{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,12]],"date-time":"2026-03-12T06:05:02Z","timestamp":1773295502768,"version":"3.50.1"},"reference-count":35,"publisher":"Elsevier BV","issue":"5","license":[{"start":{"date-parts":[[2014,9,1]],"date-time":"2014-09-01T00:00:00Z","timestamp":1409529600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":["patient-research.elsevier.com","cidjournal.com","theclinics.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Clinics in Dermatology"],"published-print":{"date-parts":[[2014,9]]},"DOI":"10.1016\/j.clindermatol.2014.04.006","type":"journal-article","created":{"date-parts":[[2014,8,23]],"date-time":"2014-08-23T10:20:40Z","timestamp":1408789240000},"page":"592-598","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":14,"title":["Alterations of skin innate immunity in lymphedematous limbs: Correlations with opportunistic diseases"],"prefix":"10.1016","volume":"32","author":[{"given":"Adone","family":"Baroni","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elisabetta","family":"Buommino","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vincenzo","family":"Piccolo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marco Adriano","family":"Chessa","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Teresa","family":"Russo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Valentina","family":"Cozza","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vincenzo","family":"Ruocco","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.clindermatol.2014.04.006_bb0005","doi-asserted-by":"crossref","first-page":"124","DOI":"10.1067\/mjd.2002.120909","article-title":"Lymphedema: An immunologically vulnerable site for development of neoplasms","volume":"47","author":"Ruocco","year":"2002","journal-title":"J Am Acad Dermatol"},{"key":"10.1016\/j.clindermatol.2014.04.006_bb0010","doi-asserted-by":"crossref","first-page":"646","DOI":"10.1111\/j.1365-2133.2010.09833.x","article-title":"Papillomatosis cutis arising on an immuno-compromised district due to paraplegia","volume":"163","author":"Baroni","year":"2010","journal-title":"Br J Dermatol"},{"key":"10.1016\/j.clindermatol.2014.04.006_bb0015","first-page":"673","article-title":"Coexistence of malignancy (skin cancer) and immune disorder (discoid lupus erythematosus) on a burn scar: A concrete example of 'immunocompromised district\u2019","volume":"164","author":"Baroni","year":"2011","journal-title":"Br J Dermatol"},{"key":"10.1016\/j.clindermatol.2014.04.006_bb0020","doi-asserted-by":"crossref","first-page":"1364","DOI":"10.1111\/j.1468-3083.2009.03345.x","article-title":"The immunocompromised district: A unifying concept for lymphoedematous, herpes-infected and otherwise damaged sites","volume":"23","author":"Ruocco","year":"2009","journal-title":"J Eur Acad Dermatol Venereol"},{"key":"10.1016\/j.clindermatol.2014.04.006_bb0025","doi-asserted-by":"crossref","first-page":"545","DOI":"10.1001\/archdermatol.2011.3199","article-title":"Recurrent blistering of the fingertips as a sign of carpal tunnel syndrome: An effect of nerve compression","volume":"148","author":"Baroni","year":"2012","journal-title":"Arch Dermatol"},{"key":"10.1016\/j.clindermatol.2014.04.006_bb0030","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1111\/j.1346-8138.2012.01647.x","article-title":"Unilateral bullous pemphigoid in hemiplegic patients: An instance of immunocompromised district","volume":"40","author":"Piccolo","year":"2013","journal-title":"J Dermatol"},{"key":"10.1016\/j.clindermatol.2014.04.006_bb0035","doi-asserted-by":"crossref","first-page":"280","DOI":"10.1007\/s00403-005-0594-4","article-title":"Toll-like receptor 2 (TLR2) mediates intracellular signalling in human keratinocytes in response to Malassezia furfur","volume":"297","author":"Baroni","year":"2006","journal-title":"Arch Dermatol Res"},{"key":"10.1016\/j.clindermatol.2014.04.006_bb0040","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1111\/1523-1747.ep12540422","article-title":"Calcium-regulated differentiation of normal human epidermal keratinocytes in chemically defined clonal culture and serum-free serial culture","volume":"81","author":"Boyce","year":"1983","journal-title":"J Invest Dermatol"},{"key":"10.1016\/j.clindermatol.2014.04.006_bb0045","doi-asserted-by":"crossref","first-page":"467","DOI":"10.1038\/sj.onc.1209802","article-title":"DSG3 is overexpressed in head neck cancer and is a potential molecular target for inhibition of oncogenesis","volume":"26","author":"Chen","year":"2007","journal-title":"Oncogene"},{"key":"10.1016\/j.clindermatol.2014.04.006_bb0050","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1038\/jid.2011.279","article-title":"Survivin: A dual player in healthy and diseased skin","volume":"132","author":"Dallaglio","year":"2012","journal-title":"J Invest Dermatol"},{"key":"10.1016\/j.clindermatol.2014.04.006_bb0055","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1146\/annurev.immunol.20.083001.084359","article-title":"Innate immune recognition","volume":"20","author":"Janeway","year":"2002","journal-title":"Annu Rev Immunol"},{"key":"10.1016\/j.clindermatol.2014.04.006_bb0060","doi-asserted-by":"crossref","first-page":"927","DOI":"10.1016\/S0092-8674(02)01201-1","article-title":"Pattern recognition receptors: Doubling up for the innate immune response","volume":"111","author":"Gordon","year":"2002","journal-title":"Cell"},{"key":"10.1016\/j.clindermatol.2014.04.006_bb0065","doi-asserted-by":"crossref","first-page":"373","DOI":"10.1038\/ni.1863","article-title":"The role of pattern-recognition receptors in innate immunity: Update on Toll-like receptors","volume":"11","author":"Kawai","year":"2010","journal-title":"Nat Immunol"},{"key":"10.1016\/j.clindermatol.2014.04.006_bb0070","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1007\/s00441-010-1022-4","article-title":"Defensins in innate immunity","volume":"343","author":"Hazlett","year":"2011","journal-title":"Cell Tissue Res"},{"key":"10.1016\/j.clindermatol.2014.04.006_bb0075","doi-asserted-by":"crossref","first-page":"437","DOI":"10.1111\/apm.12013","article-title":"Dysregulation of toll-like receptor (TLR) 2 expression on monocytes and upregulation of the frequency of T cells expressing TLR2 in patients with chronic hepatitis C virus infection","volume":"121","author":"Ronit","year":"2013","journal-title":"APMIS"},{"key":"10.1016\/j.clindermatol.2014.04.006_bb0080","doi-asserted-by":"crossref","first-page":"677","DOI":"10.1007\/s12253-011-9368-9","article-title":"Increased expression of toll-like receptors (TLR) 2, 4 and 5 in gastric dysplasia","volume":"17","author":"Pimentel-Nunes","year":"2011","journal-title":"Pathol Oncol Res"},{"key":"10.1016\/j.clindermatol.2014.04.006_bb0085","doi-asserted-by":"crossref","first-page":"466","DOI":"10.1016\/j.ccr.2012.08.010","article-title":"STAT3-Driven upregulation of TLR2 promotes gastric tumorigenesis independent of tumor inflammation","volume":"22","author":"Tye","year":"2012","journal-title":"Cancer Cell"},{"key":"10.1016\/j.clindermatol.2014.04.006_bb0090","doi-asserted-by":"crossref","first-page":"1353","DOI":"10.1002\/biot.200700148","article-title":"Defensins: Antimicrobial peptides for therapeutic development","volume":"2","author":"Verma","year":"2007","journal-title":"Biotechnol J"},{"key":"10.1016\/j.clindermatol.2014.04.006_bb0095","doi-asserted-by":"crossref","first-page":"1643","DOI":"10.1172\/JCI18761","article-title":"What is the real role of antimicrobial polypeptides that can mediate several other inflammatory responses?","volume":"111","author":"Elsbach","year":"2003","journal-title":"J Clin Invest"},{"key":"10.1016\/j.clindermatol.2014.04.006_bb0100","doi-asserted-by":"crossref","first-page":"594","DOI":"10.1038\/sj.jid.5700599","article-title":"Antimicrobial peptides human beta-defensins stimulate epidermal keratinocytes migration, proliferation and production of proinflammatory cytokines and chemokines","volume":"127","author":"Niyonsaba","year":"2007","journal-title":"J Invest Dermatol"},{"key":"10.1016\/j.clindermatol.2014.04.006_bb0105","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1076\/ceyr.22.1.64.6978","article-title":"Human beta-defensin 2 is up-regulated during re-epithelialization of the cornea","volume":"22","author":"McDermott","year":"2001","journal-title":"Curr Eye Res"},{"key":"10.1016\/j.clindermatol.2014.04.006_bb0110","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1038\/ng.2007.48","article-title":"Psoriasis is associated with increased beta-defensin genomic copy number","volume":"40","author":"Hollox","year":"2008","journal-title":"Nat Genet"},{"key":"10.1016\/j.clindermatol.2014.04.006_bb0115","first-page":"2103","article-title":"High concentration of beta-defensin-2 in oral squamous cell carcinoma","volume":"22","author":"Sawaki","year":"2002","journal-title":"Anticancer Res"},{"key":"10.1016\/j.clindermatol.2014.04.006_bb0120","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1186\/1471-2407-6-163","article-title":"Pattern of mRNA expression of \u03b2-defensins in basal cell carcinoma","volume":"6","author":"Gambichler","year":"2006","journal-title":"BMC Cancer"},{"key":"10.1016\/j.clindermatol.2014.04.006_bb0125","doi-asserted-by":"crossref","first-page":"196","DOI":"10.3109\/07357907.2010.543210","article-title":"Human beta-defensin-1, -2, and -3 exhibit opposite effects on oral squamous cell carcinoma cell proliferation","volume":"29","author":"Winter","year":"2011","journal-title":"Cancer Invest"},{"key":"10.1016\/j.clindermatol.2014.04.006_bb0130","doi-asserted-by":"crossref","DOI":"10.1111\/bjd.12419","article-title":"Human beta-defensin-2 as a marker for disease severity and skin barrier properties in Atopic Dermatitis","author":"Clausen","year":"2013","journal-title":"Br J Dermatol"},{"key":"10.1016\/j.clindermatol.2014.04.006_bb0135","doi-asserted-by":"crossref","first-page":"1705","DOI":"10.1016\/j.ajpath.2013.01.044","article-title":"Visfatin enhances the production of cathelicidin antimicrobial peptide, human \u03b2-defensin-2, human \u03b2-defensin-3, and S100 A7 in human keratinocytes and their orthologs in murine imiquimod-induced psoriatic skin","volume":"182","author":"Hau","year":"2013","journal-title":"Am J Pathol"},{"key":"10.1016\/j.clindermatol.2014.04.006_bb0140","doi-asserted-by":"crossref","first-page":"248","DOI":"10.1007\/s004280000303","article-title":"Differential expression of human beta-defensin 2 in keratinized and non-keratinized oral epithelial lesions; immunohistochemistry and in situ hybridization","volume":"438","author":"Abiko","year":"2001","journal-title":"Virchows Arch"},{"key":"10.1016\/j.clindermatol.2014.04.006_bb0145","doi-asserted-by":"crossref","first-page":"100","DOI":"10.1111\/j.1365-2249.2010.04201.x","article-title":"Role of inflammatory cells, cytokines and matrix metalloproteinases in neutrophil-mediated skin diseases","volume":"162","author":"Marzano","year":"2010","journal-title":"Clin Exp Immunol"},{"key":"10.1016\/j.clindermatol.2014.04.006_bb0150","first-page":"8221","article-title":"Expression of matrix metalloproteinases in the microenvironment of spontaneous and experimental melanoma metastases reflects the requirements for tumor formation","volume":"63","author":"Hofmann","year":"2003","journal-title":"Cancer Res"},{"key":"10.1016\/j.clindermatol.2014.04.006_bb0155","doi-asserted-by":"crossref","first-page":"541","DOI":"10.1111\/j.1365-2230.2005.01849.x","article-title":"Expression and serum levels of MMP-2 and MMP-9 during human melanoma progression","volume":"30","author":"Redondo","year":"2005","journal-title":"Clin Exp Dermatol"},{"key":"10.1016\/j.clindermatol.2014.04.006_bb0160","doi-asserted-by":"crossref","first-page":"4283","DOI":"10.4049\/jimmunol.161.8.4283","article-title":"Immunoregulatory roles of IL-10 in innate immunity: IL-10 inhibits macrophage production of IFN-gamma-inducing factors but enhances NK cell production of IFN-gamma","volume":"161","author":"Shibata","year":"1998","journal-title":"J Immunol"},{"key":"10.1016\/j.clindermatol.2014.04.006_bb0165","doi-asserted-by":"crossref","first-page":"e218","DOI":"10.1016\/S1470-2045(12)70582-X","article-title":"Cytokine patterns in patients with cancer: A systematic review","volume":"14","author":"Lippitz","year":"2013","journal-title":"Lancet Oncol"},{"key":"10.1016\/j.clindermatol.2014.04.006_bb0170","doi-asserted-by":"crossref","first-page":"901","DOI":"10.1002\/eji.201141958","article-title":"Pituitary adenylate cyclase-activating peptide and vasoactive intestinal polypeptide bias Langerhans cell Ag presentation toward Th17 cells","volume":"42","author":"Ding","year":"2012","journal-title":"Eur J Immunol"},{"key":"10.1016\/j.clindermatol.2014.04.006_bb0175","first-page":"289","article-title":"Vasoactive peptides in the pathogenesis of psoriasis","volume":"143","author":"Reich","year":"2008","journal-title":"G Ital Dermatol Venereol"}],"container-title":["Clinics in Dermatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0738081X14000972?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0738081X14000972?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2023,7,16]],"date-time":"2023-07-16T06:07:16Z","timestamp":1689487636000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0738081X14000972"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,9]]},"references-count":35,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2014,9]]}},"alternative-id":["S0738081X14000972"],"URL":"https:\/\/doi.org\/10.1016\/j.clindermatol.2014.04.006","relation":{},"ISSN":["0738-081X"],"issn-type":[{"value":"0738-081X","type":"print"}],"subject":[],"published":{"date-parts":[[2014,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Alterations of skin innate immunity in lymphedematous limbs: Correlations with opportunistic diseases","name":"articletitle","label":"Article Title"},{"value":"Clinics in Dermatology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.clindermatol.2014.04.006","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"simple-article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2014 Published by Elsevier Inc.","name":"copyright","label":"Copyright"}]}}