{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,16]],"date-time":"2025-09-16T20:04:37Z","timestamp":1758053077804,"version":"3.44.0"},"reference-count":44,"publisher":"Elsevier BV","issue":"18","license":[{"start":{"date-parts":[[2013,12,1]],"date-time":"2013-12-01T00:00:00Z","timestamp":1385856000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2013,12,1]],"date-time":"2013-12-01T00:00:00Z","timestamp":1385856000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Clinical Biochemistry"],"published-print":{"date-parts":[[2013,12]]},"DOI":"10.1016\/j.clinbiochem.2013.09.011","type":"journal-article","created":{"date-parts":[[2013,9,21]],"date-time":"2013-09-21T00:53:54Z","timestamp":1379724834000},"page":"1798-1803","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":16,"title":["Altered red cell and platelet adhesion in hemolytic diseases: Hereditary spherocytosis, paroxysmal nocturnal hemoglobinuria and sickle cell disease"],"prefix":"10.1016","volume":"46","author":[{"given":"Tatiana M.","family":"Sakamoto","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andreia A.","family":"Canalli","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fabiola","family":"Traina","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carla F.","family":"Franco-Penteado","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sheley","family":"Gambero","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sara T.O.","family":"Saad","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nicola","family":"Conran","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fernando F.","family":"Costa","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.clinbiochem.2013.09.011_bb0005","doi-asserted-by":"crossref","first-page":"1383","DOI":"10.1038\/nm1202-799","article-title":"Cell-free hemoglobin limits nitric oxide bioavailability in sickle-cell disease","volume":"8","author":"Reiter","year":"2002","journal-title":"Nat Med"},{"key":"10.1016\/j.clinbiochem.2013.09.011_bb0010","doi-asserted-by":"crossref","first-page":"1237","DOI":"10.1016\/j.biocel.2006.01.010","article-title":"Sickle cell disease and nitric oxide: a paradigm shift?","volume":"38","author":"Mack","year":"2006","journal-title":"Int J Biochem Cell Biol"},{"key":"10.1016\/j.clinbiochem.2013.09.011_bb0015","doi-asserted-by":"crossref","first-page":"1653","DOI":"10.1001\/jama.293.13.1653","article-title":"The clinical sequelae of intravascular hemolysis and extracellular plasma hemoglobin: a novel mechanism of human disease","volume":"293","author":"Rother","year":"2005","journal-title":"JAMA"},{"key":"10.1016\/j.clinbiochem.2013.09.011_bb0020","doi-asserted-by":"crossref","first-page":"1289","DOI":"10.1111\/j.1538-7836.2008.03024.x","article-title":"Delayed adverse vascular events after splenectomy in hereditary spherocytosis","volume":"6","author":"Schilling","year":"2008","journal-title":"J Thromb Haemost"},{"key":"10.1016\/j.clinbiochem.2013.09.011_bb0025","doi-asserted-by":"crossref","first-page":"728","DOI":"10.1016\/j.exphem.2004.04.010","article-title":"Increased adhesive properties of eosinophils in sickle cell disease","volume":"32","author":"Canalli","year":"2004","journal-title":"Exp Hematol"},{"key":"10.1016\/j.clinbiochem.2013.09.011_bb0030","doi-asserted-by":"crossref","first-page":"330","DOI":"10.1111\/j.1600-0609.2007.00926.x","article-title":"Role for cAMP-protein kinase a signalling in augmented neutrophil adhesion and chemotaxis in sickle cell disease","volume":"79","author":"Canalli","year":"2007","journal-title":"Eur J Haematol"},{"key":"10.1016\/j.clinbiochem.2013.09.011_bb0035","doi-asserted-by":"crossref","first-page":"144","DOI":"10.1111\/j.1600-0609.2006.00788.x","article-title":"Therapy with hydroxyurea is associated with reduced adhesion molecule gene and protein expression in sickle red cells with a concomitant reduction in adhesive properties","volume":"78","author":"Gambero","year":"2007","journal-title":"Eur J Haematol"},{"key":"10.1016\/j.clinbiochem.2013.09.011_bb0040","doi-asserted-by":"crossref","first-page":"3545","DOI":"10.1182\/blood.V82.12.3548.3548","article-title":"Integrin alpha 4 beta 1 and glycoprotein IV (CD36) are expressed on circulating reticulocytes in sickle cell anemia","volume":"82","author":"Joneckis","year":"1993","journal-title":"Blood"},{"key":"10.1016\/j.clinbiochem.2013.09.011_bb0045","doi-asserted-by":"crossref","first-page":"771","DOI":"10.1016\/j.hoc.2005.08.002","article-title":"Sickle cell vaso-occlusion","volume":"19","author":"Chiang","year":"2005","journal-title":"Hematol Oncol Clin North Am"},{"key":"10.1016\/j.clinbiochem.2013.09.011_bb0050","doi-asserted-by":"crossref","first-page":"138","DOI":"10.1016\/j.tracli.2010.05.006","article-title":"Hereditary spherocytosis","volume":"17","author":"Iolascon","year":"2010","journal-title":"Transfus Clin Biol"},{"key":"10.1016\/j.clinbiochem.2013.09.011_bb0055","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1016\/j.tracli.2010.06.002","article-title":"Role of Lu\/BCAM glycoproteins in red cell diseases","volume":"17","author":"El Nemer","year":"2010","journal-title":"Transfus Clin Biol"},{"key":"10.1016\/j.clinbiochem.2013.09.011_bb0060","doi-asserted-by":"crossref","first-page":"369","DOI":"10.1016\/j.exphem.2007.12.003","article-title":"Oxidative status of red blood cells, neutrophils, and platelets in paroxysmal nocturnal hemoglobinuria","volume":"36","author":"Amer","year":"2007","journal-title":"Exp Hematol"},{"key":"10.1016\/j.clinbiochem.2013.09.011_bb0065","doi-asserted-by":"crossref","first-page":"398","DOI":"10.1182\/blood-2007-12-126714","article-title":"Vascular dysfunction in a murine model of severe hemolysis","volume":"112","author":"Frei","year":"2008","journal-title":"Blood"},{"key":"10.1016\/j.clinbiochem.2013.09.011_bb0070","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1016\/S0006-2952(03)00243-0","article-title":"Nitric oxide has a role in regulating VLA-4-integrin expression on the human neutrophil cell surface","volume":"66","author":"Conran","year":"2003","journal-title":"Biochem Pharmacol"},{"key":"10.1016\/j.clinbiochem.2013.09.011_bb0075","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1172\/JCI118074","article-title":"Nitric oxide decreases cytokines-induced endothelial activation. Nitric oxide selectively reduces endothelial expression of adhesion molecules and proinflammatory cytokines","volume":"96","author":"De Caterina","year":"1995","journal-title":"J Clin Invest"},{"key":"10.1016\/j.clinbiochem.2013.09.011_bb0080","doi-asserted-by":"crossref","first-page":"1529","DOI":"10.1016\/j.febslet.2007.02.072","article-title":"cGMP-independent inhibition of integrin alphaIIbbeta3-mediated platelet adhesion and outside-in signaling by nitric oxide","volume":"581","author":"Oberprieler","year":"2007","journal-title":"FEBS Lett"},{"key":"10.1016\/j.clinbiochem.2013.09.011_bb0085","doi-asserted-by":"crossref","first-page":"2166","DOI":"10.1182\/blood-2006-12-061697","article-title":"Platelet activation in patients with sickle disease, hemolysis-associated pulmonary hypertension, and nitric oxide scavenging by cell-free hemoglobin","volume":"110","author":"Villagra","year":"2007","journal-title":"Blood"},{"key":"10.1016\/j.clinbiochem.2013.09.011_bb0090","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1016\/j.blre.2007.10.002","article-title":"Advances in the diagnosis and therapy of paroxysmal nocturnal hemoglobinuria","volume":"22","author":"Brodsky","year":"2008","journal-title":"Blood Rev"},{"key":"10.1016\/j.clinbiochem.2013.09.011_bb0095","doi-asserted-by":"crossref","first-page":"444","DOI":"10.1006\/abio.1994.1066","article-title":"A colorimetric method for the measurement of platelet adhesion in microtiter plates","volume":"216","author":"Bellavite","year":"1994","journal-title":"Anal Biochem"},{"key":"10.1016\/j.clinbiochem.2013.09.011_bb0100","doi-asserted-by":"crossref","first-page":"1343","DOI":"10.1016\/S0140-6736(04)17192-4","article-title":"Sickle-cell disease","volume":"364","author":"Stuart","year":"2004","journal-title":"Lancet"},{"key":"10.1016\/j.clinbiochem.2013.09.011_bb0105","doi-asserted-by":"crossref","first-page":"723","DOI":"10.1097\/PAS.0b013e31821247a8","article-title":"CD71 is selectively and ubiquitously expressed at high levels in erythroid precursors of all maturation stages: a comparative immunochemical study with glycophorin A and hemoglobin A","volume":"35","author":"Dong","year":"2011","journal-title":"Am J Surg Pathol"},{"issue":"2","key":"10.1016\/j.clinbiochem.2013.09.011_bb0110","doi-asserted-by":"crossref","first-page":"130","DOI":"10.1016\/S0037-1963(00)90038-6","article-title":"Red blood cell surface adhesion molecules: their possible roles in normal human physiology and disease","volume":"37","author":"Telen","year":"2000","journal-title":"Semin Hematol"},{"key":"10.1016\/j.clinbiochem.2013.09.011_bb0115","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1111\/j.1365-2257.2007.00897.x","article-title":"Shortned lifespan of paroxysmal nocturnal haemoglobinuria-affected RBC estimated from differences in ratios of CD59-negative populations between reticulocytes and whole RBC","volume":"30","author":"Ninomiya","year":"2008","journal-title":"Int J Lab Hematol"},{"issue":"2","key":"10.1016\/j.clinbiochem.2013.09.011_bb0120","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1093\/ajcp\/52.2.167","article-title":"Lactic acid dehydrogenase activity and plasma hemoglobin elevations in sickle cell disease","volume":"52","author":"Neely","year":"1969","journal-title":"Am J Clin Pathol"},{"issue":"6","key":"10.1016\/j.clinbiochem.2013.09.011_bb0125","first-page":"2279","article-title":"Lactate dehydrogenase as a biomarker of hemolysis-associated nitric oxide resistance, priapism, leg ulceration, pulmonary hypertension, and death in patients with sickle cell disease","volume":"107","author":"Kato","year":"2006"},{"key":"10.1016\/j.clinbiochem.2013.09.011_bb0130","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1182\/blood-2012-10-462135","article-title":"Lactate dehydrogenase and hemolysis in sickle cell disease","volume":"121","author":"Ballas","year":"2013","journal-title":"Blood"},{"issue":"6","key":"10.1016\/j.clinbiochem.2013.09.011_bb0135","doi-asserted-by":"crossref","first-page":"1091","DOI":"10.1182\/blood-2013-05-505016","article-title":"Lactate dehydrogenase and hemolysis in sickle cell disease","volume":"122","author":"Kato","year":"2013","journal-title":"Blood"},{"key":"10.1016\/j.clinbiochem.2013.09.011_bb0140","doi-asserted-by":"crossref","first-page":"970","DOI":"10.1093\/annonc\/mdm595","article-title":"Prognostic significance of serial determinations of lactate dehydrogenase (LDH) in the follow-up of patients with myelodysplastic syndromes","volume":"19","author":"Wimazal","year":"2008","journal-title":"Ann Oncol"},{"issue":"1","key":"10.1016\/j.clinbiochem.2013.09.011_bb0145","doi-asserted-by":"crossref","first-page":"146","DOI":"10.1055\/s-0038-1646664","article-title":"Evaluation of platelet tests for measurement of cell integrity","volume":"39","author":"Akkerman","year":"1978","journal-title":"Thromb Haemost"},{"key":"10.1016\/j.clinbiochem.2013.09.011_bb0150","doi-asserted-by":"crossref","first-page":"632","DOI":"10.1038\/sj.bjp.0704295","article-title":"Nitric oxide regulates human eosinophil adhesion mechanisms in vitro by changing integrin expression and activity on the eosinophil cell surface","volume":"134","author":"Conran","year":"2001","journal-title":"Br J Pharmacol"},{"key":"10.1016\/j.clinbiochem.2013.09.011_bb0155","doi-asserted-by":"crossref","first-page":"481","DOI":"10.1046\/j.1365-2567.1999.00790.x","article-title":"Interferon-gamma regulates the interaction of RBL-2H3 cells with fibronectin through production of nitric oxide","volume":"97","author":"Wills","year":"1999","journal-title":"Immunology"},{"key":"10.1016\/j.clinbiochem.2013.09.011_bb0160","doi-asserted-by":"crossref","first-page":"710","DOI":"10.1182\/blood-2003-02-0492","article-title":"Increased erythrocyte adhesion in mice and humans with hereditary spherocytosis and hereditary elliptocytosis","volume":"103","author":"Wandersee","year":"2004","journal-title":"Blood"},{"key":"10.1016\/j.clinbiochem.2013.09.011_bb0165","doi-asserted-by":"crossref","first-page":"280","DOI":"10.1111\/j.1365-2141.2010.08087.x","article-title":"Increased adhesive properties of patients in sickle cell disease: roles for \u03b1IIb\u03b23-mediated ligand binding, diminished cAMP signaling and increased phosphodiesterase 3A activity","volume":"149","author":"Proen\u00e7a-Ferreira","year":"2009","journal-title":"Br J Haematol"},{"key":"10.1016\/j.clinbiochem.2013.09.011_bb0170","doi-asserted-by":"crossref","first-page":"4985","DOI":"10.1182\/blood-2012-09-311381","article-title":"Thrombosis in paroxysmal nocturnal hemoglobinuria","volume":"121","author":"Hill","year":"2013","journal-title":"Blood"},{"key":"10.1016\/j.clinbiochem.2013.09.011_bb0175","doi-asserted-by":"crossref","first-page":"573","DOI":"10.1007\/s002770100350","article-title":"Abnormal platelet adhesion on abdominal vessels in asymptomatic patients with paroxysmal nocturnal hemoglobinuria","volume":"80","author":"Louwes","year":"2001","journal-title":"Ann Hematol"},{"key":"10.1016\/j.clinbiochem.2013.09.011_bb0180","doi-asserted-by":"crossref","first-page":"1276","DOI":"10.1182\/blood-2012-11-451229","article-title":"Hemolysis and free hemoglobin revisited: exploring hemoglobin and hemin scavengers as a novel class of therapeutic proteins","volume":"121","author":"Schaer","year":"2013","journal-title":"Blood"},{"key":"10.1016\/j.clinbiochem.2013.09.011_bb0185","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1080\/03630260802625709","article-title":"Newer aspects of the pathophysiology of sickle cell disease vaso-occlusion","volume":"33","author":"Conran","year":"2009","journal-title":"Hemoglobin"},{"key":"10.1016\/j.clinbiochem.2013.09.011_bb0190","doi-asserted-by":"crossref","first-page":"641","DOI":"10.1007\/s00011-013-0633-0","article-title":"TNF-\u03b1 signalling and inflammation: interactions between old acquaintances","volume":"62","author":"Zelov\u00e1","year":"2013","journal-title":"Inflamm Res"},{"key":"10.1016\/j.clinbiochem.2013.09.011_bb0195","doi-asserted-by":"crossref","first-page":"587","DOI":"10.7326\/0003-4819-148-8-200804150-00003","article-title":"Narrative review: paroxysmal nocturnal hemoglobinuria: the physiology of complement-related hemolytic anemia","volume":"148","author":"Brodsky","year":"2008","journal-title":"Ann Intern Med"},{"key":"10.1016\/j.clinbiochem.2013.09.011_bb0200","series-title":"Williams hematology","first-page":"571","article-title":"Disorders of red blood cell membrane: hereditary spherocytosis, elliptocytosis and related disorders","author":"Gallagher","year":"2006"},{"key":"10.1016\/j.clinbiochem.2013.09.011_bb0205","doi-asserted-by":"crossref","first-page":"118","DOI":"10.1053\/j.seminhematol.2004.01.002","article-title":"Hereditary spherocytosis\u2014defects in proteins that connect the membrane skeleton to the lipid bilayer","volume":"41","author":"Eber","year":"2004","journal-title":"Semin Hematol"},{"key":"10.1016\/j.clinbiochem.2013.09.011_bb0210","doi-asserted-by":"crossref","first-page":"20","DOI":"10.3324\/haematol.11763","article-title":"Coagulation activation and inflammation in sickle cell disease-associated pulmonary hypertension","volume":"93","author":"Ataga","year":"2008","journal-title":"Haematologica"},{"key":"10.1016\/j.clinbiochem.2013.09.011_bb0215","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1189\/jlb.0708445","article-title":"Altered levels of cytokines and inflammatory mediators in plasma and leukocytes of sickle cell anemia patients and effects of hydroxyurea therapy","volume":"85","author":"Lanaro","year":"2009","journal-title":"J Leukoc Biol"},{"key":"10.1016\/j.clinbiochem.2013.09.011_bb0220","doi-asserted-by":"crossref","first-page":"3953","DOI":"10.1182\/blood-2002-10-3313","article-title":"Transgenic sickle mice have vascular inflammation","volume":"101","author":"Belcher","year":"2003","journal-title":"Blood"}],"container-title":["Clinical Biochemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0009912013004426?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0009912013004426?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,14]],"date-time":"2025-09-14T15:42:49Z","timestamp":1757864569000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0009912013004426"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,12]]},"references-count":44,"journal-issue":{"issue":"18","published-print":{"date-parts":[[2013,12]]}},"alternative-id":["S0009912013004426"],"URL":"https:\/\/doi.org\/10.1016\/j.clinbiochem.2013.09.011","relation":{},"ISSN":["0009-9120"],"issn-type":[{"type":"print","value":"0009-9120"}],"subject":[],"published":{"date-parts":[[2013,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Altered red cell and platelet adhesion in hemolytic diseases: Hereditary spherocytosis, paroxysmal nocturnal hemoglobinuria and sickle cell disease","name":"articletitle","label":"Article Title"},{"value":"Clinical Biochemistry","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.clinbiochem.2013.09.011","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2013 The Canadian Society of Clinical Chemists. Published by Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}