{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,29]],"date-time":"2026-08-29T10:44:42Z","timestamp":1788000282322,"version":"build-2784847793"},"reference-count":26,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2021,12,1]],"date-time":"2021-12-01T00:00:00Z","timestamp":1638316800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2021,12,1]],"date-time":"2021-12-01T00:00:00Z","timestamp":1638316800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/501100002322","name":"Coordena\u00e7\u00e3o de Aperfei\u00e7oamento de Pessoal de N\u00edvel Superior","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002322","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003593","name":"Conselho Nacional de Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico","doi-asserted-by":"publisher","award":["404353\/2016\u20139"],"award-info":[{"award-number":["404353\/2016\u20139"]}],"id":[{"id":"10.13039\/501100003593","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004901","name":"Funda\u00e7\u00e3o de Amparo \u00e0 Pesquisa do Estado de Minas Gerais","doi-asserted-by":"publisher","award":["00764\u201316"],"award-info":[{"award-number":["00764\u201316"]}],"id":[{"id":"10.13039\/501100004901","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004901","name":"Funda\u00e7\u00e3o de Amparo \u00e0 Pesquisa do Estado de Minas Gerais","doi-asserted-by":"publisher","award":["02600\u201318"],"award-info":[{"award-number":["02600\u201318"]}],"id":[{"id":"10.13039\/501100004901","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004901","name":"Funda\u00e7\u00e3o de Amparo \u00e0 Pesquisa do Estado de Minas Gerais","doi-asserted-by":"publisher","award":["03318\u201315"],"award-info":[{"award-number":["03318\u201315"]}],"id":[{"id":"10.13039\/501100004901","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Clinical Biochemistry"],"published-print":{"date-parts":[[2021,12]]},"DOI":"10.1016\/j.clinbiochem.2021.09.002","type":"journal-article","created":{"date-parts":[[2021,9,4]],"date-time":"2021-09-04T10:27:36Z","timestamp":1630751256000},"page":"24-28","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":12,"special_numbering":"C","title":["Longitudinal assessment of leukotriene B4, lipoxin A4, and resolvin D1 plasma levels in pregnant women with risk factors for preeclampsia"],"prefix":"10.1016","volume":"98","author":[{"given":"Luiza Oliveira","family":"Perucci","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kelerson Mauro","family":"de Castro Pinto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sirlaine Pio Gomes","family":"da Silva","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eura Martins","family":"Lage","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patr\u00edcia Gon\u00e7alves","family":"Teixeira","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexandre Sim\u00f5es","family":"Barbosa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patr\u00edcia Nessralla","family":"Alpoim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lirl\u00e2ndia Pires","family":"de Sousa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andr\u00e9","family":"Talvani","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luci Maria SantAna","family":"Dusse","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"6","key":"10.1016\/j.clinbiochem.2021.09.002_b0005","doi-asserted-by":"crossref","first-page":"e237","DOI":"10.1097\/AOG.0000000000003891","article-title":"Gestational Hypertension and Preeclampsia: ACOG Practice Bulletin, Number 222","volume":"135","author":"American College of Obstetricians and Gynecologists","year":"2020","journal-title":"Obstet. Gynecol."},{"issue":"1","key":"10.1016\/j.clinbiochem.2021.09.002_b0010","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-019-46011-3","article-title":"Incidence and risk factors for Preeclampsia in a cohort of healthy nulliparous pregnant women: a nested case-control study","volume":"9","author":"Mayrink","year":"2019","journal-title":"Sci. Rep."},{"issue":"1","key":"10.1016\/j.clinbiochem.2021.09.002_b0015","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.ejogrb.2013.05.005","article-title":"Global and regional estimates of preeclampsia and eclampsia: a systematic review","volume":"170","author":"Abalos","year":"2013","journal-title":"Eur. J. Obstet. Gynecol. Reprod. Biol."},{"issue":"5","key":"10.1016\/j.clinbiochem.2021.09.002_b0020","doi-asserted-by":"crossref","first-page":"e97401","DOI":"10.1371\/journal.pone.0097401","article-title":"The burden of eclampsia: results from a multicenter study on surveillance of severe maternal morbidity in Brazil","volume":"9","author":"Giordano","year":"2014","journal-title":"PLoS ONE"},{"key":"10.1016\/j.clinbiochem.2021.09.002_b0025","doi-asserted-by":"crossref","first-page":"i1753","DOI":"10.1136\/bmj.i1753","article-title":"High Risk of Pre-eclampsia Identification G. Clinical risk factors for pre-eclampsia determined in early pregnancy: systematic review and meta-analysis of large cohort studies","volume":"353","author":"Bartsch","year":"2016","journal-title":"BMJ"},{"issue":"5","key":"10.1016\/j.clinbiochem.2021.09.002_b0030","doi-asserted-by":"crossref","first-page":"1430","DOI":"10.1161\/HYPERTENSIONAHA.120.14781","article-title":"Subtypes of Preeclampsia: Recognition and Determining Clinical Usefulness","volume":"77","author":"Roberts","year":"2021","journal-title":"Hypertension"},{"issue":"4","key":"10.1016\/j.clinbiochem.2021.09.002_b0035","doi-asserted-by":"crossref","first-page":"1042","DOI":"10.1016\/0002-9378(95)91324-6","article-title":"Underlying disorders associated with severe early-onset preeclampsia","volume":"173","author":"Dekker","year":"1995","journal-title":"Am. J. Obstet. Gynecol."},{"issue":"5","key":"10.1016\/j.clinbiochem.2021.09.002_b0040","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1038\/s41581-019-0119-6","article-title":"Pre-eclampsia: pathogenesis, novel diagnostics and therapies","volume":"15","author":"Phipps","year":"2019","journal-title":"Nat. Rev. Nephrol."},{"key":"10.1016\/j.clinbiochem.2021.09.002_b0045","doi-asserted-by":"crossref","first-page":"114","DOI":"10.1016\/j.mam.2017.03.005","article-title":"Structural elucidation and physiologic functions of specialized pro-resolving mediators and their receptors","volume":"58","author":"Chiang","year":"2017","journal-title":"Mol. Aspects Med."},{"issue":"1","key":"10.1016\/j.clinbiochem.2021.09.002_b0050","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1016\/j.it.2013.10.008","article-title":"Lipid mediators in immune dysfunction after severe inflammation","volume":"35","author":"Fullerton","year":"2014","journal-title":"Trends Immunol."},{"key":"10.1016\/j.clinbiochem.2021.09.002_b0055","doi-asserted-by":"crossref","unstructured":"M. Nadeau-Vall\u00e9e, D. Obari, J. Palacios, M.-\u00c8. Brien, C. Duval, S. Chemtob, S. Girard, Sterile inflammation and pregnancy complications: a review Reproduction. 2016;152(6):R277-R292.","DOI":"10.1530\/REP-16-0453"},{"issue":"5","key":"10.1016\/j.clinbiochem.2021.09.002_b0060","doi-asserted-by":"crossref","first-page":"e97632","DOI":"10.1371\/journal.pone.0097632","article-title":"Soluble endoglin, transforming growth factor-Beta 1 and soluble tumor necrosis factor alpha receptors in different clinical manifestations of preeclampsia","volume":"9","author":"Perucci","year":"2014","journal-title":"PLoS ONE"},{"issue":"1","key":"10.1016\/j.clinbiochem.2021.09.002_b0065","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1016\/j.cyto.2013.02.027","article-title":"Severe preeclampsia goes along with a cytokine network disturbance towards a systemic inflammatory state","volume":"62","author":"Pinheiro","year":"2013","journal-title":"Cytokine"},{"issue":"3","key":"10.1016\/j.clinbiochem.2021.09.002_b0070","doi-asserted-by":"crossref","first-page":"242","DOI":"10.1097\/NNR.0000000000000285","article-title":"Inflammatory Markers and Preeclampsia: A Systematic Review","volume":"67","author":"Black","year":"2018","journal-title":"Nurs. Res."},{"issue":"3","key":"10.1016\/j.clinbiochem.2021.09.002_b0075","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1016\/j.ijgo.2015.10.024","article-title":"Association between the maternal serum levels of 19 eicosanoids and pre-eclampsia","volume":"133","author":"Long","year":"2016","journal-title":"Int. J. Gynaecol. Obstet."},{"key":"10.1016\/j.clinbiochem.2021.09.002_b0080","first-page":"182","article-title":"Assessment of the Relationship Between Luekotriene B4 and Luekotriene D4 Levels in Prediction of Preeclampsia","volume":"31","author":"Fareed","year":"2015","journal-title":"Int. J. Pharmaceut. Sci. Rev. Res."},{"key":"10.1016\/j.clinbiochem.2021.09.002_b0085","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1016\/j.placenta.2020.10.007","article-title":"Serum leukotriene B4 and hydroxyeicosatetraenoic acid in the prediction of pre-eclampsia","volume":"103","author":"Santos","year":"2021","journal-title":"Placenta"},{"issue":"4","key":"10.1016\/j.clinbiochem.2021.09.002_b0090","doi-asserted-by":"crossref","first-page":"769","DOI":"10.1007\/s00404-013-2823-y","article-title":"The change of LTB4 and 5-LO during pregnancy","volume":"288","author":"Jian","year":"2013","journal-title":"Arch. Gynecol. Obstet."},{"key":"10.1016\/j.clinbiochem.2021.09.002_b0095","doi-asserted-by":"crossref","unstructured":"R. Shanmugalingam, X. Wang, P. Motum et al., The 15-Epilipoxin-A4 Pathway with Prophylactic Aspirin in Preventing Preeclampsia: A Longitudinal Cohort Study. J. Clin. Endocrinol. Metab. 2020;105(12).","DOI":"10.1210\/clinem\/dgaa642"},{"key":"10.1016\/j.clinbiochem.2021.09.002_b0100","article-title":"Preeclampsia is associated with reduced resolvin D1 and maresin 1 to leukotriene B4 ratios in the plasma","author":"Perucci","year":"2019","journal-title":"Am. J. Reprod. Immunol."},{"issue":"10","key":"10.1016\/j.clinbiochem.2021.09.002_b0105","doi-asserted-by":"crossref","first-page":"1179","DOI":"10.1093\/ajh\/hpw053","article-title":"Lipoxin A4 Is Increased in the Plasma of Preeclamptic Women","volume":"29","author":"Perucci","year":"2016","journal-title":"Am. J. Hypertens."},{"issue":"4","key":"10.1016\/j.clinbiochem.2021.09.002_b0110","doi-asserted-by":"crossref","first-page":"449","DOI":"10.3109\/10641955.2014.931419","article-title":"Expression of lipoxin A4, TNF\u03b1 and IL-1\u03b2 in maternal peripheral blood, umbilical cord blood and placenta, and their significance in pre-eclampsia","volume":"33","author":"Dong","year":"2014","journal-title":"Hypertens Pregnancy."},{"issue":"5","key":"10.1016\/j.clinbiochem.2021.09.002_b0115","doi-asserted-by":"crossref","first-page":"561","DOI":"10.12891\/ceog17902014","article-title":"Expression of anti-inflammatory mediator lipoxin A4 and inflammation responsive transcriptive factors NF-kappa B in patients with preeclampsia","volume":"41","author":"Huang","year":"2014","journal-title":"Clin. Exp. Obstet. Gynecol."},{"issue":"2","key":"10.1016\/j.clinbiochem.2021.09.002_b0120","doi-asserted-by":"crossref","DOI":"10.1111\/aji.13207","article-title":"Role of aspirin-triggered lipoxin A4, aspirin, and salicylic acid in the modulation of the oxidative and inflammatory responses induced by plasma from women with pre-eclampsia","volume":"83","author":"Gil\u2010Villa","year":"2020","journal-title":"Am. J. Reprod. Immunol."},{"issue":"8","key":"10.1016\/j.clinbiochem.2021.09.002_b0125","doi-asserted-by":"crossref","first-page":"705","DOI":"10.1111\/1440-1681.13095","article-title":"Metabolomics revealed decreased level of omega-3 PUFA-derived protective eicosanoids in pregnant women with pre-eclampsia","volume":"46","author":"Liu","year":"2019","journal-title":"Clin. Exp. Pharmacol. Physiol."},{"issue":"4","key":"10.1016\/j.clinbiochem.2021.09.002_b0130","doi-asserted-by":"crossref","first-page":"774","DOI":"10.1007\/s12026-017-8921-3","article-title":"Resolution of inflammation pathways in preeclampsia-a narrative review","volume":"65","author":"Perucci","year":"2017","journal-title":"Immunol. Res."}],"container-title":["Clinical Biochemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0009912021002307?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0009912021002307?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,2]],"date-time":"2025-11-02T20:10:20Z","timestamp":1762114220000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0009912021002307"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,12]]},"references-count":26,"alternative-id":["S0009912021002307"],"URL":"https:\/\/doi.org\/10.1016\/j.clinbiochem.2021.09.002","relation":{},"ISSN":["0009-9120"],"issn-type":[{"value":"0009-9120","type":"print"}],"subject":[],"published":{"date-parts":[[2021,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Longitudinal assessment of leukotriene B4, lipoxin A4, and resolvin D1 plasma levels in pregnant women with risk factors for preeclampsia","name":"articletitle","label":"Article Title"},{"value":"Clinical Biochemistry","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.clinbiochem.2021.09.002","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2021 The Canadian Society of Clinical Chemists. Published by Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}