{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,19]],"date-time":"2026-05-19T19:36:17Z","timestamp":1779219377301,"version":"3.51.4"},"reference-count":5,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2023,2,1]],"date-time":"2023-02-01T00:00:00Z","timestamp":1675209600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2023,2,1]],"date-time":"2023-02-01T00:00:00Z","timestamp":1675209600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/501100013696","name":"National Fund of Science and Technology","doi-asserted-by":"publisher","award":["2008001053"],"award-info":[{"award-number":["2008001053"]}],"id":[{"id":"10.13039\/501100013696","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Clinical Biochemistry"],"published-print":{"date-parts":[[2023,2]]},"DOI":"10.1016\/j.clinbiochem.2022.11.007","type":"journal-article","created":{"date-parts":[[2022,11,16]],"date-time":"2022-11-16T22:38:48Z","timestamp":1668638328000},"page":"75-76","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":2,"special_numbering":"C","title":["MELAS a clinically and genetically heterogeneous syndrome"],"prefix":"10.1016","volume":"112","author":[{"given":"Liliana","family":"Casique","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marisel","family":"De Lucca","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Antonieta","family":"Mahfoud","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jos\u00e9","family":"Luis Ram\u00edrez","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.clinbiochem.2022.11.007_b0005","article-title":"Independent origin for M.3243A>G mitochondrial mutation in three venezuelan cases of melas syndrome","volume":"18","author":"Florez","year":"2022","journal-title":"Clin. Biochem."},{"issue":"13","key":"10.1016\/j.clinbiochem.2022.11.007_b0010","article-title":"Efficacy and safety of the ketogenic diet for mitochondrial disease with epilepsy: A prospective, open labeled, controlled study","volume":"1","author":"Huang","year":"2022","journal-title":"Front. Neurol."},{"key":"10.1016\/j.clinbiochem.2022.11.007_b0015","doi-asserted-by":"crossref","first-page":"e8262","DOI":"10.15252\/emmm.201708262","article-title":"mtDNA heteroplasmy level and copy number indicate disease burden in m.3243A>G mitochondrial disease","volume":"10","author":"Grady","year":"2018","journal-title":"EMBO Mol. Med."},{"key":"10.1016\/j.clinbiochem.2022.11.007_b0020","first-page":"334","article-title":"Alteration in the copy number of mitochondrial DNA in leukocytes of patients with mitochondrial encephalomyopathies","volume":"113","author":"Liu","year":"2006","journal-title":"Acta Neurologica Scandinavica"},{"key":"10.1016\/j.clinbiochem.2022.11.007_b0025","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1016\/j.mito.2015.03.001","article-title":"Mutation loads in different tissues from six pathogenic mtDNA point mutations","volume":"22","author":"O\u2019Callaghan","year":"2015","journal-title":"Mitochondrion"}],"container-title":["Clinical Biochemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0009912022002442?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0009912022002442?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,2]],"date-time":"2025-11-02T20:10:48Z","timestamp":1762114248000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0009912022002442"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,2]]},"references-count":5,"alternative-id":["S0009912022002442"],"URL":"https:\/\/doi.org\/10.1016\/j.clinbiochem.2022.11.007","relation":{},"ISSN":["0009-9120"],"issn-type":[{"value":"0009-9120","type":"print"}],"subject":[],"published":{"date-parts":[[2023,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"MELAS a clinically and genetically heterogeneous syndrome","name":"articletitle","label":"Article Title"},{"value":"Clinical Biochemistry","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.clinbiochem.2022.11.007","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"simple-article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2022 The Canadian Society of Clinical Chemists. Published by Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}