{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,18]],"date-time":"2026-03-18T22:14:17Z","timestamp":1773872057011,"version":"3.50.1"},"reference-count":32,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2023,2,1]],"date-time":"2023-02-01T00:00:00Z","timestamp":1675209600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2023,2,1]],"date-time":"2023-02-01T00:00:00Z","timestamp":1675209600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/100007834","name":"Natural Science Foundation of Ningbo","doi-asserted-by":"publisher","award":["202003N4115"],"award-info":[{"award-number":["202003N4115"]}],"id":[{"id":"10.13039\/100007834","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100007834","name":"Natural Science Foundation of Ningbo","doi-asserted-by":"publisher","award":["202003N4118"],"award-info":[{"award-number":["202003N4118"]}],"id":[{"id":"10.13039\/100007834","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100007834","name":"Natural Science Foundation of Ningbo","doi-asserted-by":"publisher","award":["2021J080"],"award-info":[{"award-number":["2021J080"]}],"id":[{"id":"10.13039\/100007834","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100007834","name":"Natural Science Foundation of Ningbo","doi-asserted-by":"publisher","award":["2021J246"],"award-info":[{"award-number":["2021J246"]}],"id":[{"id":"10.13039\/100007834","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100007834","name":"Natural Science Foundation of Ningbo","doi-asserted-by":"publisher","award":["2021J280"],"award-info":[{"award-number":["2021J280"]}],"id":[{"id":"10.13039\/100007834","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81970735"],"award-info":[{"award-number":["81970735"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Clinical Biochemistry"],"published-print":{"date-parts":[[2023,2]]},"DOI":"10.1016\/j.clinbiochem.2022.11.014","type":"journal-article","created":{"date-parts":[[2022,12,5]],"date-time":"2022-12-05T15:55:34Z","timestamp":1670255734000},"page":"61-66","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":3,"special_numbering":"C","title":["Clinical significance of elevated serum IL-36\u03b3 levels in patients with early-stage Hashimoto's thyroiditis"],"prefix":"10.1016","volume":"112","author":[{"given":"Shanjun","family":"Shi","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yinxin","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Luping","family":"Gong","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jialu","family":"Xu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yan","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mingcai","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"issue":"10","key":"10.1016\/j.clinbiochem.2022.11.014_b0005","doi-asserted-by":"crossref","DOI":"10.1016\/j.autrev.2020.102649","article-title":"Hashimoto's thyroiditis: An update on pathogenic mechanisms, diagnostic protocols, therapeutic strategies, and potential malignant transformation","volume":"19","author":"Ralli","year":"2020","journal-title":"Autoimmun. Rev."},{"key":"10.1016\/j.clinbiochem.2022.11.014_b0010","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1016\/j.semcancer.2019.05.019","article-title":"Thyroid autoimmune disorders and cancer","volume":"64","author":"Ferrari","year":"2020","journal-title":"Semin. Cancer Biol."},{"key":"10.1016\/j.clinbiochem.2022.11.014_b0015","article-title":"Discoveries in Thyroid Autoimmunity in the Past Century","author":"McLachlan","year":"2022","journal-title":"Thyroid"},{"issue":"5","key":"10.1016\/j.clinbiochem.2022.11.014_b0020","doi-asserted-by":"crossref","first-page":"883","DOI":"10.1007\/s40618-020-01477-1","article-title":"An update on the pathogenesis of Hashimoto's thyroiditis","volume":"44","author":"Weetman","year":"2021","journal-title":"J. Endocrinol. Invest."},{"issue":"3","key":"10.1016\/j.clinbiochem.2022.11.014_b0025","doi-asserted-by":"crossref","first-page":"2204","DOI":"10.1002\/jcp.27180","article-title":"The pathogenesis of thyroid autoimmune diseases: New T lymphocytes - Cytokines circuits beyond the Th1-Th2 paradigm","volume":"234","author":"Li","year":"2019","journal-title":"J. Cell. Physiol."},{"issue":"4","key":"10.1016\/j.clinbiochem.2022.11.014_b0030","doi-asserted-by":"crossref","first-page":"778","DOI":"10.1016\/j.immuni.2019.03.012","article-title":"Interleukin-1 and Related Cytokines in the Regulation of Inflammation and Immunity","volume":"50","author":"Mantovani","year":"2019","journal-title":"Immunity"},{"issue":"2","key":"10.1016\/j.clinbiochem.2022.11.014_b0035","doi-asserted-by":"crossref","first-page":"e144336","DOI":"10.1172\/JCI144336","article-title":"IL-36 in chronic inflammation and fibrosis - bridging the gap?","volume":"131","author":"Elias","year":"2021","journal-title":"J. Clin. Invest."},{"issue":"1","key":"10.1016\/j.clinbiochem.2022.11.014_b0040","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1111\/imr.12610","article-title":"Regulation and function of interleukin-36 cytokines","volume":"281","author":"Bassoy","year":"2018","journal-title":"Immunol. Rev."},{"issue":"4","key":"10.1016\/j.clinbiochem.2022.11.014_b0045","doi-asserted-by":"crossref","first-page":"369","DOI":"10.1111\/joim.12395","article-title":"Human autoimmune diseases: a comprehensive update","volume":"278","author":"Wang","year":"2015","journal-title":"J. Intern. Med."},{"key":"10.1016\/j.clinbiochem.2022.11.014_b0050","article-title":"The Role of IL-36 in the Pathophysiological Processes of Autoimmune Diseases","volume":"12","author":"Chen","year":"2021","journal-title":"Front. Pharmacol."},{"issue":"1","key":"10.1016\/j.clinbiochem.2022.11.014_b0055","doi-asserted-by":"crossref","first-page":"15631","DOI":"10.1038\/s41598-017-15892-7","article-title":"The psoriasis-associated IL-17A induces and cooperates with IL-36 cytokines to control keratinocyte differentiation and function","volume":"7","author":"Pfaff","year":"2017","journal-title":"Sci. Rep."},{"issue":"12","key":"10.1016\/j.clinbiochem.2022.11.014_b0060","doi-asserted-by":"crossref","first-page":"2428","DOI":"10.1038\/jid.2011.234","article-title":"Inter-regulation of Th17 cytokines and the IL-36 cytokines in vitro and in vivo: implications in psoriasis pathogenesis","volume":"131","author":"Carrier","year":"2011","journal-title":"J. Invest. Dermatol."},{"issue":"7","key":"10.1016\/j.clinbiochem.2022.11.014_b0065","doi-asserted-by":"crossref","first-page":"2022","DOI":"10.1681\/ASN.2016080840","article-title":"IL-36 Signaling Facilitates Activation of the NLRP3 Inflammasome and IL-23\/IL-17 Axis in Renal Inflammation and Fibrosis","volume":"28","author":"Chi","year":"2017","journal-title":"J. Am. Soc. Nephrol."},{"key":"10.1016\/j.clinbiochem.2022.11.014_b0070","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1016\/j.cca.2022.02.015","article-title":"Serum IL-36 cytokines levels in idiopathic pulmonary fibrosis and connective tissue disease-associated interstitial lung diseases","volume":"530","author":"Zhang","year":"2022","journal-title":"Clin. Chim. Acta"},{"issue":"5","key":"10.1016\/j.clinbiochem.2022.11.014_b0075","doi-asserted-by":"crossref","first-page":"1646","DOI":"10.1016\/j.jaci.2017.12.972","article-title":"The activation and function of IL-36\u03b3 in neutrophilic inflammation in chronic rhinosinusitis","volume":"141","author":"Wang","year":"2018","journal-title":"J. Allergy Clin. Immunol."},{"issue":"3","key":"10.1016\/j.clinbiochem.2022.11.014_b0080","doi-asserted-by":"crossref","first-page":"438","DOI":"10.1002\/glia.23552","article-title":"Spinal IL-36\u03b3\/IL-36R participates in the maintenance of chronic inflammatory pain through astroglial JNK pathway","volume":"67","author":"Li","year":"2019","journal-title":"Glia"},{"issue":"5","key":"10.1016\/j.clinbiochem.2022.11.014_b0085","doi-asserted-by":"crossref","first-page":"2230","DOI":"10.4049\/jimmunol.1501263","article-title":"IRF6 Regulates the Expression of IL-36\u03b3 by Human Oral Epithelial Cells in Response to Porphyromonas gingivalis","volume":"196","author":"Huynh","year":"2016","journal-title":"J. Immunol."},{"issue":"2","key":"10.1016\/j.clinbiochem.2022.11.014_b0090","doi-asserted-by":"crossref","first-page":"397","DOI":"10.1074\/mcp.M113.035600","article-title":"Analysis of the human tissue-specific expression by genome-wide integration of transcriptomics and antibody-based proteomics","volume":"13","author":"Fagerberg","year":"2014","journal-title":"Mol. Cell. Proteomics"},{"issue":"1","key":"10.1016\/j.clinbiochem.2022.11.014_b0095","doi-asserted-by":"crossref","first-page":"e24101","DOI":"10.1002\/jcla.24101","article-title":"Low serum interleukin-38 levels in patients with Graves' disease and Hashimoto's thyroiditis","volume":"36","author":"Xu","year":"2022","journal-title":"J. Clin. Lab. Anal."},{"issue":"10","key":"10.1016\/j.clinbiochem.2022.11.014_b0100","doi-asserted-by":"crossref","first-page":"939","DOI":"10.1089\/thy.2007.0169","article-title":"Thyroid peroxidase as an autoantigen","volume":"17","author":"McLachlan","year":"2007","journal-title":"Thyroid"},{"key":"10.1016\/j.clinbiochem.2022.11.014_b0105","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1016\/j.cyto.2019.02.012","article-title":"IL-36\u03b3 regulates mediators of tissue homeostasis in epithelial cells","volume":"119","author":"Heath","year":"2019","journal-title":"Cytokine"},{"issue":"11","key":"10.1016\/j.clinbiochem.2022.11.014_b0110","doi-asserted-by":"crossref","first-page":"e1006737","DOI":"10.1371\/journal.ppat.1006737","article-title":"Interleukin-36\u03b3 and IL-36 receptor signaling mediate impaired host immunity and lung injury in cytotoxic Pseudomonas aeruginosa pulmonary infection: Role of prostaglandin E2","volume":"13","author":"Aoyagi","year":"2017","journal-title":"PLoS Pathog."},{"issue":"4","key":"10.1016\/j.clinbiochem.2022.11.014_b0115","doi-asserted-by":"crossref","first-page":"633","DOI":"10.1016\/j.suc.2019.04.005","article-title":"The Role of Surgery in Autoimmune Conditions of the Thyroid","volume":"99","author":"Gan","year":"2019","journal-title":"Surg. Clin. North Am."},{"issue":"6","key":"10.1016\/j.clinbiochem.2022.11.014_b0120","doi-asserted-by":"crossref","DOI":"10.1016\/j.beem.2019.101367","article-title":"Hashimotos' thyroiditis: Epidemiology, pathogenesis, clinic and therapy","volume":"33","author":"Ragusa","year":"2019","journal-title":"Best Pract. Res. Clin. Endocrinol. Metab."},{"issue":"1","key":"10.1016\/j.clinbiochem.2022.11.014_b0125","doi-asserted-by":"crossref","DOI":"10.1016\/j.beem.2019.101366","article-title":"Novel therapies for thyroid autoimmune diseases: An update","volume":"34","author":"Ferrari","year":"2020","journal-title":"Best Pract. Res. Clin. Endocrinol. Metab."},{"issue":"10","key":"10.1016\/j.clinbiochem.2022.11.014_b0130","doi-asserted-by":"crossref","first-page":"423","DOI":"10.1089\/jir.2018.0089","article-title":"Interleukin 30 to Interleukin 40","volume":"38","author":"Catalan-Dibene","year":"2018","journal-title":"J. Interferon Cytokine Res."},{"issue":"13","key":"10.1016\/j.clinbiochem.2022.11.014_b0135","doi-asserted-by":"crossref","DOI":"10.3390\/ijms20133318","article-title":"The Significance of IL-36 Hyperactivation and IL-36R Targeting in Psoriasis","volume":"20","author":"Madonna","year":"2019","journal-title":"Int. J. Mol. Sci."},{"issue":"2","key":"10.1016\/j.clinbiochem.2022.11.014_b0140","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1111\/imm.13310","article-title":"IL-36 cytokines and gut immunity","volume":"163","author":"Ngo","year":"2021","journal-title":"Immunology"},{"key":"10.1016\/j.clinbiochem.2022.11.014_b0145","doi-asserted-by":"crossref","first-page":"2532","DOI":"10.3389\/fimmu.2019.02532","article-title":"Biology of IL-36 Signaling and Its Role in Systemic Inflammatory Diseases","volume":"10","author":"Yuan","year":"2019","journal-title":"Front. Immunol."},{"issue":"1","key":"10.1016\/j.clinbiochem.2022.11.014_b0150","doi-asserted-by":"crossref","first-page":"5","DOI":"10.2340\/00015555-2808","article-title":"Highlighting Interleukin-36 Signalling in Plaque Psoriasis and Pustular Psoriasis","volume":"98","author":"Furue","year":"2018","journal-title":"Acta Derm. Venereol."},{"issue":"5","key":"10.1016\/j.clinbiochem.2022.11.014_b0155","doi-asserted-by":"crossref","first-page":"526","DOI":"10.1097\/BOR.0000000000000529","article-title":"Spondyloarthritis: new insights into clinical aspects, translational immunology and therapeutics","volume":"30","author":"Bridgewood","year":"2018","journal-title":"Curr. Opin. Rheumatol."},{"issue":"9","key":"10.1016\/j.clinbiochem.2022.11.014_b0160","doi-asserted-by":"crossref","first-page":"4344","DOI":"10.3390\/ijms22094344","article-title":"Exploring the Role of IL-36 Cytokines as a New Target in Psoriatic Disease","volume":"22","author":"Iznardo","year":"2021","journal-title":"Int. J. Mol. Sci."}],"container-title":["Clinical Biochemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0009912022002648?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0009912022002648?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,14]],"date-time":"2025-09-14T15:59:24Z","timestamp":1757865564000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0009912022002648"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,2]]},"references-count":32,"alternative-id":["S0009912022002648"],"URL":"https:\/\/doi.org\/10.1016\/j.clinbiochem.2022.11.014","relation":{},"ISSN":["0009-9120"],"issn-type":[{"value":"0009-9120","type":"print"}],"subject":[],"published":{"date-parts":[[2023,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Clinical significance of elevated serum IL-36\u03b3 levels in patients with early-stage Hashimoto's thyroiditis","name":"articletitle","label":"Article Title"},{"value":"Clinical Biochemistry","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.clinbiochem.2022.11.014","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2022 The Canadian Society of Clinical Chemists. Published by Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}