{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,11]],"date-time":"2026-10-11T03:18:57Z","timestamp":1791688737169,"version":"4.3.4"},"reference-count":98,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2019,12,1]],"date-time":"2019-12-01T00:00:00Z","timestamp":1575158400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2019,12,1]],"date-time":"2019-12-01T00:00:00Z","timestamp":1575158400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2019,9,10]],"date-time":"2019-09-10T00:00:00Z","timestamp":1568073600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/100004337","name":"Roche","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100004337","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Clinical Biochemistry"],"published-print":{"date-parts":[[2019,12]]},"DOI":"10.1016\/j.clinbiochem.2019.08.012","type":"journal-article","created":{"date-parts":[[2019,8,29]],"date-time":"2019-08-29T19:07:32Z","timestamp":1567105652000},"page":"1-11","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":62,"special_numbering":"C","title":["Best practices in mitigating the risk of biotin interference with laboratory testing"],"prefix":"10.1016","volume":"74","author":[{"given":"Raffick","family":"Bowen","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Raul","family":"Benavides","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jessica M.","family":"Col\u00f3n-Franco","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brooke M.","family":"Katzman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alagarraju","family":"Muthukumar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hossein","family":"Sadrzadeh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joely","family":"Straseski","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ursula","family":"Klause","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nam","family":"Tran","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.clinbiochem.2019.08.012_bb0005","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1016\/j.clinbiochem.2018.07.004","article-title":"Prevalence of biotin supplement usage in outpatients and plasma biotin concentrations in patients presenting to the emergency department","volume":"60","author":"Katzman","year":"2018","journal-title":"Clin. Biochem."},{"issue":"8","key":"10.1016\/j.clinbiochem.2019.08.012_bb0010","doi-asserted-by":"crossref","first-page":"989","DOI":"10.4158\/EP171761.RA","article-title":"Biotin interference with routine clinical immunoassays: understand the causes and mitigate the risks","volume":"23","author":"Samarasinghe","year":"2017","journal-title":"Endocr. Pract."},{"issue":"6","key":"10.1016\/j.clinbiochem.2019.08.012_bb0015","doi-asserted-by":"crossref","first-page":"767","DOI":"10.1016\/j.jfca.2003.09.015","article-title":"Determination of the biotin content of select foods using accurate and sensitive HPLC\/avidin binding","volume":"17","author":"Staggs","year":"2004","journal-title":"J. Food Compos. Anal."},{"issue":"2","key":"10.1016\/j.clinbiochem.2019.08.012_bb0020","first-page":"213","article-title":"Biotin, Advances in nutrition (Bethesda, Md.)","volume":"3","author":"Zempleni","year":"2012"},{"issue":"11","key":"10.1016\/j.clinbiochem.2019.08.012_bb0025","doi-asserted-by":"crossref","first-page":"1597","DOI":"10.1002\/pro.2156","article-title":"The enzymes of biotin dependent CO(2) metabolism: what structures reveal about their reaction mechanisms","volume":"21","author":"Waldrop","year":"2012","journal-title":"Protein Sci."},{"key":"10.1016\/j.clinbiochem.2019.08.012_bb0030","series-title":"Dietary Reference Intakes: Thiamin, Riboflavin, Niacin, Vitamin b6, Folate, Vitamin b12, Pantothenic Acid, Biotin, and Choline","author":"Institute of Medicine. Food and Nutrition Board","year":"1998"},{"issue":"8","key":"10.1016\/j.clinbiochem.2019.08.012_bb0035","doi-asserted-by":"crossref","first-page":"1487","DOI":"10.3945\/jn.116.238956","article-title":"Biotin: from nutrition to therapeutics","volume":"147","author":"Mock","year":"2017","journal-title":"J. Nutr."},{"issue":"6","key":"10.1016\/j.clinbiochem.2019.08.012_bb0040","doi-asserted-by":"crossref","first-page":"715","DOI":"10.1586\/17446651.3.6.715","article-title":"Biotin and biotinidase deficiency","volume":"3","author":"Zempleni","year":"2008","journal-title":"Expert. Rev. Endocrinol. Metab."},{"issue":"3","key":"10.1016\/j.clinbiochem.2019.08.012_bb0045","first-page":"169","article-title":"Biotin deficiency in protein-energy malnutrition","volume":"43","author":"Velazquez","year":"1989","journal-title":"Eur. J. Clin. Nutr."},{"issue":"6","key":"10.1016\/j.clinbiochem.2019.08.012_bb0050","doi-asserted-by":"crossref","first-page":"923","DOI":"10.1007\/BF01800475","article-title":"Worldwide survey of neonatal screening for biotinidase deficiency","volume":"14","author":"Wolf","year":"1991","journal-title":"J. Inherit. Metab. Dis."},{"issue":"2","key":"10.1016\/j.clinbiochem.2019.08.012_bb0055","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1093\/ajcn\/75.2.295","article-title":"Marginal biotin deficiency during normal pregnancy","volume":"75","author":"Mock","year":"2002","journal-title":"Am. J. Clin. Nutr."},{"issue":"1","key":"10.1016\/j.clinbiochem.2019.08.012_bb0060","first-page":"36","article-title":"Biotin, BioFactors (Oxford, England)","volume":"35","author":"Zempleni","year":"2009"},{"issue":"6","key":"10.1016\/j.clinbiochem.2019.08.012_bb0065","doi-asserted-by":"crossref","first-page":"817","DOI":"10.1515\/cclm-2016-1183","article-title":"High-dose biotin therapy leading to false biochemical endocrine profiles: validation of a simple method to overcome biotin interference","volume":"55","author":"Piketty","year":"2017","journal-title":"Clin. Chem. Lab. Med."},{"issue":"6","key":"10.1016\/j.clinbiochem.2019.08.012_bb0070","doi-asserted-by":"crossref","first-page":"R255","DOI":"10.1530\/EJE-16-0193","article-title":"Diagnosis of endocrine disease: how reliable are free thyroid and total T3 hormone assays?","volume":"175","author":"Welsh","year":"2016","journal-title":"Eur. J. Endocrinol."},{"key":"10.1016\/j.clinbiochem.2019.08.012_bb0075","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1016\/j.plabm.2018.02.003","article-title":"Multi-centre evaluation of recent troponin assays for the diagnosis of NSTEMI","volume":"11","author":"Chenevier-Gobeaux","year":"2018","journal-title":"Pract. Lab. Med."},{"issue":"5","key":"10.1016\/j.clinbiochem.2019.08.012_bb0080","doi-asserted-by":"crossref","first-page":"544","DOI":"10.1373\/jalm.2016.022640","article-title":"Comparison of 13 commercially available cardiac troponin assays in a multicenter north American study","volume":"1","author":"Christenson","year":"2017","journal-title":"J. Appl. Lab.Med."},{"issue":"10","key":"10.1016\/j.clinbiochem.2019.08.012_bb0085","doi-asserted-by":"crossref","first-page":"1669","DOI":"10.1515\/CCLM.2011.647","article-title":"Multicentre comparison of free thyroid hormones immunoassays: the Immunocheck study","volume":"49","author":"Giovannini","year":"2011","journal-title":"Clin. Chem. Lab. Med."},{"issue":"2","key":"10.1016\/j.clinbiochem.2019.08.012_bb0090","first-page":"400","article-title":"Performance characteristics of three automated immunoassays for thyroid hormones","volume":"3","author":"Kazerouni","year":"2012","journal-title":"Caspian J. Intern. Med."},{"issue":"5","key":"10.1016\/j.clinbiochem.2019.08.012_bb0095","doi-asserted-by":"crossref","first-page":"381","DOI":"10.3343\/alm.2017.37.5.381","article-title":"Comparison of intact PTH and bio-intact PTH assays among non-dialysis dependent chronic kidney disease patients","volume":"37","author":"Einbinder","year":"2017","journal-title":"Ann. Lab. Med."},{"key":"10.1016\/j.clinbiochem.2019.08.012_bb0100","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1155\/2012\/523246","article-title":"PTH assays: understanding what we have and forecasting what we will have","volume":"2012","author":"Vieira","year":"2012","journal-title":"J. Osteoporos."},{"issue":"8","key":"10.1016\/j.clinbiochem.2019.08.012_bb0105","doi-asserted-by":"crossref","first-page":"1141","DOI":"10.5858\/arpa.2012-0270-CR","article-title":"Interference from anti-streptavidin antibody","volume":"137","author":"Rulander","year":"2013","journal-title":"Arch. Pathol. Lab. Med."},{"issue":"5","key":"10.1016\/j.clinbiochem.2019.08.012_bb0110","doi-asserted-by":"crossref","first-page":"830","DOI":"10.1210\/er.2018-00119","article-title":"Interferences with thyroid function immunoassays: clinical implications and detection algorithm","volume":"39","author":"Favresse","year":"2018","journal-title":"Endocr. Rev."},{"issue":"6","key":"10.1016\/j.clinbiochem.2019.08.012_bb0115","doi-asserted-by":"crossref","first-page":"860","DOI":"10.1089\/thy.2015.0664","article-title":"Misdiagnosis of graves\u2019 disease with apparent severe hyperthyroidism in a patient taking biotin megadoses","volume":"26","author":"Barbesino","year":"2016","journal-title":"Thyroid"},{"issue":"5","key":"10.1016\/j.clinbiochem.2019.08.012_bb0120","first-page":"372","article-title":"Misdiagnosis of Graves\u2019 hyperthyroidism due to therapeutic biotin intervention","volume":"73","author":"De Roeck","year":"2018","journal-title":"Acta Clin. Belg."},{"issue":"5","key":"10.1016\/j.clinbiochem.2019.08.012_bb0125","doi-asserted-by":"crossref","first-page":"431","DOI":"10.1210\/js.2017-00054","article-title":"A somewhat bizarre case of graves disease due to vitamin treatment","volume":"1","author":"Al-Salameh","year":"2017","journal-title":"J. Endocr. Soc."},{"issue":"6","key":"10.1016\/j.clinbiochem.2019.08.012_bb0130","doi-asserted-by":"crossref","first-page":"941","DOI":"10.1373\/jalm.2017.024257","article-title":"Biotin interference in clinical immunoassays","volume":"2","author":"Colon","year":"2018","journal-title":"J. Appl. Lab. Med."},{"issue":"Pt 3","key":"10.1016\/j.clinbiochem.2019.08.012_bb0135","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1258\/000456303321610574","article-title":"A sensitive and practical competitive radioassay for plasma biotin","volume":"40","author":"Harthe","year":"2003","journal-title":"Ann. Clin. Biochem."},{"issue":"2","key":"10.1016\/j.clinbiochem.2019.08.012_bb0140","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1177\/0004563217701777","article-title":"Characterization of the scope and magnitude of biotin interference in susceptible Roche Elecsys competitive and sandwich immunoassays","volume":"55","author":"Trambas","year":"2018","journal-title":"Ann. Clin. Biochem."},{"issue":"6","key":"10.1016\/j.clinbiochem.2019.08.012_bb0145","doi-asserted-by":"crossref","first-page":"565","DOI":"10.1038\/gim.2011.6","article-title":"Biotinidase deficiency: \u201cif you have to have an inherited metabolic disease, this is the one to have\u201d","volume":"14","author":"Wolf","year":"2012","journal-title":"Genet. Med."},{"issue":"1","key":"10.1016\/j.clinbiochem.2019.08.012_bb0150","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1186\/1750-1172-8-83","article-title":"Biotin-responsive basal ganglia disease should be renamed biotin-thiamine-responsive basal ganglia disease: a retrospective review of the clinical, radiological and molecular findings of 18 new cases","volume":"8","author":"Alfadhel","year":"2013","journal-title":"Orphanet J. Rare Dis."},{"issue":"13","key":"10.1016\/j.clinbiochem.2019.08.012_bb0155","doi-asserted-by":"crossref","DOI":"10.1177\/1352458516667568","article-title":"MD1003 (high-dose biotin) for the treatment of progressive multiple sclerosis: a randomised, double-blind, placebo-controlled study","volume":"22","author":"Tourbah","year":"2016","journal-title":"Mult. Scler."},{"issue":"2","key":"10.1016\/j.clinbiochem.2019.08.012_bb0160","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1016\/j.msard.2015.01.005","article-title":"High doses of biotin in chronic progressive multiple sclerosis: a pilot study","volume":"4","author":"Sedel","year":"2015","journal-title":"Mult. Scler. Relat. Disord."},{"issue":"7","key":"10.1016\/j.clinbiochem.2019.08.012_bb0165","doi-asserted-by":"crossref","first-page":"661","DOI":"10.1007\/s40263-018-0528-2","article-title":"MD1003 (high-dose pharmaceutical-grade biotin) for the treatment of chronic visual loss related to optic neuritis in multiple sclerosis: a randomized, double-blind, placebo-controlled study","volume":"32","author":"Tourbah","year":"2018","journal-title":"CNS Drugs"},{"issue":"11","key":"10.1016\/j.clinbiochem.2019.08.012_bb0170","first-page":"28","article-title":"A double-blind, placebo-controlled study evaluating the efficacy of an oral supplement in women with self-perceived thinning hair","volume":"5","author":"Glynis","year":"2012","journal-title":"J. Clin. Aesthet. Dermatol."},{"issue":"3","key":"10.1016\/j.clinbiochem.2019.08.012_bb0175","doi-asserted-by":"crossref","first-page":"E14","DOI":"10.1111\/j.1525-1470.2007.00385.x","article-title":"Familial uncombable hair syndrome: ultrastructural hair study and response to biotin","volume":"24","author":"Boccaletti","year":"2007","journal-title":"Pediatr. Dermatol."},{"issue":"3","key":"10.1016\/j.clinbiochem.2019.08.012_bb0180","doi-asserted-by":"crossref","first-page":"166","DOI":"10.1159\/000462981","article-title":"A review of the use of biotin for hair loss","volume":"3","author":"Patel","year":"2017","journal-title":"Skin Appendage Disord."},{"issue":"4","key":"10.1016\/j.clinbiochem.2019.08.012_bb0185","doi-asserted-by":"crossref","first-page":"411","DOI":"10.1080\/09546634.2017.1395799","article-title":"Biotin for the treatment of nail disease: what is the evidence?","volume":"29","author":"Lipner","year":"2018","journal-title":"J. Dermatol. Treat."},{"issue":"4","key":"10.1016\/j.clinbiochem.2019.08.012_bb0190","doi-asserted-by":"crossref","first-page":"420","DOI":"10.1016\/j.clindermatol.2010.03.037","article-title":"Nutrition and nail disease","volume":"28","author":"Cashman","year":"2010","journal-title":"Clin. Dermatol."},{"issue":"8","key":"10.1016\/j.clinbiochem.2019.08.012_bb0195","first-page":"782","article-title":"Vitamins and minerals: their role in nail health and disease","volume":"6","author":"Scheinfeld","year":"2007","journal-title":"J. Drugs Dermatol."},{"issue":"3","key":"10.1016\/j.clinbiochem.2019.08.012_bb0200","doi-asserted-by":"crossref","first-page":"500","DOI":"10.1002\/dta.1980","article-title":"Overview of regulation of dietary supplements in the USA and issues of adulteration with phenethylamines (PEAs)","volume":"9","author":"Pawar","year":"2017","journal-title":"Drug Test. Anal."},{"key":"10.1016\/j.clinbiochem.2019.08.012_bb0205","first-page":"1","article-title":"Current regulatory guidelines and resources to support research of dietary supplements in the United States","author":"Bailey","year":"2018","journal-title":"Crit. Rev. Food Sci. Nutr."},{"issue":"2","key":"10.1016\/j.clinbiochem.2019.08.012_bb0210","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1038\/clpt.2009.263","article-title":"FDA regulation of dietary supplements and requirements regarding adverse event reporting","volume":"87","author":"Frankos","year":"2010","journal-title":"Clin. Pharmacol. Ther."},{"issue":"1","key":"10.1016\/j.clinbiochem.2019.08.012_bb0215","doi-asserted-by":"crossref","DOI":"10.3390\/nu10010041","article-title":"Dietary supplements: regulatory challenges and research resources","volume":"10","author":"Dwyer","year":"2018","journal-title":"Nutrients"},{"issue":"3","key":"10.1016\/j.clinbiochem.2019.08.012_bb0220","doi-asserted-by":"crossref","first-page":"478","DOI":"10.2105\/AJPH.2014.302348","article-title":"Too little, too late: ineffective regulation of dietary supplements in the United States","volume":"105","author":"Starr","year":"2015","journal-title":"Am. J. Public Health"},{"issue":"14","key":"10.1016\/j.clinbiochem.2019.08.012_bb0225","doi-asserted-by":"crossref","first-page":"1464","DOI":"10.1001\/jama.2016.14403","article-title":"Trends in dietary supplement use among US adults from 1999-2012","volume":"316","author":"Kantor","year":"2016","journal-title":"Jama"},{"key":"10.1016\/j.clinbiochem.2019.08.012_bb0230","series-title":"Multiple Measurements, Statistical Methods in Medical Research","author":"Armitage","year":"1987"},{"key":"10.1016\/j.clinbiochem.2019.08.012_bb0235","doi-asserted-by":"crossref","first-page":"S497","DOI":"10.1016\/j.cca.2019.03.1117","article-title":"Evaluating the clinical risk of biotin interference with the Elecsys\u00ae troponin T-high sensitive assay","volume":"493","author":"Tran","year":"2019","journal-title":"Clin. Chim. Acta"},{"key":"10.1016\/j.clinbiochem.2019.08.012_bb0240","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1016\/j.clinbiochem.2019.01.004","article-title":"Further assessment of the prevalence of biotin supplementation and its impact on risk","volume":"65","author":"Trambas","year":"2019","journal-title":"Clin. Biochem."},{"issue":"3","key":"10.1016\/j.clinbiochem.2019.08.012_bb0245","doi-asserted-by":"crossref","first-page":"278","DOI":"10.1097\/PAT.0b013e3283514002","article-title":"Biotin interference on TSH and free thyroid hormone measurement","volume":"44","author":"Kwok","year":"2012","journal-title":"Pathology"},{"key":"10.1016\/j.clinbiochem.2019.08.012_bb0250","first-page":"247","article-title":"Population pharmacokinetics of exogenous biotin and the relationship between biotin serum levels and in vitro immunoassay interference","volume":"2","author":"Grimsey","year":"2017","journal-title":"Int. J. Pharm."},{"key":"10.1016\/j.clinbiochem.2019.08.012_bb0255","series-title":"Cardiac Troponin and Natriuretic Peptide Analytical Interferences from Hemolysis and Biotin: Educational Aids from the IFCC Committee on Cardiac Biomarkers (IFCC C-CB)","author":"Saenger","year":"2018"},{"issue":"5","key":"10.1016\/j.clinbiochem.2019.08.012_bb0260","first-page":"638","article-title":"Discordant analytical results caused by biotin interference on diagnostic immunoassays in a pediatric hospital","volume":"47","author":"Ali","year":"2017","journal-title":"Ann. Clin. Lab. Sci."},{"key":"10.1016\/j.clinbiochem.2019.08.012_bb0265","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1016\/j.cca.2018.10.013","article-title":"Comprehensive assessment of biotin interference in immunoassays","volume":"487","author":"Li","year":"2018","journal-title":"Clin. Chim. Acta"},{"issue":"10","key":"10.1016\/j.clinbiochem.2019.08.012_bb0270","doi-asserted-by":"crossref","first-page":"e226","DOI":"10.1515\/cclm-2016-0980","article-title":"Evaluation of biotin interference on immunoassays: new data for troponin I, digoxin, NT-Pro-BNP, and progesterone","volume":"55","author":"Willeman","year":"2017","journal-title":"Clin. Chem. Lab. Med."},{"key":"10.1016\/j.clinbiochem.2019.08.012_bb0275","series-title":"Siemens, Biotin Interference in the Cyclosporine, DHEA-SO4, Folate and HBc IgM Assays - Urgent Field Safety Notice","year":"2018"},{"issue":"12","key":"10.1016\/j.clinbiochem.2019.08.012_bb0280","doi-asserted-by":"crossref","first-page":"1150","DOI":"10.1001\/jama.2017.13705","article-title":"Association of biotin ingestion with performance of hormone and nonhormone assays in healthy adults","volume":"318","author":"Li","year":"2017","journal-title":"JAMA"},{"key":"10.1016\/j.clinbiochem.2019.08.012_bb0285","doi-asserted-by":"crossref","first-page":"168","DOI":"10.1016\/j.clinbiochem.2018.01.018","article-title":"Assessment of biotin interference with qualitative point-of-care hCG test devices","volume":"53","author":"Williams","year":"2018","journal-title":"Clin. Biochem."},{"issue":"2","key":"10.1016\/j.clinbiochem.2019.08.012_bb0290","first-page":"164","article-title":"Biotin at high concentration interferes with the LOCI digoxin assay but the PETINIA phenytoin assay is not affected","volume":"48","author":"Rodriguez","year":"2018","journal-title":"Ann. Clin. Lab. Sci."},{"issue":"5","key":"10.1016\/j.clinbiochem.2019.08.012_bb0295","doi-asserted-by":"crossref","first-page":"486","DOI":"10.1093\/ajcp\/aqy172","article-title":"Susceptibility of cardiac troponin assays to biotin interference","volume":"151","author":"Frame","year":"2019","journal-title":"Am. J. Clin. Pathol."},{"issue":"3","key":"10.1016\/j.clinbiochem.2019.08.012_bb0300","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1093\/eurheartj\/ehv320","volume":"37","author":"Roffi","year":"2016","journal-title":"Eur. Heart J."},{"issue":"3","key":"10.1016\/j.clinbiochem.2019.08.012_bb0305","doi-asserted-by":"crossref","DOI":"10.11613\/BM.2018.030901","article-title":"Biotin and high-sensitivity cardiac troponin T assay","volume":"28","author":"Schrapp","year":"2018","journal-title":"Biochem. Med."},{"issue":"6","key":"10.1016\/j.clinbiochem.2019.08.012_bb0310","article-title":"Effect of high-dose biotin on thyroid function tests: case report and literature review","volume":"10","author":"Ardabilygazir","year":"2018","journal-title":"Cureus"},{"key":"10.1016\/j.clinbiochem.2019.08.012_bb0315","doi-asserted-by":"crossref","first-page":"320","DOI":"10.1016\/j.cca.2018.05.053","article-title":"Fake news? Biotin interference in thyroid immunoassays","volume":"484","author":"Koehler","year":"2018","journal-title":"Clin. Chim. Acta"},{"issue":"4","key":"10.1016\/j.clinbiochem.2019.08.012_bb0320","first-page":"e370","article-title":"High-dose biotin treatment for secondary progressive multiple sclerosis may interfere with thyroid assays","volume":"2","author":"Minkovsky","year":"2016","journal-title":"AACE Clin. Case Rep."},{"key":"10.1016\/j.clinbiochem.2019.08.012_bb0325","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1016\/j.nut.2018.05.005","article-title":"Erroneous thyroid diagnosis due to over-the-counter biotin","volume":"57","author":"Charles","year":"2019","journal-title":"Nutrition"},{"issue":"7","key":"10.1016\/j.clinbiochem.2019.08.012_bb0330","doi-asserted-by":"crossref","first-page":"704","DOI":"10.1056\/NEJMc1602096","article-title":"Biotin treatment mimicking Graves\u2019 disease","volume":"375","author":"Kummer","year":"2016","journal-title":"N. Engl. J. Med."},{"issue":"7","key":"10.1016\/j.clinbiochem.2019.08.012_bb0335","doi-asserted-by":"crossref","first-page":"674","DOI":"10.1097\/PAT.0b013e32835a3c17","article-title":"Positive and negative interference in immunoassays following biotin ingestion: a pharmacokinetic study","volume":"44","author":"Wijeratne","year":"2012","journal-title":"Pathology"},{"issue":"5","key":"10.1016\/j.clinbiochem.2019.08.012_bb0340","doi-asserted-by":"crossref","first-page":"e94","DOI":"10.1515\/cclm-2018-0759","article-title":"Euthyroid Graves\u2019 disease with spurious hyperthyroidism: a diagnostic challenge","volume":"57","author":"Giovanella","year":"2019","journal-title":"Clin. Chem. Lab. Med."},{"issue":"7","key":"10.1016\/j.clinbiochem.2019.08.012_bb0345","doi-asserted-by":"crossref","first-page":"553","DOI":"10.1016\/j.nephro.2017.02.016","article-title":"Chronic kidney failure and biotin: a combination inducing unusual results in thyroid and parathyroid investigations, report of 2 cases","volume":"13","author":"Ranaivosoa","year":"2017","journal-title":"Nephrol. Therapeutique"},{"key":"10.1016\/j.clinbiochem.2019.08.012_bb0350","author":"Biotin interference"},{"key":"10.1016\/j.clinbiochem.2019.08.012_bb0355","series-title":"Building Blocks for Action: Global Report 2002","author":"Innovative Care for Chronic Conditions","year":"2002"},{"key":"10.1016\/j.clinbiochem.2019.08.012_bb0360","unstructured":"The FDA warns that biotin may interfere with lab tests: FDA safety communication [(Issued 28 November 2017)]."},{"issue":"11","key":"10.1016\/j.clinbiochem.2019.08.012_bb0365","doi-asserted-by":"crossref","first-page":"1459","DOI":"10.5858\/arpa.2017-0107-LE","article-title":"Biotin interference in clinical immunoassays: a cause for concern","volume":"141","author":"Holmes","year":"2017","journal-title":"Arch. Pathol. Lab. Med."},{"issue":"2","key":"10.1016\/j.clinbiochem.2019.08.012_bb0370","doi-asserted-by":"crossref","first-page":"104","DOI":"10.1001\/jamacardio.2017.4625","article-title":"Efficacy of high-sensitivity troponin T in identifying very-low-risk patients with possible acute coronary syndrome","volume":"3","author":"Peacock","year":"2018","journal-title":"JAMA Cardiol."},{"issue":"2","key":"10.1016\/j.clinbiochem.2019.08.012_bb0375","doi-asserted-by":"crossref","first-page":"125","DOI":"10.5858\/arpa.2015-0022-CP","article-title":"Test cancellation: a college of American pathologists Q-probes study","volume":"140","author":"Darcy","year":"2016","journal-title":"Arch. Pathol. Lab. Med."},{"issue":"6","key":"10.1016\/j.clinbiochem.2019.08.012_bb0380","doi-asserted-by":"crossref","first-page":"764","DOI":"10.1515\/CCLM.2008.170","article-title":"Haemolysis: an overview of the leading cause of unsuitable specimens in clinical laboratories","volume":"46","author":"Lippi","year":"2008","journal-title":"Clin. Chem. Lab. Med."},{"issue":"1","key":"10.1016\/j.clinbiochem.2019.08.012_bb0385","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1016\/0022-1759(94)00301-C","article-title":"Reducing interference from heterophilic antibodies in a two-site immunoassay for carcinoembryonic antigen (CEA) by using a human\/mouse chimeric antibody to CEA as the tracer","volume":"180","author":"Kuroki","year":"1995","journal-title":"J. Immunol. Methods"},{"issue":"4","key":"10.1016\/j.clinbiochem.2019.08.012_bb0390","doi-asserted-by":"crossref","first-page":"417","DOI":"10.1093\/ajcp\/108.4.417","article-title":"Heterophilic antibodies remain a problem for the immunoassay laboratory","volume":"108","author":"Ward","year":"1997","journal-title":"Am. J. Clin. Pathol."},{"issue":"4","key":"10.1016\/j.clinbiochem.2019.08.012_bb0395","doi-asserted-by":"crossref","first-page":"613","DOI":"10.1093\/clinchem\/48.4.613","article-title":"Immunometric assay interference: incidence and prevention","volume":"48","author":"Bjerner","year":"2002","journal-title":"Clin. Chem."},{"issue":"Pt 6","key":"10.1016\/j.clinbiochem.2019.08.012_bb0400","doi-asserted-by":"crossref","first-page":"704","DOI":"10.1177\/000456329903600603","article-title":"Interference in immunoassay","volume":"36","author":"Selby","year":"1999","journal-title":"Ann. Clin. Biochem."},{"issue":"5","key":"10.1016\/j.clinbiochem.2019.08.012_bb0405","doi-asserted-by":"crossref","first-page":"860","DOI":"10.1093\/clinchem\/43.5.860","article-title":"Prevention of analytical false-positive increases of cardiac troponin I on the stratus II analyzer","volume":"43","author":"Roberts","year":"1997","journal-title":"Clin. Chem."},{"issue":"5","key":"10.1016\/j.clinbiochem.2019.08.012_bb0410","doi-asserted-by":"crossref","first-page":"714","DOI":"10.1093\/clinchem\/45.5.714","article-title":"False increases of troponin I attributable to incomplete separation of serum","volume":"45","author":"Nosanchuk","year":"1999","journal-title":"Clin. Chem."},{"issue":"4","key":"10.1016\/j.clinbiochem.2019.08.012_bb0415","doi-asserted-by":"crossref","first-page":"709","DOI":"10.1373\/49.4.709","article-title":"Negative thyrotropin assay interference associated with an IgGkappa paraprotein","volume":"49","author":"Luzzi","year":"2003","journal-title":"Clin. Chem."},{"key":"10.1016\/j.clinbiochem.2019.08.012_bb0420","doi-asserted-by":"crossref","first-page":"158","DOI":"10.1016\/j.clinbiochem.2018.10.014","article-title":"Pre-analytical variables affecting discordant results on repeat sample testing for cardiac troponin I","volume":"63","author":"Kittanakom","year":"2019","journal-title":"Clin. Biochem."},{"issue":"4","key":"10.1016\/j.clinbiochem.2019.08.012_bb0425","doi-asserted-by":"crossref","first-page":"699","DOI":"10.1016\/j.emc.2011.09.016","article-title":"Emergency department treatment of acute coronary syndromes","volume":"29","author":"Yiadom","year":"2011","journal-title":"Emerg. Med. Clin. North Am."},{"key":"10.1016\/j.clinbiochem.2019.08.012_bb0430","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1016\/j.cca.2013.09.004","article-title":"Interference from heterophilic antibodies in troponin testing. Case report and systematic review of the literature","volume":"426","author":"Lippi","year":"2013","journal-title":"Clin. Chim. Acta Int. J. Clin. Chem."},{"issue":"1","key":"10.1016\/j.clinbiochem.2019.08.012_bb0435","doi-asserted-by":"crossref","first-page":"102","DOI":"10.5603\/EP.a2018.0084","article-title":"The effect of biotin interference on the results of blood hormone assays [Wp\u0142yw interferencji biotyny na wyniki oznacze\u0144 st\u0119\u017cenia hormon\u00f3w we krwi]","volume":"70","author":"Ostrowska","year":"2019","journal-title":"Endokrynol Pol."},{"issue":"1","key":"10.1016\/j.clinbiochem.2019.08.012_bb0440","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1093\/clinchem\/30.1.28","article-title":"Effect of sample dilution on measurements of free (unbound) hormones","volume":"30","author":"Geiseler","year":"1984","journal-title":"Clin. Chem."},{"issue":"1","key":"10.1016\/j.clinbiochem.2019.08.012_bb0445","doi-asserted-by":"crossref","first-page":"164","DOI":"10.1111\/1751-7915.12150","article-title":"Endogenous biotin-binding proteins: an overlooked factor causing false positives in streptavidin-based protein detection","volume":"8","author":"Tytgat","year":"2015","journal-title":"Microb. Biotechnol."},{"issue":"2","key":"10.1016\/j.clinbiochem.2019.08.012_bb0450","doi-asserted-by":"crossref","first-page":"216","DOI":"10.1177\/0004563217707783","article-title":"Depletion of biotin using streptavidin-coated microparticles: a validated solution to the problem of biotin interference in streptavidin-biotin immunoassays","volume":"55","author":"Trambas","year":"2018","journal-title":"Ann. Clin. Biochem."},{"key":"10.1016\/j.clinbiochem.2019.08.012_bb0455","doi-asserted-by":"crossref","first-page":"S197","DOI":"10.1016\/j.cca.2019.03.409","article-title":"Performance evaluation of a new troponin T-high sensitive assay with increased tolerance to biotin","volume":"493","author":"Zerback","year":"2019","journal-title":"Clin. Chim. Acta"},{"key":"10.1016\/j.clinbiochem.2019.08.012_bb0460","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1016\/j.clinbiochem.2018.12.007","article-title":"Strategies for mitigating risk posed by biotin interference on clinical immunoassays","volume":"65","author":"Gifford","year":"2019","journal-title":"Clin. Biochem."},{"key":"10.1016\/j.clinbiochem.2019.08.012_bb0495","author":"Affiliated Laboratories"},{"key":"10.1016\/j.clinbiochem.2019.08.012_bb0500","author":"Beaumont Laboratory"},{"key":"10.1016\/j.clinbiochem.2019.08.012_bb0505","author":"ARUP laboratories"},{"key":"10.1016\/j.clinbiochem.2019.08.012_bb0520","author":"Quest Diagnostics"},{"issue":"6","key":"10.1016\/j.clinbiochem.2019.08.012_bb0525","doi-asserted-by":"crossref","first-page":"991","DOI":"10.1001\/jamainternmed.2014.1059","article-title":"Medicine\u2019s uncomfortable relationship with math: calculating positive predictive value","volume":"174","author":"Manrai","year":"2014","journal-title":"JAMA Intern. Med."},{"key":"10.1016\/j.clinbiochem.2019.08.012_bb0530","unstructured":"CDC, Age-adjusted prevalence of CKD Stages 1\u20134 by Gender 1999-2012. Chronic Kidney Disease (CKD) Surveillance Project website. https:\/\/nccd.cdc.gov."}],"container-title":["Clinical Biochemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0009912019307763?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0009912019307763?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,2]],"date-time":"2025-11-02T20:09:45Z","timestamp":1762114185000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0009912019307763"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,12]]},"references-count":98,"alternative-id":["S0009912019307763"],"URL":"https:\/\/doi.org\/10.1016\/j.clinbiochem.2019.08.012","relation":{},"ISSN":["0009-9120"],"issn-type":[{"value":"0009-9120","type":"print"}],"subject":[],"published":{"date-parts":[[2019,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Best practices in mitigating the risk of biotin interference with laboratory testing","name":"articletitle","label":"Article Title"},{"value":"Clinical Biochemistry","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.clinbiochem.2019.08.012","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2019 The Authors. Published by Elsevier Inc. on behalf of The Canadian Society of Clinical Chemists.","name":"copyright","label":"Copyright"}]}}