{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,19]],"date-time":"2026-06-19T12:20:38Z","timestamp":1781871638702,"version":"3.54.5"},"reference-count":31,"publisher":"Elsevier BV","issue":"1-2","license":[{"start":{"date-parts":[[2013,1,1]],"date-time":"2013-01-01T00:00:00Z","timestamp":1356998400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2013,1,1]],"date-time":"2013-01-01T00:00:00Z","timestamp":1356998400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Clinical Biochemistry"],"published-print":{"date-parts":[[2013,1]]},"DOI":"10.1016\/j.clinbiochem.2012.10.023","type":"journal-article","created":{"date-parts":[[2012,10,24]],"date-time":"2012-10-24T14:48:31Z","timestamp":1351090111000},"page":"89-93","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":51,"title":["Possible relationship between Al\/ferritin complex and Alzheimer's disease"],"prefix":"10.1016","volume":"46","author":[{"given":"Pasquale","family":"De Sole","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cristina","family":"Rossi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michela","family":"Chiarpotto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gabriele","family":"Ciasca","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Beatrice","family":"Bocca","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alessandro","family":"Alimonti","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alessandra","family":"Bizzarro","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Concetta","family":"Rossi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carlo","family":"Masullo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.clinbiochem.2012.10.023_bb0005","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1016\/0005-2728(96)00022-9","article-title":"The ferritins: molecular properties, iron storage function and cellular regulation","volume":"1275","author":"Harrison","year":"1996","journal-title":"Biochim Biophys Acta"},{"key":"10.1016\/j.clinbiochem.2012.10.023_bb0010","doi-asserted-by":"crossref","first-page":"073703","DOI":"10.1063\/1.3685706","article-title":"Transient state kinetic investigation of ferritin iron release","volume":"100","author":"Ciasca","year":"2012","journal-title":"Appl Phys Lett"},{"key":"10.1016\/j.clinbiochem.2012.10.023_bb0015","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/0009-2797(89)90087-2","article-title":"The role of iron in oxygen radical mediated lipid peroxidation","volume":"71","author":"Minotti","year":"1989","journal-title":"Chem Biol Interact"},{"key":"10.1016\/j.clinbiochem.2012.10.023_bb0020","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1042\/bj2190001","article-title":"Oxygen toxicity, oxygen radicals, transition metals and disease","volume":"219","author":"Halliwell","year":"1984","journal-title":"Biochem J"},{"key":"10.1016\/j.clinbiochem.2012.10.023_bb0025","doi-asserted-by":"crossref","first-page":"1542","DOI":"10.1001\/archinte.159.14.1542","article-title":"Iron, atherosclerosis, and ischemic heart disease","volume":"159","author":"De Valk","year":"1999","journal-title":"Arch Intern Med"},{"key":"10.1016\/j.clinbiochem.2012.10.023_bb0030","doi-asserted-by":"crossref","first-page":"242","DOI":"10.1054\/mehy.2000.1052","article-title":"Iron catalyzed oxidative damage, in spite of normal ferritin and transferrin saturation levels and its possible role in Werner's syndrome, Parkinson's disease, cancer, gout, rheumatoid arthritis, etc","volume":"55","author":"Johnson","year":"2000","journal-title":"Med Hypotheses"},{"key":"10.1016\/j.clinbiochem.2012.10.023_bb0035","doi-asserted-by":"crossref","first-page":"18148","DOI":"10.1016\/S0021-9258(19)37165-0","article-title":"Ferritin: a cytoprotective antioxidant strategem of endothelium","volume":"267","author":"Balla","year":"1992","journal-title":"J Biol Chem"},{"key":"10.1016\/j.clinbiochem.2012.10.023_bb0040","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1002\/stem.5530120305","article-title":"Most free-radical injury is iron-related: it is promoted by iron, hemin, holoferritin and vitamin C, and inhibited by desferoxamine and apoferritin","volume":"12","author":"Herbert","year":"1994","journal-title":"Stem Cells"},{"key":"10.1016\/j.clinbiochem.2012.10.023_bb0045","doi-asserted-by":"crossref","first-page":"457","DOI":"10.1016\/S0891-5849(02)00842-0","article-title":"Ferritin, iron homeostasis, and oxidative damage","volume":"33","author":"Arosio","year":"2002","journal-title":"Free Radic Biol Med"},{"key":"10.1016\/j.clinbiochem.2012.10.023_bb0050","doi-asserted-by":"crossref","first-page":"1237","DOI":"10.1016\/S0891-5849(02)00825-0","article-title":"The iron regulatory proteins: targets and modulators of free radical reactions and oxidative damage","volume":"32","author":"Cairo","year":"2002","journal-title":"Free Radic Biol Med"},{"key":"10.1016\/j.clinbiochem.2012.10.023_bb0055","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1007\/BF02917242","article-title":"Ferritin a general metal detoxicant","volume":"21","author":"Joshi","year":"1989","journal-title":"Biol Trace Elem Res"},{"key":"10.1016\/j.clinbiochem.2012.10.023_bb0060","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1016\/S0162-0134(00)00046-5","article-title":"Vanadyl (IV) binding to mammalian ferritins. An EPR study aided by site-directed mutagenesis","volume":"80","author":"Grady","year":"2000","journal-title":"J Inorg Biochem"},{"key":"10.1016\/j.clinbiochem.2012.10.023_bb0065","doi-asserted-by":"crossref","first-page":"413","DOI":"10.1016\/0197-4580(91)90066-S","article-title":"Ferritin: the role of aluminium in ferritin function","volume":"12","author":"Fleming","year":"1991","journal-title":"Neurobiol Aging"},{"key":"10.1016\/j.clinbiochem.2012.10.023_bb0070","doi-asserted-by":"crossref","first-page":"264","DOI":"10.1016\/j.neulet.2004.05.045","article-title":"Accumulation of aluminum in ferritin isolated from rat brain","volume":"366","author":"Sakamoto","year":"2004","journal-title":"Neurosci Lett"},{"key":"10.1016\/j.clinbiochem.2012.10.023_bb0075","doi-asserted-by":"crossref","first-page":"621S","DOI":"10.1093\/ajcn\/71.2.621s","article-title":"Oxidative stress and Alzheimer disease","volume":"71","author":"Christen","year":"2000","journal-title":"Am J Clin Nutr"},{"key":"10.1016\/j.clinbiochem.2012.10.023_bb0080","doi-asserted-by":"crossref","first-page":"1654","DOI":"10.1016\/j.clinbiochem.2009.07.021","article-title":"Iron, zinc and aluminium ferritin content of hemodialysis hyperferritinemic patients: comparison with other hyperferritinemic clinical conditions and normoferritinemic blood donors","volume":"42","author":"Spada","year":"2009","journal-title":"Clin Biochem"},{"key":"10.1016\/j.clinbiochem.2012.10.023_bb0085","first-page":"545","article-title":"Molecular toxicity of aluminium in relation to neurodegeneration","volume":"128","author":"Bharathi","year":"2008","journal-title":"Indian J Med Res"},{"key":"10.1016\/j.clinbiochem.2012.10.023_bb0090","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1016\/S0162-0134(99)00125-7","article-title":"A molecular mechanism of aluminium-induced Alzheimer's disease?","volume":"76","author":"Exley","year":"1999","journal-title":"J Inorg Biochem"},{"key":"10.1016\/j.clinbiochem.2012.10.023_bb0095","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1007\/s00018-004-4317-3","article-title":"Aluminium in Alzheimer's disease: are we still at a crossroad?","volume":"62","author":"Bala","year":"2005","journal-title":"Cell Mol Life Sci"},{"key":"10.1016\/j.clinbiochem.2012.10.023_bb0100","doi-asserted-by":"crossref","first-page":"575","DOI":"10.1016\/j.neuro.2010.05.009","article-title":"The neurotoxicity of environmental aluminum is still an issue","volume":"31","author":"Bondy","year":"2010","journal-title":"Neurotoxicology"},{"key":"10.1016\/j.clinbiochem.2012.10.023_bb0105","doi-asserted-by":"crossref","first-page":"939","DOI":"10.1212\/WNL.34.7.939","article-title":"Clinical diagnosis of Alzheimer's disease: report of the NINCDS-ADRDA Work Group under the auspices of Department of Health and Human Services Task Force on Alzheimer's Disease","volume":"34","author":"McKhann","year":"1984","journal-title":"Neurology"},{"key":"10.1016\/j.clinbiochem.2012.10.023_bb0110","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1016\/0022-3956(75)90026-6","article-title":"\u201cMini-mental state\u201d. A practical method for grading the cognitive state of patients for the clinician","volume":"12","author":"Folstein","year":"1975","journal-title":"J Psychiatr Res"},{"key":"10.1016\/j.clinbiochem.2012.10.023_bb0115","doi-asserted-by":"crossref","first-page":"914","DOI":"10.1001\/jama.1963.03060120024016","article-title":"Studies of illness in the aged. The index of ADL. A standardized measure of biological and psychosocial function","volume":"185","author":"Katz","year":"1963","journal-title":"JAMA"},{"key":"10.1016\/j.clinbiochem.2012.10.023_bb0120","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1093\/geront\/9.3_Part_1.179","article-title":"Assessment of older people: self-maintaining and instrumental activities of daily living","volume":"9","author":"Lawton","year":"1969","journal-title":"Gerontologist"},{"key":"10.1016\/j.clinbiochem.2012.10.023_bb0125","doi-asserted-by":"crossref","first-page":"523","DOI":"10.1016\/S0009-9120(02)00380-6","article-title":"Relation between iron content of serum ferritin and clinical status factors extracted by factor analysis in patients with hyperferritinemia","volume":"35","author":"Yamanishi","year":"2002","journal-title":"Clin Biochem"},{"key":"10.1016\/j.clinbiochem.2012.10.023_bb0130","doi-asserted-by":"crossref","first-page":"997","DOI":"10.1016\/j.clinbiochem.2008.05.003","article-title":"Ferritin iron content in haemodialysis patients: comparison with septic and hemochromatosis patients","volume":"41","author":"Spada","year":"2008","journal-title":"Clin Biochem"},{"key":"10.1016\/j.clinbiochem.2012.10.023_bb0135","doi-asserted-by":"crossref","first-page":"567","DOI":"10.3233\/JAD-2010-101494","article-title":"Aluminum and Alzheimer's disease: after a century of controversy, is there a plausible link?","volume":"23","author":"Tomljenovic","year":"2011","journal-title":"J Alzheimers Dis"},{"key":"10.1016\/j.clinbiochem.2012.10.023_bb0140","doi-asserted-by":"crossref","first-page":"6149","DOI":"10.1007\/s11051-011-0294-2","article-title":"Reconstitution of aluminium and iron core in horse spleen apoferritin","volume":"13","author":"Ciasca","year":"2011","journal-title":"J Nanopart Res"},{"key":"10.1016\/j.clinbiochem.2012.10.023_bb0145","first-page":"207","article-title":"Ferritin: an iron storage protein with diverse functions","volume":"1","author":"Joshi","year":"1988","journal-title":"Biofactors"},{"key":"10.1016\/j.clinbiochem.2012.10.023_bb0150","doi-asserted-by":"crossref","first-page":"541","DOI":"10.1038\/349541a0","article-title":"Solving the structure of human H ferritin by genetically engineering intermolecular crystal contacts","volume":"349","author":"Lawson","year":"1991","journal-title":"Nature"},{"key":"10.1016\/j.clinbiochem.2012.10.023_bb0155","first-page":"1531","article-title":"Ferritin is associated with the aberrant tau filaments present in progressive supranuclear palsy","volume":"152","author":"Perez","year":"1998","journal-title":"Am J Pathol"}],"container-title":["Clinical Biochemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0009912012005784?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0009912012005784?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,14]],"date-time":"2025-09-14T15:39:56Z","timestamp":1757864396000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0009912012005784"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,1]]},"references-count":31,"journal-issue":{"issue":"1-2","published-print":{"date-parts":[[2013,1]]}},"alternative-id":["S0009912012005784"],"URL":"https:\/\/doi.org\/10.1016\/j.clinbiochem.2012.10.023","relation":{},"ISSN":["0009-9120"],"issn-type":[{"value":"0009-9120","type":"print"}],"subject":[],"published":{"date-parts":[[2013,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Possible relationship between Al\/ferritin complex and Alzheimer's disease","name":"articletitle","label":"Article Title"},{"value":"Clinical Biochemistry","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.clinbiochem.2012.10.023","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2012 The Canadian Society of Clinical Chemists. Published by Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}