{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,18]],"date-time":"2026-03-18T22:16:48Z","timestamp":1773872208528,"version":"3.50.1"},"reference-count":27,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,11,18]],"date-time":"2025-11-18T00:00:00Z","timestamp":1763424000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100002858","name":"China Postdoctoral Science Foundation","doi-asserted-by":"publisher","award":["2023M741764"],"award-info":[{"award-number":["2023M741764"]}],"id":[{"id":"10.13039\/501100002858","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Clinical Neurology and Neurosurgery"],"published-print":{"date-parts":[[2026,1]]},"DOI":"10.1016\/j.clineuro.2025.109239","type":"journal-article","created":{"date-parts":[[2025,11,14]],"date-time":"2025-11-14T01:28:57Z","timestamp":1763083737000},"page":"109239","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":1,"special_numbering":"C","title":["Mid-long term efficacy of dihydroergotoxine mesylate in treatment of sialorrhea in Parkinson's disease"],"prefix":"10.1016","volume":"260","author":[{"given":"Huihui","family":"Jin","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ting","family":"Huang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jing","family":"Wu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yanan","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qing","family":"Gao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Youyong","family":"Tian","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"issue":"12","key":"10.1016\/j.clineuro.2025.109239_bib1","doi-asserted-by":"crossref","first-page":"2940","DOI":"10.1002\/mds.28762","article-title":"Prevalence of Parkinson's disease: a community-based study in China","volume":"36","author":"Qi","year":"2021","journal-title":"Mov. Disord."},{"issue":"4","key":"10.1016\/j.clineuro.2025.109239_bib2","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1016\/j.parkreldis.2011.11.006","article-title":"Prevalence of oropharyngeal dysphagia in Parkinson's disease: a meta-analysis","volume":"18","author":"Kalf","year":"2012","journal-title":"Park. Relat. Disord."},{"issue":"5","key":"10.1016\/j.clineuro.2025.109239_bib3","doi-asserted-by":"crossref","first-page":"312","DOI":"10.1159\/000336054","article-title":"Impact of progression of Parkinson's disease on drooling in various ethnic groups","volume":"67","author":"Rana","year":"2012","journal-title":"Eur. Neurol."},{"issue":"5","key":"10.1016\/j.clineuro.2025.109239_bib4","doi-asserted-by":"crossref","first-page":"711","DOI":"10.3390\/jpm13050711","article-title":"Hiccups, hypersalivation, hallucinations in Parkinson's disease: new insights, mechanisms, pathophysiology, and management","volume":"13","author":"Metta","year":"2023","journal-title":"J. Pers. Med"},{"issue":"2","key":"10.1016\/j.clineuro.2025.109239_bib5","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1007\/s00415-024-12739-w","article-title":"Predictors of drooling severity in people with Parkinson's disease","volume":"272","author":"Nascimento","year":"2025","journal-title":"J. Neurol."},{"issue":"11","key":"10.1016\/j.clineuro.2025.109239_bib6","doi-asserted-by":"crossref","first-page":"1109","DOI":"10.1016\/j.parkreldis.2014.08.013","article-title":"Drooling in Parkinson's disease: a review","volume":"20","author":"Srivanitchapoom","year":"2014","journal-title":"Park. Relat. Disord."},{"key":"10.1016\/j.clineuro.2025.109239_bib7","doi-asserted-by":"crossref","DOI":"10.1016\/j.parkreldis.2024.106982","article-title":"Consensus practice recommendations for management of gastrointestinal dysfunction in Parkinson disease","volume":"124","author":"Safarpour","year":"2024","journal-title":"Park. Relat. Disord."},{"issue":"8","key":"10.1016\/j.clineuro.2025.109239_bib8","doi-asserted-by":"crossref","first-page":"366","DOI":"10.3390\/toxins16080366","article-title":"Real-world observational analysis of clinical characteristics and treatment patterns of patients with chronic sialorrhea","volume":"16","author":"Hast","year":"2024","journal-title":"Toxins (Basel)"},{"issue":"23-24","key":"10.1016\/j.clineuro.2025.109239_bib9","doi-asserted-by":"crossref","first-page":"4190","DOI":"10.1111\/jocn.15009","article-title":"A systematic review of noninvasive and invasive sialorrhoea management","volume":"28","author":"Varley","year":"2019","journal-title":"J. Clin. Nurs."},{"issue":"15","key":"10.1016\/j.clineuro.2025.109239_bib10","doi-asserted-by":"crossref","first-page":"1198","DOI":"10.1212\/WNL.0b013e3181d9002b","article-title":"Gum chewing improves swallow frequency and latency in Parkinson patients: a preliminary study","volume":"74","author":"South","year":"2010","journal-title":"Neurology"},{"key":"10.1016\/j.clineuro.2025.109239_bib11","article-title":"Radiation of parotid or submandibular glands is effective for drooling in patients with parkinsonism; a randomised double-blind placebo-controlled trial","volume":"6","author":"Steenbakkers","year":"2022","journal-title":"Clin. Park Relat. Disord."},{"issue":"1","key":"10.1016\/j.clineuro.2025.109239_bib12","doi-asserted-by":"crossref","first-page":"80","DOI":"10.1002\/lary.25444","article-title":"The role of radiation therapy in the management of sialorrhea: a systematic review","volume":"126","author":"Hawkey","year":"2016","journal-title":"Laryngoscope"},{"issue":"1","key":"10.1016\/j.clineuro.2025.109239_bib13","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1186\/s40360-023-00694-7","article-title":"The effectiveness and safety of botulinum toxin injections for the treatment of sialorrhea with Parkinson's disease: a systematic review and meta-analysis","volume":"24","author":"Yang","year":"2023","journal-title":"BMC Pharm. Toxicol."},{"issue":"15","key":"10.1016\/j.clineuro.2025.109239_bib14","doi-asserted-by":"crossref","first-page":"1203","DOI":"10.1212\/WNL.0b013e3181d8c1b7","article-title":"Glycopyrrolate for sialorrhea in Parkinson disease: a randomized, double-blind, crossover trial","volume":"74","author":"Arbouw","year":"2010","journal-title":"Neurology"},{"key":"10.1016\/j.clineuro.2025.109239_bib15","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1016\/j.parkreldis.2018.08.022","article-title":"Dihydroergotoxine mesylate for the treatment of sialorrhea in Parkinson's disease","volume":"58","author":"Cheng","year":"2019","journal-title":"Park. Relat. Disord."},{"key":"10.1016\/j.clineuro.2025.109239_bib16","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1016\/j.jad.2025.01.136","article-title":"Emotional stimulated speech-based assisted early diagnosis of depressive disorders using personality-enhanced deep learning","volume":"376","author":"Ding","year":"2025","journal-title":"J. Affect Disord."},{"issue":"12","key":"10.1016\/j.clineuro.2025.109239_bib17","doi-asserted-by":"crossref","first-page":"1591","DOI":"10.1002\/mds.26424","article-title":"MDS clinical diagnostic criteria for Parkinson's disease","volume":"30","author":"Postuma","year":"2015","journal-title":"Mov. Disord."},{"issue":"7","key":"10.1016\/j.clineuro.2025.109239_bib18","doi-asserted-by":"crossref","first-page":"1236","DOI":"10.1002\/mds.29410","article-title":"Levodopa dose equivalency in parkinson's disease: updated systematic review and proposals","volume":"38","author":"Jost","year":"2023","journal-title":"Mov. Disord."},{"issue":"2","key":"10.1016\/j.clineuro.2025.109239_bib19","doi-asserted-by":"crossref","first-page":"308","DOI":"10.1002\/acn3.51236","article-title":"Design of a virtual longitudinal observational study in Parkinson's disease (AT-HOME PD)","volume":"8","author":"Schneider","year":"2021","journal-title":"Ann. Clin. Transl. Neurol."},{"issue":"8","key":"10.1016\/j.clineuro.2025.109239_bib20","doi-asserted-by":"crossref","first-page":"735","DOI":"10.1016\/S1474-4422(22)00169-7","article-title":"Diagnosis and treatment of orthostatic hypotension","volume":"21","author":"Wieling","year":"2022","journal-title":"Lancet Neurol."},{"issue":"6","key":"10.1016\/j.clineuro.2025.109239_bib21","doi-asserted-by":"crossref","first-page":"563","DOI":"10.1001\/jamapsychiatry.2024.0026","article-title":"Psychomotor slowing in psychosis and inhibitory repetitive transcranial magnetic stimulation: a randomized clinical trial","volume":"81","author":"Walther","year":"2024","journal-title":"JAMA Psychiatry"},{"issue":"1","key":"10.1016\/j.clineuro.2025.109239_bib22","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1002\/bdd.585","article-title":"Identification and human pharmacokinetics of dihydroergotoxine metabolites in man: preliminary results","volume":"29","author":"Bicalho","year":"2008","journal-title":"Biopharm. Drug Dispos."},{"issue":"2","key":"10.1016\/j.clineuro.2025.109239_bib23","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1159\/000212616","article-title":"Simultaneous study of haemodynamic, metabolic and behavioural sequelae in a model of cerebral ischaemia in aged rats: effects of nicergoline","volume":"30","author":"Le Poncin-Lafitte","year":"1984","journal-title":"Gerontology"},{"issue":"1","key":"10.1016\/j.clineuro.2025.109239_bib24","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1016\/j.autneu.2006.10.006","article-title":"Regulation of salivary gland function by autonomic nerves","volume":"133","author":"Proctor","year":"2007","journal-title":"Auton. Neurosci."},{"key":"10.1016\/j.clineuro.2025.109239_bib25","doi-asserted-by":"crossref","DOI":"10.3389\/fendo.2023.1061235","article-title":"Progress in salivary glands: endocrine glands with immune functions","volume":"14","author":"Shang","year":"2023","journal-title":"Front Endocrinol."},{"key":"10.1016\/j.clineuro.2025.109239_bib26","doi-asserted-by":"crossref","DOI":"10.1155\/2014\/610103","article-title":"Safety of nicergoline as an agent for management of cognitive function disorders","volume":"2014","author":"Saletu","year":"2014","journal-title":"Biomed. Res Int"},{"issue":"4","key":"10.1016\/j.clineuro.2025.109239_bib27","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1097\/MD.0b013e318224413b","article-title":"Nicergoline improves dysphagia by upregulating substance P in the elderly","volume":"90","author":"Nakashima","year":"2011","journal-title":"Medicine"}],"container-title":["Clinical Neurology and Neurosurgery"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0303846725005220?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0303846725005220?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,3,18]],"date-time":"2026-03-18T09:35:25Z","timestamp":1773826525000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0303846725005220"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,1]]},"references-count":27,"alternative-id":["S0303846725005220"],"URL":"https:\/\/doi.org\/10.1016\/j.clineuro.2025.109239","relation":{},"ISSN":["0303-8467"],"issn-type":[{"value":"0303-8467","type":"print"}],"subject":[],"published":{"date-parts":[[2026,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Mid-long term efficacy of dihydroergotoxine mesylate in treatment of sialorrhea in Parkinson's disease","name":"articletitle","label":"Article Title"},{"value":"Clinical Neurology and Neurosurgery","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.clineuro.2025.109239","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 The Authors. Published by Elsevier B.V.","name":"copyright","label":"Copyright"}],"article-number":"109239"}}