{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,14]],"date-time":"2026-01-14T14:16:13Z","timestamp":1768400173404,"version":"3.49.0"},"reference-count":31,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2018,3,1]],"date-time":"2018-03-01T00:00:00Z","timestamp":1519862400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2018,3,1]],"date-time":"2018-03-01T00:00:00Z","timestamp":1519862400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/501100001807","name":"Funda\u00e7\u00e3o de Amparo \u00e0 Pesquisa do Estado de S\u00e3o Paulo","doi-asserted-by":"publisher","award":["2014\/04193-0"],"award-info":[{"award-number":["2014\/04193-0"]}],"id":[{"id":"10.13039\/501100001807","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Clinical Biochemistry"],"published-print":{"date-parts":[[2018,3]]},"DOI":"10.1016\/j.clinbiochem.2017.12.005","type":"journal-article","created":{"date-parts":[[2017,12,15]],"date-time":"2017-12-15T12:46:52Z","timestamp":1513342012000},"page":"13-18","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":6,"special_numbering":"C","title":["Two Thyroid Stimulating Hormone assays correlated in clinical practice show disagreement in subclinical hypothyroidism patients"],"prefix":"10.1016","volume":"53","author":[{"given":"Valdelena Alessandra","family":"da Silva","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Robson Jos\u00e9","family":"de Almeida","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marcele Pimenta","family":"Cavalcante","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lucio Antonio","family":"Pereira Junior","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Francine Machado","family":"Reis","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mariana Fabbris","family":"Pereira","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Teresa S.","family":"Kasamatsu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cleber P.","family":"Camacho","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.clinbiochem.2017.12.005_bb0005","doi-asserted-by":"crossref","first-page":"359","DOI":"10.1210\/endo-73-3-359","article-title":"Immunologic studies of purified human and bovine thyrotropin","volume":"73","author":"Utiger","year":"1963","journal-title":"Endocrinology"},{"issue":"8","key":"10.1016\/j.clinbiochem.2017.12.005_bb0010","doi-asserted-by":"crossref","first-page":"C114","DOI":"10.12968\/hmed.2012.73.Sup8.C114","article-title":"Thyroid function testing","volume":"73","author":"Hepburn","year":"2012","journal-title":"Br. J. Hosp. Med. (Lond)"},{"issue":"2","key":"10.1016\/j.clinbiochem.2017.12.005_bb0015","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1007\/s12291-013-0339-7","article-title":"Between chemiluminescence (architect) and electrochemiluminescence (Cobas) immunoassays: an Indian population perspective","volume":"29","author":"Sarkar","year":"2014","journal-title":"Indian J. Clin. Biochem."},{"issue":"2","key":"10.1016\/j.clinbiochem.2017.12.005_bb0020","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1046\/j.1365-2265.1999.00632.x","article-title":"Comparison of serum thyrotrophin concentrations determined by a third generation assay in patients with various types of overt and subclinical thyrotoxicosis","volume":"50","author":"Kasagi","year":"1999","journal-title":"Clin. Endocrinol."},{"issue":"6","key":"10.1016\/j.clinbiochem.2017.12.005_bb0025","doi-asserted-by":"crossref","first-page":"1123","DOI":"10.1530\/EJE-10-0106","article-title":"Complex relationship between free thyroxine and TSH in the regulation of thyroid function","volume":"162","author":"Hoermann","year":"2010","journal-title":"Eur. J. Endocrinol."},{"issue":"6","key":"10.1016\/j.clinbiochem.2017.12.005_bb0030","doi-asserted-by":"crossref","first-page":"907","DOI":"10.1111\/cen.12527","article-title":"Homeostatic equilibria between free thyroid hormones and pituitary thyrotropin are modulated by various influences including age, body mass index and treatment","volume":"81","author":"Hoermann","year":"2014","journal-title":"Clin. Endocrinol."},{"issue":"5","key":"10.1016\/j.clinbiochem.2017.12.005_bb0035","doi-asserted-by":"crossref","first-page":"789","DOI":"10.1111\/cen.13107","article-title":"The log TSH-free T4 relationship in a community-based cohort is nonlinear and is influenced by age, smoking and thyroid peroxidase antibody status","volume":"85","author":"Brown","year":"2016","journal-title":"Clin. Endocrinol."},{"issue":"3","key":"10.1016\/j.clinbiochem.2017.12.005_bb0040","doi-asserted-by":"crossref","first-page":"359","DOI":"10.1677\/joe.0.1580359","article-title":"Modulation of human thyrotropin oligosaccharide structures\u2014enhanced proportion of sialylated and terminally galactosylated serum thyrotropin isoforms in subclinical and overt primary hypothyroidism","volume":"158","author":"Trojan","year":"1998","journal-title":"J. Endocrinol."},{"issue":"6","key":"10.1016\/j.clinbiochem.2017.12.005_bb0045","doi-asserted-by":"crossref","first-page":"923","DOI":"10.1111\/cen.12643","article-title":"Macro TSH in patients with subclinical hypothyroidism","volume":"83","author":"Hattori","year":"2015","journal-title":"Clin. Endocrinol."},{"issue":"4","key":"10.1016\/j.clinbiochem.2017.12.005_bb0050","doi-asserted-by":"crossref","first-page":"L40","DOI":"10.1210\/jc.2016-1115","article-title":"Letter to the editor: comment on \u201cReconciling the log-linear and non-linear aspects of the TSH-free T4 relationship: intra-individual analysis of a large population\u201d by Rothacker K.M., et al","volume":"101","author":"Midgley","year":"2016","journal-title":"J. Clin. Endocrinol. Metab."},{"issue":"2","key":"10.1016\/j.clinbiochem.2017.12.005_bb0055","doi-asserted-by":"crossref","first-page":"141","DOI":"10.11613\/BM.2015.015","article-title":"Understanding bland Altman analysis","volume":"25","author":"Giavarina","year":"2015","journal-title":"Biochem. Med. (Zagreb)"},{"issue":"12","key":"10.1016\/j.clinbiochem.2017.12.005_bb0060","doi-asserted-by":"crossref","first-page":"1670","DOI":"10.1089\/thy.2014.0028","article-title":"Guidelines for the treatment of hypothyroidism: prepared by the American thyroid association task force on thyroid hormone replacement","volume":"24","author":"Jonklaas","year":"2014","journal-title":"Thyroid"},{"key":"10.1016\/j.clinbiochem.2017.12.005_bb0065","article-title":"A proposal for strength-of-agreement criteria for Lin's concordance correlation coefficient","author":"McBride","year":"2005","journal-title":"NIWA Client Rep."},{"key":"10.1016\/j.clinbiochem.2017.12.005_bb0070","doi-asserted-by":"crossref","first-page":"130","DOI":"10.1016\/j.cca.2013.04.020","article-title":"Non-transference of biological reference interval of TSH by electrochemiluminescence immunoassay: an Indian population perspective","volume":"423","author":"Sarkar","year":"2013","journal-title":"Clin. Chim. Acta"},{"issue":"Pt 3","key":"10.1016\/j.clinbiochem.2017.12.005_bb0075","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1258\/000456307780480945","article-title":"Thyroid guidelines - are thyroid-stimulating hormone assays fit for purpose?","volume":"44","author":"Beckett","year":"2007","journal-title":"Ann. Clin. Biochem."},{"issue":"5","key":"10.1016\/j.clinbiochem.2017.12.005_bb0080","doi-asserted-by":"crossref","first-page":"284","DOI":"10.4158\/EP.3.5.284","article-title":"Serum thyrotropin determinations: comparison of second- and third-generation assays","volume":"3","author":"Kabadi","year":"1997","journal-title":"Endocr. Pract."},{"issue":"2","key":"10.1016\/j.clinbiochem.2017.12.005_bb0085","doi-asserted-by":"crossref","first-page":"387","DOI":"10.1210\/jcem-53-2-387","article-title":"Transient neonatal hyperthyrotropinemia: a factitious syndrome due to the presence of heterophilic antibodies in the plasma of infants and their mothers","volume":"53","author":"Czernichow","year":"1981","journal-title":"J. Clin. Endocrinol. Metab."},{"issue":"3","key":"10.1016\/j.clinbiochem.2017.12.005_bb0090","doi-asserted-by":"crossref","first-page":"445","DOI":"10.1590\/S0004-27302006000300006","article-title":"Unexpected high values of TSH: the presence of high molecular weight forms (macro TSH) must be investigated","volume":"50","author":"Vieira","year":"2006","journal-title":"Arq. Bras. Endocrinol. Metabol."},{"issue":"3","key":"10.1016\/j.clinbiochem.2017.12.005_bb0095","doi-asserted-by":"crossref","first-page":"240","DOI":"10.3109\/00365513.2016.1143113","article-title":"Heterophilic antibody interference affecting multiple hormone assays: is it due to rheumatoid factor?","volume":"76","author":"Mongolu","year":"2016","journal-title":"Scand. J. Clin. Lab. Invest."},{"key":"10.1016\/j.clinbiochem.2017.12.005_bb0100","first-page":"1","volume":"31","author":"Wang","year":"2016","journal-title":"J. Clin. Lab. Anal."},{"issue":"1","key":"10.1016\/j.clinbiochem.2017.12.005_bb0105","doi-asserted-by":"crossref","first-page":"108","DOI":"10.1111\/cen.13143","article-title":"Using a thyroid disease-free population to define the reference interval for TSH and free T4 on the Abbott architect analyser","volume":"86","author":"Hickman","year":"2017","journal-title":"Clin. Endocrinol."},{"issue":"12","key":"10.1016\/j.clinbiochem.2017.12.005_bb0110","doi-asserted-by":"crossref","first-page":"843","DOI":"10.1016\/j.clinbiochem.2016.06.007","article-title":"Thyroid hormone testing in the 21st century","volume":"49","author":"Singh","year":"2016","journal-title":"Clin. Biochem."},{"issue":"6","key":"10.1016\/j.clinbiochem.2017.12.005_bb0115","doi-asserted-by":"crossref","first-page":"988","DOI":"10.4158\/EP12280.GL","article-title":"Clinical practice guidelines for hypothyroidism in adults: cosponsored by the American Association of Clinical Endocrinologists and the American Thyroid Association","volume":"18","author":"Garber","year":"2012","journal-title":"Endocr. Pract."},{"issue":"2","key":"10.1016\/j.clinbiochem.2017.12.005_bb0120","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1159\/000339444","article-title":"ETA guidelines: the use of L-T4+L-T3 in the treatment of hypothyroidism","volume":"1","author":"Wiersinga","year":"2012","journal-title":"Eur. Thyroid J."},{"issue":"4","key":"10.1016\/j.clinbiochem.2017.12.005_bb0125","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1590\/S0004-27302013000400003","article-title":"Clinical practice guidelines for the management of hypothyroidism","volume":"57","author":"Brenta","year":"2013","journal-title":"Arq. Bras. Endocrinol. Metabol."},{"issue":"3","key":"10.1016\/j.clinbiochem.2017.12.005_bb0130","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1089\/thy.2016.0457","article-title":"2017 guidelines of the American Thyroid Association for the diagnosis and Management of Thyroid Disease during pregnancy and the postpartum","volume":"27","author":"Alexander","year":"2017","journal-title":"Thyroid"},{"issue":"23\u201324","key":"10.1016\/j.clinbiochem.2017.12.005_bb0135","doi-asserted-by":"crossref","first-page":"924","DOI":"10.1007\/s00508-015-0846-z","article-title":"Subclinical hypothyroidism and mortality in a large Austrian cohort: a possible impact on treatment?","volume":"127","author":"Kovar","year":"2015","journal-title":"Wien. Klin. Wochenschr."},{"key":"10.1016\/j.clinbiochem.2017.12.005_bb0140","doi-asserted-by":"crossref","first-page":"864","DOI":"10.1001\/jama.1963.03060110068020","article-title":"Statistics in the practice of medicine","volume":"185","author":"Hoffmann","year":"1963","journal-title":"JAMA"},{"issue":"2","key":"10.1016\/j.clinbiochem.2017.12.005_bb0145","doi-asserted-by":"crossref","first-page":"180","DOI":"10.1309\/AJCPN5BMTSF1CDYP","article-title":"Establishing reference intervals for clinical laboratory test results: is there a better way?","volume":"133","author":"Katayev","year":"2010","journal-title":"Am. J. Clin. Pathol."},{"issue":"6","key":"10.1016\/j.clinbiochem.2017.12.005_bb0150","doi-asserted-by":"crossref","first-page":"902","DOI":"10.1373\/clinchem.2009.140178","article-title":"Report of the IFCC working Group for standardization of thyroid function tests; part 1: thyroid-stimulating hormone","volume":"56","author":"Thienpont","year":"2010","journal-title":"Clin. Chem."},{"key":"10.1016\/j.clinbiochem.2017.12.005_bb0155","series-title":"R: a language and environment for statistical computing","author":"R Core Team","year":"2017"}],"container-title":["Clinical Biochemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0009912017308147?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0009912017308147?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,2]],"date-time":"2025-11-02T20:09:26Z","timestamp":1762114166000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0009912017308147"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,3]]},"references-count":31,"alternative-id":["S0009912017308147"],"URL":"https:\/\/doi.org\/10.1016\/j.clinbiochem.2017.12.005","relation":{},"ISSN":["0009-9120"],"issn-type":[{"value":"0009-9120","type":"print"}],"subject":[],"published":{"date-parts":[[2018,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Two Thyroid Stimulating Hormone assays correlated in clinical practice show disagreement in subclinical hypothyroidism patients","name":"articletitle","label":"Article Title"},{"value":"Clinical Biochemistry","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.clinbiochem.2017.12.005","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2017 The Canadian Society of Clinical Chemists. Published by Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}