{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,17]],"date-time":"2026-10-17T08:51:48Z","timestamp":1792227108893,"version":"4.4.0"},"reference-count":32,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2023,6,1]],"date-time":"2023-06-01T00:00:00Z","timestamp":1685577600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2023,6,1]],"date-time":"2023-06-01T00:00:00Z","timestamp":1685577600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Clinical Biochemistry"],"published-print":{"date-parts":[[2023,6]]},"DOI":"10.1016\/j.clinbiochem.2023.04.006","type":"journal-article","created":{"date-parts":[[2023,4,24]],"date-time":"2023-04-24T11:31:39Z","timestamp":1682335899000},"page":"105-112","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":8,"special_numbering":"C","title":["Variation in processes and reporting of cerebrospinal fluid oligoclonal banding and associated tests and calculated indices across Canadian clinical laboratories"],"prefix":"10.1016","volume":"116","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7463-9320","authenticated-orcid":false,"given":"V.","family":"Higgins","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D.","family":"Beriault","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9451-3787","authenticated-orcid":false,"given":"A.","family":"Mostafa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.P.","family":"Estey","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"T.","family":"Agbor","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"O.Z.","family":"Ismail","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.L.","family":"Parker","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"2","key":"10.1016\/j.clinbiochem.2023.04.006_b0005","doi-asserted-by":"crossref","first-page":"162","DOI":"10.1016\/S1474-4422(17)30470-2","article-title":"Diagnosis of multiple sclerosis: 2017 revisions of the McDonald criteria","volume":"17","author":"Thompson","year":"2018","journal-title":"Lancet Neurol."},{"issue":"6","key":"10.1016\/j.clinbiochem.2023.04.006_b0010","doi-asserted-by":"crossref","first-page":"865","DOI":"10.1001\/archneur.62.6.865","article-title":"Recommended standard of cerebrospinal fluid analysis in the diagnosis of multiple sclerosis: a consensus statement","volume":"62","author":"Freedman","year":"2005","journal-title":"Arch Neurol."},{"issue":"4","key":"10.1016\/j.clinbiochem.2023.04.006_b0015","doi-asserted-by":"crossref","first-page":"1075","DOI":"10.1093\/brain\/awy006","article-title":"The value of oligoclonal bands in the multiple sclerosis diagnostic criteria","volume":"141","author":"Arrambide","year":"2018","journal-title":"Brain"},{"issue":"8","key":"10.1016\/j.clinbiochem.2023.04.006_b0020","doi-asserted-by":"crossref","first-page":"1013","DOI":"10.1177\/1352458514568827","article-title":"Conversion from clinically isolated syndrome to multiple sclerosis: a large multicentre study","volume":"21","author":"Kuhle","year":"2015","journal-title":"Mult. Scler."},{"key":"10.1016\/j.clinbiochem.2023.04.006_b0025","unstructured":"CAP Diagnostic Immunology and Flow Cytometry Committee. M-A,2020: Cerebrospinal Fluid Chemistry and Oligoclonal Bands Proficiency Testing Program, College of American Pathologists; 2020."},{"issue":"6","key":"10.1016\/j.clinbiochem.2023.04.006_b0030","doi-asserted-by":"crossref","first-page":"245","DOI":"10.3390\/medicina55060245","article-title":"Cerebrospinal fluid analysis in multiple sclerosis diagnosis: an update","volume":"55","author":"Lo Sasso","year":"2019","journal-title":"Medicina (Kaunas)"},{"key":"10.1016\/j.clinbiochem.2023.04.006_b0035","doi-asserted-by":"crossref","first-page":"726","DOI":"10.3389\/fimmu.2019.00726","article-title":"The cerebrospinal fluid in multiple sclerosis","volume":"10","author":"Deisenhammer","year":"2019","journal-title":"Front Immunol."},{"issue":"Suppl 2","key":"10.1016\/j.clinbiochem.2023.04.006_b0040","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1007\/s10072-017-3034-2","article-title":"Cerebrospinal fluid analysis and the determination of oligoclonal bands","volume":"38","author":"Gastaldi","year":"2017","journal-title":"Neurol Sci."},{"issue":"2","key":"10.1016\/j.clinbiochem.2023.04.006_b0045","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1016\/S0022-510X(00)00501-3","article-title":"Cerebrospinal fluid analysis: disease-related data patterns and evaluation programs","volume":"184","author":"Reiber","year":"2001","journal-title":"J. Neurol. Sci."},{"issue":"1","key":"10.1016\/j.clinbiochem.2023.04.006_b0050","first-page":"2","article-title":"The diagnostic value of IgG index versus oligoclonal bands in cerebrospinal fluid of patients with multiple sclerosis","volume":"6","author":"Simonsen","year":"2020","journal-title":"Mult. Scler. J. Exp. Transl. Clin."},{"key":"10.1016\/j.clinbiochem.2023.04.006_b0055","unstructured":"CAP Diagnostic Immunology and Flow Cytometry Committee. M-B,2021: Cerebrospinal Fluid Chemistry and Oligoclonal Bands Proficiency Testing Program, College of American Pathologists; 2021."},{"issue":"1\u20132","key":"10.1016\/j.clinbiochem.2023.04.006_b0060","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.jneuroim.2013.06.014","article-title":"Intrathecal oligoclonal IgG synthesis in multiple sclerosis","volume":"262","author":"Petzold","year":"2013","journal-title":"J. Neuroimmunol."},{"key":"10.1016\/j.clinbiochem.2023.04.006_b0065","doi-asserted-by":"crossref","unstructured":"G. Pryce, D. Baker, Oligoclonal bands in multiple sclerosis; Functional significance and therapeutic implications. Does the specificity matter? Mult Scler Relat Disord. 2018;25:131\u20137.","DOI":"10.1016\/j.msard.2018.07.030"},{"issue":"8","key":"10.1016\/j.clinbiochem.2023.04.006_b0070","doi-asserted-by":"crossref","first-page":"525","DOI":"10.1111\/j.1468-1331.2004.00822.x","article-title":"CSF isoelectrofocusing in a large cohort of MS and other neurological diseases","volume":"11","author":"Bourahoui","year":"2004","journal-title":"Eur. J. Neurol."},{"issue":"6","key":"10.1016\/j.clinbiochem.2023.04.006_b0075","doi-asserted-by":"crossref","first-page":"1062","DOI":"10.1212\/01.wnl.0000237343.93389.35","article-title":"Multiple sclerosis with and without CSF bands: clinically indistinguishable but immunogenetically distinct","volume":"67","author":"Imrell","year":"2006","journal-title":"Neurology"},{"issue":"7","key":"10.1016\/j.clinbiochem.2023.04.006_b0080","doi-asserted-by":"crossref","first-page":"797","DOI":"10.1111\/j.1468-1331.2007.01859.x","article-title":"Cerebrospinal fluid oligoclonal bands and progression of disability in multiple sclerosis","volume":"14","author":"Koch","year":"2007","journal-title":"Eur. J. Neurol."},{"issue":"12","key":"10.1016\/j.clinbiochem.2023.04.006_b0085","doi-asserted-by":"crossref","first-page":"2044","DOI":"10.1001\/archneur.58.12.2044","article-title":"Oligoclonal band number as a marker for prognosis in multiple sclerosis","volume":"58","author":"Avasarala","year":"2001","journal-title":"Arch. Neurol."},{"issue":"7","key":"10.1016\/j.clinbiochem.2023.04.006_b0090","doi-asserted-by":"crossref","first-page":"1163","DOI":"10.1212\/01.WNL.0000055864.08740.CB","article-title":"The clinical significance of an intrathecal monoclonal immunoglobulin band: a follow-up study","volume":"60","author":"Davies","year":"2003","journal-title":"Neurology"},{"issue":"10","key":"10.1016\/j.clinbiochem.2023.04.006_b0095","doi-asserted-by":"crossref","first-page":"1274","DOI":"10.1007\/s00415-005-0820-1","article-title":"Clinical correlations of CSF single IgG bands","volume":"252","author":"Franciotta","year":"2005","journal-title":"J Neurol."},{"issue":"5","key":"10.1016\/j.clinbiochem.2023.04.006_b0100","doi-asserted-by":"crossref","first-page":"973","DOI":"10.1007\/s00415-017-8480-5","article-title":"A multicenter study on the diagnostic significance of a single cerebrospinal fluid IgG band","volume":"264","author":"Ferraro","year":"2017","journal-title":"J. Neurol."},{"issue":"2","key":"10.1016\/j.clinbiochem.2023.04.006_b0105","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1373\/jalm.2018.026088","article-title":"Laboratory performance on reporting monoclonal gammopathy during cerebrospinal fluid oligoclonal banding analysis from external quality assessment surveys","volume":"3","author":"Chen","year":"2018","journal-title":"J. Appl. Lab. Med."},{"issue":"12","key":"10.1016\/j.clinbiochem.2023.04.006_b0110","doi-asserted-by":"crossref","first-page":"1527","DOI":"10.5858\/arpa.2011-0343-LE","article-title":"Systemic inflammation or monoclonal gammopathy?","volume":"135","author":"Chen","year":"2011","journal-title":"Arch. Pathol. Lab. Med."},{"key":"10.1016\/j.clinbiochem.2023.04.006_b0115","doi-asserted-by":"crossref","first-page":"1799","DOI":"10.3389\/fimmu.2020.01799","article-title":"IgG index revisited: diagnostic utility and prognostic value in multiple sclerosis","volume":"11","author":"Zheng","year":"2020","journal-title":"Front. Immunol."},{"issue":"9","key":"10.1016\/j.clinbiochem.2023.04.006_b0120","doi-asserted-by":"crossref","first-page":"1134","DOI":"10.1093\/clinchem\/hvac061","article-title":"An update on laboratory-based diagnostic biomarkers for multiple sclerosis and beyond","volume":"68","author":"Saadeh","year":"2022","journal-title":"Clin Chem."},{"issue":"10","key":"10.1016\/j.clinbiochem.2023.04.006_b0125","doi-asserted-by":"crossref","first-page":"585","DOI":"10.1038\/nrneurol.2015.173","article-title":"Body fluid biomarkers for multiple sclerosis\u2013the long road to clinical application","volume":"11","author":"Teunissen","year":"2015","journal-title":"Nat. Rev. Neurol."},{"issue":"5","key":"10.1016\/j.clinbiochem.2023.04.006_b0130","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1038\/nrneurol.2013.41","article-title":"The utility of cerebrospinal fluid analysis in patients with multiple sclerosis","volume":"9","author":"Stangel","year":"2013","journal-title":"Nat. Rev. Neurol."},{"issue":"1","key":"10.1016\/j.clinbiochem.2023.04.006_b0135","doi-asserted-by":"crossref","first-page":"e200049","DOI":"10.1212\/NXI.0000000000200049","article-title":"Kappa free light chain biomarkers are efficient for the diagnosis of multiple sclerosis: a large multicenter cohort study","volume":"10","author":"Levraut","year":"2023","journal-title":"Neurol. Neuroimmunol. Neuroinflamm."},{"key":"10.1016\/j.clinbiochem.2023.04.006_b0140","article-title":"Cerebrospinal fluid kappa free light chains for the diagnosis of multiple sclerosis: a systematic review and meta-analysis","author":"Hegen","year":"2022","journal-title":"Mult. Scler."},{"key":"10.1016\/j.clinbiochem.2023.04.006_b0145","article-title":"Cerebrospinal fluid kappa free light chains for the diagnosis of multiple sclerosis: a consensus statement","author":"Hegen","year":"2022","journal-title":"Mult. Scler."},{"issue":"421","key":"10.1016\/j.clinbiochem.2023.04.006_b0150","article-title":"Diagnosis of multiple sclerosis in times of MOG and AQP4 autoantibody testing \u2013 a monocentric study","volume":"15","author":"Weber","year":"2021","journal-title":"J. Neurol. Sci."},{"key":"10.1016\/j.clinbiochem.2023.04.006_b0155","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1007\/7651_2015_223","article-title":"Detection of autoantibodies against myelin oligodendrocyte glycoprotein in multiple sclerosis and related diseases","volume":"1304","author":"Spadaro","year":"2016","journal-title":"Methods Mol. Biol."},{"issue":"2","key":"10.1016\/j.clinbiochem.2023.04.006_b0160","doi-asserted-by":"crossref","first-page":"321","DOI":"10.1136\/jim-2019-001126","article-title":"CNS inflammatory demyelinating disorders: MS, NMOSD and MOG antibody associated disease","volume":"68","author":"Rosenthal","year":"2020","journal-title":"J. Investig. Med."}],"container-title":["Clinical Biochemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0009912023000772?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0009912023000772?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,14]],"date-time":"2025-09-14T16:00:16Z","timestamp":1757865616000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0009912023000772"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,6]]},"references-count":32,"alternative-id":["S0009912023000772"],"URL":"https:\/\/doi.org\/10.1016\/j.clinbiochem.2023.04.006","relation":{},"ISSN":["0009-9120"],"issn-type":[{"value":"0009-9120","type":"print"}],"subject":[],"published":{"date-parts":[[2023,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Variation in processes and reporting of cerebrospinal fluid oligoclonal banding and associated tests and calculated indices across Canadian clinical laboratories","name":"articletitle","label":"Article Title"},{"value":"Clinical Biochemistry","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.clinbiochem.2023.04.006","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2023 The Canadian Society of Clinical Chemists. Published by Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}