{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T16:00:59Z","timestamp":1790697659504,"version":"4.1.0"},"reference-count":89,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2020,11,1]],"date-time":"2020-11-01T00:00:00Z","timestamp":1604188800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,11,1]],"date-time":"2020-11-01T00:00:00Z","timestamp":1604188800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2021,10,16]],"date-time":"2021-10-16T00:00:00Z","timestamp":1634342400000},"content-version":"am","delay-in-days":349,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Clinical Biochemistry"],"published-print":{"date-parts":[[2020,11]]},"DOI":"10.1016\/j.clinbiochem.2020.08.001","type":"journal-article","created":{"date-parts":[[2020,8,8]],"date-time":"2020-08-08T10:45:16Z","timestamp":1596883516000},"page":"5-11","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":23,"special_numbering":"C","title":["Interest of blood biomarkers to predict lesions in medical imaging in the context of mild traumatic brain injury"],"prefix":"10.1016","volume":"85","author":[{"given":"Damien","family":"Bouvier","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Charlotte","family":"Oris","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marina","family":"Brailova","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julie","family":"Durif","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vincent","family":"Sapin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.clinbiochem.2020.08.001_b0005","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1080\/16501960410023732","article-title":"Incidence, risk factors and prevention of mild traumatic brain injury: results of the who collaborating centre task force on mild traumatic brain injury","volume":"36","author":"Cassidy","year":"2004","journal-title":"J. Rehabil. Med."},{"issue":"3","key":"10.1016\/j.clinbiochem.2020.08.001_b0010","doi-asserted-by":"crossref","first-page":"270","DOI":"10.1007\/s11102-019-00957-9","article-title":"Traumatic brain injury: neuropathological, neurocognitive and neurobehavioral sequelae","volume":"22","author":"Pavlovic","year":"2019","journal-title":"Pituitary"},{"issue":"9840","key":"10.1016\/j.clinbiochem.2020.08.001_b0015","doi-asserted-by":"crossref","first-page":"499","DOI":"10.1016\/S0140-6736(12)60815-0","article-title":"Radiation exposure from CT scans in childhood and subsequent risk of leukaemia and brain tumours: a retrospective cohort study","volume":"380","author":"Pearce","year":"2012","journal-title":"The Lancet"},{"key":"10.1016\/j.clinbiochem.2020.08.001_b0020","first-page":"346","article-title":"Cancer risk in 680,000 people exposed to computed tomography scans in childhood or adolescence: data linkage study of 11 million Australians","author":"Mathews","year":"2013","journal-title":"BMJ"},{"issue":"8","key":"10.1016\/j.clinbiochem.2020.08.001_b0025","doi-asserted-by":"crossref","first-page":"700","DOI":"10.1001\/jamapediatrics.2013.311","article-title":"The use of computed tomography in pediatrics and the associated radiation exposure and estimated cancer risk","volume":"167","author":"Miglioretti","year":"2013","journal-title":"JAMA Pediatr"},{"issue":"7566","key":"10.1016\/j.clinbiochem.2020.08.001_b0030","doi-asserted-by":"crossref","first-page":"469","DOI":"10.1136\/bmj.38918.659120.4F","article-title":"Immediate computed tomography or admission for observation after mild head injury: cost comparison in randomised controlled trial","volume":"333","author":"Norlund","year":"2006","journal-title":"BMJ"},{"issue":"2","key":"10.1016\/j.clinbiochem.2020.08.001_b0035","doi-asserted-by":"crossref","first-page":"100","DOI":"10.1056\/NEJM200007133430204","article-title":"Indications for computed tomography in patients with minor head injury","volume":"343","author":"Haydel","year":"2000","journal-title":"N. Engl. J. Med."},{"issue":"6","key":"10.1016\/j.clinbiochem.2020.08.001_b0040","doi-asserted-by":"crossref","first-page":"e78","DOI":"10.1542\/peds.104.6.e78","article-title":"Technical report: minor head injury in children","volume":"104","author":"Homer","year":"1999","journal-title":"Pediatrics"},{"issue":"9266","key":"10.1016\/j.clinbiochem.2020.08.001_b0045","doi-asserted-by":"crossref","first-page":"1391","DOI":"10.1016\/S0140-6736(00)04561-X","article-title":"The Canadian CT Head Rule for patients with minor head injury","volume":"357","author":"Stiell","year":"2001","journal-title":"The Lancet"},{"issue":"10087","key":"10.1016\/j.clinbiochem.2020.08.001_b0050","doi-asserted-by":"crossref","first-page":"2393","DOI":"10.1016\/S0140-6736(17)30555-X","article-title":"Accuracy of PECARN, CATCH, and CHALICE head injury decision rules in children: a prospective cohort study","volume":"389","author":"Babl","year":"2017","journal-title":"The Lancet"},{"issue":"9696","key":"10.1016\/j.clinbiochem.2020.08.001_b0055","doi-asserted-by":"crossref","first-page":"1160","DOI":"10.1016\/S0140-6736(09)61558-0","article-title":"Identification of children at very low risk of clinically-important brain injuries after head trauma: a prospective cohort study","volume":"374","author":"Kuppermann","year":"2009","journal-title":"The Lancet"},{"issue":"12","key":"10.1016\/j.clinbiochem.2020.08.001_b0060","doi-asserted-by":"crossref","first-page":"1511","DOI":"10.1001\/jama.294.12.1511","article-title":"Comparison of the Canadian CT Head Rule and the New Orleans Criteria in patients with minor head injury","volume":"294","author":"Stiell","year":"2005","journal-title":"JAMA"},{"issue":"4","key":"10.1016\/j.clinbiochem.2020.08.001_b0065","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1038\/nrneurol.2013.9","article-title":"Biomarkers of mild traumatic brain injury in cerebrospinal fluid and blood","volume":"9","author":"Zetterberg","year":"2013","journal-title":"Nat. Rev. Neurol."},{"issue":"3","key":"10.1016\/j.clinbiochem.2020.08.001_b0070","doi-asserted-by":"crossref","first-page":"503","DOI":"10.1002\/med.21295","article-title":"The challenge of mild traumatic brain injury: role of biochemical markers in diagnosis of brain damage: serum markers for brain damage in mild TBI","volume":"34","author":"Mondello","year":"2014","journal-title":"Med. Res. Rev."},{"issue":"7","key":"10.1016\/j.clinbiochem.2020.08.001_b0075","doi-asserted-by":"crossref","first-page":"637","DOI":"10.1016\/S1357-2725(01)00046-2","article-title":"S100: a multigenic family of calcium-modulated proteins of the EF-hand type with intracellular and extracellular functional roles","volume":"33","author":"Donato","year":"2001","journal-title":"Int. J. Biochem. Cell Biol."},{"issue":"2","key":"10.1016\/j.clinbiochem.2020.08.001_b0080","first-page":"83","article-title":"S100 B: A new concept in neurocritical care","volume":"16","author":"Rezaei","year":"2017","journal-title":"Iran J. Neurol."},{"issue":"9","key":"10.1016\/j.clinbiochem.2020.08.001_b0085","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0012691","article-title":"Extracranial sources of S100B do not affect serum levels","volume":"5","author":"Pham","year":"2010","journal-title":"PloS One"},{"issue":"1","key":"10.1016\/j.clinbiochem.2020.08.001_b0090","doi-asserted-by":"crossref","first-page":"1","DOI":"10.4331\/wjbc.v4.i1.1","article-title":"S100B protein in tissue development, repair and regeneration","volume":"4","author":"Sorci","year":"2013","journal-title":"World J Biol Chem."},{"issue":"3","key":"10.1016\/j.clinbiochem.2020.08.001_b0095","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1016\/S0361-9230(03)00091-1","article-title":"Cerebrospinal fluid (CSF) and serum S100B: release and wash-out pattern","volume":"61","author":"Petzold","year":"2003","journal-title":"Brain Res. Bull."},{"issue":"6","key":"10.1016\/j.clinbiochem.2020.08.001_b0100","doi-asserted-by":"crossref","first-page":"698","DOI":"10.1053\/jcan.2000.18444","article-title":"Elimination of S100B and renal function after cardiac surgery","volume":"14","author":"J\u00f6nsson","year":"2000","journal-title":"J. Cardiothorac. Vasc. Anesth."},{"issue":"2","key":"10.1016\/j.clinbiochem.2020.08.001_b0105","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1089\/neu.2006.23.149","article-title":"Rapid elimination of protein S-100B from serum after minor head trauma","volume":"23","author":"Townend","year":"2006","journal-title":"J. Neurotrauma"},{"issue":"5","key":"10.1016\/j.clinbiochem.2020.08.001_b0110","doi-asserted-by":"crossref","first-page":"833","DOI":"10.1515\/cclm-2015-0771","article-title":"Preanalytical, analytical, gestational and pediatric aspects of the S100B immuno-assays","volume":"54","author":"Bouvier","year":"2016","journal-title":"Clin. Chem. Lab. Med."},{"key":"10.1016\/j.clinbiochem.2020.08.001_b0115","doi-asserted-by":"crossref","DOI":"10.1515\/cclm-2018-1217","article-title":"Measurement of S100B protein: evaluation of a new prototype on a bioMerieux Vidas\u00ae 3 analyzer","author":"Oris","year":"2019","journal-title":"Clin. Chem. Lab. Med."},{"issue":"5","key":"10.1016\/j.clinbiochem.2020.08.001_b0120","doi-asserted-by":"crossref","first-page":"836","DOI":"10.1373\/49.5.836","article-title":"Reference values for serum S-100B protein depend on the race of individuals","volume":"49","author":"Ben Abdesselam","year":"2003","journal-title":"Clin. Chem."},{"issue":"6","key":"10.1016\/j.clinbiochem.2020.08.001_b0125","doi-asserted-by":"crossref","first-page":"830","DOI":"10.4085\/1062-6050-49.3.33","article-title":"A systematic review of the biomarker S100B: implications for sport-related concussion management","volume":"49","author":"Schulte","year":"2014","journal-title":"J. Athl. Train."},{"issue":"4","key":"10.1016\/j.clinbiochem.2020.08.001_b0130","doi-asserted-by":"crossref","first-page":"781","DOI":"10.1007\/s40279-016-0579-9","article-title":"Utility of S100B serum level for the determination of concussion in male rugby players","volume":"47","author":"Bouvier","year":"2017","journal-title":"Sports Med."},{"issue":"5","key":"10.1016\/j.clinbiochem.2020.08.001_b0135","doi-asserted-by":"crossref","first-page":"446","DOI":"10.1097\/01.shk.0000209534.61058.35","article-title":"Serum S-100B concentration provides additional information fot the indication of computed tomography in patients after minor head injury: a prospective multicenter study","volume":"25","author":"Biberthaler","year":"2006","journal-title":"Shock"},{"issue":"4","key":"10.1016\/j.clinbiochem.2020.08.001_b0140","doi-asserted-by":"crossref","first-page":"228","DOI":"10.1097\/HTR.0b013e3181e57e22","article-title":"Can low serum levels of S100B predict normal CT findings after minor head injury in adults?: an evidence-based review and meta-analysis","volume":"25","author":"Und\u00e9n","year":"2010","journal-title":"J. Head Trauma Rehabil."},{"issue":"1","key":"10.1016\/j.clinbiochem.2020.08.001_b0145","doi-asserted-by":"crossref","DOI":"10.1186\/1741-7015-11-50","article-title":"Scandinavian guidelines for initial management of minimal, mild and moderate head injuries in adults: an evidence and consensus-based update","volume":"11","author":"Und\u00e9n","year":"2013","journal-title":"BMC Med."},{"key":"10.1016\/j.clinbiochem.2020.08.001_b0150","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1186\/1471-227X-12-13","article-title":"Clinical validation of S100B use in management of mild head injury","volume":"12","author":"Calcagnile","year":"2012","journal-title":"BMC Emerg. Med."},{"key":"10.1016\/j.clinbiochem.2020.08.001_b0155","doi-asserted-by":"crossref","first-page":"292","DOI":"10.1186\/s12916-015-0533-y","article-title":"Validation of the Scandinavian guidelines for initial management of minimal, mild and moderate traumatic brain injury in adults","volume":"13","author":"Und\u00e9n","year":"2015","journal-title":"BMC Med."},{"issue":"11","key":"10.1016\/j.clinbiochem.2020.08.001_b0160","doi-asserted-by":"crossref","first-page":"1897","DOI":"10.1515\/cclm-2018-0471","article-title":"Clinical validation of S100B in the management of a mild traumatic brain injury: issues from an interventional cohort of 1449 adult patients","volume":"56","author":"Allouchery","year":"2018","journal-title":"Clin. Chem. Lab. Med."},{"issue":"1","key":"10.1016\/j.clinbiochem.2020.08.001_b0165","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1097\/01.TA.0000130613.35877.75","article-title":"Raised serum S100B levels after acute bone fractures without cerebral injury","volume":"58","author":"Unden","year":"2005","journal-title":"J. Trauma"},{"issue":"6","key":"10.1016\/j.clinbiochem.2020.08.001_b0170","first-page":"1255","article-title":"High serum S100B levels for trauma patients without head injuries","volume":"48","author":"Anderson","year":"2001","journal-title":"Neurosurgery"},{"issue":"4","key":"10.1016\/j.clinbiochem.2020.08.001_b0175","doi-asserted-by":"crossref","first-page":"527","DOI":"10.1515\/cclm-2013-0621","article-title":"S100B blood level measurement to exclude cerebral lesions after minor head injury: the multicenter STIC-S100 French study","volume":"52","author":"Laribi","year":"2014","journal-title":"Clin. Chem. Lab. Med."},{"issue":"6","key":"10.1016\/j.clinbiochem.2020.08.001_b0180","doi-asserted-by":"crossref","DOI":"10.1542\/peds.2018-0037","article-title":"The biomarker S100B and mild traumatic brain injury: A meta-analysis","volume":"141","author":"Oris","year":"2018","journal-title":"Pediatrics"},{"issue":"10-11","key":"10.1016\/j.clinbiochem.2020.08.001_b0185","doi-asserted-by":"crossref","first-page":"927","DOI":"10.1016\/j.clinbiochem.2011.05.004","article-title":"Reference ranges for serum S100B protein during the first three years of life","volume":"44","author":"Bouvier","year":"2011","journal-title":"Clin. Biochem."},{"issue":"18","key":"10.1016\/j.clinbiochem.2020.08.001_b0190","doi-asserted-by":"crossref","first-page":"1056","DOI":"10.1016\/j.clinbiochem.2017.08.014","article-title":"Reference ranges for serum S100B neuroprotein specific to infants under four months of age","volume":"50","author":"Simon-Pimmel","year":"2017","journal-title":"Clin. Biochem."},{"issue":"2","key":"10.1016\/j.clinbiochem.2020.08.001_b0195","doi-asserted-by":"crossref","first-page":"351","DOI":"10.1016\/0006-8993(71)90668-8","article-title":"An acidic protein isolated from fibrous astrocytes","volume":"28","author":"Eng","year":"1971","journal-title":"Brain Res."},{"issue":"12","key":"10.1016\/j.clinbiochem.2020.08.001_b0200","doi-asserted-by":"crossref","DOI":"10.1101\/cshperspect.a021642","article-title":"Type III intermediate filaments desmin, glial fibrillary acidic protein (GFAP), vimentin, and peripherin","volume":"9","author":"Hol","year":"2017","journal-title":"Cold Spring Harb Perspect Biol"},{"issue":"3","key":"10.1016\/j.clinbiochem.2020.08.001_b0205","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1111\/j.1750-3639.1994.tb00839.x","article-title":"Glial fibrillary acidic protein: dynamic property and regulation by phosphorylation","volume":"4","author":"Inagaki","year":"1994","journal-title":"Brain Pathol."},{"issue":"13","key":"10.1016\/j.clinbiochem.2020.08.001_b0210","doi-asserted-by":"crossref","first-page":"4691","DOI":"10.1128\/MCB.20.13.4691-4698.2000","article-title":"Evidence for an interaction between ubiquitin-conjugating enzymes and the 26S proteasome","volume":"20","author":"Tongaonkar","year":"2000","journal-title":"Mol. Cell. Biol."},{"issue":"3","key":"10.1016\/j.clinbiochem.2020.08.001_b0215","doi-asserted-by":"crossref","first-page":"429","DOI":"10.1016\/0022-510X(81)90032-0","article-title":"The demonstration of new human brain-specific proteins by high-resolution two-dimensional polyacrylamide gel electrophoresis","volume":"49","author":"Jackson","year":"1981","journal-title":"J. Neurol. Sci."},{"issue":"1","key":"10.1016\/j.clinbiochem.2020.08.001_b0220","doi-asserted-by":"crossref","first-page":"162","DOI":"10.1089\/neu.2011.1989","article-title":"Serum concentrations of ubiquitin C-terminal hydrolase-L1 and alphaII-spectrin breakdown product 145 kDa correlate with outcome after pediatric TBI","volume":"29","author":"Berger","year":"2012","journal-title":"J. Neurotrauma"},{"issue":"4","key":"10.1016\/j.clinbiochem.2020.08.001_b0225","doi-asserted-by":"crossref","first-page":"a018309","DOI":"10.1101\/cshperspect.a018309","article-title":"Neurofilaments and neurofilament proteins in health and disease","volume":"9","author":"Yuan","year":"2017","journal-title":"Cold Spring Harb. Perspect. Biol."},{"issue":"2","key":"10.1016\/j.clinbiochem.2020.08.001_b0230","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1007\/s00701-005-0674-4","article-title":"All roads lead to disconnection? \u2013 Traumatic axonal injury revisited","volume":"148","author":"B\u00fcki","year":"2006","journal-title":"Acta Neurochir. (Wien)"},{"key":"10.1016\/j.clinbiochem.2020.08.001_b0235","doi-asserted-by":"crossref","first-page":"473","DOI":"10.1016\/j.ijbiomac.2019.04.120","article-title":"Regulation of neuronal microtubule dynamics by tau: Implications for tauopathies","volume":"133","author":"Venkatramani","year":"2019","journal-title":"Int. J. Biol. Macromol."},{"issue":"2","key":"10.1016\/j.clinbiochem.2020.08.001_b0240","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1385\/NMM:2:2:131","article-title":"Tau and axonopathy in neurodegenerative disorders","volume":"2","author":"Higuchi","year":"2002","journal-title":"Neuromol. Med."},{"issue":"5","key":"10.1016\/j.clinbiochem.2020.08.001_b0245","doi-asserted-by":"crossref","first-page":"551","DOI":"10.1001\/jamaneurol.2016.0039","article-title":"Time course and diagnostic accuracy of glial and neuronal blood biomarkers GFAP and UCH-L1 in a large Cohort of Trauma patients with and without mild traumatic brain injury","volume":"73","author":"Papa","year":"2016","journal-title":"JAMA Neurol"},{"issue":"6","key":"10.1016\/j.clinbiochem.2020.08.001_b0250","doi-asserted-by":"crossref","first-page":"471","DOI":"10.1016\/j.annemergmed.2011.08.021","article-title":"Elevated levels of serum glial fibrillary acidic protein breakdown products in mild and moderate traumatic brain injury are associated with intracranial lesions and neurosurgical intervention","volume":"59","author":"Papa","year":"2012","journal-title":"Ann. Emerg. Med."},{"issue":"5","key":"10.1016\/j.clinbiochem.2020.08.001_b0255","doi-asserted-by":"crossref","first-page":"1335","DOI":"10.1097\/TA.0b013e3182491e3d","article-title":"Serum levels of ubiquitin C-terminal hydrolase distinguish mild traumatic brain injury from trauma controls and are elevated in mild and moderate traumatic brain injury patients with intracranial lesions and neurosurgical intervention","volume":"72","author":"Papa","year":"2012","journal-title":"J. Trauma Acute Care Surg."},{"issue":"7","key":"10.1016\/j.clinbiochem.2020.08.001_b0260","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0200394","article-title":"Combining H-FABP and GFAP increases the capacity to differentiate between","volume":"13","author":"Lagerstedt","year":"2018","journal-title":"PLoS One"},{"issue":"4","key":"10.1016\/j.clinbiochem.2020.08.001_b0265","doi-asserted-by":"crossref","first-page":"391","DOI":"10.1016\/j.ajem.2006.10.008","article-title":"The value of serum tau protein for the diagnosis of intracranial injury in minor head trauma","volume":"25","author":"Kavalci","year":"2007","journal-title":"Am. J. Emerg. Med."},{"issue":"5","key":"10.1016\/j.clinbiochem.2020.08.001_b0270","doi-asserted-by":"crossref","first-page":"1232","DOI":"10.3171\/2014.7.JNS132474","article-title":"Detection of neurofilament-H in serum as a diagnostic tool to predict injury severity in patients who have suffered mild traumatic brain injury: Clinical article","volume":"121","author":"Gatson","year":"2014","journal-title":"JNS"},{"issue":"1","key":"10.1016\/j.clinbiochem.2020.08.001_b0275","doi-asserted-by":"crossref","first-page":"182","DOI":"10.1089\/neu.2017.5623","article-title":"Performance evaluation of a multiplex assay for simultaneous detection of four clinically relevant traumatic brain injury biomarkers","volume":"36","author":"Korley","year":"2019","journal-title":"J. Neurotrauma"},{"issue":"15","key":"10.1016\/j.clinbiochem.2020.08.001_b0280","doi-asserted-by":"crossref","first-page":"e1385","DOI":"10.1212\/WNL.0000000000006321","article-title":"Glial fibrillary acidic protein elevations relate to neuroimaging abnormalities after mild TBI","volume":"91","author":"Gill","year":"2018","journal-title":"Neurology"},{"issue":"9","key":"10.1016\/j.clinbiochem.2020.08.001_b0285","doi-asserted-by":"crossref","first-page":"782","DOI":"10.1016\/S1474-4422(18)30231-X","article-title":"Serum GFAP and UCH-L1 for prediction of absence of intracranial injuries on head CT (ALERT-TBI): a multicenter observational study","volume":"17","author":"Bazarian","year":"2018","journal-title":"Lancet Neurol."},{"issue":"7","key":"10.1016\/j.clinbiochem.2020.08.001_b0290","doi-asserted-by":"crossref","first-page":"759","DOI":"10.1080\/02699050500488207","article-title":"Serum S-100B and cleaved-tau are poor predictors of long-term outcome after mild traumatic brain injury","volume":"20","author":"Bazarian","year":"2006","journal-title":"Brain Inj."},{"issue":"10","key":"10.1016\/j.clinbiochem.2020.08.001_b0295","doi-asserted-by":"crossref","first-page":"1551","DOI":"10.1089\/neu.2018.5952","article-title":"Early levels of glial fibrillary acidic protein and neurofilament light protein in predicting the outcome of mild traumatic brain injury","volume":"36","author":"Hossain","year":"2019","journal-title":"J. Neurotrauma"},{"issue":"18","key":"10.1016\/j.clinbiochem.2020.08.001_b0300","doi-asserted-by":"crossref","first-page":"1428","DOI":"10.1212\/WNL.0b013e318253d5c7","article-title":"GFAP and S100B in the acute phase of mild traumatic brain injury","volume":"78","author":"Metting","year":"2012","journal-title":"Neurology"},{"issue":"10","key":"10.1016\/j.clinbiochem.2020.08.001_b0305","doi-asserted-by":"crossref","first-page":"1231","DOI":"10.1080\/02699052.2016.1178396","article-title":"Are UCH-L1 and GFAP promising biomarkers for children with mild traumatic brain injury?","volume":"30","author":"Rhine","year":"2016","journal-title":"Brain Inj."},{"key":"10.1016\/j.clinbiochem.2020.08.001_b0310","doi-asserted-by":"crossref","first-page":"206","DOI":"10.1016\/j.neubiorev.2018.02.006","article-title":"Blood biomarkers in paediatric mild traumatic brain injury: a systematic review","volume":"87","author":"Lugones","year":"2018","journal-title":"Neurosci. Biobehav. Rev."},{"issue":"3","key":"10.1016\/j.clinbiochem.2020.08.001_b0315","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1097\/NEN.0b013e3181996bfe","article-title":"Biochemical, structural, and biomarker evidence for calpain-mediated cytoskeletal change after diffuse brain injury uncomplicated by contusion","volume":"68","author":"McGinn","year":"2009","journal-title":"J. Neuropathol. Exp. Neurol."},{"issue":"17","key":"10.1016\/j.clinbiochem.2020.08.001_b0320","doi-asserted-by":"crossref","first-page":"1294","DOI":"10.1089\/neu.2014.3698","article-title":"Serum SNTF increases in concussed professional ice hockey players and relates to the severity of postconcussion symptoms","volume":"32","author":"Siman","year":"2015","journal-title":"J. Neurotrauma"},{"issue":"3-4","key":"10.1016\/j.clinbiochem.2020.08.001_b0325","doi-asserted-by":"crossref","first-page":"106","DOI":"10.1007\/BF01406367","article-title":"Increased serum creatine kinase BB and neuron specific enolase following head injury indicates brain damage","volume":"115","author":"Skogseid","year":"1992","journal-title":"Acta Neurochir."},{"issue":"5690","key":"10.1016\/j.clinbiochem.2020.08.001_b0330","doi-asserted-by":"crossref","first-page":"834","DOI":"10.1038\/276834a0","article-title":"Neurone-specific enolase is a molecular marker for peripheral and central neuroendocrine cells","volume":"276","author":"Schmechel","year":"1978","journal-title":"Nature"},{"issue":"11","key":"10.1016\/j.clinbiochem.2020.08.001_b0335","doi-asserted-by":"crossref","first-page":"1215","DOI":"10.1515\/CCLM.2005.210","article-title":"Effects of hemolysis and storage condition on neuron-specific enolase (NSE) in cerebrospinal fluid and serum: implications in clinical practice","volume":"43","author":"Ramont","year":"2005","journal-title":"Clin. Chem. Lab. Med."},{"issue":"3","key":"10.1016\/j.clinbiochem.2020.08.001_b0340","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1034\/j.1600-0404.2001.103003175.x","article-title":"S-100B and neuron-specific enolase in serum of mild traumatic brain injury patients. A comparison with health controls","volume":"103","author":"de Kruijk","year":"2001","journal-title":"Acta Neurol. Scand."},{"key":"10.1016\/j.clinbiochem.2020.08.001_b0345","first-page":"S478","article-title":"The value of serum biomarkers in prediction models of outcome after mild traumatic brain injury","volume":"71","author":"Topolovec-Vranic","year":"2011","journal-title":"J. Trauma: Injury Infect. Crit. Care"},{"issue":"8056","key":"10.1016\/j.clinbiochem.2020.08.001_b0350","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1016\/S0140-6736(78)90415-4","article-title":"Serum-myelin-basic-protein assay in diagnosis and prognosis of patients with head injury","volume":"311","author":"Thomas","year":"1978","journal-title":"Lancet"},{"issue":"2","key":"10.1016\/j.clinbiochem.2020.08.001_b0355","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1007\/BF00964057","article-title":"Proteins of myelin and their metabolism","volume":"3","author":"Benjamins","year":"1978","journal-title":"Neurochem. Res."},{"issue":"1","key":"10.1016\/j.clinbiochem.2020.08.001_b0360","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/S1016-8478(23)13130-X","article-title":"Small RNAs: classification, biogenesis, and function","volume":"19","author":"Kim","year":"2005","journal-title":"Mol. Cells"},{"issue":"1","key":"10.1016\/j.clinbiochem.2020.08.001_b0365","doi-asserted-by":"crossref","first-page":"122","DOI":"10.1111\/jnc.13534","article-title":"Elevated serum miR-93, miR-191, and miR-499 are noninvasive biomarkers for the presence and progression of traumatic brain injury","volume":"137","author":"Yang","year":"2016","journal-title":"J. Neurochem."},{"issue":"11","key":"10.1016\/j.clinbiochem.2020.08.001_b0370","doi-asserted-by":"crossref","first-page":"1749","DOI":"10.4103\/1673-5374.219025","article-title":"MicroRNAs as diagnostic markers and therapeutic targets for traumatic brain injury","volume":"12","author":"Martinez","year":"2017","journal-title":"Neural Regen. Res."},{"key":"10.1016\/j.clinbiochem.2020.08.001_b0375","doi-asserted-by":"crossref","first-page":"429","DOI":"10.3389\/fneur.2018.00429","article-title":"MicroRNA signature of traumatic brain injury: from the biomarker discovery to the point-of-care","volume":"9","author":"Di Pietro","year":"2018","journal-title":"Front. Neurol."},{"issue":"11","key":"10.1016\/j.clinbiochem.2020.08.001_b0380","doi-asserted-by":"crossref","first-page":"1948","DOI":"10.1089\/neu.2016.4857","article-title":"MicroRNAs as novel biomarkers for the diagnosis and prognosis of mild and severe traumatic brain injury","volume":"34","author":"Di Pietro","year":"2017","journal-title":"J. Neurotrauma"},{"issue":"1","key":"10.1016\/j.clinbiochem.2020.08.001_b0385","doi-asserted-by":"crossref","first-page":"28148","DOI":"10.1038\/srep28148","article-title":"A panel of serum MiRNA biomarkers for the diagnosis of severe to mild traumatic brain injury in humans","volume":"6","author":"Bhomia","year":"2016","journal-title":"Sci. Rep."},{"issue":"1","key":"10.1016\/j.clinbiochem.2020.08.001_b0390","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1089\/neu.2017.5111","article-title":"Overlapping microRNA expression in saliva and cerebrospinal fluid accurately identifies pediatric traumatic brain injury","volume":"35","author":"Hicks","year":"2018","journal-title":"J. Neurotrauma"},{"issue":"11","key":"10.1016\/j.clinbiochem.2020.08.001_b0395","doi-asserted-by":"crossref","first-page":"e024245","DOI":"10.1136\/bmjopen-2018-024245","article-title":"Study of concussion in rugby union through microRNAs (SCRUM): a study protocol of a prospective, observational cohort study","volume":"8","author":"Yakoub","year":"2018","journal-title":"BMJ Open"},{"key":"10.1016\/j.clinbiochem.2020.08.001_b0400","doi-asserted-by":"crossref","first-page":"290","DOI":"10.3389\/fnmol.2018.00290","article-title":"Salivary MicroRNAs: diagnostic markers of mild traumatic brain injury in contact-sport","volume":"11","author":"Di Pietro","year":"2018","journal-title":"Front. Mol. Neurosci."},{"issue":"1","key":"10.1016\/j.clinbiochem.2020.08.001_b0405","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0207785","article-title":"Comparison of serum and saliva miRNAs for identification and characterization of mTBI in adult mixed martial arts fighters","volume":"14","author":"LaRocca","year":"2019","journal-title":"PLoS ONE"},{"issue":"1","key":"10.1016\/j.clinbiochem.2020.08.001_b0410","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1001\/jamapediatrics.2017.3884","article-title":"Association of salivary MicroRNA changes with prolonged concussion symptoms","volume":"172","author":"Johnson","year":"2018","journal-title":"JAMA Pediatr."},{"issue":"8","key":"10.1016\/j.clinbiochem.2020.08.001_b0415","doi-asserted-by":"crossref","first-page":"1343","DOI":"10.1089\/neu.2018.6072","article-title":"Elevations in MicroRNA biomarkers in serum are associated with measures of concussion, neurocognitive function, and subconcussive trauma over a single National Collegiate Athletic Association Division I Season in Collegiate Football Players","volume":"36","author":"Papa","year":"2019","journal-title":"J. Neurotrauma"},{"issue":"19","key":"10.1016\/j.clinbiochem.2020.08.001_b0420","doi-asserted-by":"crossref","first-page":"9070","DOI":"10.1073\/pnas.90.19.9070","article-title":"Dominant expression of mRNA for prostaglandin D synthase in leptomeninges, choroid plexus, and oligodendrocytes of the adult rat brain.","volume":"90","author":"Urade","year":"1993","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"issue":"5","key":"10.1016\/j.clinbiochem.2020.08.001_b0425","doi-asserted-by":"crossref","first-page":"730","DOI":"10.1002\/(SICI)1097-4547(19990901)57:5<730::AID-JNR14>3.0.CO;2-7","article-title":"Expression of the beta-trace protein in human pachymeninx as revealed by in situ hybridization and immunocytochemistry","volume":"57","author":"Bl\u00f6dorn","year":"1999","journal-title":"J. Neurosci. Res."},{"issue":"2","key":"10.1016\/j.clinbiochem.2020.08.001_b0430","doi-asserted-by":"crossref","first-page":"1110","DOI":"10.1006\/bbrc.1994.2297","article-title":"Identification of beta-trace as prostaglandin D synthase","volume":"203","author":"Watanabe","year":"1994","journal-title":"Biochem. Biophys. Res. Commun."},{"issue":"25","key":"10.1016\/j.clinbiochem.2020.08.001_b0435","doi-asserted-by":"crossref","first-page":"15789","DOI":"10.1074\/jbc.272.25.15789","article-title":"Lipocalin-type prostaglandin D synthase (beta-trace) is a newly recognized type of retinoid transporter","volume":"272","author":"Tanaka","year":"1997","journal-title":"J. Biol. Chem."},{"issue":"2","key":"10.1016\/j.clinbiochem.2020.08.001_b0440","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1016\/S0009-8981(01)00573-3","article-title":"Dynamics of brain-derived proteins in cerebrospinal fluid","volume":"310","author":"Reiber","year":"2001","journal-title":"Clin. Chim. Acta"},{"issue":"4","key":"10.1016\/j.clinbiochem.2020.08.001_b0445","doi-asserted-by":"crossref","first-page":"554","DOI":"10.1515\/cclm-2016-0442","article-title":"Retrospective validation of a beta-trace protein interpretation algorithm for the diagnosis of cerebrospinal fluid leakage","volume":"55","author":"Bernasconi","year":"2017","journal-title":"Clin. Chem. Lab. Med."}],"container-title":["Clinical Biochemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0009912020308092?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0009912020308092?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,14]],"date-time":"2025-09-14T15:55:55Z","timestamp":1757865355000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0009912020308092"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,11]]},"references-count":89,"alternative-id":["S0009912020308092"],"URL":"https:\/\/doi.org\/10.1016\/j.clinbiochem.2020.08.001","relation":{},"ISSN":["0009-9120"],"issn-type":[{"value":"0009-9120","type":"print"}],"subject":[],"published":{"date-parts":[[2020,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Interest of blood biomarkers to predict lesions in medical imaging in the context of mild traumatic brain injury","name":"articletitle","label":"Article Title"},{"value":"Clinical Biochemistry","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.clinbiochem.2020.08.001","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2020 The Canadian Society of Clinical Chemists. Published by Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}