{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T00:06:40Z","timestamp":1790122000028,"version":"4.0.1"},"reference-count":74,"publisher":"Elsevier BV","issue":"5","license":[{"start":{"date-parts":[[2025,9,1]],"date-time":"2025-09-01T00:00:00Z","timestamp":1756684800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,9,1]],"date-time":"2025-09-01T00:00:00Z","timestamp":1756684800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,9,1]],"date-time":"2025-09-01T00:00:00Z","timestamp":1756684800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2025,9,1]],"date-time":"2025-09-01T00:00:00Z","timestamp":1756684800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2025,9,1]],"date-time":"2025-09-01T00:00:00Z","timestamp":1756684800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2025,9,1]],"date-time":"2025-09-01T00:00:00Z","timestamp":1756684800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2025,9,1]],"date-time":"2025-09-01T00:00:00Z","timestamp":1756684800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","theclinics.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Clinics in Dermatology"],"published-print":{"date-parts":[[2025,9]]},"DOI":"10.1016\/j.clindermatol.2025.03.008","type":"journal-article","created":{"date-parts":[[2025,3,15]],"date-time":"2025-03-15T03:37:46Z","timestamp":1742009866000},"page":"626-632","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":6,"title":["Evolving evidence in the neural sensitization of prurigo nodularis"],"prefix":"10.1016","volume":"43","author":[{"given":"Sarah G.","family":"Brooks","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gil","family":"Yosipovitch","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.clindermatol.2025.03.008_bib0001","first-page":"4","article-title":"Association between prurigo nodularis and etiologies of peripheral neuropathy: suggesting a role for neural dysregulation in pathogenesis","volume":"7","author":"Hughes","year":"2020","journal-title":"Medicines (Basel)"},{"key":"10.1016\/j.clindermatol.2025.03.008_bib0002","doi-asserted-by":"crossref","first-page":"613","DOI":"10.1007\/s13555-019-00321-6","article-title":"The neuromodulatory effect of antipruritic treatment of chronic prurigo","volume":"9","author":"Zeidler","year":"2019","journal-title":"Dermatol Ther (Heidelb)"},{"key":"10.1016\/j.clindermatol.2025.03.008_bib0003","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1016\/j.cell.2017.08.006","article-title":"Sensory neurons co-opt classical immune signaling pathways to mediate chronic itch","volume":"171","author":"Oetjen","year":"2017","journal-title":"Cell"},{"key":"10.1016\/j.clindermatol.2025.03.008_bib0004","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2023.1301817","article-title":"Molecular mechanisms of pruritus in prurigo nodularis","volume":"14","author":"Shao","year":"2023","journal-title":"Front Immunol"},{"key":"10.1016\/j.clindermatol.2025.03.008_bib0005","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1111\/jcpt.12005","article-title":"Treatment of prurigo nodularis with pregabalin","volume":"38","author":"Mazza","year":"2013","journal-title":"J Clin Pharm Ther"},{"key":"10.1016\/j.clindermatol.2025.03.008_bib0006","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1111\/j.1365-2133.2011.10306.x","article-title":"Reduced intraepidermal nerve fibre density in lesional and nonlesional prurigo nodularis skin as a potential sign of subclinical cutaneous neuropathy","volume":"165","author":"Schuhknecht","year":"2011","journal-title":"Br J Dermatol"},{"key":"10.1016\/j.clindermatol.2025.03.008_bib0007","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1016\/j.jid.2019.05.029","article-title":"Peripheral sensitization and loss of descending inhibition is a hallmark of chronic pruritus","volume":"140","author":"Pogatzki-Zahn","year":"2020","journal-title":"J Invest Dermatol"},{"key":"10.1016\/j.clindermatol.2025.03.008_bib0008","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1016\/0190-9622(92)70006-2","article-title":"Demonstration by S-100 protein staining of increased numbers of nerves in the papillary dermis of patients with prurigo nodularis","volume":"26","author":"Harris","year":"1992","journal-title":"J Am Acad Dermatol"},{"key":"10.1016\/j.clindermatol.2025.03.008_bib0009","doi-asserted-by":"crossref","first-page":"1009","DOI":"10.2340\/00015555-3261","article-title":"Selective nerve fibre activation in patients with generalized chronic pruritus: hint for central sensitization?","volume":"99","author":"Pereira","year":"2019","journal-title":"Acta Derm Venereol"},{"key":"10.1016\/j.clindermatol.2025.03.008_bib0010","doi-asserted-by":"crossref","first-page":"999","DOI":"10.1007\/s40265-017-0746-9","article-title":"Chronic pruritus: current and emerging treatment options","volume":"77","author":"Pereira","year":"2017","journal-title":"Drugs"},{"key":"10.1016\/j.clindermatol.2025.03.008_bib0011","doi-asserted-by":"crossref","first-page":"889","DOI":"10.1242\/dmm.011502","article-title":"Pain hypersensitivity mechanisms at a glance","volume":"6","author":"Gangadharan","year":"2013","journal-title":"Dis Model Mech"},{"key":"10.1016\/j.clindermatol.2025.03.008_bib0012","doi-asserted-by":"crossref","first-page":"1375","DOI":"10.1016\/j.jaci.2018.09.005","article-title":"Itch: from mechanism to (novel) therapeutic approaches","volume":"142","author":"Yosipovitch","year":"2018","journal-title":"J Allergy Clin Immunol"},{"key":"10.1016\/j.clindermatol.2025.03.008_bib0013","doi-asserted-by":"crossref","first-page":"328","DOI":"10.1016\/j.jaad.2014.10.034","article-title":"Pruritus: an underrecognized symptom of small-fiber neuropathies","volume":"72","author":"Brenaut","year":"2015","journal-title":"J Am Acad Dermatol"},{"key":"10.1016\/j.clindermatol.2025.03.008_bib0014","doi-asserted-by":"crossref","first-page":"2707","DOI":"10.1016\/j.pain.2013.07.054","article-title":"Inflammation meets sensitization\u2013an explanation for spontaneous nociceptor activity?","volume":"154","author":"Rukwied","year":"2013","journal-title":"Pain"},{"key":"10.1016\/j.clindermatol.2025.03.008_bib0015","series-title":"Itch: Mechanisms and Treatment","author":"Carstens","year":"2014"},{"key":"10.1016\/j.clindermatol.2025.03.008_bib0016","series-title":"Itch: Mechanisms and Treatment","article-title":"Pruriceptors","author":"Ringkamp","year":"2014"},{"key":"10.1016\/j.clindermatol.2025.03.008_bib0017","series-title":"Itch: Mechanisms and Treatment","article-title":"Sensitization of itch signaling: itch sensitization\u2014nerve growth factor, semaphorins","author":"Tominaga","year":"2014"},{"key":"10.1016\/j.clindermatol.2025.03.008_bib0018","article-title":"Extracellular matrix and dermal nerve growth factor dysregulation in prurigo nodularis compared to atopic dermatitis","volume":"9","author":"Deng","year":"2022","journal-title":"Front Med (Lausanne)"},{"key":"10.1016\/j.clindermatol.2025.03.008_bib0019","doi-asserted-by":"crossref","first-page":"264","DOI":"10.1016\/j.jid.2022.08.042","article-title":"Transcriptomic, epigenomic, and neuroanatomic signatures differ in chronic prurigo, atopic dermatitis, and brachioradial pruritus","volume":"143","author":"Agelopoulos","year":"2023","journal-title":"J Invest Dermatol"},{"key":"10.1016\/j.clindermatol.2025.03.008_bib0020","doi-asserted-by":"crossref","first-page":"509","DOI":"10.1007\/s13555-016-0146-1","article-title":"Intraepidermal nerve fiber density: diagnostic and therapeutic relevance in the management of chronic pruritus: a review","volume":"6","author":"Pereira","year":"2016","journal-title":"Dermatol Ther (Heidelb)"},{"key":"10.1016\/j.clindermatol.2025.03.008_bib0021","doi-asserted-by":"crossref","first-page":"969","DOI":"10.1111\/exd.13343","article-title":"There is no functional small-fibre neuropathy in prurigo nodularis despite neuroanatomical alterations","volume":"26","author":"Pereira","year":"2017","journal-title":"Exp Dermatol"},{"key":"10.1016\/j.clindermatol.2025.03.008_bib0022","doi-asserted-by":"crossref","first-page":"404","DOI":"10.2340\/00015555-2232","article-title":"Intraepidermal nerve fibre density is decreased in lesional and inter-lesional prurigo nodularis and reconstitutes on healing of lesions","volume":"96","author":"Bobko","year":"2016","journal-title":"Acta Derm Venereol"},{"key":"10.1016\/j.clindermatol.2025.03.008_bib0023","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1038\/nrn3641","article-title":"Sensory neurons and circuits mediating itch","volume":"15","author":"LaMotte","year":"2014","journal-title":"Nat Rev Neurosci"},{"key":"10.1016\/j.clindermatol.2025.03.008_bib0024","doi-asserted-by":"crossref","first-page":"903","DOI":"10.1111\/j.1468-1331.2010.03023.x","volume":"17","author":"Lauria","year":"2010","journal-title":"Eur J Neurol"},{"key":"10.1016\/j.clindermatol.2025.03.008_bib0025","doi-asserted-by":"crossref","first-page":"363","DOI":"10.1016\/j.jaad.2015.09.039","article-title":"Thalidomide for the treatment of chronic refractory pruritus","volume":"74","author":"Sharma","year":"2016","journal-title":"J Am Acad Dermatol"},{"key":"10.1016\/j.clindermatol.2025.03.008_bib0026","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1016\/j.jdermsci.2010.03.020","article-title":"Low density of sympathetic nerve fibers relative to substance P-positive nerve fibers in lesional skin of chronic pruritus and prurigo nodularis","volume":"58","author":"Haas","year":"2010","journal-title":"J Dermatol Sci"},{"key":"10.1016\/j.clindermatol.2025.03.008_bib0027","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1007\/s00281-018-0675-z","article-title":"Skin neurogenic inflammation","volume":"40","author":"Choi","year":"2018","journal-title":"Semin Immunopathol"},{"key":"10.1016\/j.clindermatol.2025.03.008_bib0028","doi-asserted-by":"crossref","first-page":"177","DOI":"10.2174\/1871528113666140522104422","article-title":"Brain-skin connection: stress, inflammation and skin aging","volume":"13","author":"Chen","year":"2014","journal-title":"Inflamm Allergy Drug Targets"},{"key":"10.1016\/j.clindermatol.2025.03.008_bib0029","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1111\/bph.12266","article-title":"The role of histamine in neurogenic inflammation","volume":"170","author":"Rosa","year":"2013","journal-title":"Br J Pharmacol"},{"key":"10.1016\/j.clindermatol.2025.03.008_bib0030","doi-asserted-by":"crossref","first-page":"14055","DOI":"10.1523\/JNEUROSCI.1722-14.2014","article-title":"Multimodal use of calcitonin gene-related peptide and substance P in itch and acute pain uncovered by the elimination of vesicular glutamate transporter 2 from transient receptor potential cation channel subfamily V member 1 neurons","volume":"34","author":"Rogoz","year":"2014","journal-title":"J Neurosci"},{"key":"10.1016\/j.clindermatol.2025.03.008_bib0031","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1016\/j.regpep.2013.08.001","article-title":"Keratinocytes express cytokines and nerve growth factor in response to neuropeptide activation of the ERK1\/2 and JNK MAPK transcription pathways","volume":"186","author":"Shi","year":"2013","journal-title":"Regul Pept"},{"key":"10.1016\/j.clindermatol.2025.03.008_bib0032","doi-asserted-by":"crossref","first-page":"447","DOI":"10.1016\/j.jaci.2016.12.980","article-title":"Substance P activates Mas-related G protein-coupled receptors to induce itch","volume":"140","author":"Azimi","year":"2017","journal-title":"J Allergy Clin Immunol"},{"key":"10.1016\/j.clindermatol.2025.03.008_bib0033","doi-asserted-by":"crossref","first-page":"1671","DOI":"10.1007\/s00424-013-1284-2","article-title":"New insights into the mechanisms of itch: are pain and itch controlled by distinct mechanisms?","volume":"465","author":"Liu","year":"2013","journal-title":"Pflugers Arch"},{"key":"10.1016\/j.clindermatol.2025.03.008_bib0034","doi-asserted-by":"crossref","first-page":"344","DOI":"10.1111\/j.1365-2133.1992.tb00452.x","article-title":"Increased sensory neuropeptides in nodular prurigo: a quantitative immunohistochemical analysis","volume":"127","author":"Abad\u00eda Molina","year":"1992","journal-title":"Br J Dermatol"},{"key":"10.1016\/j.clindermatol.2025.03.008_bib0035","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1159\/000531798","article-title":"Role of the sympathetic nervous system in mild chronic inflammatory diseases: focus on osteoarthritis","volume":"30","author":"Sohn","year":"2023","journal-title":"Neuroimmunomodul"},{"key":"10.1016\/j.clindermatol.2025.03.008_bib0036","doi-asserted-by":"crossref","first-page":"359","DOI":"10.1034\/j.1600-0560.2000.027007359.x","article-title":"CGRP-immunoreactive nerves in prurigo nodularis\u2013an exploration of neurogenic inflammation","volume":"27","author":"Liang","year":"2000","journal-title":"J Cutan Pathol"},{"key":"10.1016\/j.clindermatol.2025.03.008_bib0037","doi-asserted-by":"crossref","first-page":"2221","DOI":"10.1111\/jdv.16031","article-title":"Neurokinin-1 and cytokine receptors as targets for therapy of chronic prurigo","volume":"33","author":"Wallengren","year":"2019","journal-title":"J Eur Acad Dermatol Venereol"},{"key":"10.1016\/j.clindermatol.2025.03.008_bib0038","doi-asserted-by":"crossref","first-page":"619","DOI":"10.1111\/j.1365-2133.1989.tb01346.x","article-title":"Calcitonin gene-related peptide immunoreactivity in prurigo nodularis: a comparative study with neurodermatitis circumscripta","volume":"120","author":"Vaalasti","year":"1989","journal-title":"Br J Dermatol"},{"key":"10.1016\/j.clindermatol.2025.03.008_bib0039","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1016\/j.jdermsci.2006.12.007","article-title":"Changes in cutaneous sensory nerve fibers induced by skin-scratching in mice","volume":"46","author":"Yamaoka","year":"2007","journal-title":"J Dermatol Sci"},{"key":"10.1016\/j.clindermatol.2025.03.008_bib0040","doi-asserted-by":"crossref","first-page":"2081","DOI":"10.1523\/JNEUROSCI.15-03-02081.1995","article-title":"Differential influence of nerve growth factor on neuropeptide expression in vivo: a novel role in peptide suppression in adult sensory neurons","volume":"15","author":"Verge","year":"1995","journal-title":"J Neurosci"},{"key":"10.1016\/j.clindermatol.2025.03.008_bib0041","doi-asserted-by":"crossref","first-page":"353","DOI":"10.1016\/0166-2236(93)90092-Z","article-title":"Nerve growth factor and nociception","volume":"16","author":"Lewin","year":"1993","journal-title":"Trends Neurosci"},{"key":"10.1016\/j.clindermatol.2025.03.008_bib0042","doi-asserted-by":"crossref","first-page":"614","DOI":"10.1007\/s00403-001-0285-8","article-title":"Increased nerve growth factor- and tyrosine kinase A-like immunoreactivities in prurigo nodularis skin\u2013an exploration of the cause of neurohyperplasia","volume":"293","author":"Johansson","year":"2002","journal-title":"Arch Dermatol Res"},{"key":"10.1016\/j.clindermatol.2025.03.008_bib0043","doi-asserted-by":"crossref","first-page":"430","DOI":"10.1016\/j.expneurol.2005.10.006","article-title":"Nerve growth factor regulates substance P in adult sensory neurons through both TrkA and p75 receptors","volume":"197","author":"Skoff","year":"2006","journal-title":"Exp Neurol"},{"key":"10.1016\/j.clindermatol.2025.03.008_bib0044","doi-asserted-by":"crossref","first-page":"268","DOI":"10.1038\/jid.2012.242","article-title":"NGF sensitizes nociceptors for cowhage- but not histamine-induced itch in human skin","volume":"133","author":"Rukwied","year":"2013","journal-title":"J Invest Dermatol"},{"key":"10.1016\/j.clindermatol.2025.03.008_bib0045","doi-asserted-by":"crossref","first-page":"535","DOI":"10.1038\/nrn1950","article-title":"The neurobiology of itch","volume":"7","author":"Ikoma","year":"2006","journal-title":"Nat Rev Neurosci"},{"key":"10.1016\/j.clindermatol.2025.03.008_bib0046","doi-asserted-by":"crossref","first-page":"895","DOI":"10.1007\/s40265-021-01521-1","article-title":"IL-31 inhibition as a therapeutic approach for the management of chronic pruritic dermatoses","volume":"81","author":"Roh","year":"2021","journal-title":"Drugs"},{"key":"10.1016\/j.clindermatol.2025.03.008_bib0047","series-title":"Neurobiology of Nociceptors","first-page":"349","article-title":"Functional properties of human cutaneous nociceptors and their role in pain and hyperalgesia","author":"Torebj\u00d6rk","year":"1996"},{"key":"10.1016\/j.clindermatol.2025.03.008_bib0048","doi-asserted-by":"crossref","first-page":"190","DOI":"10.1152\/jn.1991.66.1.190","article-title":"Neurogenic hyperalgesia: psychophysical studies of underlying mechanisms","volume":"66","author":"LaMotte","year":"1991","journal-title":"J Neurophysiol"},{"key":"10.1016\/j.clindermatol.2025.03.008_bib0049","doi-asserted-by":"crossref","first-page":"e789","DOI":"10.1111\/jdv.18942","article-title":"Increased sensitivity to touch-evoked itch (punctate hyperknesis) in prurigo nodularis and type 2 inflammation: a cross-sectional pilot study","volume":"37","author":"Hashimoto","year":"2023","journal-title":"J Eur Acad Dermatol Venereol"},{"key":"10.1016\/j.clindermatol.2025.03.008_bib0050","doi-asserted-by":"crossref","first-page":"1475","DOI":"10.1001\/archderm.139.11.1475","article-title":"Neurophysiology of pruritus: interaction of itch and pain","volume":"139","author":"Ikoma","year":"2003","journal-title":"Arch Dermatol"},{"key":"10.1016\/j.clindermatol.2025.03.008_bib0051","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1016\/S0304-3959(98)00205-X","article-title":"Differential inhibitory effect on human nociceptive skin senses induced by local stimulation of thin cutaneous fibers","volume":"80","author":"Nilsson","year":"1999","journal-title":"Pain"},{"key":"10.1016\/j.clindermatol.2025.03.008_bib0052","doi-asserted-by":"crossref","first-page":"212","DOI":"10.1212\/WNL.62.2.212","article-title":"Painful stimuli evoke itch in patients with chronic pruritus: central sensitization for itch","volume":"62","author":"Ikoma","year":"2004","journal-title":"Neurology"},{"key":"10.1016\/j.clindermatol.2025.03.008_bib0053","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1016\/j.pain.2006.06.003","article-title":"Bradykinin is a potent pruritogen in atopic dermatitis: a switch from pain to itch","volume":"126","author":"Hosogi","year":"2006","journal-title":"Pain"},{"key":"10.1016\/j.clindermatol.2025.03.008_bib0054","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1684\/ejd.2010.1196","article-title":"Increased expression of mRNAs for IL-4, IL-17, IL-22 and IL-31 in skin lesions of subacute and chronic forms of prurigo","volume":"21","author":"Park","year":"2011","journal-title":"Eur J Dermatol"},{"key":"10.1016\/j.clindermatol.2025.03.008_bib0055","doi-asserted-by":"crossref","first-page":"804","DOI":"10.1111\/exd.14279","article-title":"Itch intensity in prurigo nodularis is closely related to dermal interleukin-31, oncostatin M, IL-31 receptor alpha and oncostatin M receptor beta","volume":"30","author":"Hashimoto","year":"2021","journal-title":"Exp Dermatol"},{"key":"10.1016\/j.clindermatol.2025.03.008_bib0056","doi-asserted-by":"crossref","DOI":"10.2340\/00015555-3347","article-title":"A new generation of treatments for itch","volume":"100","author":"Fowler","year":"2020","journal-title":"Acta Derm Venereol"},{"key":"10.1016\/j.clindermatol.2025.03.008_bib0057","doi-asserted-by":"crossref","first-page":"2039","DOI":"10.1007\/s13555-022-00782-2","article-title":"Prurigo nodularis: a review of IL-31RA blockade and other potential treatments","volume":"12","author":"Bewley","year":"2022","journal-title":"Dermatol Ther (Heidelb)"},{"key":"10.1016\/j.clindermatol.2025.03.008_bib0058","doi-asserted-by":"crossref","first-page":"448","DOI":"10.1016\/j.jaci.2013.10.048","article-title":"A sensory neuron-expressed IL-31 receptor mediates T helper cell-dependent itch: involvement of TRPV1 and TRPA1","volume":"133","author":"Cevikbas","year":"2014","journal-title":"J Allergy Clin Immunol"},{"key":"10.1016\/j.clindermatol.2025.03.008_bib0059","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1007\/s00281-015-0530-4","article-title":"Trp channels and itch","volume":"38","author":"Sun","year":"2016","journal-title":"Semin Immunopathol"},{"key":"10.1016\/j.clindermatol.2025.03.008_bib0060","series-title":"Itch: Mechanisms and Treatment","article-title":"Role of interleukin-31 and oncostatin M in itch and neuroimmune communication","author":"Cevikbas","year":"2014"},{"key":"10.1016\/j.clindermatol.2025.03.008_bib0061","doi-asserted-by":"crossref","DOI":"10.1126\/scitranslmed.abe3037","article-title":"Oncostatin M can sensitize sensory neurons in inflammatory pruritus","volume":"13","author":"Tseng","year":"2021","journal-title":"Sci Transl Med"},{"key":"10.1016\/j.clindermatol.2025.03.008_bib0062","doi-asserted-by":"crossref","first-page":"1240","DOI":"10.1097\/j.pain.0000000000000172","article-title":"A central role for spinal dorsal horn neurons that express neurokinin-1 receptors in chronic itch","volume":"156","author":"Akiyama","year":"2015","journal-title":"Pain"},{"key":"10.1016\/j.clindermatol.2025.03.008_bib0063","doi-asserted-by":"crossref","first-page":"971","DOI":"10.1213\/ANE.0b013e31820f2a16","article-title":"The effects of intrathecal and systemic gabapentin on spinal substance P release","volume":"112","author":"Takasusuki","year":"2011","journal-title":"Anesth Analg"},{"key":"10.1016\/j.clindermatol.2025.03.008_bib0064","doi-asserted-by":"crossref","first-page":"240","DOI":"10.1124\/jpet.110.178384","article-title":"Amperometric measurement of glutamate release modulation by gabapentin and pregabalin in rat neocortical slices: role of voltage-sensitive Ca2+ \u03b12\u03b4-1 subunit","volume":"338","author":"Quintero","year":"2011","journal-title":"J Pharmacol Exp Ther"},{"key":"10.1016\/j.clindermatol.2025.03.008_bib0065","doi-asserted-by":"crossref","first-page":"18195","DOI":"10.1073\/pnas.0506624102","article-title":"Pharmacological modulation of pain-related brain activity during normal and central sensitization states in humans","volume":"102","author":"Iannetti","year":"2005","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.clindermatol.2025.03.008_bib0066","doi-asserted-by":"crossref","first-page":"555","DOI":"10.2340\/00015555-1353","article-title":"Systemic kappa opioid receptor agonists in the treatment of chronic pruritus: a literature review","volume":"92","author":"Phan","year":"2012","journal-title":"Acta Derm Venereol"},{"key":"10.1016\/j.clindermatol.2025.03.008_bib0067","doi-asserted-by":"crossref","first-page":"1130","DOI":"10.1007\/s00105-004-0802-8","volume":"55","author":"Brune","year":"2004","journal-title":"Hautarzt"},{"key":"10.1016\/j.clindermatol.2025.03.008_bib0068","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1016\/S0304-3959(99)00007-X","article-title":"Topical capsaicin in humans: parallel loss of epidermal nerve fibers and pain sensation","volume":"81","author":"Nolano","year":"1999","journal-title":"Pain"},{"key":"10.1016\/j.clindermatol.2025.03.008_bib0069","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1016\/j.ijantimicag.2017.08.033","article-title":"Clinical relevance of metronidazole and peripheral neuropathy: a systematic review of the literature","volume":"51","author":"Goolsby","year":"2018","journal-title":"Int J Antimicrob Agents"},{"key":"10.1016\/j.clindermatol.2025.03.008_bib0070","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1111\/1753-0407.12013","article-title":"Association of statin use with peripheral neuropathy in the U.S. population 40 years of age or older","volume":"5","author":"Tierney","year":"2013","journal-title":"J Diabetes"},{"key":"10.1016\/j.clindermatol.2025.03.008_bib0071","first-page":"67","article-title":"Peripheral neuropathy associated with nodular prurigo","volume":"32","author":"Bharati","year":"2007","journal-title":"Clin Exp Dermatol"},{"key":"10.1016\/j.clindermatol.2025.03.008_bib0072","doi-asserted-by":"crossref","first-page":"714","DOI":"10.1016\/j.jaad.2018.04.047","article-title":"Ethnic differences and comorbidities of 909 prurigo nodularis patients","volume":"79","author":"Boozalis","year":"2018","journal-title":"J Am Acad Dermatol"},{"key":"10.1016\/j.clindermatol.2025.03.008_bib0073","doi-asserted-by":"crossref","first-page":"240","DOI":"10.1093\/bjd\/ljad121","article-title":"Prurigo nodularis is highly linked with neural sensitization disorders of pain among hospitalized adults in the United States \u2013 National Inpatient Sample 2016\u20132019","volume":"189","author":"Choragudi","year":"2023","journal-title":"Br J Dermatol"},{"key":"10.1016\/j.clindermatol.2025.03.008_bib0074","doi-asserted-by":"crossref","first-page":"1153","DOI":"10.1001\/archdermatol.2011.178","article-title":"The impact of pruritus on quality of life: the skin equivalent of pain","volume":"147","author":"Kini","year":"2011","journal-title":"Arch Dermatol"}],"container-title":["Clinics in Dermatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0738081X25000914?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0738081X25000914?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,6]],"date-time":"2025-11-06T02:22:12Z","timestamp":1762395732000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0738081X25000914"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,9]]},"references-count":74,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2025,9]]}},"alternative-id":["S0738081X25000914"],"URL":"https:\/\/doi.org\/10.1016\/j.clindermatol.2025.03.008","relation":{},"ISSN":["0738-081X"],"issn-type":[{"value":"0738-081X","type":"print"}],"subject":[],"published":{"date-parts":[[2025,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Evolving evidence in the neural sensitization of prurigo nodularis","name":"articletitle","label":"Article Title"},{"value":"Clinics in Dermatology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.clindermatol.2025.03.008","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 Elsevier Inc. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}]}}