{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,17]],"date-time":"2026-09-17T00:54:05Z","timestamp":1789606445305,"version":"build-2803163510"},"reference-count":27,"publisher":"Elsevier BV","issue":"1-2","license":[{"start":{"date-parts":[[2017,1,1]],"date-time":"2017-01-01T00:00:00Z","timestamp":1483228800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2017,1,1]],"date-time":"2017-01-01T00:00:00Z","timestamp":1483228800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Clinical Biochemistry"],"published-print":{"date-parts":[[2017,1]]},"DOI":"10.1016\/j.clinbiochem.2016.09.006","type":"journal-article","created":{"date-parts":[[2016,9,8]],"date-time":"2016-09-08T20:12:41Z","timestamp":1473365561000},"page":"27-31","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":9,"title":["Sample-dependent diagnostic accuracy of prostaglandin D synthase in cerebrospinal fluid leak"],"prefix":"10.1016","volume":"50","author":[{"given":"Daniel","family":"Morell-Garcia","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Josep Miquel","family":"Bau\u00e7a","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M. Pilar","family":"Sastre","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aina","family":"Ya\u00f1ez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Isabel","family":"Llompart","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.clinbiochem.2016.09.006_bb0005","doi-asserted-by":"crossref","first-page":"1052","DOI":"10.1373\/clinchem.2013.211714","article-title":"Peptidomics of urine and other biofluids for cancer diagnostics","volume":"60","author":"Bau\u00e7a","year":"2014","journal-title":"Clin. Chem."},{"key":"10.1016\/j.clinbiochem.2016.09.006_bb0010","doi-asserted-by":"crossref","first-page":"386","DOI":"10.1021\/pr070501k","article-title":"Integrated analysis of the cerebrospinal fluid peptidome and proteome","volume":"7","author":"Zougman","year":"2008","journal-title":"J. Proteome Res."},{"key":"10.1016\/j.clinbiochem.2016.09.006_bb0015","doi-asserted-by":"crossref","first-page":"425","DOI":"10.1177\/000456329002700503","article-title":"Laboratory investigation of cerebrospinal fluid proteins","volume":"27","author":"Thompson","year":"1990","journal-title":"Ann. Clin. Biochem."},{"key":"10.1016\/j.clinbiochem.2016.09.006_bb0020","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0042555","article-title":"Peptidome analysis of cerebrospinal fluid by LC-MALDI MS","volume":"7","author":"H\u00f6ltt\u00e4","year":"2012","journal-title":"PLoS One"},{"key":"10.1016\/j.clinbiochem.2016.09.006_bb0025","doi-asserted-by":"crossref","first-page":"425","DOI":"10.1177\/019459989110400402","article-title":"Primary spontaneous cerebrospinal fluid rhinorrhea","volume":"104","author":"Beckhardt","year":"1991","journal-title":"Otolaryngol. Head Neck Surg."},{"key":"10.1016\/j.clinbiochem.2016.09.006_bb0030","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1177\/000348949910800401","article-title":"What is \u201cspontaneous\u201d cerebrospinal fluid rhinorrhea? Classification of cerebrospinal fluid leaks","volume":"108","author":"Har-El","year":"1999","journal-title":"Ann. Otol. Rhinol. Laryngol."},{"key":"10.1016\/j.clinbiochem.2016.09.006_bb0035","doi-asserted-by":"crossref","first-page":"991","DOI":"10.1097\/00005537-200406000-00007","article-title":"Comprehensive algorithm for skull base dural lesion and cerebrospinal fluid fistula diagnosis","volume":"114","author":"Meco","year":"2004","journal-title":"Laryngoscope"},{"key":"10.1016\/j.clinbiochem.2016.09.006_bb0040","doi-asserted-by":"crossref","first-page":"749","DOI":"10.1001\/archotol.1997.01900070093016","article-title":"Prophylactic antibiotics for posttraumatic cerebrospinal fluid fistulae: a meta-analysis","volume":"123","author":"Brodie","year":"1997","journal-title":"Arch. Otolaryngol. Head Neck Surg."},{"key":"10.1016\/j.clinbiochem.2016.09.006_bb0045","doi-asserted-by":"crossref","first-page":"661","DOI":"10.1373\/clinchem.2003.024158","article-title":"Comparison of \u03b22-transferrin and \u03b2-trace protein for detection of cerebrospinal fluid in nasal and ear fluids","volume":"50","author":"Schnabel","year":"2004","journal-title":"Clin. Chem."},{"key":"10.1016\/j.clinbiochem.2016.09.006_bb0050","doi-asserted-by":"crossref","first-page":"1110","DOI":"10.1006\/bbrc.1994.2297","article-title":"Identification of beta-trace as prostaglandin D synthase","volume":"203","author":"Watanabe","year":"1994","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.clinbiochem.2016.09.006_bb0055","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1016\/S0009-8981(01)00573-3","article-title":"Dynamics of brain-derived proteins in cerebrospinal fluid","volume":"20","author":"Reiber","year":"2001","journal-title":"Clin. Chim. Acta"},{"key":"10.1016\/j.clinbiochem.2016.09.006_bb0060","doi-asserted-by":"crossref","first-page":"764","DOI":"10.1007\/BF01743251","article-title":"Beta-trace protein as marker for cerebrospinal fluid fistula","volume":"65","author":"Felgenhauer","year":"1987","journal-title":"Klin. Wochenschr."},{"key":"10.1016\/j.clinbiochem.2016.09.006_bb0065","doi-asserted-by":"crossref","first-page":"463","DOI":"10.1016\/S0090-6980(97)00062-2","article-title":"Prostaglandin D synthase concentration in cerebrospinal fluid and serum of patients with neurological disorders","volume":"54","author":"Melengos","year":"1997","journal-title":"Prostaglandins"},{"key":"10.1016\/j.clinbiochem.2016.09.006_bb0070","first-page":"508","article-title":"Beta-trace protein test: new guidelines for the reliable diagnosis of cerebrospinal fluid fistula","volume":"129","author":"Meco","year":"2003","journal-title":"Otolaryngol. Head Neck Surg."},{"key":"10.1016\/j.clinbiochem.2016.09.006_bb0075","first-page":"82","article-title":"Diagnostic values of beta-2 transferrin and beta-trace protein as markers for cerebrospinal fluid fistula","volume":"46","author":"Bachmann-Harildstad","year":"2008","journal-title":"Rhinology"},{"key":"10.1016\/j.clinbiochem.2016.09.006_bb0080","doi-asserted-by":"crossref","first-page":"585","DOI":"10.2500\/ajra.2009.23.3409","article-title":"Predictability of quantification of beta-trace protein for diagnosis of cerebrospinal fluid leak: cutoff determination in nasal fluids with two control groups","volume":"23","author":"Sampaio","year":"2009","journal-title":"Am. J. Rhinol. Allergy"},{"key":"10.1016\/j.clinbiochem.2016.09.006_bb0085","doi-asserted-by":"crossref","first-page":"382","DOI":"10.1007\/s002160050078","article-title":"Quantification of beta-trace protein and detection of transferrin isoforms in mixtures of cerebrospinal fluid and blood serum as models of rhinorrhea and otorrhea diagnosis","volume":"366","author":"Kleine TO","year":"2000","journal-title":"Fresenius J. Anal. Chem."},{"key":"10.1016\/j.clinbiochem.2016.09.006_bb0090","doi-asserted-by":"crossref","first-page":"359","DOI":"10.1034\/j.1600-0404.2003.00173.x","article-title":"Beta-trace protein as sensitive marker for CSF rhinorrhea and CSF otorhea","volume":"108","author":"Reiber","year":"2003","journal-title":"Acta Neurol. Scand."},{"key":"10.1016\/j.clinbiochem.2016.09.006_bb0095","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1016\/j.cccn.2004.09.008","article-title":"Rapid, accurate and non-invasive detection of cerebrospinal fluid leakage using combined determination of beta-trace protein in secretion and serum","volume":"351","author":"Risch","year":"2005","journal-title":"Clin. Chim. Acta"},{"key":"10.1016\/j.clinbiochem.2016.09.006_bb0100","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1515\/cclm-2012-0408","article-title":"Evaluation of high resolution gel beta2-transferrin for detection of cerebrospinal fluid leak","volume":"51","author":"McCudden","year":"2013","journal-title":"Clin. Chem. Lab. Med."},{"key":"10.1016\/j.clinbiochem.2016.09.006_bb0105","doi-asserted-by":"crossref","first-page":"347","DOI":"10.1136\/jnnp.71.3.347","article-title":"A new nephelometric assay for beta-trace protein (prostaglandin D synthase) as an indicator of liquorrhoea","volume":"71","author":"Petereit","year":"2001","journal-title":"J. Neurol. Neurosurg. Psychiatry"},{"key":"10.1016\/j.clinbiochem.2016.09.006_bb0110","doi-asserted-by":"crossref","first-page":"1984","DOI":"10.1093\/clinchem\/42.12.1984","article-title":"Immunofluorometric assay of prostaglandin D synthase in human tissue extracts and fluids","volume":"42","author":"Melegos","year":"1996","journal-title":"Clin. Chem."},{"key":"10.1016\/j.clinbiochem.2016.09.006_bb0115","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1016\/S0090-4295(98)00453-1","article-title":"Highly elevated levels of prostaglandin D synthase in the serum of patients with renal failure","volume":"53","author":"Melengos","year":"1999","journal-title":"Urology"},{"key":"10.1016\/j.clinbiochem.2016.09.006_bb0120","doi-asserted-by":"crossref","first-page":"523","DOI":"10.1016\/j.otc.2006.01.001","article-title":"Endoscopic management of cerebrospinal fluid rhinorrhea","volume":"39","author":"Schlosser","year":"2006","journal-title":"Otolaryngol. Clin. N. Am."},{"key":"10.1016\/j.clinbiochem.2016.09.006_bb0125","doi-asserted-by":"crossref","first-page":"151","DOI":"10.2500\/ajr.2008.22.3150","article-title":"Utility of preoperative high-resolution CT and intraoperative image guidance in identification of cerebrospinal fluid leaks for endoscopic repair","volume":"22","author":"Zuckerman","year":"2008","journal-title":"Am. J. Rhinol."},{"key":"10.1016\/j.clinbiochem.2016.09.006_bb0130","doi-asserted-by":"crossref","first-page":"729","DOI":"10.2500\/ajr.2007.21.3105","article-title":"Efficacy of cerebrospinal fluid fistula repair: sensitive quality control using the beta-trace protein test","volume":"21","author":"Meco","year":"2007","journal-title":"Am. J. Rhinol."},{"issue":"9","key":"10.1016\/j.clinbiochem.2016.09.006_bb0135","doi-asserted-by":"crossref","first-page":"1817","DOI":"10.1089\/neu.2011.1877","article-title":"Beta-trace protein in ascites and pleural effusions: limits of CSF leakage detection","volume":"29","author":"Dietzel","year":"2012","journal-title":"J. Neurotrauma"}],"container-title":["Clinical Biochemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0009912016302454?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0009912016302454?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,14]],"date-time":"2025-09-14T15:50:25Z","timestamp":1757865025000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0009912016302454"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,1]]},"references-count":27,"journal-issue":{"issue":"1-2","published-print":{"date-parts":[[2017,1]]}},"alternative-id":["S0009912016302454"],"URL":"https:\/\/doi.org\/10.1016\/j.clinbiochem.2016.09.006","relation":{},"ISSN":["0009-9120"],"issn-type":[{"value":"0009-9120","type":"print"}],"subject":[],"published":{"date-parts":[[2017,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Sample-dependent diagnostic accuracy of prostaglandin D synthase in cerebrospinal fluid leak","name":"articletitle","label":"Article Title"},{"value":"Clinical Biochemistry","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.clinbiochem.2016.09.006","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2016 The Canadian Society of Clinical Chemists. Published by Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}