{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T18:12:07Z","timestamp":1790014327487,"version":"4.0.1"},"reference-count":49,"publisher":"Elsevier BV","issue":"4","license":[{"start":{"date-parts":[[2025,7,1]],"date-time":"2025-07-01T00:00:00Z","timestamp":1751328000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,7,1]],"date-time":"2025-07-01T00:00:00Z","timestamp":1751328000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,7,1]],"date-time":"2025-07-01T00:00:00Z","timestamp":1751328000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2025,7,1]],"date-time":"2025-07-01T00:00:00Z","timestamp":1751328000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2025,7,1]],"date-time":"2025-07-01T00:00:00Z","timestamp":1751328000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2025,7,1]],"date-time":"2025-07-01T00:00:00Z","timestamp":1751328000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2025,7,1]],"date-time":"2025-07-01T00:00:00Z","timestamp":1751328000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","theclinics.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Clinics in Dermatology"],"published-print":{"date-parts":[[2025,7]]},"DOI":"10.1016\/j.clindermatol.2025.05.006","type":"journal-article","created":{"date-parts":[[2025,5,11]],"date-time":"2025-05-11T18:42:37Z","timestamp":1746988957000},"page":"479-484","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":5,"title":["The role of lipocalin-2 in the pathophysiology of hidradenitis suppurativa"],"prefix":"10.1016","volume":"43","author":[{"given":"Josko","family":"Mise","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Branka","family":"Marinovic","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zrinka Bukvic","family":"Mokos","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.clindermatol.2025.05.006_bib0001","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1038\/s41572-020-0149-1","volume":"6","author":"Sabat","year":"2020","journal-title":"Hidradenitis suppurativa. Nat Rev Dis Primers"},{"key":"10.1016\/j.clindermatol.2025.05.006_bib0002","doi-asserted-by":"crossref","first-page":"917","DOI":"10.1111\/bjd.16101","article-title":"Population-based clinical practice research datalink study using algorithm modelling to identify the true burden of hidradenitis suppurativa","volume":"178","author":"Ingram","year":"2018","journal-title":"Br J Dermatol"},{"key":"10.1016\/j.clindermatol.2025.05.006_bib0003","doi-asserted-by":"crossref","first-page":"1546","DOI":"10.1111\/bjd.14038","article-title":"Diagnostic delay in hidradenitis suppurativa is a global problem","volume":"173","author":"Saunte","year":"2015","journal-title":"Br J Dermatol"},{"key":"10.1016\/j.clindermatol.2025.05.006_bib0004","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1016\/j.det.2015.08.004","article-title":"Inflammatory mechanisms in hidradenitis suppurativa","volume":"34","author":"Kelly","year":"2016","journal-title":"Dermatol Clin"},{"key":"10.1016\/j.clindermatol.2025.05.006_bib0005","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1016\/S0167-4838(00)00148-5","article-title":"The lipocalin protein family: structural and sequence overview","volume":"1482","author":"Flower","year":"2000","journal-title":"Biochim Biophys Acta"},{"key":"10.1016\/j.clindermatol.2025.05.006_bib0006","doi-asserted-by":"crossref","DOI":"10.1016\/j.biopha.2021.112002","article-title":"Lipocalin-2: structure, function, distribution and role in metabolic disorders","volume":"142","author":"Al Jaberi","year":"2021","journal-title":"Biomed Pharmacother"},{"key":"10.1016\/j.clindermatol.2025.05.006_bib0007","doi-asserted-by":"crossref","first-page":"917","DOI":"10.1038\/nature03104","article-title":"Lipocalin 2 mediates an innate immune response to bacterial infection by sequestrating iron","volume":"432","author":"Flo","year":"2004","journal-title":"Nature"},{"key":"10.1016\/j.clindermatol.2025.05.006_bib0008","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1007\/s12026-022-09352-2","article-title":"Lipocalin 2 - not only a biomarker: a study of current literature and systematic findings of ongoing clinical trials","volume":"71","author":"Asaf","year":"2023","journal-title":"Immunol Res"},{"key":"10.1016\/j.clindermatol.2025.05.006_bib0009","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1016\/j.jdermsci.2017.03.014","article-title":"Serum peptides as putative modulators of inflammation in psoriasis","volume":"87","author":"Matsuura","year":"2017","journal-title":"J Dermatol Sci"},{"key":"10.1016\/j.clindermatol.2025.05.006_bib0010","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1186\/s13075-020-2111-8","article-title":"A set of serum markers detecting systemic inflammation in psoriatic skin, entheseal and joint disease in the absence of C-reactive protein and its link to clinical disease manifestations","volume":"22","author":"Sokolova","year":"2020","journal-title":"Arthritis Res Ther"},{"key":"10.1016\/j.clindermatol.2025.05.006_bib0011","doi-asserted-by":"crossref","first-page":"4088","DOI":"10.1038\/ncomms5088","article-title":"Tcf3 promotes cell migration and wound repair through regulation of lipocalin 2","volume":"5","author":"Miao","year":"2014","journal-title":"Nat Commun"},{"key":"10.1016\/j.clindermatol.2025.05.006_bib0012","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0268086","article-title":"Lipocalin-2 and insulin as new biomarkers of alopecia areata","volume":"17","author":"Wa\u015bkiel-Burnat","year":"2022","journal-title":"PLoS ONE"},{"key":"10.1016\/j.clindermatol.2025.05.006_bib0013","doi-asserted-by":"crossref","first-page":"358","DOI":"10.3892\/mmr.2022.12875","article-title":"Lipocalin 2 activates the NLRP3 inflammasome via LPS-induced NF-\u03baB signaling and plays a role as a pro-inflammatory regulator in murine macrophages","volume":"26","author":"Kim","year":"2022","journal-title":"Mol Med Rep"},{"key":"10.1016\/j.clindermatol.2025.05.006_bib0014","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1016\/j.mce.2019.04.002","article-title":"Estrogen interacts with glucocorticoids in the regulation of lipocalin 2 expression in human adipose tissue. Reciprocal roles of estrogen receptor \u03b1 and \u03b2 in insulin resistance?","volume":"490","author":"Kamble","year":"2019","journal-title":"Mol Cell Endocrinol"},{"key":"10.1016\/j.clindermatol.2025.05.006_bib0015","doi-asserted-by":"crossref","first-page":"129","DOI":"10.2337\/dc08-1236","article-title":"Ex vivo and in vivo regulation of lipocalin-2, a novel adipokine, by insulin","volume":"32","author":"Tan","year":"2009","journal-title":"Diabetes Care"},{"key":"10.1016\/j.clindermatol.2025.05.006_bib0016","doi-asserted-by":"crossref","first-page":"344","DOI":"10.1016\/j.cell.2008.01.020","article-title":"Shared principles in NF-kappaB signaling","volume":"132","author":"Hayden","year":"2008","journal-title":"Cell"},{"key":"10.1016\/j.clindermatol.2025.05.006_bib0017","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1016\/j.molmet.2013.04.003","article-title":"STAT1, NF-\u03baB, and ERKs play a role in the induction of lipocalin-2 expression in adipocytes","volume":"3","author":"Zhao","year":"2013","journal-title":"Mol Metab"},{"key":"10.1016\/j.clindermatol.2025.05.006_bib0018","doi-asserted-by":"crossref","first-page":"1063","DOI":"10.1084\/jem.20071978","article-title":"Regulation of inflammatory responses by IL-17F","volume":"205","author":"Yang","year":"2008","journal-title":"J Exp Med"},{"key":"10.1016\/j.clindermatol.2025.05.006_bib0019","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1146\/annurev-nutr-071816-064559","article-title":"Lipocalin 2: an emerging player in iron homeostasis and inflammation","volume":"37","author":"Xiao","year":"2017","journal-title":"Annu Rev Nutr"},{"key":"10.1016\/j.clindermatol.2025.05.006_bib0020","doi-asserted-by":"crossref","first-page":"565","DOI":"10.3109\/1354750X.2015.1123354","article-title":"The potential of lipocalin-2\/NGAL as biomarker for inflammatory and metabolic diseases","volume":"20","author":"Abella","year":"2015","journal-title":"Biomarkers"},{"key":"10.1016\/j.clindermatol.2025.05.006_bib0021","first-page":"129","article-title":"The multifaceted roles of neutrophil gelatinase associated lipocalin (NGAL) in inflammation and cancer","volume":"1826","author":"Chakraborty","year":"2012","journal-title":"Biochim Biophys Acta"},{"key":"10.1016\/j.clindermatol.2025.05.006_bib0022","doi-asserted-by":"crossref","first-page":"1036","DOI":"10.1016\/j.placenta.2013.08.004","article-title":"Lipocalin2 enhances the matrix metalloproteinase-9 activity and invasion of extravillous trophoblasts under hypoxia","volume":"34","author":"Kobara","year":"2013","journal-title":"Placenta"},{"key":"10.1016\/j.clindermatol.2025.05.006_bib0023","doi-asserted-by":"crossref","first-page":"335","DOI":"10.4196\/kjpp.2019.23.5.335","article-title":"Effects of caloric restriction on the expression of lipocalin-2 and its receptor in the brown adipose tissue of high-fat diet-fed mice","volume":"23","author":"Park","year":"2019","journal-title":"Korean J Physiol Pharmacol"},{"key":"10.1016\/j.clindermatol.2025.05.006_bib0024","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1373\/clinchem.2006.075614","article-title":"Lipocalin-2 is an inflammatory marker closely associated with obesity, insulin resistance, and hyperglycemia in humans","volume":"53","author":"Wang","year":"2007","journal-title":"Clin Chem"},{"key":"10.1016\/j.clindermatol.2025.05.006_bib0025","first-page":"3875","article-title":"Diagnostic value of urinary neutrophil gelatinase-associated lipocalin (NGAL) in detection of pediatric acute kidney injury; a systematic review and meta-analysis","volume":"4","author":"Izadi","year":"2016","journal-title":"Int J Pediatr"},{"key":"10.1016\/j.clindermatol.2025.05.006_bib0026","doi-asserted-by":"crossref","first-page":"2157","DOI":"10.2147\/JIR.S358492","article-title":"Lipocalin 2 participates in the epidermal differentiation and inflammatory processes of psoriasis","volume":"15","author":"Ren","year":"2022","journal-title":"J Inflamm Res"},{"key":"10.1016\/j.clindermatol.2025.05.006_bib0027","doi-asserted-by":"crossref","first-page":"302","DOI":"10.3346\/jkms.2008.23.2.302","article-title":"Expression of neutrophil gelatinase-associated lipocalin in calcium-induced keratinocyte differentiation","volume":"23","author":"Lee","year":"2008","journal-title":"J Korean Med Sci"},{"key":"10.1016\/j.clindermatol.2025.05.006_bib0028","doi-asserted-by":"crossref","DOI":"10.7554\/eLife.23242","article-title":"TCF7L1 promotes skin tumorigenesis independently of \u03b2-catenin through induction of LCN2","volume":"6","author":"Ku","year":"2017","journal-title":"eLife"},{"key":"10.1016\/j.clindermatol.2025.05.006_bib0029","doi-asserted-by":"crossref","first-page":"584","DOI":"10.1034\/j.1600-0625.2002.110611.x","article-title":"Neutrophil gelatinase-associated lipocalin is a marker for dysregulated keratinocyte differentiation in human skin","volume":"11","author":"Mallbris","year":"2002","journal-title":"Exp Dermatol"},{"key":"10.1016\/j.clindermatol.2025.05.006_bib0030","doi-asserted-by":"crossref","first-page":"3143","DOI":"10.1242\/dev.106989","article-title":"Tcf3 expression marks both stem and progenitor cells in multiple epithelia","volume":"141","author":"Howard","year":"2014","journal-title":"Development"},{"key":"10.1016\/j.clindermatol.2025.05.006_bib0031","doi-asserted-by":"crossref","first-page":"519","DOI":"10.1080\/09546634.2019.1605141","article-title":"Tissue lipocalin-2 in psoriasis: is it a marker of metabolic disturbance or a possible marker of therapeutic efficacy after narrow band ultraviolet B?","volume":"31","author":"Abdel Hay","year":"2020","journal-title":"J Dermatolog Treat"},{"key":"10.1016\/j.clindermatol.2025.05.006_bib0032","doi-asserted-by":"crossref","DOI":"10.1038\/cddiscovery.2016.28","article-title":"Transcription factor 7-like 1 dysregulates keratinocyte differentiation through upregulating lipocalin 2","volume":"2","author":"Xu","year":"2016","journal-title":"Cell Death Discov"},{"key":"10.1016\/j.clindermatol.2025.05.006_bib0033","doi-asserted-by":"crossref","first-page":"1314","DOI":"10.3390\/ijms21041314","article-title":"The role of Th17-related cytokines in atopic dermatitis","volume":"21","author":"Sugaya","year":"2020","journal-title":"Int J Mol Sci"},{"key":"10.1016\/j.clindermatol.2025.05.006_bib0034","doi-asserted-by":"crossref","first-page":"296","DOI":"10.1111\/j.1365-2230.2011.04265.x","article-title":"Serum lipocalin-2 levels are increased in patients with psoriasis","volume":"37","author":"Kamata","year":"2012","journal-title":"Clin Exp Dermatol"},{"key":"10.1016\/j.clindermatol.2025.05.006_bib0035","doi-asserted-by":"crossref","first-page":"136","DOI":"10.1080\/09546634.2016.1180340","article-title":"Effect of psoriasis activity and topical treatment on serum lipocalin-2 levels","volume":"28","author":"Baran","year":"2017","journal-title":"J Dermatolog Treat"},{"key":"10.1016\/j.clindermatol.2025.05.006_bib0036","doi-asserted-by":"crossref","DOI":"10.1155\/2019\/8171373","article-title":"Relationship between the degrees of itch and serum lipocalin-2 levels in patients with psoriasis","volume":"2019","author":"Aizawa","year":"2019","journal-title":"J Immunol Res"},{"key":"10.1016\/j.clindermatol.2025.05.006_bib0037","doi-asserted-by":"crossref","first-page":"2213","DOI":"10.1016\/j.jaci.2020.12.651","article-title":"Epithelialized tunnels are a source of inflammation in hidradenitis suppurativa","volume":"147","author":"Navrazhina","year":"2021","journal-title":"J Allergy Clin Immunol"},{"key":"10.1016\/j.clindermatol.2025.05.006_bib0038","doi-asserted-by":"crossref","first-page":"785","DOI":"10.1111\/1346-8138.13227","article-title":"Lipocalin-2 exacerbates psoriasiform skin inflammation by augmenting T-helper 17 response","volume":"43","author":"Hau","year":"2016","journal-title":"J Dermatol"},{"key":"10.1016\/j.clindermatol.2025.05.006_bib0039","doi-asserted-by":"crossref","first-page":"1004","DOI":"10.1111\/bjd.19538","article-title":"Identifying key components and therapeutic targets of the immune system in hidradenitis suppurativa with an emphasis on neutrophils","volume":"184","author":"Narla","year":"2021","journal-title":"Br J Dermatol"},{"key":"10.1016\/j.clindermatol.2025.05.006_bib0040","doi-asserted-by":"crossref","first-page":"e2241","DOI":"10.1038\/cddis.2016.152","article-title":"A transcription factor 7-like 1-lipocalin 2 axis in the differentiation of keratinocytes","volume":"7","author":"Liu","year":"2016","journal-title":"Cell Death Dis"},{"key":"10.1016\/j.clindermatol.2025.05.006_bib0041","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1007\/s00403-012-1306-5","article-title":"Circulating levels of lipocalin-2 and retinol-binding protein-4 are increased in psoriatic patients and correlated with baseline PASI","volume":"305","author":"Roman\u00ed","year":"2013","journal-title":"Arch Dermatol Res"},{"key":"10.1016\/j.clindermatol.2025.05.006_bib0042","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1007\/s00403-013-1414-x","article-title":"Estimation of tissue and serum lipocalin-2 in psoriasis vulgaris and its relation to metabolic syndrome","volume":"306","author":"El-Hadidi","year":"2014","journal-title":"Arch Dermatol Res"},{"key":"10.1016\/j.clindermatol.2025.05.006_bib0043","doi-asserted-by":"crossref","first-page":"1045","DOI":"10.1111\/bjd.18556","article-title":"Interleukin 17C is elevated in lesional tissue of hidradenitis suppurativa","volume":"182","author":"Navrazhina","year":"2020","journal-title":"Br J Dermatol"},{"key":"10.1016\/j.clindermatol.2025.05.006_bib0044","doi-asserted-by":"crossref","first-page":"514","DOI":"10.1111\/bjd.14214","article-title":"Keratinocytes and neutrophils are important sources of proinflammatory molecules in hidradenitis suppurativa","volume":"174","author":"Lima","year":"2016","journal-title":"Br J Dermatol"},{"key":"10.1016\/j.clindermatol.2025.05.006_bib0045","doi-asserted-by":"crossref","first-page":"1385","DOI":"10.1111\/bjd.15424","article-title":"Lipocalin-2 is expressed by activated granulocytes and keratinocytes in affected skin and reflects disease activity in acne inversa\/hidradenitis suppurativa","volume":"177","author":"Wolk","year":"2017","journal-title":"Br J Dermatol"},{"key":"10.1016\/j.clindermatol.2025.05.006_bib0046","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1016\/j.jaci.2021.05.027","article-title":"High inflammation in hidradenitis suppurativa extends to perilesional skin and can be subdivided by lipocalin-2 expression","volume":"49","author":"Navrazhina","year":"2022","journal-title":"J Allergy Clin Immunol"},{"key":"10.1016\/j.clindermatol.2025.05.006_bib0047","doi-asserted-by":"crossref","first-page":"306","DOI":"10.1111\/ced.14448","article-title":"Dermal tunnels influence time to clinical and family history influences time to loss of clinical response in patients with hidradenitis suppurativa treated with adalimumab","volume":"46","author":"Frew","year":"2021","journal-title":"Clin Exp Dermatol"},{"key":"10.1016\/j.clindermatol.2025.05.006_bib0048","doi-asserted-by":"crossref","first-page":"684","DOI":"10.1111\/bjd.20642","article-title":"Large-scale serum analysis identifies unique systemic biomarkers in psoriasis and hidradenitis suppurativa","volume":"186","author":"Navrazhina","year":"2022","journal-title":"Br J Dermatol"},{"key":"10.1016\/j.clindermatol.2025.05.006_bib0049","doi-asserted-by":"crossref","DOI":"10.1016\/j.intimp.2021.107587","article-title":"miR-383 reduces keratinocyte proliferation and induces the apoptosis in psoriasis via disruption of LCN2-dependent JAK\/STAT pathway activation","volume":"96","author":"Wang","year":"2021","journal-title":"Int Immunopharmacol"}],"container-title":["Clinics in Dermatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0738081X25001488?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0738081X25001488?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,7,23]],"date-time":"2025-07-23T01:39:25Z","timestamp":1753234765000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0738081X25001488"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,7]]},"references-count":49,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2025,7]]}},"alternative-id":["S0738081X25001488"],"URL":"https:\/\/doi.org\/10.1016\/j.clindermatol.2025.05.006","relation":{},"ISSN":["0738-081X"],"issn-type":[{"value":"0738-081X","type":"print"}],"subject":[],"published":{"date-parts":[[2025,7]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"The role of lipocalin-2 in the pathophysiology of hidradenitis suppurativa","name":"articletitle","label":"Article Title"},{"value":"Clinics in Dermatology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.clindermatol.2025.05.006","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 Elsevier Inc. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}]}}