{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,4]],"date-time":"2026-06-04T11:22:55Z","timestamp":1780572175417,"version":"3.54.1"},"reference-count":22,"publisher":"Elsevier BV","issue":"3","license":[{"start":{"date-parts":[[2007,5,1]],"date-time":"2007-05-01T00:00:00Z","timestamp":1177977600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clinical Imaging"],"published-print":{"date-parts":[[2007,5]]},"DOI":"10.1016\/j.clinimag.2007.01.008","type":"journal-article","created":{"date-parts":[[2007,4,21]],"date-time":"2007-04-21T07:10:29Z","timestamp":1177139429000},"page":"151-154","source":"Crossref","is-referenced-by-count":9,"title":["Hemodynamic studies on brain CT perfusion imaging with varied injection rates"],"prefix":"10.1016","volume":"31","author":[{"given":"Chun-Hong","family":"Hu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qing-De","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiao-Yun","family":"Hu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiang-Ming","family":"Fang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tong-Hua","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yi","family":"Ding","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.clinimag.2007.01.008_bib1","doi-asserted-by":"crossref","first-page":"727","DOI":"10.1097\/00004728-198012000-00001","article-title":"Quantitative measurement of regional cerebral blood flow and oxygen metabolism in man using 15O and positron emission tomography: theory, procedure, and normal values","volume":"4","author":"Frackowiak","year":"1980","journal-title":"J Comput Assist Tomogr"},{"issue":"Pt 1","key":"10.1016\/j.clinimag.2007.01.008_bib2","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1093\/brain\/113.1.27","article-title":"Cerebral blood flow, blood volume and oxygen utilization: normal values and effect of age","volume":"113","author":"Leenders","year":"1990","journal-title":"Brain"},{"key":"10.1016\/j.clinimag.2007.01.008_bib3","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1038\/jcbfm.1985.27","article-title":"Regional cerebral blood volume and hematocrit measured in normal human volunteers by single-photon emission computed tomography","volume":"5","author":"Sakai","year":"1985","journal-title":"J Cereb Blood Flow Metab"},{"key":"10.1016\/j.clinimag.2007.01.008_bib4","doi-asserted-by":"crossref","first-page":"2208","DOI":"10.1161\/01.STR.28.11.2208","article-title":"Quantitative cerebral blood flow determinations in acute ischemic stroke: relationship to computed tomography and angiography","volume":"28","author":"Firlik","year":"1997","journal-title":"Stroke"},{"key":"10.1016\/j.clinimag.2007.01.008_bib5","doi-asserted-by":"crossref","first-page":"400","DOI":"10.1002\/1522-2586(200009)12:3<400::AID-JMRI5>3.0.CO;2-C","article-title":"Whole brain quantitative CBF, CBV, and MTT measurements using MRI bolus tracking: implementation and application to data acquired from hyperacute stroke patients","volume":"12","author":"Smith","year":"2000","journal-title":"J Magn Reson Imaging"},{"key":"10.1016\/j.clinimag.2007.01.008_bib6","doi-asserted-by":"crossref","first-page":"96","DOI":"10.1007\/BF02678472","article-title":"Absolute cerebral blood flow measured by dynamic susceptibility contrast MRI: a direct comparison with Xe-133 SPECT","volume":"11","author":"Wirestam","year":"2000","journal-title":"Magma"},{"key":"10.1016\/j.clinimag.2007.01.008_bib7","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1148\/radiology.213.1.r99oc03141","article-title":"CT assessment of cerebral perfusion: experimental validation and initial clinical experience","volume":"213","author":"Nabavi","year":"1999","journal-title":"Radiology"},{"key":"10.1016\/j.clinimag.2007.01.008_bib8","first-page":"63","article-title":"Dynamic CT measurement of cerebral blood flow: a validation study","volume":"20","author":"Cenic","year":"1999","journal-title":"Am J Neuroradiol"},{"key":"10.1016\/j.clinimag.2007.01.008_bib9","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1148\/radiol.2221010471","article-title":"CT perfusion scanning with deconvolution analysis: pilot study in patients with acute middle cerebral artery stroke","author":"Eastwood","year":"2002","journal-title":"Radiology"},{"key":"10.1016\/j.clinimag.2007.01.008_bib10","first-page":"905","article-title":"Simultaneous measurement of regional cerebral blood flow by perfusion CT and stable xenon CT: a validation study","volume":"22","author":"Wintermark","year":"2001","journal-title":"Am J Neuroradiol"},{"key":"10.1016\/j.clinimag.2007.01.008_bib11","doi-asserted-by":"crossref","first-page":"359","DOI":"10.1148\/radiology.206.2.9457186","article-title":"Dynamic helical CT of the abdomen: prospective comparison of pre- and postprandial contrast enhancement","volume":"206","author":"Sheafor","year":"1998","journal-title":"Radiology"},{"key":"10.1016\/j.clinimag.2007.01.008_bib12","first-page":"210","article-title":"Cerebral perfusion CT: theoretical aspects, methodical implementation and clinical experience in the diagnosis of ischemic cerebral infarction","volume":"172","author":"Konig","year":"2000","journal-title":"RoFo Fortschr Geb Rontgenstr Nuklearmed"},{"key":"10.1016\/j.clinimag.2007.01.008_bib13","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1016\/S1076-6332(03)00578-6","article-title":"Quantitative perfusion map of malignant liver tumors, created from dynamic computed tomography data","volume":"11","author":"Tsushima","year":"2004","journal-title":"Acad Radiol"},{"key":"10.1016\/j.clinimag.2007.01.008_bib14","doi-asserted-by":"crossref","first-page":"962","DOI":"10.6009\/jjrt.KJ00001364338","article-title":"Method of injection of contrast medium for brain perfusion CT","volume":"58","author":"Machida","year":"2002","journal-title":"Nippon Hoshasen Gijutsu Gakkai Zasshi"},{"key":"10.1016\/j.clinimag.2007.01.008_bib15","doi-asserted-by":"crossref","first-page":"922","DOI":"10.1016\/S1076-6332(03)80462-2","article-title":"Development of perfusion CT software for personal computers","volume":"9","author":"Tsushima","year":"2002","journal-title":"Acad Radiol"},{"key":"10.1016\/j.clinimag.2007.01.008_bib16","doi-asserted-by":"crossref","first-page":"823","DOI":"10.1097\/00006231-198710000-00009","article-title":"Noninvasive measurement of blood flow and extraction fraction","volume":"8","author":"Peters","year":"1987","journal-title":"Nucl Med Commun"},{"key":"10.1016\/j.clinimag.2007.01.008_bib17","doi-asserted-by":"crossref","first-page":"170","DOI":"10.1016\/S0720-048X(99)00009-1","article-title":"Perfusion measurements of the brain: using dynamic CT for the quantitative assessment of cerebral ischemia in acute stroke","volume":"30","author":"Klotz","year":"1999","journal-title":"Eur J Radiol"},{"key":"10.1016\/j.clinimag.2007.01.008_bib18","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1148\/radiology.209.1.9769817","article-title":"Perfusion CT of the brain: diagnostic approach for early detection of ischemic stroke","volume":"209","author":"Koenig","year":"1998","journal-title":"Radiology"},{"key":"10.1016\/j.clinimag.2007.01.008_bib19","first-page":"419","article-title":"Quantitative cerebral blood flow measurement with dynamic perfusion CT using the vascular-pixel elimination method: comparison with H2(15)O positron emission tomography","volume":"24","author":"Kudo","year":"2003","journal-title":"Am J Neuroradiol"},{"issue":"Suppl 1","key":"10.1016\/j.clinimag.2007.01.008_bib20","doi-asserted-by":"crossref","first-page":"S11","DOI":"10.1016\/S0720-048X(02)00359-5","article-title":"Brain perfusion CT in acute stroke: current status","volume":"45","author":"Konig","year":"2003","journal-title":"Eur J Radiol"},{"key":"10.1016\/j.clinimag.2007.01.008_bib21","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1097\/00004424-199311001-00023","article-title":"Contrast bolus dynamic computed tomography for the measurement of solid organ perfusion","volume":"28","author":"Blomley","year":"1993","journal-title":"Invest Radiol"},{"key":"10.1016\/j.clinimag.2007.01.008_bib22","doi-asserted-by":"crossref","first-page":"365","DOI":"10.1148\/radiology.153.2.6484168","article-title":"Bolus geometry and dynamics after intravenous contrast medium injection","volume":"153","author":"Claussen","year":"1984","journal-title":"Radiology"}],"container-title":["Clinical Imaging"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0899707107000332?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0899707107000332?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2019,4,27]],"date-time":"2019-04-27T08:24:39Z","timestamp":1556353479000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0899707107000332"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2007,5]]},"references-count":22,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2007,5]]}},"alternative-id":["S0899707107000332"],"URL":"https:\/\/doi.org\/10.1016\/j.clinimag.2007.01.008","relation":{},"ISSN":["0899-7071"],"issn-type":[{"value":"0899-7071","type":"print"}],"subject":[],"published":{"date-parts":[[2007,5]]}}}