{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,2]],"date-time":"2025-11-02T20:10:51Z","timestamp":1762114251121,"version":"build-2065373602"},"reference-count":37,"publisher":"Elsevier BV","issue":"13-14","license":[{"start":{"date-parts":[[2016,9,1]],"date-time":"2016-09-01T00:00:00Z","timestamp":1472688000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2016,9,1]],"date-time":"2016-09-01T00:00:00Z","timestamp":1472688000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/501100005247","name":"University of British Columbia","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100005247","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001804","name":"Canada Research Chairs","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001804","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Clinical Biochemistry"],"published-print":{"date-parts":[[2016,9]]},"DOI":"10.1016\/j.clinbiochem.2016.03.007","type":"journal-article","created":{"date-parts":[[2016,4,15]],"date-time":"2016-04-15T00:15:32Z","timestamp":1460679332000},"page":"973-978","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":8,"title":["Reference interval of methylmalonic acid concentrations in dried blood spots of healthy, term newborns to facilitate neonatal screening of vitamin B12 deficiency"],"prefix":"10.1016","volume":"49","author":[{"given":"Theresa H.","family":"Schroder","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andre","family":"Mattman","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Graham","family":"Sinclair","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hilary D.","family":"Vallance","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yvonne","family":"Lamers","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.clinbiochem.2016.03.007_bb0005","doi-asserted-by":"crossref","first-page":"250","DOI":"10.1111\/j.1753-4887.2008.00031.x","article-title":"Effect of vitamin B12 deficiency on neurodevelopment in infants: current knowledge and possible mechanisms","volume":"66","author":"Dror","year":"2008","journal-title":"Nutr. Rev."},{"key":"10.1016\/j.clinbiochem.2016.03.007_bb0010","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1177\/15648265080292S114","article-title":"Effects of folate and vitamin B12 deficiencies during pregnancy on fetal, infant, and child development","volume":"29","author":"Molloy","year":"2008","journal-title":"Food Nutr. Bull."},{"key":"10.1016\/j.clinbiochem.2016.03.007_bb0015","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1177\/156482650802900401","article-title":"Vitamin B12 status of pregnant Indian women and cognitive function in their 9-year-old children","volume":"29","author":"Bhate","year":"2008","journal-title":"Food Nutr. Bull."},{"key":"10.1016\/j.clinbiochem.2016.03.007_bb0020","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1179\/147683009X388913","article-title":"Maternal MTHFR 677C>T genotype and dietary intake of folate and vitamin B12: their impact on child neurodevelopment","volume":"12","author":"del R\u00edo Garcia","year":"2009","journal-title":"Nutr. Neurosci."},{"key":"10.1016\/j.clinbiochem.2016.03.007_bb0025","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1067\/mpd.2001.112160","article-title":"Vitamin B12 deficiency in children and adolescents","volume":"138","author":"Rasmussen","year":"2001","journal-title":"J. Pediatr."},{"key":"10.1016\/j.clinbiochem.2016.03.007_bb0030","doi-asserted-by":"crossref","first-page":"792","DOI":"10.1007\/s10995-011-0782-0","article-title":"A longitudinal study of maternal folate and vitamin B12 status in pregnancy and postpartum, with the same infant markers at 6months of age","volume":"16","author":"Hure","year":"2012","journal-title":"Matern. Child Health J."},{"key":"10.1016\/j.clinbiochem.2016.03.007_bb0035","doi-asserted-by":"crossref","first-page":"3319","DOI":"10.3945\/jn.113.187278","article-title":"Vitamin B-12 supplementation during pregnancy and early lactation increases maternal, breast milk, and infant measures of vitamin B-12 status","volume":"144","author":"Duggan","year":"2014","journal-title":"J. Nutr."},{"key":"10.1016\/j.clinbiochem.2016.03.007_bb0040","doi-asserted-by":"crossref","first-page":"624","DOI":"10.1542\/peds.108.3.624","article-title":"Determinants of cobalamin status in newborns","volume":"108","author":"Bj\u00f8rke Monsen","year":"2001","journal-title":"J. Pediatr."},{"key":"10.1016\/j.clinbiochem.2016.03.007_bb0045","doi-asserted-by":"crossref","first-page":"3319","DOI":"10.1093\/jn\/134.12.3319","article-title":"Long-term ovo-lacto vegetarian diet impairs vitamin B-12 status in pregnant women","volume":"134","author":"Koebnick","year":"2004","journal-title":"J. Nutr."},{"key":"10.1016\/j.clinbiochem.2016.03.007_bb0050","doi-asserted-by":"crossref","first-page":"S20","DOI":"10.1177\/15648265080292S105","article-title":"Causes of vitamin B12 and folate deficiency","volume":"29","author":"Allen","year":"2008","journal-title":"Food Nutr. Bull."},{"key":"10.1016\/j.clinbiochem.2016.03.007_bb0055","doi-asserted-by":"crossref","first-page":"3932S","DOI":"10.1093\/jn\/133.11.3932S","article-title":"Nutritional importance of animal source foods","volume":"133","author":"Murphy","year":"2003","journal-title":"J. Nutr."},{"key":"10.1016\/j.clinbiochem.2016.03.007_bb0060","doi-asserted-by":"crossref","first-page":"162","DOI":"10.1016\/j.jpeds.2010.03.006","article-title":"Maternal and neonatal vitamin B12 deficiency detected through expanded newborn screening\u2014United States, 2003\u20132007","volume":"157","author":"Hinton","year":"2010","journal-title":"J. Pediatr."},{"key":"10.1016\/j.clinbiochem.2016.03.007_bb0065","doi-asserted-by":"crossref","first-page":"475","DOI":"10.1093\/qjmed\/hcn031","article-title":"High rate of maternal vitamin B12 deficiency nearly a decade after Canadian folic acid flour fortification","volume":"101","author":"Ray","year":"2008","journal-title":"QJM"},{"key":"10.1016\/j.clinbiochem.2016.03.007_bb0070","doi-asserted-by":"crossref","first-page":"1013","DOI":"10.1093\/ajcn\/62.5.1013","article-title":"Vitamin B-12 deficiency and malabsorption are highly prevalent in rural Mexican communities","volume":"62","author":"Allen","year":"1995","journal-title":"Am. J. Clin. Nutr."},{"key":"10.1016\/j.clinbiochem.2016.03.007_bb0075","doi-asserted-by":"crossref","first-page":"1073","DOI":"10.1093\/ajcn\/52.6.1073","article-title":"Vitamin B-12: low milk concentrations are related to low serum concentrations in vegetarian women and to methylmalonic aciduria in their infants","volume":"52","author":"Specker","year":"1990","journal-title":"Am. J. Clin. Nutr."},{"key":"10.1016\/j.clinbiochem.2016.03.007_bb0080","doi-asserted-by":"crossref","first-page":"348S","DOI":"10.3945\/ajcn.111.013441","article-title":"Biomarkers of cobalamin (vitamin B-12) status in the epidemiologic setting: a critical overview of context, applications, and performance characteristics of cobalamin, methylmalonic acid, and holotranscobalamin II","volume":"94","author":"Carmel","year":"2011","journal-title":"Am. J. Clin. Nutr."},{"key":"10.1016\/j.clinbiochem.2016.03.007_bb0085","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1016\/0002-9343(94)90149-X","article-title":"Sensitivity of serum methylmalonic acid and total homocysteine determinations for diagnosing cobalamin and folate deficiencies","volume":"96","author":"Savage","year":"1994","journal-title":"Am. J. Med."},{"key":"10.1016\/j.clinbiochem.2016.03.007_bb0090","doi-asserted-by":"crossref","first-page":"1769","DOI":"10.1373\/clinchem.2004.036194","article-title":"Screening for serum total homocysteine in newborn children","volume":"50","author":"Refsum","year":"2004","journal-title":"Clin. Chem."},{"key":"10.1016\/j.clinbiochem.2016.03.007_bb0095","doi-asserted-by":"crossref","first-page":"1364","DOI":"10.1373\/clinchem.2007.087775","article-title":"Rapid 2nd-tier test for measurement of 3-OH-propionic and methylmalonic acids on dried blood spots: reducing the false-positive rate for propionylcarnitine during expanded newborn screening by liquid chromatography\u2013tandem mass spectrometry","volume":"53","author":"la Marca","year":"2007","journal-title":"Clin. Chem."},{"key":"10.1016\/j.clinbiochem.2016.03.007_bb0100","doi-asserted-by":"crossref","first-page":"312","DOI":"10.1016\/j.clinbiochem.2014.08.020","article-title":"Maternal vitamin B12 deficiency detected in expanded newborn screening","volume":"47","author":"Scolamiero","year":"2014","journal-title":"Clin. Biochem."},{"key":"10.1016\/j.clinbiochem.2016.03.007_bb0105","doi-asserted-by":"crossref","first-page":"1686","DOI":"10.1373\/clinchem.2010.148957","article-title":"Determination of total homocysteine, methylmalonic acid, and 2-methylcitric acid in dried blood spots by tandem mass spectrometry","volume":"56","author":"Turgeon","year":"2010","journal-title":"Clin. Chem."},{"key":"10.1016\/j.clinbiochem.2016.03.007_bb0110","doi-asserted-by":"crossref","first-page":"S21","DOI":"10.1007\/s00431-003-1345-1","article-title":"The impact of screening for propionic and methylmalonic acidaemia","volume":"162","author":"Leonard","year":"2003","journal-title":"Eur. J. Pediatr."},{"key":"10.1016\/j.clinbiochem.2016.03.007_bb0115","doi-asserted-by":"crossref","first-page":"1658","DOI":"10.3945\/jn.114.194829","article-title":"Methylmalonic acid quantified in dried blood spots provides a precise, valid, and stable measure of functional vitamin B-12 status in healthy women","volume":"144","author":"Schroder","year":"2014","journal-title":"J. Nutr."},{"key":"10.1016\/j.clinbiochem.2016.03.007_bb0120","article-title":"Vitamin B12 deficiency in infancy: the case for screening","author":"Singh","year":"2015","journal-title":"Pediatr. Blood Cancer"},{"year":"2008","series-title":"Defining, Establishing, and Verifying Reference Intervals in the Clinical Laboratory, Approved Guideline, CLSI Document EP28-A3c","author":"Clinical and Laboratory Standards Institute","key":"10.1016\/j.clinbiochem.2016.03.007_bb0125"},{"key":"10.1016\/j.clinbiochem.2016.03.007_bb0130","doi-asserted-by":"crossref","first-page":"622","DOI":"10.1093\/clinchem\/44.3.622","article-title":"A robust approach to reference interval estimation and evaluation","volume":"44","author":"Horn","year":"1998","journal-title":"Clin. Chem."},{"key":"10.1016\/j.clinbiochem.2016.03.007_bb0135","doi-asserted-by":"crossref","first-page":"2284","DOI":"10.1093\/clinchem\/45.12.2284","article-title":"Reference interval computation using robust vs parametric and nonparametric analyses","volume":"45","author":"Horn","year":"1999","journal-title":"Clin. Chem."},{"key":"10.1016\/j.clinbiochem.2016.03.007_bb0140","doi-asserted-by":"crossref","first-page":"2137","DOI":"10.1093\/clinchem\/47.12.2137","article-title":"Effect of outliers and nonhealthy individuals on reference interval estimation","volume":"47","author":"Horn","year":"2001","journal-title":"Clin. Chem."},{"key":"10.1016\/j.clinbiochem.2016.03.007_bb0145","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1373\/clinchem.2004.040022","article-title":"Diagnosis of methylmalonic acidemia from dried blood spots by HPLC and intramolecular-excimer fluorescence derivatization","volume":"51","author":"Al-Dirbashi","year":"2005","journal-title":"Clin. Chem."},{"key":"10.1016\/j.clinbiochem.2016.03.007_bb0150","doi-asserted-by":"crossref","first-page":"435","DOI":"10.1016\/j.aca.2014.10.043","article-title":"Suitability of methylmalonic acid and total homocysteine analysis in dried bloodspots","volume":"853","author":"de Sain-van der Velden","year":"2015","journal-title":"Anal. Chim. Acta"},{"key":"10.1016\/j.clinbiochem.2016.03.007_bb0155","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1007\/s10545-010-9111-9","article-title":"Useful second-tier tests in expanded newborn screening of isovaleric acidemia and methylmalonic aciduria","volume":"33","author":"Shigematsu","year":"2010","journal-title":"J. Inherit. Metab. Dis."},{"key":"10.1016\/j.clinbiochem.2016.03.007_bb0160","doi-asserted-by":"crossref","first-page":"2067","DOI":"10.1373\/clinchem.2003.019869","article-title":"Cobalamin status and its biochemical markers methylmalonic acid and homocysteine in different age groups from 4days to 19years","volume":"49","author":"Bj\u00f8rke Monsen","year":"2003","journal-title":"Clin. Chem."},{"key":"10.1016\/j.clinbiochem.2016.03.007_bb0165","doi-asserted-by":"crossref","first-page":"1279","DOI":"10.1139\/apnm-2015-0200","article-title":"High prevalence of suboptimal vitamin B12 status in young adult women of South Asian and European ethnicity","volume":"40","author":"Quay","year":"2015","journal-title":"Appl. Physiol. Nutr. Metab."},{"key":"10.1016\/j.clinbiochem.2016.03.007_bb0170","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1093\/ajcn\/82.1.133","article-title":"Biochemical indexes of the B vitamins in cord serum are predicted by maternal B vitamin status","volume":"82","author":"Obeid","year":"2005","journal-title":"Am. J. Clin. Nutr."},{"key":"10.1016\/j.clinbiochem.2016.03.007_bb0175","doi-asserted-by":"crossref","first-page":"1863","DOI":"10.1093\/jn\/137.8.1863","article-title":"Longitudinal study of the effect of pregnancy on maternal and fetal cobalamin status in healthy women and their offspring","volume":"137","author":"Murphy","year":"2007","journal-title":"J. Nutr."},{"key":"10.1016\/j.clinbiochem.2016.03.007_bb0180","doi-asserted-by":"crossref","first-page":"1183","DOI":"10.1007\/s40262-015-0298-7","article-title":"Effect of kidney function on drug kinetics and dosing in neonates, infants, and children","volume":"54","author":"Rodieux","year":"2015","journal-title":"Clin. Pharmacokinet."},{"key":"10.1016\/j.clinbiochem.2016.03.007_bb0185","doi-asserted-by":"crossref","first-page":"593","DOI":"10.1079\/BJN20041395","article-title":"The influence of erythrocyte folate and serum vitamin B12 status on birth weight","volume":"93","author":"Relton","year":"2005","journal-title":"Br. J. Nutr."}],"container-title":["Clinical Biochemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0009912016300030?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0009912016300030?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,2]],"date-time":"2025-11-02T20:09:17Z","timestamp":1762114157000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0009912016300030"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,9]]},"references-count":37,"journal-issue":{"issue":"13-14","published-print":{"date-parts":[[2016,9]]}},"alternative-id":["S0009912016300030"],"URL":"https:\/\/doi.org\/10.1016\/j.clinbiochem.2016.03.007","relation":{},"ISSN":["0009-9120"],"issn-type":[{"type":"print","value":"0009-9120"}],"subject":[],"published":{"date-parts":[[2016,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Reference interval of methylmalonic acid concentrations in dried blood spots of healthy, term newborns to facilitate neonatal screening of vitamin B12 deficiency","name":"articletitle","label":"Article Title"},{"value":"Clinical Biochemistry","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.clinbiochem.2016.03.007","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2016 The Canadian Society of Clinical Chemists. Published by Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}