{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,12]],"date-time":"2026-09-12T21:05:54Z","timestamp":1789247154008,"version":"build-2803163510"},"reference-count":32,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","theclinics.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Clinics in Dermatology"],"published-print":{"date-parts":[[2026,8]]},"DOI":"10.1016\/j.clindermatol.2026.08.004","type":"journal-article","created":{"date-parts":[[2026,8,8]],"date-time":"2026-08-08T15:09:23Z","timestamp":1786201763000},"update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"title":["Mechanism of action: Glucagon-like peptide-1 receptors in skin biology"],"prefix":"10.1016","author":[{"given":"Shilpa","family":"Mehta","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.clindermatol.2026.08.004_bib0001","doi-asserted-by":"crossref","first-page":"345","DOI":"10.1073\/pnas.79.2.345","article-title":"Pancreatic preproglucagon cDNA contains two glucagon-related coding sequences arranged in tandem","volume":"79","author":"Lund","year":"1982","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.clindermatol.2026.08.004_bib0002","doi-asserted-by":"crossref","first-page":"716","DOI":"10.1038\/302716a0","article-title":"Hamster preproglucagon contains the sequence of glucagon and two related peptides","volume":"302","author":"Bell","year":"1983","journal-title":"Nature"},{"key":"10.1016\/j.clindermatol.2026.08.004_bib0003","doi-asserted-by":"crossref","first-page":"616","DOI":"10.1172\/JCI112855","article-title":"Insulinotropin: glucagon-like peptide I (7-37) co-encoded in the glucagon gene is a potent stimulator of insulin release in the perfused rat pancreas","volume":"79","author":"Mojsov","year":"1987","journal-title":"J Clin Invest"},{"key":"10.1016\/j.clindermatol.2026.08.004_bib0004","doi-asserted-by":"crossref","first-page":"7402","DOI":"10.1016\/S0021-9258(18)42531-8","article-title":"Isolation and characterization of exendin-4, an exendin-3 analogue, from Heloderma suspectum venom","volume":"267","author":"Eng","year":"1992","journal-title":"J Biol Chem"},{"key":"10.1016\/j.clindermatol.2026.08.004_bib0005","unstructured":"U.S. Food and Drug Administration. BYETTA\u00ae (exenatide) injection: prescribing information. Accessed 31 August, 2026 https:\/\/www.accessdata.fda.gov\/drugsatfda_docs\/label\/2009\/021773s9s11s18s22s25lbl.pdf"},{"key":"10.1016\/j.clindermatol.2026.08.004_bib0006","first-page":"952","article-title":"Degradation of glucagon-like peptide-1 by human plasma in vitro yields an N-terminally truncated peptide that is a major endogenous metabolite in vivo","volume":"80","author":"Deacon","year":"1995","journal-title":"J Clin Endocrinol Metab"},{"key":"10.1016\/j.clindermatol.2026.08.004_bib0007","doi-asserted-by":"crossref","first-page":"468","DOI":"10.1021\/acsptsci.9b00048","article-title":"Inventing liraglutide, a glucagon-like peptide-1 analogue, for the treatment of diabetes and obesity","volume":"2","author":"Knudsen","year":"2019","journal-title":"ACS Pharmacol Transl Sci"},{"key":"10.1016\/j.clindermatol.2026.08.004_bib0008","doi-asserted-by":"crossref","first-page":"7370","DOI":"10.1021\/acs.jmedchem.5b00726","article-title":"Discovery of the once-weekly glucagon-like peptide-1 (GLP-1) analogue semaglutide","volume":"58","author":"Lau","year":"2015","journal-title":"J Med Chem"},{"key":"10.1016\/j.clindermatol.2026.08.004_bib0009","unstructured":"Narla S, Narla RR, Corbett JA. JAAD CME part 1: mechanism of action of GLP-1 receptor agonists and potential pathways in skin health. J Am Acad Dermatol, in press."},{"key":"10.1016\/j.clindermatol.2026.08.004_bib0010","doi-asserted-by":"crossref","first-page":"749","DOI":"10.1038\/nchembio.209","article-title":"A new glucagon and GLP-1 co-agonist eliminate obesity in rodents","volume":"5","author":"Day","year":"2009","journal-title":"Nat Chem Biol"},{"key":"10.1016\/j.clindermatol.2026.08.004_bib0011","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1038\/nm.3761","article-title":"A rationally designed monomeric peptide triagonist corrects obesity and diabetes in rodents","volume":"21","author":"Finan","year":"2015","journal-title":"Nat Med"},{"key":"10.1016\/j.clindermatol.2026.08.004_bib0012","doi-asserted-by":"crossref","first-page":"503","DOI":"10.1056\/NEJMoa2107519","article-title":"Tirzepatide versus semaglutide once weekly in patients with type 2 diabetes","volume":"385","author":"Fr\u00edas","year":"2021","journal-title":"N Engl J Med"},{"key":"10.1016\/j.clindermatol.2026.08.004_bib0013","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1210\/endrev\/bnaa032","article-title":"Revisiting the complexity of GLP-1 action from sites of synthesis to receptor activation","volume":"42","author":"McLean","year":"2021","journal-title":"Endocr Rev"},{"key":"10.1016\/j.clindermatol.2026.08.004_bib0014","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1016\/j.cmet.2006.01.004","article-title":"The biology of incretin hormones","volume":"3","author":"Drucker","year":"2006","journal-title":"Cell Metab"},{"key":"10.1016\/j.clindermatol.2026.08.004_bib0015","doi-asserted-by":"crossref","first-page":"2131","DOI":"10.1053\/j.gastro.2007.03.054","article-title":"Biology of incretins: GLP-1 and GIP","volume":"132","author":"Baggio","year":"2007","journal-title":"Gastroenterology"},{"key":"10.1016\/j.clindermatol.2026.08.004_bib0016","doi-asserted-by":"crossref","first-page":"1036","DOI":"10.3390\/pharmaceutics17081036","article-title":"Emerging frontiers in GLP-1 therapeutics: a comprehensive evidence base (2025)","volume":"17","author":"Patel","year":"2025","journal-title":"Pharmaceutics"},{"key":"10.1016\/j.clindermatol.2026.08.004_bib0017","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2022.997578","article-title":"GLP-1 receptor agonist as a modulator of innate immunity","volume":"13","author":"Chen","year":"2022","journal-title":"Front Immunol"},{"key":"10.1016\/j.clindermatol.2026.08.004_bib0018","doi-asserted-by":"crossref","first-page":"6292","DOI":"10.3390\/jcm13216292","article-title":"The therapeutic potential of GLP-1 receptor agonists in the management of hidradenitis suppurativa: a systematic review of anti-inflammatory and metabolic effects","volume":"13","author":"Krajewski","year":"2024","journal-title":"J Clin Med"},{"key":"10.1016\/j.clindermatol.2026.08.004_bib0019","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1016\/j.regpep.2006.02.007","article-title":"Glucagon-like peptide-1 receptor and proglucagon expression in mouse skin","volume":"134","author":"List","year":"2006","journal-title":"Regul Pept"},{"key":"10.1016\/j.clindermatol.2026.08.004_bib0020","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1016\/j.diabres.2018.10.013","article-title":"Glucagon-like peptide-1 analogue liraglutide facilitates wound healing by activating PI3K\/Akt pathway in keratinocytes","volume":"146","author":"Nagae","year":"2018","journal-title":"Diabetes Res Clin Pract"},{"key":"10.1016\/j.clindermatol.2026.08.004_bib0021","doi-asserted-by":"crossref","first-page":"150","DOI":"10.1111\/exd.12081","article-title":"Increased expression of glucagon-like peptide-1 receptors in psoriasis plaques","volume":"22","author":"Faurschou","year":"2013","journal-title":"Exp Dermatol"},{"key":"10.1016\/j.clindermatol.2026.08.004_bib0022","doi-asserted-by":"crossref","first-page":"124","DOI":"10.1016\/j.yexmp.2019.01.014","article-title":"GLP-1 receptor agonist impairs keratinocytes inflammatory signals by activating AMPK","volume":"107","author":"Yang","year":"2019","journal-title":"Exp Mol Pathol"},{"key":"10.1016\/j.clindermatol.2026.08.004_bib0023","doi-asserted-by":"crossref","first-page":"2023","DOI":"10.1242\/jcs.02330","article-title":"Cyclic AMP mediates keratinocyte directional migration in an electric field","volume":"118","author":"Pullar","year":"2005","journal-title":"J Cell Sci"},{"key":"10.1016\/j.clindermatol.2026.08.004_bib0024","doi-asserted-by":"crossref","first-page":"416","DOI":"10.1159\/000544023","article-title":"Dermatologic implications of glucagon-like peptide-1 receptor agonist medications","volume":"11","author":"Burke","year":"2025","journal-title":"Skin Appendage Disord"},{"key":"10.1016\/j.clindermatol.2026.08.004_bib0025","doi-asserted-by":"crossref","first-page":"56","DOI":"10.3390\/cells15010056","article-title":"Integration of cAMP and TRPV4 signaling to optimize collagen remodeling for management of fibrosis","volume":"15","author":"Di Raimo","year":"2025","journal-title":"Cells"},{"key":"10.1016\/j.clindermatol.2026.08.004_bib0026","doi-asserted-by":"crossref","first-page":"262","DOI":"10.1016\/j.ejphar.2018.10.053","article-title":"Anti-inflammatory and pro-healing impacts of exendin-4 treatment in Zucker diabetic rats: effects on skin wound fibroblasts","volume":"842","author":"Wolak","year":"2019","journal-title":"Eur J Pharmacol"},{"key":"10.1016\/j.clindermatol.2026.08.004_bib0027","doi-asserted-by":"crossref","first-page":"1115","DOI":"10.3390\/pharmaceutics17091115","article-title":"Semaglutide enhances cellular regeneration in skin and retinal cells in vitro","volume":"17","author":"Anastasiou","year":"2025","journal-title":"Pharmaceutics"},{"key":"10.1016\/j.clindermatol.2026.08.004_bib0028","doi-asserted-by":"crossref","DOI":"10.1111\/phpp.12931","article-title":"Collagen study advances for photoaging skin","volume":"40","author":"Liu","year":"2024","journal-title":"Photodermatol Photoimmunol Photomed"},{"key":"10.1016\/j.clindermatol.2026.08.004_bib0029","doi-asserted-by":"crossref","first-page":"127","DOI":"10.3390\/diseases13050127","article-title":"A closer look at the dermatological profile of GLP-1 agonists","volume":"13","author":"Persson","year":"2025","journal-title":"Diseases"},{"key":"10.1016\/j.clindermatol.2026.08.004_bib0030","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1177\/1479164111404257","article-title":"A GLP-1 receptor agonist liraglutide inhibits endothelial cell dysfunction and vascular adhesion molecule expression in an ApoE-\/- mouse model","volume":"8","author":"Gaspari","year":"2011","journal-title":"Diab Vasc Dis Res"},{"key":"10.1016\/j.clindermatol.2026.08.004_bib0031","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1161\/atv.0000615456.97862.30","article-title":"Endothelial GLP-1 (glucagon-like peptide-1) receptor mediates cardiovascular protection by liraglutide in mice with experimental arterial hypertension","volume":"40","author":"Helmst\u00e4dter","year":"2020","journal-title":"Arterioscler Thromb Vasc Biol"},{"key":"10.1016\/j.clindermatol.2026.08.004_bib0032","doi-asserted-by":"crossref","first-page":"H1159","DOI":"10.1152\/ajpheart.00574.2023","article-title":"GLP-1 receptor agonists and atherosclerosis protection: the vascular endothelium takes center stage","volume":"326","author":"Park","year":"2024","journal-title":"Am J Physiol Heart Circ Physiol"}],"container-title":["Clinics in Dermatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0738081X26002142?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0738081X26002142?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,9,12]],"date-time":"2026-09-12T20:11:06Z","timestamp":1789243866000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0738081X26002142"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,8]]},"references-count":32,"alternative-id":["S0738081X26002142"],"URL":"https:\/\/doi.org\/10.1016\/j.clindermatol.2026.08.004","relation":{},"ISSN":["0738-081X"],"issn-type":[{"value":"0738-081X","type":"print"}],"subject":[],"published":{"date-parts":[[2026,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Mechanism of action: Glucagon-like peptide-1 receptors in skin biology","name":"articletitle","label":"Article Title"},{"value":"Clinics in Dermatology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.clindermatol.2026.08.004","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 Elsevier Inc. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}]}}