{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T18:41:04Z","timestamp":1790620864690,"version":"4.1.0"},"reference-count":56,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2018,1,1]],"date-time":"2018-01-01T00:00:00Z","timestamp":1514764800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":["clinicalkey.jp","clinicalkey.com","cidjournal.com","clinicalkey.es","theclinics.com","clinicalkey.fr","clinicalkey.com.au","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Clinics in Dermatology"],"published-print":{"date-parts":[[2018,1]]},"DOI":"10.1016\/j.clindermatol.2017.09.007","type":"journal-article","created":{"date-parts":[[2017,9,12]],"date-time":"2017-09-12T06:00:33Z","timestamp":1505196033000},"page":"41-47","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":58,"title":["Hidradenitis suppurativa and the metabolic syndrome"],"prefix":"10.1016","volume":"36","author":[{"given":"Tulin","family":"Ergun","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.clindermatol.2017.09.007_bb0005","first-page":"693","article-title":"Studies on skin tumors; some diseases of the sweat glands","volume":"94","author":"Verneuil","year":"1854","journal-title":"Arch Gen Med"},{"key":"10.1016\/j.clindermatol.2017.09.007_bb0010","series-title":"Hidradenitis Suppurativa","first-page":"58","article-title":"Epidemiology","volume":"vol. 1","author":"Naldi","year":"2006"},{"key":"10.1016\/j.clindermatol.2017.09.007_bb0015","doi-asserted-by":"crossref","first-page":"412","DOI":"10.1016\/j.jaad.2012.07.027","article-title":"Analysis of patient claims data to determine the prevalence of hidradenitis suppurativa in the United States","volume":"68","author":"Cosmatos","year":"2013","journal-title":"J Am Acad Dermatol"},{"key":"10.1016\/j.clindermatol.2017.09.007_bb0020","doi-asserted-by":"crossref","first-page":"464","DOI":"10.1111\/bjd.13777","article-title":"Hidradenitis suppurativa and metabolic syndrome: A comparative cross-sectional study of 3207 patients","volume":"173","author":"Shalom","year":"2015","journal-title":"Br J Dermatol"},{"key":"10.1016\/j.clindermatol.2017.09.007_bb0025","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1016\/j.jaad.2015.07.051","article-title":"Hidradenitis suppurativa in the pediatric population","volume":"73","author":"Liy-Wong","year":"2015","journal-title":"J Am Acad Dermatol"},{"key":"10.1016\/j.clindermatol.2017.09.007_bb0030","doi-asserted-by":"crossref","first-page":"539","DOI":"10.1016\/j.jaad.2008.11.911","article-title":"Hidradenitis suppurativa: A comprehensive review","volume":"60","author":"Alikhan","year":"2009","journal-title":"J Am Acad Dermatol"},{"key":"10.1016\/j.clindermatol.2017.09.007_bb0035","doi-asserted-by":"crossref","first-page":"985","DOI":"10.1111\/j.1468-3083.2009.03356.x","article-title":"Hidradenitis suppurativa","volume":"23","author":"Revuz","year":"2009","journal-title":"J Eur Acad Dermatol Venereol"},{"key":"10.1016\/j.clindermatol.2017.09.007_bb0040","doi-asserted-by":"crossref","first-page":"389","DOI":"10.1046\/j.1468-3083.2000.00087.x","article-title":"The natural history of hidradenitis suppurativa","volume":"14","author":"von der Werth","year":"2000","journal-title":"J Eur Acad Dermatol Venereol"},{"key":"10.1016\/j.clindermatol.2017.09.007_bb0045","doi-asserted-by":"crossref","first-page":"182","DOI":"10.1001\/archdermatol.2011.315","article-title":"Hidradenitis suppurativa. The role of deficient cutaneous innate immunity","volume":"148","author":"Dreno","year":"2012","journal-title":"Arch Dermatol"},{"key":"10.1016\/j.clindermatol.2017.09.007_bb0050","doi-asserted-by":"crossref","first-page":"1186","DOI":"10.1111\/ijd.12550","article-title":"Hidradenitis suppurativa: The role of immune dysregulation","volume":"53","author":"Kelly","year":"2014","journal-title":"Int J Dermatol"},{"key":"10.1016\/j.clindermatol.2017.09.007_bb0055","doi-asserted-by":"crossref","first-page":"533","DOI":"10.1111\/j.1600-0625.2009.00915.x","article-title":"Hidradenitis suppurativa (acne inversa): Early inflammatory events at terminal follicles and at interfollicular epidermis","volume":"19","author":"Von Laffert","year":"2009","journal-title":"Exp Dermatol"},{"key":"10.1016\/j.clindermatol.2017.09.007_bb0060","doi-asserted-by":"crossref","first-page":"419","DOI":"10.1111\/j.1365-2230.1996.tb00145.x","article-title":"Hidradenitis suppurativa\u2014characteristics and consequences","volume":"21","author":"Jemec","year":"1996","journal-title":"Clin Exp Dermatol"},{"key":"10.1016\/j.clindermatol.2017.09.007_bb0065","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1016\/j.det.2015.08.010","article-title":"The microbiology of hidradenitis suppurativa","volume":"34","author":"Ring","year":"2016","journal-title":"Dermatol Clin"},{"key":"10.1016\/j.clindermatol.2017.09.007_bb0070","doi-asserted-by":"crossref","first-page":"621","DOI":"10.1016\/j.jaad.2006.08.061","article-title":"Quality of life impairment in hidradenitis suppurativa: A study of 61 cases","volume":"56","author":"Wolkenstein","year":"2007","journal-title":"J Am Acad Dermatol"},{"key":"10.1016\/j.clindermatol.2017.09.007_bb0075","doi-asserted-by":"crossref","first-page":"328-232","DOI":"10.2340\/00015555-1082","article-title":"Psychosocial impact of hidradenitis suppurativa: A qualitative study","volume":"91","author":"Esmann","year":"2011","journal-title":"Acta Derm Venereol"},{"key":"10.1016\/j.clindermatol.2017.09.007_bb0080","doi-asserted-by":"crossref","first-page":"673","DOI":"10.1111\/bjd.13002","article-title":"The prevalence of hidradenitis suppurativa in 1093 patients with inflammatory bowel disease","volume":"171","author":"Van der Zee","year":"2014","journal-title":"Br J Dermatol"},{"key":"10.1016\/j.clindermatol.2017.09.007_bb0085","doi-asserted-by":"crossref","first-page":"4802","DOI":"10.3748\/wjg.v22.i20.4802","article-title":"Hidradenitis suppurativa and inflammatory bowel disease: An unusual, but existing association","volume":"22","author":"Principi","year":"2016","journal-title":"World J Gastroenterol"},{"key":"10.1016\/j.clindermatol.2017.09.007_bb0090","article-title":"Inflammatory bowel disease is associated with hidradenitis suppurativa: Results from a multicenter cross-sectional study","volume":"25","author":"Deckers","year":"2016","journal-title":"J Am Acad Dermatol"},{"key":"10.1016\/j.clindermatol.2017.09.007_bb0095","doi-asserted-by":"crossref","first-page":"762","DOI":"10.1001\/jamadermatol.2013.2907","article-title":"Pyogenic arthritis, pyoderma gangrenosum, acne, and hidradenitis suppurativa (PAPASH): A new auto inflammatory syndrome associated with a novel mutation of the PSTPIP1 gene","volume":"149","author":"Marzano","year":"2013","journal-title":"JAMA Dermatol"},{"key":"10.1016\/j.clindermatol.2017.09.007_bb0100","doi-asserted-by":"crossref","first-page":"e187","DOI":"10.1097\/MD.0000000000000187","article-title":"Association of pyoderma gangrenosum, acne, and suppurative hidradenitis (PASH) shares genetic and cytokine profiles with other auto inflammatory diseases","volume":"93","author":"Marzano","year":"2014","journal-title":"Medicine (Baltimore)"},{"key":"10.1016\/j.clindermatol.2017.09.007_bb0105","doi-asserted-by":"crossref","first-page":"789","DOI":"10.1007\/s10067-005-0199-5","article-title":"A hidradenitis suppurativa related SAPHO case associated with features resembling spondyloarthropathy and proteinuria","volume":"26","author":"Ozyemisci-Taskiran","year":"2007","journal-title":"Clin Rheumatol"},{"key":"10.1016\/j.clindermatol.2017.09.007_bb0110","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1016\/j.clindermatol.2016.10.019","article-title":"Squamous cell carcinoma arising in long-standing hidradenitis suppurativa: An overlooked facet of the immunocompromised district","volume":"35","author":"Fabbrocini","year":"2017","journal-title":"Clin Dermatol"},{"key":"10.1016\/j.clindermatol.2017.09.007_bb0115","doi-asserted-by":"crossref","first-page":"1014","DOI":"10.1016\/j.jaad.2013.06.053","article-title":"Meta-analysis of psoriasis, cardiovascular disease, and associated risk factors","volume":"69","author":"Miller","year":"2013","journal-title":"J Am Acad Dermatol"},{"key":"10.1016\/j.clindermatol.2017.09.007_bb0120","doi-asserted-by":"crossref","first-page":"691","DOI":"10.1038\/nrrheum.2014.121","article-title":"Rheumatoid arthritis and metabolic syndrome","volume":"10","author":"Kerekes","year":"2014","journal-title":"Nat Rev Rheumatol"},{"key":"10.1016\/j.clindermatol.2017.09.007_bb0125","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1016\/j.atherosclerosis.2003.12.022","article-title":"The metabolic syndrome and mortality from cardiovascular disease and all-causes: Findings from the National Health and Nutrition Examination Survey II Mortality Study","volume":"173","author":"Ford","year":"2004","journal-title":"Atherosclerosis"},{"key":"10.1016\/j.clindermatol.2017.09.007_bb0130","doi-asserted-by":"crossref","first-page":"777","DOI":"10.1210\/er.2008-0024","article-title":"The metabolic syndrome","volume":"29","author":"Cornier","year":"2008","journal-title":"Endocr Rev"},{"key":"10.1016\/j.clindermatol.2017.09.007_bb0135","doi-asserted-by":"crossref","first-page":"206","DOI":"10.1016\/j.physbeh.2007.10.010","article-title":"The role of adipose tissue dysfunction in the pathogenesis of obesity-related insulin resistance","volume":"94","author":"Goossens","year":"2008","journal-title":"Physiol Behav"},{"key":"10.1016\/j.clindermatol.2017.09.007_bb0140","doi-asserted-by":"crossref","first-page":"1273","DOI":"10.1001\/jamadermatol.2014.1165","article-title":"Association of metabolic syndrome and hidradenitis suppurativa","volume":"150","author":"Miller","year":"2014","journal-title":"JAMA Dermatol"},{"key":"10.1016\/j.clindermatol.2017.09.007_bb0145","doi-asserted-by":"crossref","first-page":"699","DOI":"10.1016\/j.jaad.2013.11.014","article-title":"The prevalence of metabolic syndrome in patients with hidradenitis suppurativa","volume":"70","author":"Gold","year":"2014","journal-title":"J Am Acad Dermatol"},{"key":"10.1016\/j.clindermatol.2017.09.007_bb0150","doi-asserted-by":"crossref","first-page":"e31810","DOI":"10.1371\/journal.pone.0031810","article-title":"Increased prevalence of metabolic syndrome in patients with acne inversa","volume":"7","author":"Sabat","year":"2012","journal-title":"PLoS ONE"},{"key":"10.1016\/j.clindermatol.2017.09.007_bb0155","doi-asserted-by":"crossref","first-page":"1142","DOI":"10.1111\/bjd.14024","article-title":"Cardiovascular disease risk factors in patients with hidradenitis suppurativa: A systematic review and metaanalysis of observational studies","volume":"173","author":"Tzellos","year":"2015","journal-title":"Br J Dermatol"},{"key":"10.1016\/j.clindermatol.2017.09.007_bb0160","doi-asserted-by":"crossref","first-page":"1144","DOI":"10.1016\/j.jaad.2014.09.012","article-title":"Hidradenitis suppurativa is a systemic disease with substantial comorbidity burden: A chart-verified case\u2013control analysis","volume":"71","author":"Shlyankevich","year":"2014","journal-title":"J Am Acad Dermatol"},{"key":"10.1016\/j.clindermatol.2017.09.007_bb0165","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1016\/j.jaad.2016.03.025","article-title":"Increased prevalence of subclinical atherosclerosis in patients with hidradenitis suppurativa","volume":"75","author":"Gonzalez-Lopez","year":"2016","journal-title":"J Am Acad Dermatol"},{"key":"10.1016\/j.clindermatol.2017.09.007_bb0170","doi-asserted-by":"crossref","first-page":"556","DOI":"10.1038\/jid.2011.365","article-title":"Prevalence of metabolic syndrome in patients with psoriasis: A population-based study in the United Kingdom","volume":"132","author":"Langan","year":"2012","journal-title":"J Invest Dermatol"},{"key":"10.1016\/j.clindermatol.2017.09.007_bb0175","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1016\/j.jaad.2009.02.013","article-title":"Clinical characteristics of a series of 302 French patients with hidradenitis suppurativa, with an analysis of factors associated with disease severity","volume":"61","author":"Canoui-Poitrine","year":"2009","journal-title":"J Am Acad Dermatol"},{"key":"10.1016\/j.clindermatol.2017.09.007_bb0180","doi-asserted-by":"crossref","first-page":"831","DOI":"10.1111\/j.1365-2133.2009.09198.x","article-title":"Objective scoring of hidradenitis suppurativa reflecting the role of tobacco smoking and obesity","volume":"161","author":"Sartorius","year":"2009","journal-title":"Br J Dermatol"},{"key":"10.1016\/j.clindermatol.2017.09.007_bb0185","doi-asserted-by":"crossref","first-page":"819","DOI":"10.1111\/bjd.13090","article-title":"Risk factors, clinical course and long-term prognosis in hidradenitis suppurativa: A cross-sectional study","volume":"171","author":"Kromann","year":"2014","journal-title":"Br J Dermatol"},{"key":"10.1016\/j.clindermatol.2017.09.007_bb0190","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1097\/DSS.0000000000000264","article-title":"Recurrence rate and patient satisfaction of CO2 laser evaporation of lesions in patients with hidradenitis suppurativa: A retrospective study","volume":"41","author":"Mikkelsen","year":"2015","journal-title":"Dermatol Surg"},{"key":"10.1016\/j.clindermatol.2017.09.007_bb0195","doi-asserted-by":"crossref","first-page":"414","DOI":"10.1111\/bjd.14013","article-title":"Systemic inflammation and proinflammatory interleukin-17 signalling persist at the end of therapy in patients with metabolic syndrome and psoriasis, reducing the length of remission","volume":"174","author":"Coimbra","year":"2016","journal-title":"Br J Dermatol"},{"key":"10.1016\/j.clindermatol.2017.09.007_bb0200","doi-asserted-by":"crossref","first-page":"1101","DOI":"10.1111\/j.1468-3083.2012.04668.x","article-title":"Metformin for the treatment of hidradenitis suppurativa: A little help along the way","volume":"27","author":"Verdolini","year":"2013","journal-title":"J Eur Acad Dermatol Venereol"},{"key":"10.1016\/j.clindermatol.2017.09.007_bb0205","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1111\/ced.12269","article-title":"Rapid resolution of hidradenitis suppurativa after bariatric surgical intervention","volume":"39","author":"Thomas","year":"2014","journal-title":"Clin Exp Dermatol"},{"key":"10.1016\/j.clindermatol.2017.09.007_bb0210","doi-asserted-by":"crossref","first-page":"852","DOI":"10.1111\/jdv.13059","article-title":"Resolution of hidradenitis suppurativa after weight loss by dietary measures, especially on frictional locations","volume":"30","author":"Boer","year":"2016","journal-title":"J Eur Acad Dermatol Venereol"},{"key":"10.1016\/j.clindermatol.2017.09.007_bb0215","doi-asserted-by":"crossref","first-page":"218","DOI":"10.1016\/j.clindermatol.2016.10.018","article-title":"Treatments for hidradenitis suppurativa","volume":"35","author":"Kj\u00e6rsgaard Andersen","year":"2017","journal-title":"Clin Dermatol"},{"key":"10.1016\/j.clindermatol.2017.09.007_bb0220","doi-asserted-by":"crossref","first-page":"461","DOI":"10.1093\/ajcn\/83.2.461S","article-title":"Obesity and the role of adipose tissue in inflammation and metabolism","volume":"83","author":"Greenberg","year":"2006","journal-title":"Am J Clin Nutr"},{"key":"10.1016\/j.clindermatol.2017.09.007_bb0225","doi-asserted-by":"crossref","first-page":"790","DOI":"10.1016\/j.jaad.2010.07.010","article-title":"Expression of the IL-23\/Th17 pathway in lesions of hidradenitis suppurativa","volume":"65","author":"Schlapbach","year":"2011","journal-title":"J Am Acad Dermatol"},{"key":"10.1016\/j.clindermatol.2017.09.007_bb0230","article-title":"Increased interleukin (IL)-17 serum levels in patients with hidradenitis suppurativa: Implications for treatment with anti-IL-17 agents","volume":"29","author":"Matusiak","year":"2016","journal-title":"J Am Acad Dermatol"},{"key":"10.1016\/j.clindermatol.2017.09.007_bb0235","doi-asserted-by":"crossref","first-page":"601","DOI":"10.2340\/00015555-0749","article-title":"Increased serum tumor necrosis factor-alpha in hidradenitis suppurativa patients: Is there a basis for treatment with anti-tumor necrosis factor-alpha agents?","volume":"89","author":"Matusiak","year":"2009","journal-title":"Acta Derm Venereol"},{"key":"10.1016\/j.clindermatol.2017.09.007_bb0240","doi-asserted-by":"crossref","first-page":"514","DOI":"10.1111\/bjd.14214","article-title":"Keratinocytes and neutrophils are important sources of proinflammatory molecules in hidradenitis suppurativa","volume":"174","author":"Lima","year":"2016","journal-title":"Br J Dermatol"},{"key":"10.1016\/j.clindermatol.2017.09.007_bb0245","doi-asserted-by":"crossref","first-page":"397","DOI":"10.1016\/j.clindermatol.2013.11.006","article-title":"Hidradenitis suppurativa (acne inversa) as a systemic disease","volume":"32","author":"Dessinioti","year":"2014","journal-title":"Clin Dermatol"},{"key":"10.1016\/j.clindermatol.2017.09.007_bb0250","doi-asserted-by":"crossref","first-page":"422","DOI":"10.1056\/NEJMoa1504370","article-title":"Two phase 3 trials of adalimumab for hidradenitis suppurativa","volume":"375","author":"Kimball","year":"2016","journal-title":"N Engl J Med"},{"key":"10.1016\/j.clindermatol.2017.09.007_bb0255","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1001\/jamadermatol.2015.3903","article-title":"Safety and efficacy of anakinra in severe hidradenitis suppurativa: A randomized clinical trial","volume":"152","author":"Tzanetakou","year":"2016","journal-title":"JAMA Dermatol"},{"key":"10.1016\/j.clindermatol.2017.09.007_bb0260","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1111\/j.1365-2133.1986.tb05740.x","article-title":"A double blind controlled cross-over trial of cyproterone acetate in females with hidradenitis suppurativa","volume":"115","author":"Mortimer","year":"1986","journal-title":"Br J Dermatol"},{"key":"10.1016\/j.clindermatol.2017.09.007_bb0265","doi-asserted-by":"crossref","first-page":"125","DOI":"10.2310\/7750.2007.00019","article-title":"Hidradenitis suppurativa in 64 female patients: Retrospective study comparing oral antibiotics and antiandrogen therapy","volume":"11","author":"Kraft","year":"2007","journal-title":"J Cutan Med Surg"},{"key":"10.1016\/j.clindermatol.2017.09.007_bb0270","doi-asserted-by":"crossref","first-page":"732","DOI":"10.1001\/jamadermatol.2013.2874","article-title":"Finasteride for the treatment of hidradenitis suppurativa in children and adolescents","volume":"149","author":"Randhawa","year":"2013","journal-title":"JAMA Dermatol"},{"key":"10.1016\/j.clindermatol.2017.09.007_bb0275","doi-asserted-by":"crossref","first-page":"429","DOI":"10.1001\/jamadermatol.2015.6264","article-title":"Risk of major adverse cardiovascular events and all-cause mortality in patients with hidradenitis suppurativa","volume":"152","author":"Egeberg","year":"2016","journal-title":"JAMA Dermatol"},{"key":"10.1016\/j.clindermatol.2017.09.007_bb0280","doi-asserted-by":"crossref","first-page":"619","DOI":"10.1111\/jdv.12966","article-title":"European S1 guideline for the treatment of hidradenitis suppurativa\/acne inversa","volume":"29","author":"Zouboulis","year":"2015","journal-title":"J Eur Acad Dermatol Venereol"}],"container-title":["Clinics in Dermatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0738081X17301621?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0738081X17301621?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2019,10,3]],"date-time":"2019-10-03T06:42:23Z","timestamp":1570084943000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0738081X17301621"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,1]]},"references-count":56,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2018,1]]}},"alternative-id":["S0738081X17301621"],"URL":"https:\/\/doi.org\/10.1016\/j.clindermatol.2017.09.007","relation":{},"ISSN":["0738-081X"],"issn-type":[{"value":"0738-081X","type":"print"}],"subject":[],"published":{"date-parts":[[2018,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Hidradenitis suppurativa and the metabolic syndrome","name":"articletitle","label":"Article Title"},{"value":"Clinics in Dermatology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.clindermatol.2017.09.007","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2017 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}