{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T09:53:58Z","timestamp":1782899638526,"version":"3.54.5"},"reference-count":31,"publisher":"Elsevier BV","issue":"18","license":[{"start":{"date-parts":[[2015,12,1]],"date-time":"2015-12-01T00:00:00Z","timestamp":1448928000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2015,12,1]],"date-time":"2015-12-01T00:00:00Z","timestamp":1448928000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2015,7,24]],"date-time":"2015-07-24T00:00:00Z","timestamp":1437696000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Clinical Biochemistry"],"published-print":{"date-parts":[[2015,12]]},"DOI":"10.1016\/j.clinbiochem.2015.07.023","type":"journal-article","created":{"date-parts":[[2015,7,22]],"date-time":"2015-07-22T12:45:37Z","timestamp":1437569137000},"page":"1330-1336","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":14,"title":["Development and evaluation of analytical performance of a fully automated chemiluminescent immunoassay for protein induced by vitamin K absence or antagonist II"],"prefix":"10.1016","volume":"48","author":[{"given":"Kenju","family":"Fujita","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hideki","family":"Kinukawa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kenichi","family":"Ohno","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yumiko","family":"Ito","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haruhisa","family":"Saegusa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Toru","family":"Yoshimura","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.clinbiochem.2015.07.023_bb0005","doi-asserted-by":"crossref","first-page":"2918","DOI":"10.1002\/ijc.25516","article-title":"Estimates of worldwide burden of cancer in 2008: GLOBOCAN 2008","volume":"127","author":"Ferlay","year":"2010","journal-title":"Int. J. Cancer"},{"key":"10.1016\/j.clinbiochem.2015.07.023_bb0010","author":"American Cancer Society"},{"key":"10.1016\/j.clinbiochem.2015.07.023_bb0015","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1016\/S1089-3261(05)70155-0","article-title":"Epidemiology of hepatocellular carcinoma","volume":"5","author":"El Serag","year":"2001","journal-title":"Clin. Liver Dis."},{"key":"10.1016\/j.clinbiochem.2015.07.023_bb0020","doi-asserted-by":"crossref","first-page":"529","DOI":"10.1016\/j.jhep.2006.05.013","article-title":"The contributions of hepatitis B virus and hepatitis C virus infections to cirrhosis and primary liver cancer worldwide","volume":"45","author":"Perz","year":"2006","journal-title":"J. Hepatol."},{"key":"10.1016\/j.clinbiochem.2015.07.023_bb0025","doi-asserted-by":"crossref","first-page":"1129","DOI":"10.1016\/S0140-6736(81)90585-7","article-title":"Hepatocellular carcinoma and hepatitis B virus. A prospective study of 22 707 men in Taiwan","volume":"2","author":"Beasley","year":"1981","journal-title":"Lancet"},{"key":"10.1016\/j.clinbiochem.2015.07.023_bb0030","first-page":"1326","article-title":"Viral pathogenesis of hepatocellular carcinoma in the United States","volume":"18","author":"Liang","year":"1993","journal-title":"Hepatology"},{"key":"10.1016\/j.clinbiochem.2015.07.023_bb0035","first-page":"69","article-title":"Global cancer statistics","volume":"61","author":"Jemal","year":"2011","journal-title":"CA Cancer J. Clin."},{"key":"10.1016\/j.clinbiochem.2015.07.023_bb0040","author":"National Cancer Institute"},{"key":"10.1016\/j.clinbiochem.2015.07.023_bb0045","doi-asserted-by":"crossref","first-page":"330","DOI":"10.1002\/hep.510310211","article-title":"Early detection of hepatocellular carcinoma increases the chance of treatment: Hong Kong experience","volume":"31","author":"Yuen","year":"2000","journal-title":"Hepatology"},{"key":"10.1016\/j.clinbiochem.2015.07.023_bb0050","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1002\/jso.2930530516","article-title":"Subclinical hepatocellular carcinoma: an analysis of 391 patients","volume":"3","author":"Tang","year":"1993","journal-title":"J. Surg. Oncol. Suppl."},{"key":"10.1016\/j.clinbiochem.2015.07.023_bb0055","doi-asserted-by":"crossref","first-page":"417","DOI":"10.1007\/s00432-004-0552-0","article-title":"Randomized controlled trial of screening for hepatocellular carcinoma","volume":"130","author":"Zhang","year":"2004","journal-title":"J. Cancer Res. Clin. Oncol."},{"key":"10.1016\/j.clinbiochem.2015.07.023_bb0060","doi-asserted-by":"crossref","first-page":"1470","DOI":"10.1111\/j.1572-0241.2004.30137.x","article-title":"Surveillance for hepatocellular carcinoma in elderly Italian patients with cirrhosis: effects on cancer staging and patient survival","volume":"99","author":"Trevisani","year":"2004","journal-title":"Am. J. Gastroenterol."},{"key":"10.1016\/j.clinbiochem.2015.07.023_bb0065","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1136\/gut.48.2.251","article-title":"Surveillance programme of cirrhotic patients for early diagnosis and treatment of hepatocellular carcinoma: a cost effectiveness analysis","volume":"48","author":"Bolondi","year":"2001","journal-title":"Gut"},{"key":"10.1016\/j.clinbiochem.2015.07.023_bb0070","first-page":"1152","article-title":"Can hepatocellular cancer screening increase the proportion of long-term survivors?","volume":"56","author":"Gannon","year":"2009","journal-title":"Hepatogastroenterology"},{"key":"10.1016\/j.clinbiochem.2015.07.023_bb0075","doi-asserted-by":"crossref","first-page":"2730","DOI":"10.1073\/pnas.71.7.2730","article-title":"Vitamin K dependent modifications of glutamic acid residues in prothrombin","volume":"71","author":"Stenflo","year":"1974","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.clinbiochem.2015.07.023_bb0080","doi-asserted-by":"crossref","first-page":"1427","DOI":"10.1056\/NEJM198405313102204","article-title":"Des-gamma-carboxy prothrombin (abnormal) prothrombin as a serum marker of primary hepatocellular carcinoma","volume":"310","author":"Liebman","year":"1984","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.clinbiochem.2015.07.023_bb0085","doi-asserted-by":"crossref","first-page":"1621","DOI":"10.1002\/1097-0142(19880415)61:8<1621::AID-CNCR2820610820>3.0.CO;2-C","article-title":"Plasma abnormal prothrombin (des-gamma-carboxy prothrombin) as a marker of hepatocellular carcinoma","volume":"61","author":"Fujiyama","year":"1988","journal-title":"Cancer"},{"key":"10.1016\/j.clinbiochem.2015.07.023_bb0090","doi-asserted-by":"crossref","first-page":"861","DOI":"10.1080\/00365520902903034","article-title":"Role of serum prothrombin induced by vitamin K absence or antagonist-II in the early detection of hepatocellular carcinoma in patients with chronic hepatitis B virus infection","volume":"44","author":"Yoon","year":"2009","journal-title":"Scand. J. Gastroenterol."},{"issue":"Suppl. 1","key":"10.1016\/j.clinbiochem.2015.07.023_bb0095","first-page":"16","article-title":"Clinical practice guidelines for hepatocellular carcinoma \u2014 the Japan society of hepatology 2009 update","volume":"40","author":"The Japan Society of Hepatology","year":"2010","journal-title":"Hepatol. Res."},{"key":"10.1016\/j.clinbiochem.2015.07.023_bb0100","doi-asserted-by":"crossref","first-page":"1032","DOI":"10.1046\/j.1365-2168.1999.01185.x","article-title":"Prognostic. significance of anatomical resection and des-gammacarboxy prothrombin in patients with hepatocellular carcinoma","volume":"86","author":"Imamura","year":"1999","journal-title":"Br. J. Surg."},{"key":"10.1016\/j.clinbiochem.2015.07.023_bb0105","first-page":"25","article-title":"Des-gamma-carboxyprothrombin expression in cancer and\/or non-cancer liver tissues: association with survival of patients with resectable hepatocellular carcinoma","volume":"13","author":"Tang","year":"2005","journal-title":"Oncol. Rep."},{"key":"10.1016\/j.clinbiochem.2015.07.023_bb0110","first-page":"2222","article-title":"Clinical significance of abnormal prothrombin (DCP) in relation to postoperative survival and prognosis in patients with hepatocellular carcinoma","volume":"89","author":"Inoue","year":"1994","journal-title":"Am. J. Gastroenterol."},{"key":"10.1016\/j.clinbiochem.2015.07.023_bb0115","doi-asserted-by":"crossref","first-page":"561","DOI":"10.1002\/1097-0142(20010201)91:3<561::AID-CNCR1035>3.0.CO;2-N","article-title":"Des-gamma-carboxy prothrombin as a useful predisposing factor for the development of portal venous invasion in patients with hepatocellular carcinoma: a prospective analysis of 227 patients","volume":"91","author":"Koike","year":"2001","journal-title":"Cancer"},{"key":"10.1016\/j.clinbiochem.2015.07.023_bb0120","doi-asserted-by":"crossref","first-page":"1557","DOI":"10.1002\/(SICI)1097-0142(20000401)88:7<1557::AID-CNCR9>3.0.CO;2-G","article-title":"Unique clinical characteristics of patients with hepatocellular carcinoma who present with high plasma des-gamma-carboxy prothrombin and low serum alpha-fetoprotein","volume":"88","author":"Hamamura","year":"2000","journal-title":"Cancer"},{"key":"10.1016\/j.clinbiochem.2015.07.023_bb0125","doi-asserted-by":"crossref","first-page":"3726","DOI":"10.1016\/S0021-9258(18)34841-5","article-title":"Decarboxylation of gamma-carboxyglutamic acid residues in human prothrombin","volume":"257","author":"Bajaj","year":"1982","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.clinbiochem.2015.07.023_bb0130","series-title":"CLSI Document EP5-A3","article-title":"Evaluation of precision performance of quantitative measurement methods; approved guideline","author":"CLSI","year":"2014"},{"key":"10.1016\/j.clinbiochem.2015.07.023_bb0135","series-title":"CLSI Document EP17\u2013A2","article-title":"Evaluation of detection capability for clinical laboratory measurement procedures; approved guideline","author":"CLSI","year":"2012"},{"key":"10.1016\/j.clinbiochem.2015.07.023_bb0140","series-title":"CLSI Document EP6-A","article-title":"Evaluation of the linearity of quantitative measurement procedures: a statistical approach","author":"CLSI","year":"2003"},{"key":"10.1016\/j.clinbiochem.2015.07.023_bb0145","series-title":"CLSI Document EP7-A2","article-title":"Interference testing in clinical chemistry; approved guideline","author":"CLSI","year":"2005"},{"key":"10.1016\/j.clinbiochem.2015.07.023_bb0150","first-page":"2656","article-title":"Development and performance of an assay kit for PIVKA-II (ED-038) by ECL technique","volume":"73","author":"Takatsu","year":"1996","journal-title":"Jpn. J. Clin. Exp. Med."},{"key":"10.1016\/j.clinbiochem.2015.07.023_bb0155","doi-asserted-by":"crossref","first-page":"1969","DOI":"10.1073\/pnas.74.5.1969","article-title":"Amino acid sequence of human prothrombin fragments 1 and 2","volume":"74","author":"Walz","year":"1977","journal-title":"Proc. Natl. Acad. Sci. U. S. A."}],"container-title":["Clinical Biochemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0009912015003033?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0009912015003033?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,14]],"date-time":"2025-09-14T15:47:03Z","timestamp":1757864823000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0009912015003033"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,12]]},"references-count":31,"journal-issue":{"issue":"18","published-print":{"date-parts":[[2015,12]]}},"alternative-id":["S0009912015003033"],"URL":"https:\/\/doi.org\/10.1016\/j.clinbiochem.2015.07.023","relation":{},"ISSN":["0009-9120"],"issn-type":[{"value":"0009-9120","type":"print"}],"subject":[],"published":{"date-parts":[[2015,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Development and evaluation of analytical performance of a fully automated chemiluminescent immunoassay for protein induced by vitamin K absence or antagonist II","name":"articletitle","label":"Article Title"},{"value":"Clinical Biochemistry","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.clinbiochem.2015.07.023","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2015 The Canadian Society of Clinical Chemists. Published by Elsevier Inc.","name":"copyright","label":"Copyright"}]}}