{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,25]],"date-time":"2026-07-25T23:27:23Z","timestamp":1785022043573,"version":"3.55.0"},"reference-count":52,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2016,7,1]],"date-time":"2016-07-01T00:00:00Z","timestamp":1467331200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":["clinicalkey.jp","clinicalkey.com","clinicalkey.es","clinicalkey.com.au","clinicalkey.fr","clineu-journal.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Clinical Neurology and Neurosurgery"],"published-print":{"date-parts":[[2016,7]]},"DOI":"10.1016\/j.clineuro.2016.04.011","type":"journal-article","created":{"date-parts":[[2016,4,29]],"date-time":"2016-04-29T02:15:16Z","timestamp":1461896116000},"page":"1-11","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":35,"special_numbering":"C","title":["Effect of stem cell-based therapy for ischemic stroke treatment: A meta-analysis"],"prefix":"10.1016","volume":"146","author":[{"given":"Qian","family":"Wang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Feng","family":"Duan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ming-xin","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiao-dong","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peng","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li-zhi","family":"Ma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.clineuro.2016.04.011_bib0005","doi-asserted-by":"crossref","first-page":"154","DOI":"10.1212\/WNL.46.1.154","article-title":"Dementia after ischemic stroke: a population-based study in Rochester, Minnesota (1960\u20131984)","volume":"46","author":"Kokmen","year":"1996","journal-title":"Neurology"},{"key":"10.1016\/j.clineuro.2016.04.011_bib0010","doi-asserted-by":"crossref","first-page":"4140","DOI":"10.2337\/dc13-0669","article-title":"Incidence of stroke according to presence of diabetic nephropathy and severe diabetic retinopathy in patients with type 1 diabetes","volume":"36","author":"H\u00e4gg","year":"2013","journal-title":"Diabetes Care"},{"key":"10.1016\/j.clineuro.2016.04.011_bib0015","doi-asserted-by":"crossref","first-page":"S234","DOI":"10.1212\/WNL.0b013e318269595b","article-title":"Performance and training standards for endovascular acute ischemic stroke treatment","volume":"79","author":"Meyers","year":"2012","journal-title":"Neurology"},{"key":"10.1016\/j.clineuro.2016.04.011_bib0020","doi-asserted-by":"crossref","first-page":"1059","DOI":"10.1161\/STROKEAHA.113.004307","article-title":"Baseline National Institutes of Health stroke scale-adjusted time window for intravenous tissue-type plasminogen activator in acute ischemic stroke","volume":"45","author":"Muchada","year":"2014","journal-title":"Stroke"},{"key":"10.1016\/j.clineuro.2016.04.011_bib0025","doi-asserted-by":"crossref","first-page":"e0131448","DOI":"10.1371\/journal.pone.0131448","article-title":"Self-management support interventions for stroke survivors: a systematic meta-review","volume":"10","author":"Parke","year":"2015","journal-title":"PLoS One"},{"key":"10.1016\/j.clineuro.2016.04.011_bib0030","doi-asserted-by":"crossref","first-page":"1029","DOI":"10.1007\/s00270-012-0438-5","article-title":"Endovascular acute stroke treatment performed by vascular interventional radiologists: is it safe and efficacious?","volume":"35","author":"Fjetland","year":"2012","journal-title":"Cardiovasc. Intervent. Radiol."},{"key":"10.1016\/j.clineuro.2016.04.011_bib0035","doi-asserted-by":"crossref","first-page":"1263","DOI":"10.1016\/j.jvir.2013.05.050","article-title":"Society of interventional radiology position statement on endovascular acute ischemic stroke interventions","volume":"24","author":"Sacks","year":"2013","journal-title":"J. Vasc. Interv. Radiol."},{"key":"10.1016\/j.clineuro.2016.04.011_bib0040","first-page":"2928","article-title":"Intravenously delivered neural stem cells migrate into ischemic brain, differentiate and improve functional recovery after transient ischemic stroke in adult rats","volume":"8","author":"Cheng","year":"2015","journal-title":"Int. J. Clin. Exp. Pathol."},{"key":"10.1016\/j.clineuro.2016.04.011_bib0045","doi-asserted-by":"crossref","first-page":"487","DOI":"10.3727\/096368915X686940","article-title":"Adipose tissue-derived stem cells in neural regenerative medicine","volume":"24","author":"Yeh","year":"2015","journal-title":"Cell Transplant."},{"issue":"347","key":"10.1016\/j.clineuro.2016.04.011_bib0050","article-title":"Stem cell therapies in preclinical models of stroke associated with aging","volume":"8","author":"Popa-Wagner","year":"2014","journal-title":"Front. Cell. Neurosci."},{"key":"10.1016\/j.clineuro.2016.04.011_bib0055","doi-asserted-by":"crossref","first-page":"72","DOI":"10.7150\/ijms.10706","article-title":"The regenerative medicine in oral and maxillofacial surgery: the most important innovations in the clinical application of mesenchymal stem cells","volume":"12","author":"Tatullo","year":"2015","journal-title":"Int. J. Med. Sci."},{"key":"10.1016\/j.clineuro.2016.04.011_bib0060","doi-asserted-by":"crossref","first-page":"1580","DOI":"10.1016\/j.bbmt.2014.06.015","article-title":"Sequential third-party mesenchymal stromal cell therapy for refractory acute graft-versus-host disease","volume":"20","author":"S\u00e1nchez-Guijo","year":"2014","journal-title":"Biol. Blood Marrow Transplant."},{"key":"10.1016\/j.clineuro.2016.04.011_bib0065","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1155\/2011\/427863","article-title":"Clinical application of mesenchymal stem cells in the treatment and prevention of graft-versus-host disease","volume":"2011","author":"Lin","year":"2011","journal-title":"Adv. Hematol."},{"key":"10.1016\/j.clineuro.2016.04.011_bib0070","doi-asserted-by":"crossref","first-page":"597","DOI":"10.1586\/eci.10.27","article-title":"Stem cell treatment for Crohn's disease","volume":"6","author":"Pan\u00e9s","year":"2010","journal-title":"Expert Rev. Clin. Immunol."},{"key":"10.1016\/j.clineuro.2016.04.011_bib0075","doi-asserted-by":"crossref","first-page":"763","DOI":"10.1586\/1744666X.2015.1037741","article-title":"Stem cell therapies for systemic lupus erythematosus: current progress and established evidence","volume":"11","author":"Wang","year":"2015","journal-title":"Expert Rev. Clin. Immunol."},{"key":"10.1016\/j.clineuro.2016.04.011_bib0080","doi-asserted-by":"crossref","first-page":"254","DOI":"10.1007\/s12015-012-9375-6","article-title":"Mesenchymal stem cells for cardiac therapy: practical challenges and potential mechanisms","volume":"9","author":"Cashman","year":"2013","journal-title":"Stem Cell Rev."},{"key":"10.1016\/j.clineuro.2016.04.011_bib0085","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1007\/s10354-013-0222-4","article-title":"Percutaneous injection of autologous, culture-expanded mesenchymal stem cells into carpometacarpal hand joints: a case series with an untreated comparison group","volume":"164","author":"Centeno","year":"2014","journal-title":"Wien Med. Wochenschr."},{"key":"10.1016\/j.clineuro.2016.04.011_bib0090","doi-asserted-by":"crossref","first-page":"510","DOI":"10.1161\/STROKEAHA.108.526863","article-title":"Stem cell therapies as an emerging paradigm in stroke participants, stem cell therapies as an emerging paradigm in stroke (STEPS): bridging basic and clinical science for cellular and neurogenic factor therapy in treating stroke","volume":"40","author":"Brent Reynolds","year":"2009","journal-title":"Stroke"},{"key":"10.1016\/j.clineuro.2016.04.011_bib0095","doi-asserted-by":"crossref","first-page":"825","DOI":"10.1161\/STROKEAHA.110.601914","article-title":"Stem cell therapy as an emerging paradigm for stroke (STEPS) II","volume":"42","author":"Savitz","year":"2011","journal-title":"Stroke"},{"key":"10.1016\/j.clineuro.2016.04.011_bib0100","doi-asserted-by":"crossref","first-page":"63","DOI":"10.15283\/ijsc.2014.7.2.63","article-title":"Efficacy and safety of stem cell therapies for patients with stroke: a systematic review and single arm meta-analysis","volume":"7","author":"Jeong","year":"2014","journal-title":"Int. J. Stem Cells"},{"key":"10.1016\/j.clineuro.2016.04.011_bib0105","doi-asserted-by":"crossref","first-page":"e52599","DOI":"10.1371\/journal.pone.0052599","article-title":"The totally extraperitoneal method versus Lichtenstein's technique for inguinal hernia repair: a systematic review with meta-analyses and trial sequential analyses of randomized clinical trials","volume":"8","author":"Koning","year":"2013","journal-title":"PLoS One"},{"key":"10.1016\/j.clineuro.2016.04.011_bib0110","first-page":"CD008318","article-title":"Open, small-incision, or laparoscopic cholecystectomy for patients with symptomatic cholecystolithiasis. An overview of Cochrane Hepato-Biliary Group reviews","volume":"1","author":"Keus","year":"2010","journal-title":"Cochrane Database Syst. Rev."},{"key":"10.1016\/j.clineuro.2016.04.011_bib0115","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1016\/S0140-6736(13)61687-6","article-title":"Benefits and harms of adhesion barriers for abdominal surgery: a systematic review and meta-analysis","volume":"383","author":"ten Broek","year":"2014","journal-title":"Lancet"},{"key":"10.1016\/j.clineuro.2016.04.011_bib0120","article-title":"Cochrane Handbook for Systematic Reviews of Interventions Version 5.1.0","year":"2011"},{"key":"10.1016\/j.clineuro.2016.04.011_bib0125","doi-asserted-by":"crossref","first-page":"891","DOI":"10.1111\/add.12788","volume":"110","author":"Davoli","year":"2015","journal-title":"Addiction"},{"key":"10.1016\/j.clineuro.2016.04.011_bib0130","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1186\/1471-2288-5-13","article-title":"Estimating the mean and variance from the median, range, and the size of a sample","volume":"5","author":"Hozo","year":"2005","journal-title":"BMC Med. Res. Methodol."},{"key":"10.1016\/j.clineuro.2016.04.011_bib0135","doi-asserted-by":"crossref","first-page":"e8539","DOI":"10.1136\/bmj.e8539","article-title":"Egg consumption and risk of coronary heart disease and stroke: dose-response meta-analysis of prospective cohort studies","volume":"346","author":"Rong","year":"2013","journal-title":"BMJ"},{"key":"10.1016\/j.clineuro.2016.04.011_bib0140","doi-asserted-by":"crossref","first-page":"874","DOI":"10.1002\/ana.20501","article-title":"Autologous mesenchymal stem cell transplantation in stroke patients","volume":"57","author":"Bang","year":"2005","journal-title":"Ann. Neurol."},{"key":"10.1016\/j.clineuro.2016.04.011_bib0145","doi-asserted-by":"crossref","first-page":"1099","DOI":"10.1002\/stem.430","article-title":"A long-term follow-up study of intravenous autologous mesenchymal stem cell transplantation in patients with ischemic stroke","volume":"28","author":"Lee","year":"2010","journal-title":"Stem Cells"},{"key":"10.1016\/j.clineuro.2016.04.011_bib0150","doi-asserted-by":"crossref","first-page":"2242","DOI":"10.1161\/STROKEAHA.112.659409","article-title":"Intra-arterial bone marrow mononuclear cells in ischemic stroke: a pilot clinical trial","volume":"43","author":"Moniche","year":"2012","journal-title":"Stroke"},{"key":"10.1016\/j.clineuro.2016.04.011_bib0155","doi-asserted-by":"crossref","first-page":"3618","DOI":"10.1161\/STROKEAHA.114.007028","article-title":"Intravenous autologous bone marrow mononuclear stem cell therapy for ischemic stroke: a multicentric, randomized trial","volume":"45","author":"Prasad","year":"2014","journal-title":"Stroke"},{"key":"10.1016\/j.clineuro.2016.04.011_bib0160","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1159\/000333381","article-title":"Autologous mesenchymal stem cells in chronic stroke","volume":"1","author":"Bhasin","year":"2011","journal-title":"Cerebrovasc. Dis. Extra"},{"key":"10.1016\/j.clineuro.2016.04.011_bib0165","doi-asserted-by":"crossref","first-page":"181","DOI":"10.46582\/jsrm.0803011","article-title":"Autologous intravenous mononuclear stem cell therapy in chronic ischemic stroke","volume":"8","author":"Bhasin","year":"2012","journal-title":"J. Stem Cells Regen. Med."},{"key":"10.1016\/j.clineuro.2016.04.011_bib0170","doi-asserted-by":"crossref","first-page":"1599","DOI":"10.3727\/096368914X678562","article-title":"Intracerebral implantation of autologous peripheral blood stem cells in stroke patients: a randomized phase II study","volume":"23","author":"Chen","year":"2014","journal-title":"Cell Transplant."},{"key":"10.1016\/j.clineuro.2016.04.011_bib0175","first-page":"370","article-title":"A patient with pure red cell aplasia after allogenic stem-cell transplantation. Parvo B19 infection","volume":"71","author":"Berrevoets","year":"2013","journal-title":"Neth. J. Med."},{"key":"10.1016\/j.clineuro.2016.04.011_bib0180","doi-asserted-by":"crossref","first-page":"2086","DOI":"10.1016\/j.bbmt.2015.07.009","article-title":"Colonoscopy and sigmoidoscopy are equally effective for the diagnosis of colonic acute graft-versus-host disease in patients with diarrhea after allogeneic stem cell transplantation: a prospective controlled trial","volume":"21","author":"Johansson","year":"2015","journal-title":"Biol. Blood Marrow Transplant."},{"key":"10.1016\/j.clineuro.2016.04.011_bib0185","doi-asserted-by":"crossref","first-page":"R79","DOI":"10.1186\/ar4520","article-title":"Umbilical cord mesenchymal stem cell transplantation in active and refractory systemic lupus erythematosus: a multicenter clinical study","volume":"16","author":"Wang","year":"2014","journal-title":"Arthritis Res. Ther."},{"key":"10.1016\/j.clineuro.2016.04.011_bib0190","first-page":"4715","article-title":"Bone marrow mesenchymal stem cells ameliorate neurological deficits and blood\u2013brain barrier dysfunction after intracerebral hemorrhage in spontaneously hypertensive rats","volume":"8","author":"Wang","year":"2015","journal-title":"Int. J. Clin. Exp. Pathol."},{"key":"10.1016\/j.clineuro.2016.04.011_bib0195","first-page":"435093","article-title":"From blood to the brain: can systemically transplanted mesenchymal stem cells cross the blood\u2013brain barrier?","author":"Liu","year":"2013","journal-title":"Stem Cells Int."},{"key":"10.1016\/j.clineuro.2016.04.011_bib0200","doi-asserted-by":"crossref","first-page":"272","DOI":"10.1016\/j.cardfail.2010.11.007","article-title":"Effects of intracoronary stem cell transplantation in patients with dilated cardiomyopathy","volume":"17","author":"Vrtovec","year":"2011","journal-title":"J. Card. Fail."},{"key":"10.1016\/j.clineuro.2016.04.011_bib0205","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1159\/000358297","article-title":"Increased blood-brain barrier permeability on perfusion computed tomography predicts hemorrhagic transformation in acute ischemic stroke","volume":"72","author":"Ozkul-Wermester","year":"2014","journal-title":"Eur. Neurol."},{"key":"10.1016\/j.clineuro.2016.04.011_bib0210","doi-asserted-by":"crossref","first-page":"959","DOI":"10.1111\/jon.12225","article-title":"Early blood brain barrier changes in acute ischemic stroke: a sequential MRI study","volume":"25","author":"Giraud","year":"2015","journal-title":"J. Neuroimaging"},{"key":"10.1016\/j.clineuro.2016.04.011_bib0215","doi-asserted-by":"crossref","first-page":"78","DOI":"10.1016\/j.expneurol.2011.02.021","article-title":"Variable behavior and complications of autologous bone marrow mesenchymal stem cells transplanted in experimental autoimmune encephalomyelitis","volume":"230","author":"Grigoriadis","year":"2011","journal-title":"Exp. Neurol."},{"key":"10.1016\/j.clineuro.2016.04.011_bib0220","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1016\/j.expneurol.2011.03.012","article-title":"The risk of putting something where it does not belong: mesenchymal stem cells produce masses in the brain","volume":"230","author":"Snyder","year":"2011","journal-title":"Exp. Neurol."},{"issue":"249","key":"10.1016\/j.clineuro.2016.04.011_bib0225","article-title":"Mesenchymal stem cells secretome as a modulator of the neurogenic niche: basic insights and therapeutic opportunities","volume":"9","author":"Salgado","year":"2015","journal-title":"Front. Cell. Neurosci."},{"issue":"127","key":"10.1016\/j.clineuro.2016.04.011_bib0230","article-title":"Human bone marrow- and adipose-mesenchymal stem cells secrete exosomes enriched in distinctive miRNA and tRNA species","volume":"6","author":"Baglio","year":"2015","journal-title":"Stem Cell. Res. Ther."},{"key":"10.1016\/j.clineuro.2016.04.011_bib0235","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1016\/j.bbmt.2014.10.007","article-title":"Race and ethnicity influences collection of granulocyte colony-stimulating factor-mobilized peripheral blood progenitor cells from unrelated donors, a Center for International Blood and Marrow Transplant Research analysis","volume":"21","author":"Hsu","year":"2015","journal-title":"Biol. Blood Marrow Transplant."},{"key":"10.1016\/j.clineuro.2016.04.011_bib0240","first-page":"229","article-title":"Hematopoietic stem cell transplantation in sickle cell disease: patient selection and special considerations","volume":"6","author":"Bhatia","year":"2015","journal-title":"J. Blood Med."},{"key":"10.1016\/j.clineuro.2016.04.011_bib0245","doi-asserted-by":"crossref","first-page":"38","DOI":"10.3171\/jns.2005.103.1.0038","article-title":"Neurotransplantation for patients with subcortical motor stroke: a phase 2 randomized trial","volume":"103","author":"Kondziolka","year":"2005","journal-title":"J. Neurosurg."},{"key":"10.1016\/j.clineuro.2016.04.011_bib0250","doi-asserted-by":"crossref","first-page":"381","DOI":"10.1111\/ijs.12065","article-title":"A double-blind placebo-controlled clinical evaluation of MultiStem for the treatment of ischemic stroke","volume":"9","author":"Hess","year":"2014","journal-title":"Int. J. Stroke"},{"key":"10.1016\/j.clineuro.2016.04.011_bib0255","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1186\/1745-6215-14-317","article-title":"Intravenous transplantation of mesenchymal stem cells preconditioned with early phase stroke serum: current evidence and study protocol for a randomized trial","volume":"14","author":"Kim","year":"2013","journal-title":"Trials"},{"key":"10.1016\/j.clineuro.2016.04.011_bib0260","doi-asserted-by":"crossref","first-page":"2694","DOI":"10.1016\/j.jstrokecerebrovasdis.2014.06.011","article-title":"Reparative therapy for acute ischemic stroke with allogeneic mesenchymal stem cells from adipose tissue: a safety assessment: a phase II randomized, double-blind, placebo-controlled, single-center, pilot clinical trial","volume":"23","author":"D\u00edez-Tejedor","year":"2014","journal-title":"J. Stroke Cerebrovasc. Dis."}],"container-title":["Clinical Neurology and Neurosurgery"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0303846716301445?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0303846716301445?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2020,9,19]],"date-time":"2020-09-19T06:08:44Z","timestamp":1600495724000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0303846716301445"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,7]]},"references-count":52,"alternative-id":["S0303846716301445"],"URL":"https:\/\/doi.org\/10.1016\/j.clineuro.2016.04.011","relation":{},"ISSN":["0303-8467"],"issn-type":[{"value":"0303-8467","type":"print"}],"subject":[],"published":{"date-parts":[[2016,7]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Effect of stem cell-based therapy for ischemic stroke treatment: A meta-analysis","name":"articletitle","label":"Article Title"},{"value":"Clinical Neurology and Neurosurgery","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.clineuro.2016.04.011","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2016 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}]}}