{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T22:57:36Z","timestamp":1790204256711,"version":"4.1.0"},"reference-count":41,"publisher":"Elsevier BV","issue":"4","license":[{"start":{"date-parts":[[2015,7,1]],"date-time":"2015-07-01T00:00:00Z","timestamp":1435708800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":["cidjournal.com","theclinics.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Clinics in Dermatology"],"published-print":{"date-parts":[[2015,7]]},"DOI":"10.1016\/j.clindermatol.2015.04.010","type":"journal-article","created":{"date-parts":[[2015,4,10]],"date-time":"2015-04-10T00:03:35Z","timestamp":1428624215000},"page":"466-470","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":58,"title":["Acanthosis nigricans: A fold (intertriginous) dermatosis"],"prefix":"10.1016","volume":"33","author":[{"given":"Zekayi","family":"Kutlubay","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Burhan","family":"Engin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Orkhan","family":"Bairamov","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yal\u00e7\u0131n","family":"T\u00fcz\u00fcn","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.clindermatol.2015.04.010_bb0005","doi-asserted-by":"crossref","first-page":"502","DOI":"10.1016\/j.jaad.2006.08.016","article-title":"Juvenile acanthosis nigricans","volume":"57","author":"Sinha","year":"2007","journal-title":"J Am Acad Dermatol"},{"key":"10.1016\/j.clindermatol.2015.04.010_bb0010","doi-asserted-by":"crossref","first-page":"341","DOI":"10.1016\/j.jaad.2004.10.867","article-title":"Insulin resistance, acanthosis nigricans, and hypertriglyceridemia","volume":"52","author":"Eberting","year":"2005","journal-title":"J Am Acad Dermatol"},{"key":"10.1016\/j.clindermatol.2015.04.010_bb0015","doi-asserted-by":"crossref","first-page":"1096","DOI":"10.1046\/j.1365-2133.2002.05150.x","article-title":"Genes, growth factors and acanthosis nigricans","volume":"147","author":"Torley","year":"2002","journal-title":"Br J Dermatol"},{"key":"10.1016\/j.clindermatol.2015.04.010_bb0020","first-page":"254","article-title":"Paraneoplastic type of acanthosis nigricans in patient with hepatocellular carcinoma","volume":"52","author":"Kami\u0144ska-Winciorek","year":"2007","journal-title":"Adv Med Sci"},{"key":"10.1016\/j.clindermatol.2015.04.010_bb0025","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1590\/S0365-05962012000100012","article-title":"Association of acanthosis nigricans and skin tags with insulin resistance","volume":"87","author":"Barbato","year":"2012","journal-title":"An Bras Dermatol"},{"key":"10.1016\/j.clindermatol.2015.04.010_bb0030","doi-asserted-by":"crossref","first-page":"1009","DOI":"10.2337\/diacare.25.6.1009","article-title":"Association of acanthosis nigricans with hyperinsulinemia compared with other selected risk factors for type 2 diabetes in Cherokee Indians: The Cherokee Diabetes Study","volume":"25","author":"Stoddart","year":"2002","journal-title":"Diabetes Care"},{"key":"10.1016\/j.clindermatol.2015.04.010_bb0035","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1111\/j.1600-0781.2012.00663.x","article-title":"Quantitative skin color measurements in acanthosis nigricans patients: Colorimetry and diffuse reflectance spectroscopy","volume":"28","author":"Pattamadilok","year":"2012","journal-title":"Photodermatol Photoimmunol Photomed"},{"key":"10.1016\/j.clindermatol.2015.04.010_bb0040","author":"Miller"},{"key":"10.1016\/j.clindermatol.2015.04.010_bb0045","doi-asserted-by":"crossref","first-page":"651","DOI":"10.5144\/0256-4947.1997.651","article-title":"Acanthosis nigricans: A new analysis of associated endocrine and malignant disorders","volume":"17","author":"Mishal","year":"1997","journal-title":"Ann Saudi Med"},{"key":"10.1016\/j.clindermatol.2015.04.010_bb0050","doi-asserted-by":"crossref","first-page":"180","DOI":"10.20452\/pamw.642","article-title":"Acanthosis nigricans as a paraneoplastic syndrome. Case reports and review of literature","volume":"119","author":"Krawczyk","year":"2009","journal-title":"Pol Arch Med Wewn"},{"key":"10.1016\/j.clindermatol.2015.04.010_bb0055","doi-asserted-by":"crossref","first-page":"2","DOI":"10.5070\/D37MF6G290","article-title":"Acanthosis nigricans: A practical approach to evaluation and management","volume":"14","author":"Higgins","year":"2008","journal-title":"Dermatol Online J"},{"key":"10.1016\/j.clindermatol.2015.04.010_bb0060","doi-asserted-by":"crossref","first-page":"661","DOI":"10.1016\/S0001-7310(08)74768-9","article-title":"Cruces M","volume":"99","author":"Pardavila","year":"2008","journal-title":"Actas Dermosifiliogr"},{"key":"10.1016\/j.clindermatol.2015.04.010_bb0065","first-page":"5","article-title":"A case of exogenous insulin-derived acanthosis nigricans caused by insulin injections","volume":"39","author":"Yahagi","year":"2014","journal-title":"Tokai J Exp Clin Med"},{"key":"10.1016\/j.clindermatol.2015.04.010_bb0070","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/S0190-9622(94)70128-8","article-title":"Acanthosis nigricans","volume":"31","author":"Schwartz","year":"1994","journal-title":"J Am Acad Dermatol"},{"key":"10.1016\/j.clindermatol.2015.04.010_bb0075","first-page":"91","article-title":"Oral acanthosis nigricans: Case report and comparison with literature reports","volume":"16","author":"Canjuga","year":"2008","journal-title":"Acta Dermatovenerol Croat"},{"key":"10.1016\/j.clindermatol.2015.04.010_bb0080","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1186\/1756-0500-4-25","article-title":"Prevalence of acanthosis nigricans in an urban population in Sri Lanka and its utility to detect metabolic syndrome","volume":"4","author":"Dassanayake","year":"2011","journal-title":"BMC Res Notes"},{"key":"10.1016\/j.clindermatol.2015.04.010_bb0085","first-page":"37","article-title":"Malignant acanthosis nigricans and tripe palms associated with pancreatic adenocarcinoma","volume":"78","author":"McGinness","year":"2006","journal-title":"Cutis"},{"key":"10.1016\/j.clindermatol.2015.04.010_bb0090","first-page":"940","article-title":"Acanthosis nigricans as an indicator of insulin resistance in Chilean adult population","volume":"26","author":"Pinheiro","year":"2011","journal-title":"Nutr Hosp"},{"key":"10.1016\/j.clindermatol.2015.04.010_bb0095","first-page":"85","article-title":"Acanthosis nigricans vulgaris. A marker of hyperinsulinemia","volume":"13","author":"Garofalo","year":"2003","journal-title":"Eur J Pediatr Dermatol"},{"key":"10.1016\/j.clindermatol.2015.04.010_bb0100","doi-asserted-by":"crossref","first-page":"208","DOI":"10.5021\/ad.2011.23.S2.S208","article-title":"Acral-type malignant acanthosis nigricans associated with gastric adenocarcinoma","volume":"23","author":"Lee","year":"2011","journal-title":"Ann Dermatol"},{"key":"10.1016\/j.clindermatol.2015.04.010_bb0105","doi-asserted-by":"crossref","first-page":"507","DOI":"10.1100\/tsw.2004.106","article-title":"Clinical profiles, occurrence, and management of adolescent patients with HAIR-AN syndrome","volume":"4","author":"Omar","year":"2004","journal-title":"Sci World J"},{"key":"10.1016\/j.clindermatol.2015.04.010_bb0110","doi-asserted-by":"crossref","first-page":"670","DOI":"10.1016\/j.metabol.2006.12.016","article-title":"Regression of acanthosis nigricans correlates with disappearance of anti-insulin receptor autoantibodies and achievement of euglycemia in type B insulin resistance syndrome","volume":"56","author":"Fareau","year":"2007","journal-title":"Metabolism"},{"key":"10.1016\/j.clindermatol.2015.04.010_bb0115","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1159\/000337751","article-title":"A case of generalized acanthosis nigricans with positive lupus erythematosus-related autoantibodies and antimicrosomal antibody: Autoimmune acanthosis nigricans?","volume":"4","author":"Kondo","year":"2012","journal-title":"Case Rep Dermatol"},{"key":"10.1016\/j.clindermatol.2015.04.010_bb0120","doi-asserted-by":"crossref","first-page":"737","DOI":"10.1001\/jamadermatol.2013.3019","article-title":"Cutaneous features of Crouzon syndrome with acanthosis nigricans","volume":"149","author":"Mir","year":"2013","journal-title":"JAMA Dermatol"},{"key":"10.1016\/j.clindermatol.2015.04.010_bb0125","doi-asserted-by":"crossref","first-page":"573","DOI":"10.1590\/S0365-05962011000300025","article-title":"Florid cutaneous papillomatosis and acanthosis nigricans maligna revealing gastric adenocarcinoma","volume":"86","author":"Brinca","year":"2011","journal-title":"An Bras Dermatol"},{"key":"10.1016\/j.clindermatol.2015.04.010_bb0130","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1016\/j.det.2007.08.008","article-title":"Epidermal manifestations of internal malignancy","volume":"26","author":"Moore","year":"2008","journal-title":"Dermatol Clin"},{"key":"10.1016\/j.clindermatol.2015.04.010_bb0135","doi-asserted-by":"crossref","first-page":"299","DOI":"10.3747\/co.19.997","article-title":"Occult cause of paraneoplastic acanthosis nigricans in a patient with known breast DC\u0130S: Case and review","volume":"19","author":"Jakubovic","year":"2012","journal-title":"Curr Oncol"},{"key":"10.1016\/j.clindermatol.2015.04.010_bb0140","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.det.2007.08.002","article-title":"Cutaneous manifestations of internal malignancies: An overview","volume":"26","author":"Pipkin","year":"2008","journal-title":"Dermatol Clin"},{"key":"10.1016\/j.clindermatol.2015.04.010_bb0145","doi-asserted-by":"crossref","first-page":"353","DOI":"10.1016\/j.ygyno.2005.12.024","article-title":"Malignant acanthosis nigricans, tripe palms and the sign of Leser-Tre'lat, a hint to the diagnosis of early stage ovarian cancer: A case report and review of the literature","volume":"101","author":"Kebria","year":"2006","journal-title":"Gynecol Oncol"},{"key":"10.1016\/j.clindermatol.2015.04.010_bb0150","doi-asserted-by":"crossref","first-page":"95","DOI":"10.5021\/ad.2011.23.1.95","article-title":"Unilateral nevoid acanthosis nigricans with a submammary location","volume":"23","author":"Jeong","year":"2011","journal-title":"Ann Dermatol"},{"key":"10.1016\/j.clindermatol.2015.04.010_bb0155","doi-asserted-by":"crossref","first-page":"1297","DOI":"10.1177\/0960327113514099","article-title":"A case of hyperpigmentation and acanthosis nigricans by testosterone injections","volume":"33","author":"Karadag","year":"2014","journal-title":"Hum Exp Toxicol"},{"key":"10.1016\/j.clindermatol.2015.04.010_bb0160","doi-asserted-by":"crossref","first-page":"553","DOI":"10.4103\/0378-6323.113112","article-title":"Acanthosis nigricans\u2014an uncommon cutaneous adverse effect of a common medication: Report of two cases","volume":"79","author":"Sawatkar","year":"2013","journal-title":"Indian J Dermatol Venereol Leprol"},{"key":"10.1016\/j.clindermatol.2015.04.010_bb0165","doi-asserted-by":"crossref","first-page":"941","DOI":"10.1001\/archderm.1992.01680170073009","article-title":"Prevalence and significance of acanthosis nigricans in an adult obese population","volume":"128","author":"Hud","year":"1992","journal-title":"Arch Dermatol"},{"key":"10.1016\/j.clindermatol.2015.04.010_bb0170","doi-asserted-by":"crossref","first-page":"697","DOI":"10.1111\/j.1365-2133.1982.tb11685.x","article-title":"Treatment of malignant acanthosis nigricans with cyproheptadine","volume":"106","author":"Greenwood","year":"1982","journal-title":"Br J Dermatol"},{"key":"10.1016\/j.clindermatol.2015.04.010_bb0175","first-page":"33","article-title":"Topical therapy with tretinoin and ammonium lactate for acanthosis nigricans associated with obesity","volume":"71","author":"Blobstein","year":"2003","journal-title":"Cutis"},{"key":"10.1016\/j.clindermatol.2015.04.010_bb0180","doi-asserted-by":"crossref","first-page":"199","DOI":"10.2165\/00128071-200405030-00008","article-title":"Acanthosis nigricans associated with insulin resistance: Pathophysiology and management","volume":"5","author":"Hermanns-L\u00ea","year":"2004","journal-title":"Am J Clin Dermatol"},{"key":"10.1016\/j.clindermatol.2015.04.010_bb0185","doi-asserted-by":"crossref","first-page":"486","DOI":"10.1111\/j.1468-3083.2008.02931.x","article-title":"Improvement of idiopathic acanthosis nigricans with a triple combination depigmenting cream","volume":"23","author":"Adigun","year":"2009","journal-title":"J Eur Acad Dermatol Venereol"},{"key":"10.1016\/j.clindermatol.2015.04.010_bb0190","doi-asserted-by":"crossref","first-page":"699","DOI":"10.1007\/BF03349042","article-title":"Long-term octreotide treatment reduced hyperinsulinemia, excess body weight and skin lesions in severe obesity with acanthosis nigricans","volume":"19","author":"Lunetta","year":"1996","journal-title":"J Endocrinol Invest"},{"key":"10.1016\/j.clindermatol.2015.04.010_bb0195","doi-asserted-by":"crossref","first-page":"1094","DOI":"10.1001\/archderm.1988.01670070082026","article-title":"Improved acanthosis nigricans with lipodystrophic diabetes during dietary fish oil supplementation","volume":"124","author":"Sherertz","year":"1988","journal-title":"Arch Dermatol"},{"key":"10.1016\/j.clindermatol.2015.04.010_bb0200","first-page":"295","article-title":"Significance of acanthosis nigricans as marker for metabolic syndrome","volume":"10","author":"Balaji","year":"2014","journal-title":"World J Med Sci"},{"key":"10.1016\/j.clindermatol.2015.04.010_bb0205","first-page":"1158","article-title":"Treatment of acanthosis nigricans of the axillae using a long-pulsed (5-msec) alexandrite laser","volume":"30","author":"Rosenbach","year":"2004","journal-title":"Dermatol Surg"}],"container-title":["Clinics in Dermatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0738081X15000747?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0738081X15000747?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,5,22]],"date-time":"2025-05-22T00:03:03Z","timestamp":1747872183000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0738081X15000747"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,7]]},"references-count":41,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2015,7]]}},"alternative-id":["S0738081X15000747"],"URL":"https:\/\/doi.org\/10.1016\/j.clindermatol.2015.04.010","relation":{},"ISSN":["0738-081X"],"issn-type":[{"value":"0738-081X","type":"print"}],"subject":[],"published":{"date-parts":[[2015,7]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Acanthosis nigricans: A fold (intertriginous) dermatosis","name":"articletitle","label":"Article Title"},{"value":"Clinics in Dermatology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.clindermatol.2015.04.010","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2015 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}