{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,24]],"date-time":"2026-01-24T17:25:36Z","timestamp":1769275536675,"version":"3.49.0"},"reference-count":44,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2020,12,1]],"date-time":"2020-12-01T00:00:00Z","timestamp":1606780800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,12,1]],"date-time":"2020-12-01T00:00:00Z","timestamp":1606780800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/501100010586","name":"Haukeland\u00a0Universitetssjukehus","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100010586","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012446","name":"Akershus Universitetssykehus","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100012446","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100005366","name":"Universitetet i Oslo","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100005366","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100021697","name":"Sykehuset i Vestfold","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100021697","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Clinical Biochemistry"],"published-print":{"date-parts":[[2020,12]]},"DOI":"10.1016\/j.clinbiochem.2020.09.006","type":"journal-article","created":{"date-parts":[[2020,9,26]],"date-time":"2020-09-26T00:24:56Z","timestamp":1601079896000},"page":"36-44","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":9,"special_numbering":"C","title":["Gastric bypass surgery is associated with reduced subclinical myocardial injury and greater activation of the cardiac natriuretic peptide system than lifestyle intervention"],"prefix":"10.1016","volume":"86","author":[{"given":"Kristin M.","family":"Aakre","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Torbj\u00f8rn","family":"Omland","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Njord","family":"Nordstrand","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Espen S.","family":"Gjevestad","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kirsten B.","family":"Holven","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5994-9304","authenticated-orcid":false,"given":"Magnus N.","family":"Lyngbakken","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1995-0562","authenticated-orcid":false,"given":"J\u00f8ran","family":"Hjelmes\u00e6th","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.clinbiochem.2020.09.006_b0005","unstructured":"World Health Organization. Global Health Observatory (GHO) data. Overweight and obesity. https:\/\/wwwwhoint\/gho\/ncd\/risk_factors\/overweight\/en\/. Assessed February 2020."},{"issue":"2","key":"10.1016\/j.clinbiochem.2020.09.006_b0010","doi-asserted-by":"crossref","first-page":"142","DOI":"10.1016\/j.pcad.2018.07.003","article-title":"An overview and update on obesity and the obesity paradox in cardiovascular diseases","volume":"61","author":"Elagizi","year":"2018","journal-title":"Prog. Cardiovasc. Dis."},{"issue":"1","key":"10.1016\/j.clinbiochem.2020.09.006_b0015","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1016\/j.mcna.2017.08.006","article-title":"Guideline recommendations for obesity management","volume":"102","author":"Ryan","year":"2018","journal-title":"Med. Clin. N. Am."},{"issue":"22","key":"10.1016\/j.clinbiochem.2020.09.006_b0020","doi-asserted-by":"crossref","first-page":"2503","DOI":"10.1001\/jama.2010.1768","article-title":"Association of troponin T detected with a highly sensitive assay and cardiac structure and mortality risk in the general population","volume":"304","author":"de Lemos","year":"2010","journal-title":"JAMA"},{"issue":"26","key":"10.1016\/j.clinbiochem.2020.09.006_b0025","doi-asserted-by":"crossref","first-page":"2538","DOI":"10.1056\/NEJMoa0805299","article-title":"A sensitive cardiac troponin T assay in stable coronary artery disease","volume":"361","author":"Omland","year":"2009","journal-title":"N. Engl. J. Med."},{"issue":"16","key":"10.1016\/j.clinbiochem.2020.09.006_b0030","doi-asserted-by":"crossref","first-page":"1494","DOI":"10.1161\/CIRCULATIONAHA.116.025505","article-title":"High-sensitive cardiac troponin t as an early biochemical signature for clinical and subclinical heart failure: MESA (multi-ethnic study of atherosclerosis)","volume":"135","author":"Seliger","year":"2017","journal-title":"Circulation"},{"issue":"12","key":"10.1016\/j.clinbiochem.2020.09.006_b0035","doi-asserted-by":"crossref","first-page":"1240","DOI":"10.1016\/j.jacc.2012.12.026","article-title":"Prognostic value of cardiac troponin I measured with a highly sensitive assay in patients with stable coronary artery disease","volume":"61","author":"Omland","year":"2013","journal-title":"J. Am. Coll. Cardiol."},{"issue":"4","key":"10.1016\/j.clinbiochem.2020.09.006_b0040","doi-asserted-by":"crossref","first-page":"646","DOI":"10.1373\/clinchem.2014.234369","article-title":"Impact of sex on the prognostic value of high-sensitivity cardiac troponin I in the general population: the HUNT study","volume":"61","author":"Omland","year":"2015","journal-title":"Clin. Chem."},{"issue":"8","key":"10.1016\/j.clinbiochem.2020.09.006_b0045","doi-asserted-by":"crossref","first-page":"874","DOI":"10.1177\/2047487315618796","article-title":"Effect of weight loss on subclinical myocardial injury: a clinical trial comparing gastric bypass surgery and intensive lifestyle intervention","volume":"23","author":"Lyngbakken","year":"2016","journal-title":"Eur. J. Prev. Cardiol."},{"issue":"24","key":"10.1016\/j.clinbiochem.2020.09.006_b0050","doi-asserted-by":"crossref","first-page":"2754","DOI":"10.1161\/CIRCULATIONAHA.118.038529","article-title":"Cardiac troponin t and troponin i in the general population","volume":"139","author":"Welsh","year":"2019","journal-title":"Circulation"},{"issue":"4","key":"10.1016\/j.clinbiochem.2020.09.006_b0055","doi-asserted-by":"crossref","first-page":"567","DOI":"10.1093\/clinchem\/hvaa023","article-title":"Cardiac troponin I and T are associated with left ventricular function and structure: data from the akershus cardiac examination 1950 study","volume":"66","author":"Lyngbakken","year":"2020","journal-title":"Clin. Chem."},{"issue":"1","key":"10.1016\/j.clinbiochem.2020.09.006_b0060","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1016\/j.pharmthera.2014.04.007","article-title":"Metabolic actions of natriuretic peptides and therapeutic potential in the metabolic syndrome","volume":"144","author":"Schlueter","year":"2014","journal-title":"Pharmacol. Ther."},{"issue":"3","key":"10.1016\/j.clinbiochem.2020.09.006_b0065","doi-asserted-by":"crossref","first-page":"348","DOI":"10.1038\/ng.328","article-title":"Association of common variants in NPPA and NPPB with circulating natriuretic peptides and blood pressure","volume":"41","author":"Newton-Cheh","year":"2009","journal-title":"Nat. Genet."},{"issue":"4","key":"10.1016\/j.clinbiochem.2020.09.006_b0070","doi-asserted-by":"crossref","first-page":"695","DOI":"10.1016\/j.yjmcc.2011.01.010","article-title":"Association of genetic variation in the natriuretic peptide system with cardiovascular outcomes","volume":"50","author":"Ellis","year":"2011","journal-title":"J. Mol. Cell Cardiol."},{"issue":"4","key":"10.1016\/j.clinbiochem.2020.09.006_b0075","doi-asserted-by":"crossref","DOI":"10.1161\/JAHA.116.005257","article-title":"An NPPB promoter polymorphism associated with elevated n-terminal pro-B-type natriuretic peptide and lower blood pressure, hypertension, and mortality","volume":"6","author":"Seidelmann","year":"2017","journal-title":"J. Am. Heart Assoc."},{"issue":"20","key":"10.1016\/j.clinbiochem.2020.09.006_b0080","doi-asserted-by":"crossref","first-page":"2247","DOI":"10.1001\/archinte.164.20.2247","article-title":"Relationship between obesity and B-type natriuretic peptide levels","volume":"164","author":"McCord","year":"2004","journal-title":"Arch. Intern Med."},{"issue":"9","key":"10.1016\/j.clinbiochem.2020.09.006_b0085","doi-asserted-by":"crossref","first-page":"1115","DOI":"10.1373\/clinchem.2019.302547","article-title":"ProBNP that is not glycosylated at threonine 71 is decreased with obesity in patients with heart failure","volume":"65","author":"Lewis","year":"2019","journal-title":"Clin. Chem."},{"issue":"1","key":"10.1016\/j.clinbiochem.2020.09.006_b0090","doi-asserted-by":"crossref","first-page":"440","DOI":"10.1186\/s13104-016-2241-x","article-title":"The effect of surgical and non-surgical weight loss on N-terminal pro-B-type natriuretic peptide and its relation to obstructive sleep apnea and pulmonary function","volume":"9","author":"Gabrielsen","year":"2016","journal-title":"BMC Res. Notes"},{"issue":"10","key":"10.1016\/j.clinbiochem.2020.09.006_b0095","doi-asserted-by":"crossref","first-page":"1141","DOI":"10.1111\/j.1471-0528.2006.01004.x","article-title":"Is obesity an inflammatory illness? Role of low-grade inflammation and macrophage infiltration in human white adipose tissue","volume":"113","author":"Cancello","year":"2006","journal-title":"BJOG"},{"issue":"8","key":"10.1016\/j.clinbiochem.2020.09.006_b0100","doi-asserted-by":"crossref","first-page":"2631","DOI":"10.1007\/s11695-019-03926-0","article-title":"Effect of bariatric surgery on serum inflammatory factors of obese patients: a systematic review and meta-analysis","volume":"29","author":"Askarpour","year":"2019","journal-title":"Obes Surg."},{"key":"10.1016\/j.clinbiochem.2020.09.006_b0105","article-title":"Modifiable lifestyle risk factors and C-reactive protein in patients with coronary artery disease: Implications for an anti-inflammatory treatment target population","author":"Blaum","year":"2019","journal-title":"Eur. J. Prev. Cardiol."},{"issue":"1","key":"10.1016\/j.clinbiochem.2020.09.006_b0110","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1001\/archinte.167.1.31","article-title":"The effect of weight loss on C-reactive protein: a systematic review","volume":"167","author":"Selvin","year":"2007","journal-title":"Arch. Int. Med."},{"issue":"5","key":"10.1016\/j.clinbiochem.2020.09.006_b0115","doi-asserted-by":"crossref","first-page":"443","DOI":"10.2165\/00007256-200636050-00006","article-title":"Physical activity and high-sensitivity C-reactive protein","volume":"36","author":"Plaisance","year":"2006","journal-title":"Sports Med."},{"issue":"4","key":"10.1016\/j.clinbiochem.2020.09.006_b0120","doi-asserted-by":"crossref","first-page":"690","DOI":"10.1002\/oby.20099","article-title":"Arterial stiffness, lifestyle intervention and a low-calorie diet in morbidly obese patients-a nonrandomized clinical trial","volume":"21","author":"Nordstrand","year":"2013","journal-title":"Obesity (Silver Spring)"},{"issue":"1","key":"10.1016\/j.clinbiochem.2020.09.006_b0125","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1002\/oby.20880","article-title":"Effects of intensive lifestyle intervention and gastric bypass on aortic stiffness: a 1-year nonrandomized clinical study","volume":"23","author":"Gjevestad","year":"2015","journal-title":"Obesity (Silver Spring)"},{"key":"10.1016\/j.clinbiochem.2020.09.006_b0130","unstructured":"High-Sensitivity* Cardiac Troponin I and T Assay Analytical Characteristics Designated by Manufacturer. IFCC Committee on Clinical Applications of Cardiac Bio-Markers (C-CB) v012019. https:\/\/wwwifccorg\/media\/477656\/high-sensitivity-cardiac-troponin-i-and-t-assay-analytical-characteristics-designated-by-manufacturer-v012019pdf. Assessed February 2020."},{"key":"10.1016\/j.clinbiochem.2020.09.006_b0135","doi-asserted-by":"crossref","unstructured":"American Diabetes Association. Diagnosis and Classification of Diabetes Mellitus. Diabetes Care. 2008;Jan; 31(Supplement 1):S55-S60.","DOI":"10.2337\/dc08-S055"},{"issue":"4","key":"10.1016\/j.clinbiochem.2020.09.006_b0140","doi-asserted-by":"crossref","first-page":"468","DOI":"10.1161\/01.HYP.0000090360.78539.CD","article-title":"Measures of obesity are associated with vascular stiffness in young and older adults","volume":"42","author":"Wildman","year":"2003","journal-title":"Hypertension"},{"issue":"7","key":"10.1016\/j.clinbiochem.2020.09.006_b0145","doi-asserted-by":"crossref","first-page":"412","DOI":"10.1007\/BF00280883","article-title":"Homeostasis model assessment: insulin resistance and beta-cell function from fasting plasma glucose and insulin concentrations in man","volume":"28","author":"Matthews","year":"1985","journal-title":"Diabetologia"},{"issue":"21","key":"10.1016\/j.clinbiochem.2020.09.006_b0150","doi-asserted-by":"crossref","first-page":"2588","DOI":"10.1093\/eurheartj\/ehl254","article-title":"Expert consensus document on arterial stiffness: methodological issues and clinical applications","volume":"27","author":"Laurent","year":"2006","journal-title":"Eur. Heart J."},{"issue":"5","key":"10.1016\/j.clinbiochem.2020.09.006_b0155","doi-asserted-by":"crossref","first-page":"409","DOI":"10.3109\/10408368909106595","article-title":"Generation and application of data on biological variation in clinical chemistry","volume":"27","author":"Fraser","year":"1989","journal-title":"Crit. Rev. Clin. Lab Sci."},{"key":"10.1016\/j.clinbiochem.2020.09.006_b0160","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1016\/j.cca.2020.06.021","article-title":"Analytical performance of cardiac troponin assays \u2013 Current status and future needs","volume":"509","author":"Aakre","year":"2020","journal-title":"Clin. Chim. Acta"},{"issue":"4","key":"10.1016\/j.clinbiochem.2020.09.006_b0165","doi-asserted-by":"crossref","first-page":"345","DOI":"10.1016\/j.jacc.2013.08.1643","volume":"63","author":"White","year":"2014","journal-title":"J. Am. Coll. Cardiol."},{"issue":"3","key":"10.1016\/j.clinbiochem.2020.09.006_b0170","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1016\/j.jchf.2017.11.003","article-title":"High-sensitivity cardiac troponin and new-onset heart failure: a systematic review and meta-analysis of 67,063 Patients With 4,165 incident heart failure events","volume":"6","author":"Evans","year":"2018","journal-title":"JACC Heart Fail."},{"issue":"12","key":"10.1016\/j.clinbiochem.2020.09.006_b0175","doi-asserted-by":"crossref","first-page":"1524","DOI":"10.1373\/clinchem.2015.244160","article-title":"Prognostic significance of high-sensitivity cardiac troponin t concentrations between the limit of blank and limit of detection in community-dwelling adults: a metaanalysis","volume":"61","author":"Parikh","year":"2015","journal-title":"Clin. Chem."},{"issue":"17","key":"10.1016\/j.clinbiochem.2020.09.006_b0180","doi-asserted-by":"crossref","first-page":"1577","DOI":"10.1161\/CIRCULATIONAHA.116.025629","article-title":"Weight Loss and heart failure: a nationwide study of gastric bypass surgery versus intensive lifestyle treatment","volume":"135","author":"Sundstrom","year":"2017","journal-title":"Circulation"},{"key":"10.1016\/j.clinbiochem.2020.09.006_b0185","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1016\/j.ahj.2016.07.001","article-title":"Impact of moderate physical activity on the longitudinal trajectory of a cardiac specific biomarker of injury: results from a randomized pilot study of exercise intervention","volume":"179","author":"deFilippi","year":"2016","journal-title":"Am. Heart J."},{"issue":"24","key":"10.1016\/j.clinbiochem.2020.09.006_b0190","doi-asserted-by":"crossref","first-page":"2539","DOI":"10.1016\/j.jacc.2012.08.1006","article-title":"Physical activity, change in biomarkers of myocardial stress and injury, and subsequent heart failure risk in older adults","volume":"60","author":"deFilippi","year":"2012","journal-title":"J. Am. Coll. Cardiol."},{"issue":"15","key":"10.1016\/j.clinbiochem.2020.09.006_b0195","doi-asserted-by":"crossref","first-page":"1451","DOI":"10.1161\/CIRCULATIONAHA.117.029493","article-title":"Sedentary behavior and subclinical cardiac injury: results from the dallas heart study","volume":"136","author":"Harrington","year":"2017","journal-title":"Circulation"},{"issue":"25","key":"10.1016\/j.clinbiochem.2020.09.006_b0200","doi-asserted-by":"crossref","first-page":"2719","DOI":"10.1016\/j.jacc.2016.10.020","article-title":"High-sensitivity cardiac troponin, statin therapy, and risk of coronary heart disease","volume":"68","author":"Ford","year":"2016","journal-title":"J. Am. Coll. Cardiol."},{"issue":"2","key":"10.1016\/j.clinbiochem.2020.09.006_b0205","doi-asserted-by":"crossref","first-page":"108","DOI":"10.1016\/j.pcad.2019.02.005","article-title":"Physical activity, exercise and cardiac troponins: clinical implications","volume":"62","author":"Aakre","year":"2019","journal-title":"Prog. Cardiovasc. Dis."},{"key":"10.1016\/j.clinbiochem.2020.09.006_b0210","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1016\/j.mce.2018.01.023","article-title":"Regulation of natriuretic peptides postprandially in vivo and of their receptors in adipocytes by fatty acids in vitro","volume":"473","author":"Schmid","year":"2018","journal-title":"Mol. Cell Endocrinol."},{"issue":"1","key":"10.1016\/j.clinbiochem.2020.09.006_b0215","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1056\/NEJMoa042378","article-title":"C-reactive protein levels and outcomes after statin therapy","volume":"352","author":"Ridker","year":"2005","journal-title":"N. Engl. J. Med."},{"issue":"3","key":"10.1016\/j.clinbiochem.2020.09.006_b0220","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1001\/jama.2017.21055","article-title":"Association of bariatric surgery vs medical obesity treatment with long-term medical complications and obesity-related comorbidities","volume":"319","author":"Jakobsen","year":"2018","journal-title":"JAMA"}],"container-title":["Clinical Biochemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0009912020308456?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0009912020308456?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,2]],"date-time":"2025-11-02T20:10:05Z","timestamp":1762114205000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0009912020308456"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,12]]},"references-count":44,"alternative-id":["S0009912020308456"],"URL":"https:\/\/doi.org\/10.1016\/j.clinbiochem.2020.09.006","relation":{},"ISSN":["0009-9120"],"issn-type":[{"value":"0009-9120","type":"print"}],"subject":[],"published":{"date-parts":[[2020,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Gastric bypass surgery is associated with reduced subclinical myocardial injury and greater activation of the cardiac natriuretic peptide system than lifestyle intervention","name":"articletitle","label":"Article Title"},{"value":"Clinical Biochemistry","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.clinbiochem.2020.09.006","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2020 Published by Elsevier Inc. on behalf of The Canadian Society of Clinical Chemists.","name":"copyright","label":"Copyright"}]}}