{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,26]],"date-time":"2026-10-26T03:21:00Z","timestamp":1792984860371,"version":"4.5.0"},"reference-count":44,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2022,6,1]],"date-time":"2022-06-01T00:00:00Z","timestamp":1654041600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2022,6,1]],"date-time":"2022-06-01T00:00:00Z","timestamp":1654041600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Clinical Biochemistry"],"published-print":{"date-parts":[[2022,6]]},"DOI":"10.1016\/j.clinbiochem.2022.02.003","type":"journal-article","created":{"date-parts":[[2022,2,15]],"date-time":"2022-02-15T01:58:00Z","timestamp":1644890280000},"page":"22-29","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":12,"special_numbering":"C","title":["Diagnostic performance and predictive value of D-dimer testing in patients referred to the emergency department for suspected myocardial infarction"],"prefix":"10.1016","volume":"104","author":[{"given":"Vitali","family":"Koch","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christian","family":"Booz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leon D.","family":"Gruenewald","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Moritz H.","family":"Albrecht","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tatjana","family":"Gruber-Rouh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katrin","family":"Eichler","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ibrahim","family":"Yel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Scherwin","family":"Mahmoudi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jan-Erik","family":"Scholtz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Simon S.","family":"Martin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christiana","family":"Graf","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas J.","family":"Vogl","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christophe","family":"Weber","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stefan E.","family":"Hardt","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Norbert","family":"Frey","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Evangelos","family":"Giannitsis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"12","key":"10.1016\/j.clinbiochem.2022.02.003_b0005","first-page":"721","article-title":"Acute chest pain in adults: outpatient evaluation","volume":"102","author":"McConaghy","year":"2020","journal-title":"Am. Fam. Physician"},{"issue":"1","key":"10.1016\/j.clinbiochem.2022.02.003_b0010","doi-asserted-by":"crossref","first-page":"17","DOI":"10.14740\/cr620w","article-title":"Diagnostic value of D-dimer in acute myocardial infarction among patients with suspected acute coronary syndrome","volume":"9","author":"Reihani","year":"2018","journal-title":"Cardiol. Res."},{"issue":"2","key":"10.1016\/j.clinbiochem.2022.02.003_b0015","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1016\/j.cccn.2004.03.036","article-title":"Evaluation of a point-of-care assay for cardiac markers for patients suspected of acute myocardial infarction","volume":"346","author":"Wu","year":"2004","journal-title":"Clin. Chim. Acta"},{"issue":"1","key":"10.1016\/j.clinbiochem.2022.02.003_b0020","first-page":"69","article-title":"Biomarker study group of the european society of cardiology acute cardiovascular care, how to use D-dimer in acute cardiovascular care","volume":"6","author":"Giannitsis","year":"2017","journal-title":"Eur. Heart J Acute Cardiovasc. Care"},{"issue":"5","key":"10.1016\/j.clinbiochem.2022.02.003_b0025","doi-asserted-by":"crossref","first-page":"1772","DOI":"10.1177\/147323001003800523","article-title":"The role of serum D-dimer level in the diagnosis of patients admitted to the emergency department complaining of chest pain","volume":"38","author":"Orak","year":"2010","journal-title":"J. Int. Med. Res."},{"issue":"7","key":"10.1016\/j.clinbiochem.2022.02.003_b0030","doi-asserted-by":"crossref","first-page":"712","DOI":"10.1161\/CIRCULATIONAHA.117.029901","article-title":"D-Dimer predicts long-term cause-specific mortality, cardiovascular events, and cancer in patients with stable coronary heart disease: LIPID study","volume":"138","author":"Simes","year":"2018","journal-title":"Circulation"},{"issue":"5","key":"10.1016\/j.clinbiochem.2022.02.003_b0035","first-page":"559","article-title":"Diagnostic performance of D-dimer in predicting venous thromboembolism and acute aortic dissection","volume":"10","author":"Koch","year":"2021","journal-title":"Eur. Heart J. Acute Cardiovasc. Care"},{"issue":"1","key":"10.1016\/j.clinbiochem.2022.02.003_b0040","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1373\/clinchem.2016.255240","article-title":"Biomarkers for clinical decision-making in the management of pulmonary embolism","volume":"63","author":"Giannitsis","year":"2017","journal-title":"Clin. Chem."},{"issue":"19","key":"10.1016\/j.clinbiochem.2022.02.003_b0045","doi-asserted-by":"crossref","first-page":"2345","DOI":"10.1001\/archinte.163.19.2345","article-title":"Global registry of acute coronary events, predictors of hospital mortality in the global registry of acute coronary events","volume":"163","author":"Granger","year":"2003","journal-title":"Arch. Intern. Med."},{"issue":"7578","key":"10.1016\/j.clinbiochem.2022.02.003_b0050","doi-asserted-by":"crossref","first-page":"1091","DOI":"10.1136\/bmj.38985.646481.55","article-title":"Prediction of risk of death and myocardial infarction in the six months after presentation with acute coronary syndrome: prospective multinational observational study (GRACE)","volume":"333","author":"Fox","year":"2006","journal-title":"BMJ"},{"issue":"1","key":"10.1016\/j.clinbiochem.2022.02.003_b0055","doi-asserted-by":"crossref","first-page":"2","DOI":"10.2174\/157340311795677662","article-title":"Risk scores for patients with chest pain: evaluation in the emergency department","volume":"7","author":"Backus","year":"2011","journal-title":"Curr. Cardiol. Rev."},{"issue":"20","key":"10.1016\/j.clinbiochem.2022.02.003_b0060","first-page":"2551","article-title":"Third universal definition of myocardial infarction","volume":"33","author":"Thygesen","year":"2012","journal-title":"J. Am. Coll. Cardiol."},{"key":"10.1016\/j.clinbiochem.2022.02.003_b0065","doi-asserted-by":"crossref","unstructured":"J.P. Collet, H. Thiele, E. Barbato, O. Barthelemy, J. Bauersachs, D.L. Bhatt, P. Dendale, M. Dorobantu, T. Edvardsen, T. Folliguet, C.P. Gale, M. Gilard, A. Jobs, P. Juni, E. Lambrinou, B.S. Lewis, J. Mehilli, E. Meliga, B. Merkely, C. Mueller, M. Roffi, F.H. Rutten, D. Sibbing, G.C.M. Siontis, E.S.C.S.D. Group, 2020 ESC Guidelines for the management of acute coronary syndromes in patients presenting without persistent ST-segment elevation, Eur. Heart J. 42(14) (2021) 1289-1367.","DOI":"10.15829\/1560-4071-2021-4418"},{"key":"10.1016\/j.clinbiochem.2022.02.003_b0070","doi-asserted-by":"crossref","unstructured":"B. Ibanez, S. James, S. Agewall, M.J. Antunes, C. Bucciarelli-Ducci, H. Bueno, A.L.P. Caforio, F. Crea, J.A. Goudevenos, S. Halvorsen, G. Hindricks, A. Kastrati, M.J. Lenzen, E. Prescott, M. Roffi, M. Valgimigli, C. Varenhorst, P. Vranckx, P. Widimsky, E.S.C.S.D. Group, 2017 ESC Guidelines for the management of acute myocardial infarction in patients presenting with ST-segment elevation: The Task Force for the management of acute myocardial infarction in patients presenting with ST-segment elevation of the European Society of Cardiology (ESC), Eur. Heart J. 39(2) (2018) 119-177.","DOI":"10.5603\/KP.2018.0041"},{"key":"10.1016\/j.clinbiochem.2022.02.003_b0075","doi-asserted-by":"crossref","unstructured":"M. Roffi, C. Patrono, J.P. Collet, C. Mueller, M. Valgimigli, F. Andreotti, J.J. Bax, M.A. Borger, C. Brotons, D.P. Chew, B. Gencer, G. Hasenfuss, K. Kjeldsen, P. Lancellotti, U. Landmesser, J. Mehilli, D. Mukherjee, R.F. Storey, S. Windecker, E.S.C.S.D. Group, 2015 ESC Guidelines for the management of acute coronary syndromes in patients presenting without persistent ST-segment elevation: Task Force for the Management of Acute Coronary Syndromes in Patients Presenting without Persistent ST-Segment Elevation of the European Society of Cardiology (ESC), Eur. Heart J. 37(3) (2016) 267-315.","DOI":"10.1093\/eurheartj\/ehv320"},{"issue":"may03 1","key":"10.1016\/j.clinbiochem.2022.02.003_b0080","doi-asserted-by":"crossref","first-page":"f2492","DOI":"10.1136\/bmj.f2492","article-title":"Diagnostic accuracy of conventional or age adjusted D-dimer cut-off values in older patients with suspected venous thromboembolism: systematic review and meta-analysis","volume":"346","author":"Schouten","year":"2013","journal-title":"BMJ"},{"issue":"6947","key":"10.1016\/j.clinbiochem.2022.02.003_b0085","doi-asserted-by":"crossref","first-page":"102","DOI":"10.1136\/bmj.309.6947.102","article-title":"Diagnostic tests 2: predictive values","volume":"309","author":"Altman","year":"1994","journal-title":"BMJ"},{"key":"10.1016\/j.clinbiochem.2022.02.003_b0090","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1186\/s40945-019-0056-5","article-title":"Questioning the \u201cSPIN and SNOUT\u201d rule in clinical testing","volume":"9","author":"Baeyens","year":"2019","journal-title":"Arch. Physiother."},{"issue":"6","key":"10.1016\/j.clinbiochem.2022.02.003_b0095","first-page":"717","article-title":"Interpretation of diagnostic tests: likelihood ratio vs. predictive value, Iran","volume":"23","author":"Sedighi","year":"2013","journal-title":"J. Pediatr."},{"issue":"2","key":"10.1016\/j.clinbiochem.2022.02.003_b0100","first-page":"127","article-title":"Using the likelihood ratio","volume":"54","author":"Okada","year":"2005","journal-title":"J. Fam. Pract."},{"issue":"8735","key":"10.1016\/j.clinbiochem.2022.02.003_b0105","doi-asserted-by":"crossref","first-page":"196","DOI":"10.1016\/0140-6736(91)92158-X","article-title":"Measurement of D-dimer in plasma as diagnostic aid in suspected pulmonary embolism","volume":"337","author":"Bounameaux","year":"1991","journal-title":"Lancet"},{"issue":"1","key":"10.1016\/j.clinbiochem.2022.02.003_b0110","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1016\/j.thromres.2010.03.012","article-title":"Effects of distal embolization on the timing of platelet and inflammatory cell activation in interventional coronary no-reflow","volume":"126","author":"Charron","year":"2010","journal-title":"Thromb. Res."},{"issue":"22","key":"10.1016\/j.clinbiochem.2022.02.003_b0115","doi-asserted-by":"crossref","first-page":"3226","DOI":"10.1182\/bloodadvances.2018024828","article-title":"American Society of Hematology 2018 guidelines for management of venous thromboembolism: diagnosis of venous thromboembolism","volume":"2","author":"Lim","year":"2018","journal-title":"Blood Adv."},{"issue":"3","key":"10.1016\/j.clinbiochem.2022.02.003_b0120","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1093\/ehjcvp\/pvv039","article-title":"The current role and future prospects of D-dimer biomarker","volume":"2","author":"Soomro","year":"2016","journal-title":"Eur. Heart J. Cardiovasc. Pharmacother."},{"issue":"1","key":"10.1016\/j.clinbiochem.2022.02.003_b0125","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1016\/j.ejim.2013.07.012","article-title":"Causes of elevated D-dimer in patients admitted to a large urban emergency department","volume":"25","author":"Lippi","year":"2014","journal-title":"Eur. J. Intern. Med."},{"issue":"1","key":"10.1016\/j.clinbiochem.2022.02.003_b0130","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1007\/s11239-011-0648-8","article-title":"D-dimer for risk stratification in patients with acute pulmonary embolism","volume":"33","author":"Becattini","year":"2012","journal-title":"J. Thromb. Thrombolysis"},{"issue":"6","key":"10.1016\/j.clinbiochem.2022.02.003_b0135","doi-asserted-by":"crossref","first-page":"802","DOI":"10.1093\/ajcp\/102.6.802","article-title":"Variability of plasma IL-6 and crosslinked fibrin dimers over time in community dwelling elderly subjects","volume":"102","author":"Murali Krishna Rao","year":"1994","journal-title":"Am. J. Clin. Pathol."},{"issue":"3","key":"10.1016\/j.clinbiochem.2022.02.003_b0140","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1007\/s10140-017-1478-6","article-title":"Negative D-dimer testing excludes pulmonary embolism in non-high risk patients in the emergency department","volume":"24","author":"Harringa","year":"2017","journal-title":"Emerg. Radiol."},{"issue":"22","key":"10.1016\/j.clinbiochem.2022.02.003_b0145","doi-asserted-by":"crossref","first-page":"1361","DOI":"10.1056\/NEJM198711263172201","article-title":"Fibrin and fibrinogen-related antigens in patients with stable and unstable coronary artery disease","volume":"317","author":"Kruskal","year":"1987","journal-title":"N. Engl. J. Med."},{"issue":"6","key":"10.1016\/j.clinbiochem.2022.02.003_b0150","doi-asserted-by":"crossref","first-page":"1170","DOI":"10.1161\/01.CIR.75.6.1170","article-title":"Increased plasma concentration of cross-linked fibrin polymers in acute myocardial infarction","volume":"75","author":"Francis","year":"1987","journal-title":"Circulation"},{"issue":"4","key":"10.1016\/j.clinbiochem.2022.02.003_b0155","doi-asserted-by":"crossref","first-page":"628","DOI":"10.1161\/01.ATV.17.4.628","article-title":"The relationship of soluble fibrin and cross-linked fibrin degradation products to the clinical course of myocardial infarction","volume":"17","author":"Lee","year":"1997","journal-title":"Arterioscler. Thromb. Vasc. Biol."},{"issue":"6","key":"10.1016\/j.clinbiochem.2022.02.003_b0160","doi-asserted-by":"crossref","first-page":"282","DOI":"10.1002\/jcla.20082","article-title":"Lack of association between cardiac troponin T and D-dimer in the evaluation of myocardial damage","volume":"19","author":"Moresco","year":"2005","journal-title":"J. Clin. Lab. Anal."},{"issue":"3","key":"10.1016\/j.clinbiochem.2022.02.003_b0165","doi-asserted-by":"crossref","first-page":"379","DOI":"10.1067\/mhj.2000.108823","article-title":"D-Dimer is an early diagnostic marker of coronary ischemia in patients with chest pain","volume":"140","author":"Bayes-Genis","year":"2000","journal-title":"Am. Heart J."},{"issue":"8","key":"10.1016\/j.clinbiochem.2022.02.003_b0170","doi-asserted-by":"crossref","first-page":"548","DOI":"10.1080\/10408363.2018.1529734","article-title":"D-dimer: preanalytical, analytical, postanalytical variables, and clinical applications","volume":"55","author":"Favresse","year":"2018","journal-title":"Crit. Rev. Clin. Lab. Sci."},{"issue":"10","key":"10.1016\/j.clinbiochem.2022.02.003_b0175","first-page":"443","article-title":"Never ignore extremely elevated D-dimer levels: they are specific for serious illness","volume":"74","author":"Schutte","year":"2016","journal-title":"Neth. J. Med."},{"key":"10.1016\/j.clinbiochem.2022.02.003_b0180","first-page":"CD010864","article-title":"D-dimer test for excluding the diagnosis of pulmonary embolism","volume":"8","author":"Crawford","year":"2016","journal-title":"Cochrane Database Syst. Rev."},{"issue":"45","key":"10.1016\/j.clinbiochem.2022.02.003_b0185","first-page":"3145","article-title":"2014 ESC Guidelines on the diagnosis and management of acute pulmonary embolism","volume":"35","author":"Konstantinides","year":"2014","journal-title":"Eur. Heart J."},{"issue":"8","key":"10.1016\/j.clinbiochem.2022.02.003_b0190","doi-asserted-by":"crossref","first-page":"594","DOI":"10.1080\/07853890802161015","article-title":"Help me, Doctor! My D-dimer is raised","volume":"40","author":"Lippi","year":"2008","journal-title":"Ann. Med."},{"issue":"2","key":"10.1016\/j.clinbiochem.2022.02.003_b0195","doi-asserted-by":"crossref","first-page":"90","DOI":"10.1093\/labmed\/lmw001","article-title":"Widely used types and clinical applications of D-Dimer assay","volume":"47","author":"Riley","year":"2016","journal-title":"Lab. Med."},{"issue":"8","key":"10.1016\/j.clinbiochem.2022.02.003_b0200","doi-asserted-by":"crossref","first-page":"621","DOI":"10.1097\/01.mbc.0000252594.93067.f8","article-title":"The role of enzyme-linked immunosorbent assay D-dimer in patients with acute coronary syndrome presenting with normal cardiac enzymes","volume":"17","author":"Shitrit","year":"2006","journal-title":"Blood Coagul. Fibrinolysis"},{"issue":"2","key":"10.1016\/j.clinbiochem.2022.02.003_b0205","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1002\/ajh.20167","article-title":"Role of ELISA D-dimer test in patients with unstable angina pectoris presenting at the emergency department with a normal electrocardiogram","volume":"77","author":"Shitrit","year":"2004","journal-title":"Am. J. Hematol."},{"issue":"Suppl 2","key":"10.1016\/j.clinbiochem.2022.02.003_b0210","first-page":"1","article-title":"Impact of d-dimers on the differential diagnosis of acute chest pain: current aspects besides the widely known","volume":"8","author":"Hahne","year":"2014","journal-title":"Clin. Med. Insights Cardiol."},{"issue":"3","key":"10.1016\/j.clinbiochem.2022.02.003_b0215","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1007\/s11239-007-0060-6","article-title":"Diagnostic value of D-dimer measurement in patients referred to the emergency department with suspected myocardial ischemia","volume":"25","author":"Lippi","year":"2008","journal-title":"J. Thromb. Thrombolysis"},{"issue":"6","key":"10.1016\/j.clinbiochem.2022.02.003_b0220","first-page":"1578","article-title":"The early course of D-dimer concentration following pulmonary artery embolisation","volume":"86","author":"Mager","year":"2001","journal-title":"Thromb. Haemost."}],"container-title":["Clinical Biochemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0009912022000510?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0009912022000510?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,14]],"date-time":"2025-09-14T15:59:18Z","timestamp":1757865558000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0009912022000510"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,6]]},"references-count":44,"alternative-id":["S0009912022000510"],"URL":"https:\/\/doi.org\/10.1016\/j.clinbiochem.2022.02.003","relation":{},"ISSN":["0009-9120"],"issn-type":[{"value":"0009-9120","type":"print"}],"subject":[],"published":{"date-parts":[[2022,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Diagnostic performance and predictive value of D-dimer testing in patients referred to the emergency department for suspected myocardial infarction","name":"articletitle","label":"Article Title"},{"value":"Clinical Biochemistry","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.clinbiochem.2022.02.003","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2022 The Canadian Society of Clinical Chemists. Published by Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}