{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,10]],"date-time":"2026-07-10T01:21:05Z","timestamp":1783646465518,"version":"3.55.0"},"reference-count":47,"publisher":"Elsevier BV","issue":"6","license":[{"start":{"date-parts":[[2017,4,1]],"date-time":"2017-04-01T00:00:00Z","timestamp":1491004800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2017,4,1]],"date-time":"2017-04-01T00:00:00Z","timestamp":1491004800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Clinical Biochemistry"],"published-print":{"date-parts":[[2017,4]]},"DOI":"10.1016\/j.clinbiochem.2016.11.035","type":"journal-article","created":{"date-parts":[[2016,12,5]],"date-time":"2016-12-05T00:45:35Z","timestamp":1480898735000},"page":"274-278","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":39,"title":["Association between total serum cholesterol and suicide attempts in subjects with major depressive disorder: Exploring the role of clinical and biochemical confounding factors"],"prefix":"10.1016","volume":"50","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2612-4119","authenticated-orcid":false,"given":"Francesco","family":"Bartoli","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cristina","family":"Crocamo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2328-3862","authenticated-orcid":false,"given":"Antonios","family":"Dakanalis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ilaria","family":"Riboldi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alessio","family":"Miotto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Enrico","family":"Brosio","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Massimo","family":"Clerici","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6877-6169","authenticated-orcid":false,"given":"Giuseppe","family":"Carr\u00e0","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.clinbiochem.2016.11.035_bb0005","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1093\/epirev\/mxn002","article-title":"Suicide and suicidal behavior","volume":"30","author":"Nock","year":"2008","journal-title":"Epidemiol. Rev."},{"key":"10.1016\/j.clinbiochem.2016.11.035_bb0010","author":"World Health Organization"},{"key":"10.1016\/j.clinbiochem.2016.11.035_bb0015","author":"Center for Disease and Control Prevention"},{"key":"10.1016\/j.clinbiochem.2016.11.035_bb0020","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1016\/j.jad.2013.01.004","article-title":"Risk factors for suicide in individuals with depression: a systematic review","volume":"147","author":"Hawton","year":"2013","journal-title":"J. Affect. Disord."},{"key":"10.1016\/j.clinbiochem.2016.11.035_bb0025","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1136\/bmj.301.6747.309","article-title":"Lowering cholesterol concentrations and mortality: a quantitative review of primary prevention trials","volume":"301","author":"Muldoon","year":"1990","journal-title":"BMJ"},{"key":"10.1016\/j.clinbiochem.2016.11.035_bb0030","doi-asserted-by":"crossref","first-page":"727","DOI":"10.1016\/0140-6736(92)90609-7","article-title":"Low serum cholesterol and suicide","volume":"339","author":"Engelberg","year":"1992","journal-title":"Lancet"},{"key":"10.1016\/j.clinbiochem.2016.11.035_bb0035","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1016\/j.pnpbp.2014.01.018","article-title":"Serum lipids, recent suicide attempt and recent suicide status in patients with major depressive disorder","volume":"51","author":"Baek","year":"2014","journal-title":"Prog. Neuro-Psychopharmacol. Biol. Psychiatry"},{"key":"10.1016\/j.clinbiochem.2016.11.035_bb0040","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1016\/S0165-0327(03)00166-6","article-title":"Clinical application of low serum cholesterol as an indicator for suicide risk in major depression","volume":"81","author":"Kim","year":"2004","journal-title":"J. Affect. Disord."},{"key":"10.1016\/j.clinbiochem.2016.11.035_bb0045","doi-asserted-by":"crossref","first-page":"234","DOI":"10.1016\/j.jad.2011.03.028","article-title":"Measurement of total serum cholesterol in the evaluation of suicidal risk","volume":"133","author":"Oli\u00e9","year":"2011","journal-title":"J. Affect. Disord."},{"key":"10.1016\/j.clinbiochem.2016.11.035_bb0050","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1503\/jpn.150079","article-title":"Serum lipid levels and suicidality: a meta-analysis of 65 epidemiological studies","volume":"41","author":"Wu","year":"2016","journal-title":"J. Psychiatry Neurosci."},{"key":"10.1016\/j.clinbiochem.2016.11.035_bb0055","doi-asserted-by":"crossref","first-page":"278","DOI":"10.1027\/0227-5910\/a000260","article-title":"Lipophilic statin use and suicidal ideation in a sample of adults with mood disorders","volume":"35","author":"Davison","year":"2014","journal-title":"Crisis"},{"key":"10.1016\/j.clinbiochem.2016.11.035_bb0060","doi-asserted-by":"crossref","first-page":"387901","DOI":"10.5402\/2012\/387901","article-title":"The relationships between cholesterol and suicide: an update","volume":"2012","author":"De Berardis","year":"2012","journal-title":"ISRN Psychiatry"},{"key":"10.1016\/j.clinbiochem.2016.11.035_bb0065","doi-asserted-by":"crossref","first-page":"648","DOI":"10.1176\/appi.ajp.157.4.648","article-title":"High serum cholesterol and risk of suicide","volume":"157","author":"Tanskanen","year":"2000","journal-title":"Am. J. Psychiatry"},{"key":"10.1016\/j.clinbiochem.2016.11.035_bb0070","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1016\/S0924-9338(02)00011-1","article-title":"Cholesterol concentrations in violent and non-violent women suicide attempters","volume":"18","author":"Vevera","year":"2003","journal-title":"Eur. Psychiatry"},{"key":"10.1016\/j.clinbiochem.2016.11.035_bb0075","doi-asserted-by":"crossref","first-page":"745","DOI":"10.1016\/j.psychres.2014.10.017","article-title":"Potential neurochemical links between cholesterol and suicidal behavior","volume":"220","author":"da Gra\u00e7a","year":"2014","journal-title":"Psychiatry Res."},{"key":"10.1016\/j.clinbiochem.2016.11.035_bb0080","doi-asserted-by":"crossref","first-page":"403","DOI":"10.1016\/j.jad.2014.10.033","article-title":"Serum triglycerides, but not cholesterol or leptin, are decreased in suicide attempters with mood disorders","volume":"172","author":"da Gra\u00e7a","year":"2015","journal-title":"J. Affect. Disord."},{"key":"10.1016\/j.clinbiochem.2016.11.035_bb0085","doi-asserted-by":"crossref","first-page":"136","DOI":"10.1016\/j.pnpbp.2011.12.009","article-title":"Serum lipids, metabolic syndrome and lifetime suicide attempts in patients with bipolar disorder","volume":"37","author":"D'Ambrosio","year":"2012","journal-title":"Prog. Neuro-Psychopharmacol. Biol. Psychiatry"},{"key":"10.1016\/j.clinbiochem.2016.11.035_bb0090","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1016\/j.jad.2004.11.005","article-title":"Serum lipid profiles in major depression with clinical subtypes, suicide attempts and episodes","volume":"86","author":"Huang","year":"2005","journal-title":"J. Affect. Disord."},{"key":"10.1016\/j.clinbiochem.2016.11.035_bb0095","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1016\/0165-0327(96)00023-7","article-title":"Suicidal behavior in patients with major depression and comorbid personality disorders","volume":"39","author":"Corbitt","year":"1996","journal-title":"J. Affect. Disord."},{"key":"10.1016\/j.clinbiochem.2016.11.035_bb0100","doi-asserted-by":"crossref","first-page":"946","DOI":"10.1016\/j.jpsychires.2012.04.009","article-title":"Predicting future suicide attempts among depressed suicide ideators: a 10-year longitudinal study","volume":"46","author":"May","year":"2012","journal-title":"J. Psychiatr. Res."},{"key":"10.1016\/j.clinbiochem.2016.11.035_bb0105","doi-asserted-by":"crossref","first-page":"1392","DOI":"10.3390\/ijerph7041392","article-title":"Suicidal behavior and alcohol abuse","volume":"7","author":"Pompili","year":"2010","journal-title":"Int. J. Environ. Res. Public Health"},{"key":"10.1016\/j.clinbiochem.2016.11.035_bb0110","doi-asserted-by":"crossref","first-page":"601","DOI":"10.1176\/appi.ajp.157.4.601","article-title":"Characteristics of suicide attempts of patients with major depressive episode and borderline personality disorder: a comparative study","volume":"157","author":"Soloff","year":"2000","journal-title":"Am. J. Psychiatry"},{"issue":"4","key":"10.1016\/j.clinbiochem.2016.11.035_bb0115","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1016\/j.jegh.2015.02.002","article-title":"Association between worldwide dietary and lifestyle patterns with total cholesterol concentrations and DALYs for infectious and cardiovascular diseases: an ecological analysis","volume":"5","author":"Oggioni","year":"2015","journal-title":"J. Epidemiol Glob. Health"},{"key":"10.1016\/j.clinbiochem.2016.11.035_bb0120","doi-asserted-by":"crossref","first-page":"344","DOI":"10.1016\/j.jclinepi.2007.11.008","article-title":"The Strengthening the Reporting of Observational Studies in Epidemiology (STROBE) statement: guidelines for reporting observational studies","volume":"61","author":"von Elm","year":"2008","journal-title":"J. Clin. Epidemiol."},{"key":"10.1016\/j.clinbiochem.2016.11.035_bb0125","series-title":"The ICD-10 Classification of Mental and Behavioural Disorders: Clinical Descriptions and Diagnostic Guidelines","author":"World Health Organization","year":"1992"},{"key":"10.1016\/j.clinbiochem.2016.11.035_bb0130","article-title":"Purinergic system dysfunctions in subjects with bipolar disorder: a comparative cross-sectional study","author":"Bartoli","year":"2016","journal-title":"Compr. Psychiatry"},{"key":"10.1016\/j.clinbiochem.2016.11.035_bb0135","doi-asserted-by":"crossref","first-page":"1739","DOI":"10.1007\/s00127-014-0835-y","article-title":"The prevalence of metabolic syndrome in people with severe mental illness: a mediation analysis","volume":"49","author":"Carr\u00e0","year":"2014","journal-title":"Soc. Psychiatry Psychiatr. Epidemiol."},{"key":"10.1016\/j.clinbiochem.2016.11.035_bb0140","doi-asserted-by":"crossref","first-page":"698","DOI":"10.1016\/j.genhosppsych.2014.08.005","article-title":"Cardiovascular risk factors among people with severe mental illness in Italy: a cross-sectional comparative study","volume":"36","author":"Clerici","year":"2014","journal-title":"Gen. Hosp. Psychiatry"},{"key":"10.1016\/j.clinbiochem.2016.11.035_bb0145","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1016\/j.jad.2014.05.066","article-title":"Attempted suicide in people with co-occurring bipolar and substance use disorders: systematic review and meta-analysis","volume":"167","author":"Carr\u00e0","year":"2014","journal-title":"J. Affect. Disord."},{"key":"10.1016\/j.clinbiochem.2016.11.035_bb0150","doi-asserted-by":"crossref","first-page":"726","DOI":"10.2471\/BLT.07.043489","article-title":"Methods of suicide: international suicide patterns derived from the WHO mortality database","volume":"86","author":"Ajdacic-Gross","year":"2008","journal-title":"Bull. World Health Organ."},{"key":"10.1016\/j.clinbiochem.2016.11.035_bb0155","doi-asserted-by":"crossref","first-page":"196","DOI":"10.1186\/s12888-015-0570-2","article-title":"Violent and non-violent methods of attempted and completed suicide in Swedish young men: the role of early risk factors","volume":"15","author":"Stenbacka","year":"2015","journal-title":"BMC Psychiatry"},{"key":"10.1016\/j.clinbiochem.2016.11.035_bb0160","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1034\/j.1600-0447.2003.00115.x","article-title":"Serum lipid levels and suicide attempts","volume":"108","author":"Lee","year":"2003","journal-title":"Acta Psychiatr. Scand."},{"key":"10.1016\/j.clinbiochem.2016.11.035_bb0165","doi-asserted-by":"crossref","first-page":"472","DOI":"10.1016\/0006-3223(94)90643-2","article-title":"Total cholesterol and suicidality in depression","volume":"36","author":"Sullivan","year":"1994","journal-title":"Biol. Psychiatry"},{"key":"10.1016\/j.clinbiochem.2016.11.035_bb0170","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1027\/0227-5910\/a000018","article-title":"Engagement and retention of suicide attempters in clinical research: challenges and solutions","volume":"31","author":"Gibbons","year":"2010","journal-title":"Crisis"},{"key":"10.1016\/j.clinbiochem.2016.11.035_bb0175","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1038\/nmeth.2811","article-title":"BoxPlotR: a web tool for generation of box plots","volume":"11","author":"Spitzer","year":"2014","journal-title":"Nat. Methods"},{"key":"10.1016\/j.clinbiochem.2016.11.035_bb0180","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1186\/1744-9081-9-45","article-title":"No association between serum cholesterol and death by suicide in patients with schizophrenia, bipolar affective disorder, or major depressive disorder","volume":"9","author":"Park","year":"2013","journal-title":"Behav. Brain Funct."},{"key":"10.1016\/j.clinbiochem.2016.11.035_bb0185","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1192\/bjp.175.3.259","article-title":"Association of low serum total cholesterol with major depression and suicide","volume":"175","author":"Partonen","year":"1999","journal-title":"Br. J. Psychiatry"},{"key":"10.1016\/j.clinbiochem.2016.11.035_bb0190","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1016\/j.jad.2014.01.016","article-title":"The association between serum lipid levels, suicide ideation, and central serotonergic activity in patients with major depressive disorder","volume":"159","author":"Park","year":"2014","journal-title":"J. Affect. Disord."},{"key":"10.1016\/j.clinbiochem.2016.11.035_bb0195","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1016\/j.psychres.2006.09.003","article-title":"Cholesterol and suicide attempts: a prospective study of depressed inpatients","volume":"152","author":"Fiedorowicz","year":"2007","journal-title":"Psychiatry Res."},{"key":"10.1016\/j.clinbiochem.2016.11.035_bb0200","doi-asserted-by":"crossref","first-page":"361.e7","DOI":"10.1016\/j.jcrc.2009.08.006","article-title":"Severe hypocholesterolemia in surgical patients, sepsis, and critical illness","volume":"25","author":"Chiarla","year":"2010","journal-title":"J. Crit. Care"},{"key":"10.1016\/j.clinbiochem.2016.11.035_bb0205","doi-asserted-by":"crossref","first-page":"1017","DOI":"10.4088\/JCP.v65n0720b","article-title":"The effects of newer antidepressants on low-density lipoprotein cholesterol levels","volume":"65","author":"Le Mell\u00e9do","year":"2004","journal-title":"J. Clin. Psychiatry."},{"key":"10.1016\/j.clinbiochem.2016.11.035_bb0210","doi-asserted-by":"crossref","first-page":"523","DOI":"10.1517\/14740338.5.4.523","article-title":"The effect of antidepressants on lipid homeostasis: a cardiac safety concern?","volume":"5","author":"McIntyre","year":"2006","journal-title":"Expert Opin. Drug Saf."},{"key":"10.1016\/j.clinbiochem.2016.11.035_bb0215","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.schres.2004.01.014","article-title":"The effects of antipsychotic therapy on serum lipids: a comprehensive review","volume":"70","author":"Meyer","year":"2004","journal-title":"Schizophr. Res."},{"key":"10.1016\/j.clinbiochem.2016.11.035_bb0220","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1159\/000052768","article-title":"The inverse association between age and cholesterol level among older patients: the role of poor health status","volume":"47","author":"Volpato","year":"2001","journal-title":"Gerontology"},{"key":"10.1016\/j.clinbiochem.2016.11.035_bb0225","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1017\/neu.2014.18","article-title":"Suicidal behaviour and lipid levels in unipolar and bipolar depression","volume":"26","author":"Ainiyet","year":"2014","journal-title":"Acta Neuropsychiatr."},{"key":"10.1016\/j.clinbiochem.2016.11.035_bb0230","doi-asserted-by":"crossref","first-page":"524","DOI":"10.1111\/bdi.12089","article-title":"Biological basis of suicide and suicidal behavior","volume":"15","author":"Pandey","year":"2013","journal-title":"Bipolar Disord."},{"key":"10.1016\/j.clinbiochem.2016.11.035_bb0235","doi-asserted-by":"crossref","first-page":"842","DOI":"10.1016\/j.pnpbp.2010.08.001","article-title":"Potential peripheral biological predictors of suicidal behavior in major depressive disorder","volume":"35","author":"Lee","year":"2011","journal-title":"Prog. Neuro-Psychopharmacol. Biol. Psychiatry"}],"container-title":["Clinical Biochemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0009912016303289?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0009912016303289?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,14]],"date-time":"2025-09-14T15:49:50Z","timestamp":1757864990000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0009912016303289"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,4]]},"references-count":47,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2017,4]]}},"alternative-id":["S0009912016303289"],"URL":"https:\/\/doi.org\/10.1016\/j.clinbiochem.2016.11.035","relation":{},"ISSN":["0009-9120"],"issn-type":[{"value":"0009-9120","type":"print"}],"subject":[],"published":{"date-parts":[[2017,4]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Association between total serum cholesterol and suicide attempts in subjects with major depressive disorder: Exploring the role of clinical and biochemical confounding factors","name":"articletitle","label":"Article Title"},{"value":"Clinical Biochemistry","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.clinbiochem.2016.11.035","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2016 The Canadian Society of Clinical Chemists. Published by Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}