis"},{"key":"10.1016\/j.clinbiochem.2012.05.031_bb0285","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1016\/S1051-2276(01)31274-8","article-title":"Homocysteine lowering effect of different multivitamin preparations in patients with end-stage renal disease","volume":"11","author":"Dierkes","year":"2001","journal-title":"J Ren Nutr"},{"key":"10.1016\/j.clinbiochem.2012.05.031_bb0290","doi-asserted-by":"crossref","first-page":"1106","DOI":"10.1681\/ASN.V1161106","article-title":"Effect of high dose folic acid therapy on hyperhomocysteinemia in hemodialysis patients: results of the Vienna multicenter study","volume":"11","author":"Sunder-Plassmann","year":"2000","journal-title":"J Am Soc Nephrol"},{"key":"10.1016\/j.clinbiochem.2012.05.031_bb0295","doi-asserted-by":"crossref","first-page":"725","DOI":"10.1007\/s11255-005-5791-8","article-title":"The effect of two different doses comprising the simultaneous administration of intravenous B-complex vitamins and oral folic acid on serum homocysteine levels in hemodialysis patients","volume":"38","author":"Sombolos","year":"2006","journal-title":"Int Urol Nephrol"},{"issue":"Suppl. 2","key":"10.1016\/j.clinbiochem.2012.05.031_bb0655","first-page":"S39","article-title":"Disorders of homocysteine metabolism: from rare genetic defects to common risk factors","volume":"157","year":"1998","journal-title":"Eur J Pediatr"},{"key":"10.1016\/j.clinbiochem.2012.05.031_bb0305","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1038\/ki.1996.19","article-title":"High dose-B-vitamin treatment of hyperhomocysteinemia in dialysis patients","volume":"49","author":"Bostom","year":"1996","journal-title":"Kidney Int"},{"key":"10.1016\/j.clinbiochem.2012.05.031_bb0310","first-page":"779","article-title":"Efficacy of folate and vitamin B12 in lowering homocysteine concentrations in hemodialysis patients","volume":"20","author":"Azadibakhsh","year":"2009","journal-title":"Saudi J Kidney Dis Transpl"},{"key":"10.1016\/j.clinbiochem.2012.05.031_bb0315","doi-asserted-by":"crossref","first-page":"1262","DOI":"10.1001\/archinte.167.12.1262","volume":"167","author":"Nanayakkara","year":"2007","journal-title":"Arch Intern Med"},{"key":"10.1016\/j.clinbiochem.2012.05.031_bb0320","doi-asserted-by":"crossref","first-page":"482","DOI":"10.2215\/CJN.05310610","article-title":"Folic acid therapy and cardiovascular disease in ESRD or advanced chronic kidney disease: a meta-analysis","volume":"6","author":"Qin","year":"2011","journal-title":"Clin J Am Soc Nephrol"},{"key":"10.1016\/j.clinbiochem.2012.05.031_bb0325","doi-asserted-by":"crossref","first-page":"1163","DOI":"10.1001\/jama.298.10.1163","article-title":"Effect of homocysteine lowering on mortality and vascular disease in advanced chronic kidney disease and end-stage renal disease: a randomized controlled trial","volume":"298","author":"Jamison","year":"2007","journal-title":"JAMA"},{"key":"10.1016\/j.clinbiochem.2012.05.031_bb0330","doi-asserted-by":"crossref","first-page":"1567","DOI":"10.1056\/NEJMoa060900","article-title":"Homocysteine lowering with folic acid and B vitamins in vascular disease","volume":"354","author":"Lonn","year":"2006","journal-title":"N Engl J Med"},{"key":"10.1016\/j.clinbiochem.2012.05.031_bb0335","doi-asserted-by":"crossref","first-page":"645","DOI":"10.1093\/ndt\/gfm485","article-title":"Homocysteine lowering with folic acid and B vitamins in people with chronic kidney disease\u2014results of the renal Hope-2 study","volume":"23","author":"Mann","year":"2008","journal-title":"Nephrol Dial Transplant"},{"key":"10.1016\/j.clinbiochem.2012.05.031_bb0340","doi-asserted-by":"crossref","first-page":"1603","DOI":"10.1001\/jama.2010.490","article-title":"Effect of B-vitamin therapy on progression of diabetic nephropathy: a randomized controlled trial","volume":"303","author":"House","year":"2010","journal-title":"JAMA"},{"key":"10.1016\/j.clinbiochem.2012.05.031_bb0345","first-page":"1","article-title":"Homocysteine-lowering therapy does not lead to reduction in cardiovascular outcomes in chronic kidney disease patients: a meta-analysis of randomised, controlled trials","author":"Pan","year":"2012","journal-title":"Br J Nutr"},{"key":"10.1016\/j.clinbiochem.2012.05.031_bb0350","doi-asserted-by":"crossref","first-page":"584","DOI":"10.1016\/S0140-6736(11)60872-6","article-title":"Effect modification by population dietary folate on the association between MTHFR genotype, homocysteine, and stroke risk: a meta-analysis of genetic studies and randomised trials","volume":"378","author":"Holmes","year":"2011","journal-title":"Lancet"},{"key":"10.1016\/j.clinbiochem.2012.05.031_bb0355","doi-asserted-by":"crossref","first-page":"11","DOI":"10.3945\/ajcn.2010.29427","article-title":"A dose-finding trial of the effect of long-term folic acid intervention: implications for food fortification policy","volume":"93","author":"Tighe","year":"2011","journal-title":"Am J Clin Nutr"},{"key":"10.1016\/j.clinbiochem.2012.05.031_bb0360","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1016\/0378-4347(87)80438-3","article-title":"Determination of free and total homocysteine in human plasma by high-performance liquid chromatography with fluorescence detection","volume":"422","author":"Araki","year":"1987","journal-title":"J Chromatogr"},{"key":"10.1016\/j.clinbiochem.2012.05.031_bb0365","first-page":"940","article-title":"Protective effects of N-acetylcysteine on homocysteine induced injury in chick embryos","volume":"2","author":"Han","year":"2010","journal-title":"Front Biosci (Elite Ed)"},{"key":"10.1016\/j.clinbiochem.2012.05.031_bb0370","doi-asserted-by":"crossref","first-page":"369","DOI":"10.1161\/01.CIR.0000109492.65802.AD","article-title":"Acetylcysteine reduces plasma homocysteine concentration and improves pulse pressure and endothelial function in patients with end-stage renal failure","volume":"109","author":"Scholze","year":"2004","journal-title":"Circulation"},{"key":"10.1016\/j.clinbiochem.2012.05.031_bb0375","doi-asserted-by":"crossref","first-page":"1588","DOI":"10.2215\/CJN.00210110","article-title":"Multiple-dose pharmacokinetics and pharmacodynamics of N-acetylcysteine in patients with end-stage renal disease","volume":"5","author":"Nolin","year":"2010","journal-title":"Clin J Am Soc Nephrol"},{"key":"10.1016\/j.clinbiochem.2012.05.031_bb0380","doi-asserted-by":"crossref","first-page":"336","DOI":"10.3747\/pdi.2009.00073","article-title":"Effect of oral N-acetylcysteine treatment on plasma inflammatory and oxidative stress markers in peritoneal dialysis patients: a placebo-controlled study","volume":"30","author":"Nascimento","year":"2010","journal-title":"Perit Dial Int"},{"key":"10.1016\/j.clinbiochem.2012.05.031_bb0385","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1053\/j.ajkd.2006.10.002","article-title":"The effect of mesna on plasma total homocysteine concentration in hemodialysis patients","volume":"49","author":"Urquhart","year":"2007","journal-title":"Am J Kidney Dis"},{"key":"10.1016\/j.clinbiochem.2012.05.031_bb0390","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1016\/0014-2999(95)00861-6","article-title":"The cardiovascular protective role of docosahexaenoic acid","volume":"300","author":"McLennan","year":"1996","journal-title":"Eur J Pharmacol"},{"key":"10.1016\/j.clinbiochem.2012.05.031_bb0395","doi-asserted-by":"crossref","first-page":"732","DOI":"10.1038\/sj.ejcn.1601871","article-title":"Evidence for a protective (synergistic?) effect of B-vitamins and omega-3 fatty acids on cardiovascular diseases","volume":"58","author":"de Bree","year":"2004","journal-title":"Eur J Clin Nutr"},{"key":"10.1016\/j.clinbiochem.2012.05.031_bb0400","doi-asserted-by":"crossref","first-page":"496","DOI":"10.1123\/ijsnem.20.6.496","article-title":"Effect of 6 Weeks of n-3 fatty-acid supplementation on oxidative stress in Judo athletes","volume":"20","author":"Filaire","year":"2010","journal-title":"Int J Sport Nutr Exerc Metab"},{"key":"10.1016\/j.clinbiochem.2012.05.031_bb0405","doi-asserted-by":"crossref","first-page":"584","DOI":"10.1161\/CIRCULATIONAHA.110.971853","article-title":"Omega-3 fatty acids prevent pressure overload-induced cardiac fibrosis through activation of cyclic GMP\/protein kinase G signaling in cardiac fibroblasts","volume":"123","author":"Chen","year":"2011","journal-title":"Circulation"},{"key":"10.1016\/j.clinbiochem.2012.05.031_bb0410","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1093\/jn\/130.2.129","article-title":"Folate and carcinogenesis: an integrated scheme","volume":"130","author":"Choi","year":"2000","journal-title":"J Nutr"},{"key":"10.1016\/j.clinbiochem.2012.05.031_bb0415","doi-asserted-by":"crossref","first-page":"762","DOI":"10.1017\/S1368980008002358","article-title":"Food, nutrition, physical activity and cancer prevention. Authoritative report from World Cancer Research Fund provides global update","volume":"11","author":"McMichael","year":"2008","journal-title":"Public Health Nutr"},{"key":"10.1016\/j.clinbiochem.2012.05.031_bb0420","doi-asserted-by":"crossref","first-page":"1171","DOI":"10.1093\/aje\/kwq491","article-title":"Dietary B vitamin and methionine intakes and breast cancer risk among Chinese women","volume":"173","author":"Shrubsole","year":"2011","journal-title":"Am J Epidemiol"},{"key":"10.1016\/j.clinbiochem.2012.05.031_bb0425","doi-asserted-by":"crossref","first-page":"3222","DOI":"10.1200\/JCO.2008.16.1943","article-title":"Prediagnostic plasma folate and the risk of death in patients with colorectal cancer","volume":"26","author":"Wolpin","year":"2008","journal-title":"J Clin Oncol"},{"key":"10.1016\/j.clinbiochem.2012.05.031_bb0430","first-page":"3191","article-title":"Chemopreventive effects of dietary folate on intestinal polyps in Apc+\/\u2212Msh2\u2212\/\u2212mice","volume":"60","author":"Song","year":"2000","journal-title":"Cancer Res"},{"key":"10.1016\/j.clinbiochem.2012.05.031_bb0435","doi-asserted-by":"crossref","first-page":"432","DOI":"10.1093\/jnci\/djp019","article-title":"Folic acid and risk of prostate cancer: results from a randomized clinical trial","volume":"101","author":"Figueiredo","year":"2009","journal-title":"J Natl Cancer Inst"},{"key":"10.1016\/j.clinbiochem.2012.05.031_bb0440","doi-asserted-by":"crossref","first-page":"2119","DOI":"10.1001\/jama.2009.1622","article-title":"Cancer incidence and mortality after treatment with folic acid and vitamin B12","volume":"302","author":"Ebbing","year":"2009","journal-title":"JAMA"},{"key":"10.1016\/j.clinbiochem.2012.05.031_bb0445","doi-asserted-by":"crossref","first-page":"384","DOI":"10.1111\/j.1440-1797.2008.00946.x","article-title":"Washout of water-soluble vitamins and of homocysteine during haemodialysis: effect of high-flux and low-flux dialyser membranes","volume":"13","author":"Heinz","year":"2008","journal-title":"Nephrology (Carlton)"},{"key":"10.1016\/j.clinbiochem.2012.05.031_bb0450","doi-asserted-by":"crossref","first-page":"2054","DOI":"10.1046\/j.1523-1755.1999.00437.x","article-title":"Peritoneal elimination of homocysteine moieties in continuous ambulatory peritoneal dialysis patients","volume":"55","author":"Vychytil","year":"1999","journal-title":"Kidney Int"},{"key":"10.1016\/j.clinbiochem.2012.05.031_bb0455","doi-asserted-by":"crossref","first-page":"154","DOI":"10.1093\/ndt\/14.1.154","article-title":"The impact of an amino acid-based peritoneal dialysis fluid on plasma total homocysteine levels, lipid profile and body fat mass","volume":"14","author":"Brulez","year":"1999","journal-title":"Nephrol Dial Transplant"},{"key":"10.1016\/j.clinbiochem.2012.05.031_bb0460","doi-asserted-by":"crossref","first-page":"571","DOI":"10.1111\/j.1440-1797.2005.00483.x","article-title":"Peritoneal clearance of homocysteine with icodextrin or standard glucose solution exchange","volume":"10","author":"Czupryniak","year":"2005","journal-title":"Nephrology (Carlton)"},{"key":"10.1016\/j.clinbiochem.2012.05.031_bb0465","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1681\/ASN.V61121","article-title":"Hyperhomocysteinemia and the risk for vascular disease in hemodialysis patients","volume":"6","author":"Bachmann","year":"1995","journal-title":"J Am Soc Nephrol"},{"key":"10.1016\/j.clinbiochem.2012.05.031_bb0470","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1016\/0021-9150(94)05470-4","article-title":"Hyperhomocysteinemia and traditional cardiovascular disease risk factors in end-stage renal disease patients on dialysis: a case\u2013control study","volume":"114","author":"Bostom","year":"1995","journal-title":"Atherosclerosis"},{"key":"10.1016\/j.clinbiochem.2012.05.031_bb0475","doi-asserted-by":"crossref","first-page":"2743","DOI":"10.1161\/01.CIR.94.11.2743","article-title":"Hyperhomocysteinemia confers an independent increased risk of atherosclerosis in end-stage renal disease and is closely linked to plasma folate and pyridoxine concentrations","volume":"94","author":"Robinson","year":"1996","journal-title":"Circulation"},{"key":"10.1016\/j.clinbiochem.2012.05.031_bb0480","doi-asserted-by":"crossref","first-page":"1775","DOI":"10.1046\/j.1523-1755.1998.00918.x","article-title":"Major determinants of hyperhomocysteinemia in peritoneal dialysis patients","volume":"53","author":"Vychytil","year":"1998","journal-title":"Kidney Int"},{"key":"10.1016\/j.clinbiochem.2012.05.031_bb0485","doi-asserted-by":"crossref","first-page":"1934","DOI":"10.1093\/ndt\/14.8.1934","article-title":"Cardiovascular morbidity and endothelial dysfunction in chronic haemodialysis patients: is homocyst(e)ine the missing link?","volume":"14","author":"Kunz","year":"1999","journal-title":"Nephrol Dial Transplant"},{"key":"10.1016\/j.clinbiochem.2012.05.031_bb0490","doi-asserted-by":"crossref","first-page":"669","DOI":"10.1016\/S0272-6386(99)70392-6","article-title":"Hyperhomocyst(e)inemia and the prevalence of atherosclerotic vascular disease in patients with end-stage renal disease","volume":"34","author":"Manns","year":"1999","journal-title":"Am J Kidney Dis"},{"key":"10.1016\/j.clinbiochem.2012.05.031_bb0495","doi-asserted-by":"crossref","first-page":"1727","DOI":"10.1046\/j.1523-1755.2000.00018.x","article-title":"Hyperhomocysteinemia, nutritional status, and cardiovascular disease in hemodialysis patients","volume":"57","author":"Suliman","year":"2000","journal-title":"Kidney Int"},{"key":"10.1016\/j.clinbiochem.2012.05.031_bb0500","first-page":"132","article-title":"Hyperhomocysteinemia, diabetes mellitus, and carotid atherosclerosis independently increase atherosclerotic vascular disease outcome in Japanese patients with end-stage renal disease","volume":"56","author":"Haraki","year":"2001","journal-title":"Clin Nephrol"},{"key":"10.1016\/j.clinbiochem.2012.05.031_bb0505","first-page":"365","article-title":"Elevated homocysteine levels in patients with end-stage renal disease","volume":"72","author":"Nair","year":"2005","journal-title":"Mt Sinai J Med"},{"key":"10.1016\/j.clinbiochem.2012.05.031_bb0510","doi-asserted-by":"crossref","first-page":"1106","DOI":"10.1046\/j.1523-1755.2001.0600031106.x","article-title":"An MTHFR variant, homocysteine, and cardiovascular comorbidity in renal disease","volume":"60","author":"Wrone","year":"2001","journal-title":"Kidney Int"},{"key":"10.1016\/j.clinbiochem.2012.05.031_bb0515","doi-asserted-by":"crossref","first-page":"656","DOI":"10.1016\/j.metabol.2005.12.007","article-title":"Hyperhomocysteinemia is a significant risk factor for silent cerebral infarction in patients with chronic renal failure undergoing hemodialysis","volume":"55","author":"Anan","year":"2006","journal-title":"Metabolism"},{"key":"10.1016\/j.clinbiochem.2012.05.031_bb0520","doi-asserted-by":"crossref","first-page":"2554","DOI":"10.1161\/01.ATV.17.11.2554","article-title":"Elevated fasting total plasma homocysteine levels and cardiovascular disease outcomes in maintenance dialysis patients. A prospective study","volume":"17","author":"Bostom","year":"1997","journal-title":"Arterioscler Thromb Vasc Biol"},{"key":"10.1016\/j.clinbiochem.2012.05.031_bb0525","doi-asserted-by":"crossref","first-page":"138","DOI":"10.1161\/01.CIR.97.2.138","article-title":"Prospective study of hyperhomocysteinemia as an adverse cardiovascular risk factor in end-stage renal disease","volume":"97","author":"Moustapha","year":"1998","journal-title":"Circulation"},{"key":"10.1016\/j.clinbiochem.2012.05.031_bb0530","doi-asserted-by":"crossref","first-page":"738","DOI":"10.1093\/ndt\/14.3.738","article-title":"Homocyst(e)ine and vascular access complications in haemodialysis patients: insights into a complex metabolic relationship","volume":"14","author":"Sirrs","year":"1999","journal-title":"Nephrol Dial Transplant"},{"key":"10.1016\/j.clinbiochem.2012.05.031_bb0535","doi-asserted-by":"crossref","first-page":"1964","DOI":"10.1161\/01.CIR.102.16.1964","article-title":"Cardiac troponin T predicts mortality in patients with end-stage renal disease","volume":"102","author":"Dierkes","year":"2000","journal-title":"Circulation"},{"key":"10.1016\/j.clinbiochem.2012.05.031_bb0540","doi-asserted-by":"crossref","first-page":"1417","DOI":"10.1111\/j.1523-1755.2002.kid562.x","article-title":"C-reactive protein and cardiovascular disease in peritoneal dialysis patients","volume":"62","author":"Ducloux","year":"2002","journal-title":"Kidney Int"},{"key":"10.1016\/j.clinbiochem.2012.05.031_bb0545","doi-asserted-by":"crossref","first-page":"609","DOI":"10.1046\/j.1523-1755.2002.00144.x","article-title":"Hyperhomocysteinemia predicts cardiovascular outcomes in hemodialysis patients","volume":"61","author":"Mallamaci","year":"2002","journal-title":"Kidney Int"},{"key":"10.1016\/j.clinbiochem.2012.05.031_bb0550","first-page":"405","article-title":"Plasma homocysteine levels and cardiovascular mortality in patients with end-stage renal disease","volume":"17","author":"Buccianti","year":"2004","journal-title":"J Nephrol"},{"key":"10.1016\/j.clinbiochem.2012.05.031_bb0555","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1038\/sj.ki.5000096","article-title":"Impact of malnutrition-inflammation on the association between homocysteine and mortality","volume":"69","author":"Ducloux","year":"2006","journal-title":"Kidney Int"},{"key":"10.1016\/j.clinbiochem.2012.05.031_bb0560","doi-asserted-by":"crossref","first-page":"517","DOI":"10.1038\/ki.1997.362","article-title":"Mutation (677 C to T) in the methylenetetrahydrofolate reductase gene aggravates hyperhomocysteinemia in hemodialysis patients","volume":"52","author":"Fodinger","year":"1997","journal-title":"Kidney Int"},{"key":"10.1016\/j.clinbiochem.2012.05.031_bb0565","doi-asserted-by":"crossref","first-page":"1072","DOI":"10.1046\/j.1523-1755.1999.0550031072.x","article-title":"Effect of MTHFR 677C>T on plasma total homocysteine levels in renal graft recipients","volume":"55","author":"Fodinger","year":"1999","journal-title":"Kidney Int"},{"key":"10.1016\/j.clinbiochem.2012.05.031_bb0570","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1053\/ajkd.2001.25197","article-title":"Association of two MTHFR polymorphisms with total homocysteine plasma levels in dialysis patients","volume":"38","author":"Fodinger","year":"2001","journal-title":"Am J Kidney Dis"},{"key":"10.1016\/j.clinbiochem.2012.05.031_bb0575","doi-asserted-by":"crossref","first-page":"1032","DOI":"10.1053\/ajkd.2002.32779","article-title":"Methylenetetrahydrofolate reductase genotype, vitamin B12, and folate influence plasma homocysteine in hemodialysis patients","volume":"39","author":"Nakamura","year":"2002","journal-title":"Am J Kidney Dis"},{"key":"10.1016\/j.clinbiochem.2012.05.031_bb0580","doi-asserted-by":"crossref","first-page":"1918","DOI":"10.1681\/ASN.V11101918","article-title":"Effect of MTHFR 1298A\u2013>C and MTHFR 677C\u2013>T genotypes on total homocysteine, folate, and vitamin B(12) plasma concentrations in kdiney graft recipients","volume":"11","author":"Fodinger","year":"2000","journal-title":"J Am Soc Nephrol"},{"key":"10.1016\/j.clinbiochem.2012.05.031_bb0585","doi-asserted-by":"crossref","first-page":"1980","DOI":"10.1111\/j.1523-1755.2005.00298.x","article-title":"Associations between MTHFR 1793G>A and plasma total homocysteine, folate, and vitamin B in kidney transplant recipients","volume":"67","author":"Winkelmayer","year":"2005","journal-title":"Kidney Int"},{"key":"10.1016\/j.clinbiochem.2012.05.031_bb0590","doi-asserted-by":"crossref","first-page":"956","DOI":"10.1053\/ajkd.2001.28581","article-title":"Increased prevalence of combined MTR and MTHFR genotypes among individuals with severely elevated total homocysteine plasma levels","volume":"38","author":"Feix","year":"2001","journal-title":"Am J Kidney Dis"},{"key":"10.1016\/j.clinbiochem.2012.05.031_bb0595","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1016\/j.atherosclerosis.2003.12.036","article-title":"Methionine synthase reductase MTRR 66A > G has no effect on total homocysteine, folate, and Vitamin B12 concentrations in renal transplant patients","volume":"174","author":"Feix","year":"2004","journal-title":"Atherosclerosis"},{"key":"10.1016\/j.clinbiochem.2012.05.031_bb0600","doi-asserted-by":"crossref","first-page":"1314","DOI":"10.1097\/01.ASN.0000064949.67401.D3","article-title":"Effect of glutamate carboxypeptidase II and reduced folate carrier polymorphisms on folate and total homocysteine concentrations in dialysis patients","volume":"14","author":"Fodinger","year":"2003","journal-title":"J Am Soc Nephrol"},{"key":"10.1016\/j.clinbiochem.2012.05.031_bb0605","doi-asserted-by":"crossref","first-page":"2280","DOI":"10.1046\/j.1523-1755.2003.00025.x","article-title":"Effects of the glutamate carboxypeptidase II (GCP2 1561C>T) and reduced folate carrier (RFC1 80G>A) allelic variants on folate and total homocysteine levels in kidney transplant patients","volume":"63","author":"Winkelmayer","year":"2003","journal-title":"Kidney Int"},{"key":"10.1016\/j.clinbiochem.2012.05.031_bb0610","doi-asserted-by":"crossref","first-page":"1095","DOI":"10.1046\/j.1523-1755.2003.00173.x","article-title":"Effect of TCN2 776C>G on vitamin B12 cellular availability in end-stage renal disease patients","volume":"64","author":"Fodinger","year":"2003","journal-title":"Kidney Int"},{"key":"10.1016\/j.clinbiochem.2012.05.031_bb0615","doi-asserted-by":"crossref","first-page":"1877","DOI":"10.1111\/j.1523-1755.2004.00592.x","article-title":"Effects of TCN2 776C>G on vitamin B, folate, and total homocysteine levels in kidney transplant patients","volume":"65","author":"Winkelmayer","year":"2004","journal-title":"Kidney Int"},{"key":"10.1016\/j.clinbiochem.2012.05.031_bb0620","first-page":"PI19","article-title":"Effects of folic acid treatment on homocysteine levels and vascular disease in hemodialysis patients","volume":"9","author":"Righetti","year":"2003","journal-title":"Med Sci Monit"},{"key":"10.1016\/j.clinbiochem.2012.05.031_bb0625","doi-asserted-by":"crossref","first-page":"420","DOI":"10.1097\/01.ASN.0000110181.64655.6C","article-title":"Randomized trial of folic acid for prevention of cardiovascular events in end-stage renal disease","volume":"15","author":"Wrone","year":"2004","journal-title":"J Am Soc Nephrol"},{"key":"10.1016\/j.clinbiochem.2012.05.031_bb0630","doi-asserted-by":"crossref","first-page":"379","DOI":"10.1159\/000093680","article-title":"Homocysteine-lowering vitamin B treatment decreases cardiovascular events in hemodialysis patients","volume":"24","author":"Righetti","year":"2006","journal-title":"Blood Purif"},{"key":"10.1016\/j.clinbiochem.2012.05.031_bb0635","doi-asserted-by":"crossref","first-page":"1108","DOI":"10.1016\/j.jacc.2005.10.064","article-title":"Cardiovascular morbidity and mortality in the Atherosclerosis and Folic Acid Supplementation Trial (ASFAST) in chronic renal failure: a multicenter, randomized, controlled trial","volume":"47","author":"Zoungas","year":"2006","journal-title":"J Am Coll Cardiol"},{"key":"10.1016\/j.clinbiochem.2012.05.031_bb0640","doi-asserted-by":"crossref","first-page":"210","DOI":"10.1111\/j.1542-4758.2007.00171.x","article-title":"Uremic hyperhomocysteinemia: a randomized trial of folate treatment for the prevention of cardiovascular events","volume":"11","author":"Vianna","year":"2007","journal-title":"Hemodial Int"},{"key":"10.1016\/j.clinbiochem.2012.05.031_bb0645","doi-asserted-by":"crossref","first-page":"1432","DOI":"10.1161\/CIRCULATIONAHA.109.904672","article-title":"B vitamins and the risk of total mortality and cardiovascular disease in end-stage renal disease: results of a randomized controlled trial","volume":"121","author":"Heinz","year":"2010","journal-title":"Circulation"}],"container-title":["Clinical Biochemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0009912012002664?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0009912012002664?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,14]],"date-time":"2025-09-14T15:38:44Z","timestamp":1757864324000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0009912012002664"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,11]]},"references-count":129,"journal-issue":{"issue":"16-17","published-print":{"date-parts":[[2012,11]]}},"alternative-id":["S0009912012002664"],"URL":"https:\/\/doi.org\/10.1016\/j.clinbiochem.2012.05.031","relation":{},"ISSN":["0009-9120"],"issn-type":[{"value":"0009-9120","type":"print"}],"subject":[],"published":{"date-parts":[[2012,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Role of homocysteine in end-stage renal disease","name":"articletitle","label":"Article Title"},{"value":"Clinical Biochemistry","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.clinbiochem.2012.05.031","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2012 The Canadian Society of Clinical Chemists. Published by Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}