{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T02:23:27Z","timestamp":1769912607316,"version":"3.49.0"},"reference-count":38,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2020,3,1]],"date-time":"2020-03-01T00:00:00Z","timestamp":1583020800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,3,1]],"date-time":"2020-03-01T00:00:00Z","timestamp":1583020800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Clinical Biochemistry"],"published-print":{"date-parts":[[2020,3]]},"DOI":"10.1016\/j.clinbiochem.2020.01.005","type":"journal-article","created":{"date-parts":[[2020,1,21]],"date-time":"2020-01-21T02:18:33Z","timestamp":1579573113000},"page":"26-31","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":23,"special_numbering":"C","title":["Very high rate of false positive biochemical results when screening for pheochromocytoma in a large, undifferentiated population with variable indications for testing"],"prefix":"10.1016","volume":"77","author":[{"given":"G.A.","family":"Kline","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J.","family":"Boyd","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.A.","family":"Leung","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.","family":"Tang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"H.M.","family":"Sadrzadeh","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"issue":"12","key":"10.1016\/j.clinbiochem.2020.01.005_b0005","doi-asserted-by":"crossref","first-page":"2331","DOI":"10.1097\/01.hjh.0000251887.01885.54","article-title":"Pheochromocytoma: presentation, diagnosis and treatment","volume":"24","author":"Reisch","year":"2006","journal-title":"J. Hypertens."},{"issue":"6","key":"10.1016\/j.clinbiochem.2020.01.005_b0010","doi-asserted-by":"crossref","first-page":"1853","DOI":"10.1210\/jc.2008-2291","article-title":"Prevalence and incidence of endocrine and metabolic disorders in the United States: a comprehensive review","volume":"94","author":"Golden","year":"2009","journal-title":"J. Clin. Endocrinol. Metabol."},{"issue":"6","key":"10.1016\/j.clinbiochem.2020.01.005_b0015","doi-asserted-by":"crossref","first-page":"675","DOI":"10.1111\/j.1365-2796.1994.tb00861.x","article-title":"GARC\u00cdA-MAYOR RVG. Incidence of pheochromocytoma in South Galicia Spain","volume":"236","author":"Fern\u00e1ndez-Calvet","year":"1994","journal-title":"J Intern Med."},{"issue":"6","key":"10.1016\/j.clinbiochem.2020.01.005_b0020","doi-asserted-by":"crossref","first-page":"727","DOI":"10.1016\/j.jamcollsurg.2009.09.022","article-title":"Clinical spectrum of pheochromocytoma","volume":"209","author":"Guerrero","year":"2009","journal-title":"J. Am. Coll. Surg."},{"issue":"1","key":"10.1016\/j.clinbiochem.2020.01.005_b0025","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1186\/s40200-016-0226-x","article-title":"Does this patient have pheochromocytoma? A systematic review of clinical signs and symptoms","volume":"15","author":"Pourian","year":"2016","journal-title":"J Diabetes Metab. Disord."},{"issue":"5","key":"10.1016\/j.clinbiochem.2020.01.005_b0030","doi-asserted-by":"crossref","first-page":"689","DOI":"10.1046\/j.1365-2265.2001.01096.x","article-title":"Cardiac phaeochromocytoma presenting with severe hypertension and chest pain","volume":"54","author":"Sawka","year":"2001","journal-title":"Clin. Endocrinol. (Oxf.)."},{"issue":"2","key":"10.1016\/j.clinbiochem.2020.01.005_b0035","doi-asserted-by":"crossref","first-page":"74","DOI":"10.1111\/j.1751-7176.2009.00073.x","article-title":"Pheochromocytoma presenting with myocardial infarction, cardiomyopathy, renal failure, pulmonary hemorrhage, and cyclic hypotension: Case report and review of unusual presentations of pheochromocytoma","volume":"11","author":"Park","year":"2009","journal-title":"J. Clin. Hypertens."},{"issue":"9","key":"10.1016\/j.clinbiochem.2020.01.005_b0040","doi-asserted-by":"crossref","first-page":"3296","DOI":"10.1210\/jc.2017-00992","article-title":"Malignant pheochromocytoma and paraganglioma: 272 patients over 55 years","volume":"02","author":"Hamidi","year":"2017","journal-title":"J. Clin. Endocrinol. Metab. [Internet]"},{"issue":"8","key":"10.1016\/j.clinbiochem.2020.01.005_b0045","doi-asserted-by":"crossref","first-page":"2851","DOI":"10.1210\/jc.2005-2178","article-title":"Should patients with apparently sporadic pheochromocytomas or paragangliomas be screened for hereditary syndromes?","volume":"91","author":"Jim\u00e9nez","year":"2006","journal-title":"J. Clin. Endocrinol. Metab."},{"issue":"2","key":"10.1016\/j.clinbiochem.2020.01.005_b0050","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1097\/00006842-199003000-00001","article-title":"Peripheral catecholamine levels and the symptoms of anxiety: studies in patients with and without pheochromocytoma","volume":"52","author":"Starkman","year":"1990","journal-title":"Psychosom Med."},{"issue":"1","key":"10.1016\/j.clinbiochem.2020.01.005_b0055","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1016\/0165-1781(85)90090-3","article-title":"Urinary catecholamines and mitral valve prolapse in panic-anxiety patients","volume":"14","author":"Nesse","year":"1985","journal-title":"Psychiatry Res."},{"key":"10.1016\/j.clinbiochem.2020.01.005_b0060","doi-asserted-by":"crossref","first-page":"469","DOI":"10.1196\/annals.1410.019","article-title":"Unexplained symptomatic paroxysmal hypertension in pseudopheochromocytoma: a stress response disorder?","volume":"1148","author":"Eisenhofer","year":"2008","journal-title":"Ann. NY Acad. Sci."},{"issue":"10","key":"10.1016\/j.clinbiochem.2020.01.005_b0065","doi-asserted-by":"crossref","first-page":"754","DOI":"10.1001\/jama.1966.03110100062014","article-title":"The neurologist\u2019s experience with pheochromocytoma: a review of 100 cases","volume":"197","author":"Thomas","year":"1966","journal-title":"JAMA J Am Med Assoc."},{"issue":"4","key":"10.1016\/j.clinbiochem.2020.01.005_b0070","doi-asserted-by":"crossref","first-page":"382","DOI":"10.1111\/j.1085-9489.2005.00051.x","article-title":"Acute dysautonomia: A rare manifestation of diabetic autonomic neuropathy masquerading as pheochromocytoma [1]","volume":"10","author":"Leow","year":"2005","journal-title":"J Peripher Nerv Syst."},{"key":"10.1016\/j.clinbiochem.2020.01.005_b0075","doi-asserted-by":"crossref","first-page":"757","DOI":"10.4065\/70.8.757","article-title":"In search of a cause","volume":"70","author":"Young","year":"1995","journal-title":"Mayo Clin Proc."},{"issue":"1","key":"10.1016\/j.clinbiochem.2020.01.005_b0080","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1038\/nrneph.2012.260","article-title":"Resistant hypertension\u2014its identification and epidemiology","volume":"9","author":"Sarafidis","year":"2013","journal-title":"Nat. Rev. Nephrol."},{"issue":"6","key":"10.1016\/j.clinbiochem.2020.01.005_b0085","doi-asserted-by":"crossref","first-page":"1076","DOI":"10.1161\/HYPERTENSIONAHA.111.170308","article-title":"Prevalence of resistant hypertension in the United States, 2003\u20132008","volume":"57","author":"Persell","year":"2011","journal-title":"Hypertension"},{"key":"10.1016\/j.clinbiochem.2020.01.005_b0090","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1196\/annals.1353.001","article-title":"An overview of pheochromocytoma: history, current concepts, vagaries, and diagnostic challenges","volume":"1073","author":"Manger","year":"2006","journal-title":"Ann. N.Y. Acad. Sci."},{"key":"10.1016\/j.clinbiochem.2020.01.005_b0095","series-title":"Annals of the New York Academy of Sciences","first-page":"47","article-title":"Lack of symptoms in patients with histologic evidence of pheochromocytoma: A diagnostic challenge","author":"Cohen","year":"2006"},{"issue":"1","key":"10.1016\/j.clinbiochem.2020.01.005_b0100","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1016\/j.ejim.2007.02.029","article-title":"Unexpected metastatic pheochromocytoma \u2013 An unusual presentation","volume":"19","author":"Birrenbach","year":"2008","journal-title":"Eur. J. Intern. Med."},{"issue":"3","key":"10.1016\/j.clinbiochem.2020.01.005_b0105","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1530\/EJE-19-0176","article-title":"A high rate of modestly elevated plasma normetanephrine in a population referred for suspected PPGL when measured in a seated position","volume":"181","author":"Boyd","year":"2019","journal-title":"Eur. J. Endocrinol."},{"issue":"4","key":"10.1016\/j.clinbiochem.2020.01.005_b0110","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1093\/nop\/npv035","article-title":"Diagnostic tests: How to estimate the positive predictive value","volume":"2","author":"Molinaro","year":"2015","journal-title":"Neuro-Oncol. Pract."},{"key":"10.1016\/j.clinbiochem.2020.01.005_b0115","doi-asserted-by":"crossref","first-page":"272","DOI":"10.1097\/00060793-200308000-00008","article-title":"The spectrum effect in the evaluation of Cushing syndrome","volume":"10","author":"Ayala","year":"2003","journal-title":"Curr. Opin. Endocrinol Diabetes."},{"issue":"3","key":"10.1016\/j.clinbiochem.2020.01.005_b0120","doi-asserted-by":"crossref","first-page":"533","DOI":"10.1093\/clinchem\/48.3.533","article-title":"Validation of liquid chromatography-tandem mass spectrometry method for analysis of urinary conjugated metanephrine and normetanephrine for screening of pheochromocytoma","volume":"48","author":"Taylor","year":"2002","journal-title":"Clin. Chem."},{"issue":"6","key":"10.1016\/j.clinbiochem.2020.01.005_b0125","doi-asserted-by":"crossref","first-page":"461","DOI":"10.7326\/0003-4819-130-6-199903160-00002","article-title":"A more accurate method to estimate glomerular filtration rate from serum creatinine: a new prediction equation. Modification of diet in renal disease study group","volume":"130","author":"Levey","year":"1999","journal-title":"Ann. Intern. Med."},{"issue":"11","key":"10.1016\/j.clinbiochem.2020.01.005_b0130","first-page":"1427","article-title":"Biochemical diagnosis of pheochromocytoma","volume":"287","author":"Lenders","year":"2002","journal-title":"JAMA [Internet]"},{"issue":"1","key":"10.1016\/j.clinbiochem.2020.01.005_b0135","doi-asserted-by":"crossref","first-page":"102","DOI":"10.1097\/01.sla.0000193833.51108.24","article-title":"Detecting pheochromocytoma","volume":"243","author":"Guller","year":"2006","journal-title":"Ann. Surg. [Internet]"},{"issue":"May","key":"10.1016\/j.clinbiochem.2020.01.005_b0140","first-page":"612","article-title":"Pheochromocytoma and paraganglioma: an endocrine society clinical practice guideline","volume":"99","author":"Lenders","year":"2014","journal-title":"Mayo Clin. Eunice Kennedy Shriver Natl. Inst. Child Heal. Hum. Dev. Mayo Clin. [Internet]"},{"issue":"3","key":"10.1016\/j.clinbiochem.2020.01.005_b0145","doi-asserted-by":"crossref","first-page":"680","DOI":"10.1213\/01.ANE.0000133136.01381.52","article-title":"Pheochromocytoma crisis: the use of magnesium sulfate","volume":"99","author":"James","year":"2004","journal-title":"Anesth. Analg."},{"key":"10.1016\/j.clinbiochem.2020.01.005_b0150","doi-asserted-by":"crossref","DOI":"10.1373\/clinchem.2010.153320","article-title":"Measurements of plasma methoxytyramine, normetanephrine, and metanephrine as discriminators of different hereditary forms of pheochromocytoma","author":"Eisenhofer","year":"2011","journal-title":"Clin. Chem."},{"issue":"3","key":"10.1016\/j.clinbiochem.2020.01.005_b0155","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1023\/A:1011572617314","article-title":"Understanding catecholamine metabolism as a guide to the biochemical diagnosis of pheochromocytoma","volume":"2","author":"Eisenhofer","year":"2001","journal-title":"Rev. Endocr. Metab. Disord. [Internet]"},{"key":"10.1016\/j.clinbiochem.2020.01.005_b0160","doi-asserted-by":"crossref","DOI":"10.1177\/0004563216646395","article-title":"Screening for phaeochromocytoma and paraganglioma: impact of using supine reference intervals for plasma metanephrines with samples collected from fasted\/seated patients","author":"Casey","year":"2017","journal-title":"Ann. Clin. Biochem."},{"key":"10.1016\/j.clinbiochem.2020.01.005_b0165","first-page":"218","article-title":"Catecholamine excess: Pseudopheochromocytoma and beyond. Vol. 22, Advances in Chronic Kidney Disease","author":"Garcha","year":"2015","journal-title":"W.B. Saunders"},{"issue":"3","key":"10.1016\/j.clinbiochem.2020.01.005_b0170","doi-asserted-by":"crossref","first-page":"194","DOI":"10.4158\/EP.15.3.194","article-title":"Comparison of pheochromocytomas and abdominal and pelvic paragangliomas with head and neck paragangliomas","volume":"15","author":"Al-Harthy","year":"2009","journal-title":"Endocr Pract [Internet]."},{"key":"10.1016\/j.clinbiochem.2020.01.005_b0175","doi-asserted-by":"crossref","first-page":"464","DOI":"10.1111\/cen.12624","article-title":"Supine or sitting? The voice of the patient stakeholders: economics vs clinically and medically sound","volume":"82","author":"Sussman","year":"2015","journal-title":"Clin. Endocrinol. (Oxf)."},{"key":"10.1016\/j.clinbiochem.2020.01.005_b0180","doi-asserted-by":"crossref","DOI":"10.1373\/clinchem.2018.291369","article-title":"Biochemical diagnosis of chromaffin cell tumors in patients at high and low risk of disease: plasma versus urinary free or deconjugated o-methylated catecholamine metabolites","author":"Eisenhofer","year":"2018","journal-title":"Clin. Chem."},{"issue":"5","key":"10.1016\/j.clinbiochem.2020.01.005_b0185","doi-asserted-by":"crossref","first-page":"2033","DOI":"10.1210\/jc.2003-031348","article-title":"Obstructive sleep apnea presenting as pseudopheochromocytoma: a case report","volume":"89","author":"Hoy","year":"2004","journal-title":"J. Clin. Endocrinol. Metab."},{"issue":"1","key":"10.1016\/j.clinbiochem.2020.01.005_b0190","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1258\/acb.2012.012066","article-title":"Reference intervals for plasma free metanephrines with an age adjustment for normetanephrine for optimized laboratory testing of phaeochromocytoma","volume":"50","author":"Eisenhofer","year":"2013","journal-title":"Ann. Clin. Biochem."}],"container-title":["Clinical Biochemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0009912019311968?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0009912019311968?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,14]],"date-time":"2025-09-14T15:54:42Z","timestamp":1757865282000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0009912019311968"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,3]]},"references-count":38,"alternative-id":["S0009912019311968"],"URL":"https:\/\/doi.org\/10.1016\/j.clinbiochem.2020.01.005","relation":{},"ISSN":["0009-9120"],"issn-type":[{"value":"0009-9120","type":"print"}],"subject":[],"published":{"date-parts":[[2020,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Very high rate of false positive biochemical results when screening for pheochromocytoma in a large, undifferentiated population with variable indications for testing","name":"articletitle","label":"Article Title"},{"value":"Clinical Biochemistry","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.clinbiochem.2020.01.005","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2020 The Canadian Society of Clinical Chemists. Published by Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}