{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,18]],"date-time":"2026-01-18T07:40:48Z","timestamp":1768722048399,"version":"3.49.0"},"reference-count":27,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2013,1,1]],"date-time":"2013-01-01T00:00:00Z","timestamp":1356998400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clinical Imaging"],"published-print":{"date-parts":[[2013,1]]},"DOI":"10.1016\/j.clinimag.2012.02.017","type":"journal-article","created":{"date-parts":[[2012,6,8]],"date-time":"2012-06-08T08:46:59Z","timestamp":1339145219000},"page":"104-110","source":"Crossref","is-referenced-by-count":18,"title":["Attenuation of hepatic fibrosis through ultrasound-microbubble-mediated HGF gene transfer in rats"],"prefix":"10.1016","volume":"37","author":[{"given":"Zhen-zhen","family":"Jiang","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Guo-yuan","family":"Xia","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yong","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Liang","family":"Dong","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ben-zhen","family":"He","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jian-gang","family":"Sun","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.clinimag.2012.02.017_bb0005","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1016\/S0168-8278(02)00429-4","article-title":"Liver fibrosis\u2014from bench to bedside","volume":"38","author":"Friedman","year":"2003","journal-title":"J Hepatol"},{"key":"10.1016\/j.clinimag.2012.02.017_bb0010","doi-asserted-by":"crossref","first-page":"395","DOI":"10.1053\/jhep.2001.26371","article-title":"A randomized, double-blind trial comparing pegylated interferon alfa-2b to interferon alfa-2b as initial treatment for chronic hepatitis C","volume":"34","author":"Lindsay","year":"2001","journal-title":"Hepatology"},{"key":"10.1016\/j.clinimag.2012.02.017_bb0015","doi-asserted-by":"crossref","first-page":"958","DOI":"10.1016\/S0140-6736(01)06102-5","article-title":"Peginterferon alfa-2b plus ribavirin compared with interferon alfa-2b plus ribavirin for initial treatment of chronic hepatitis C: a randomised trial","volume":"358","author":"Manns","year":"2001","journal-title":"Lancet"},{"key":"10.1016\/j.clinimag.2012.02.017_bb0020","doi-asserted-by":"crossref","first-page":"1426","DOI":"10.1016\/S0140-6736(98)07124-4","volume":"352","author":"Poynard","year":"1998","journal-title":"Lancet"},{"key":"10.1016\/j.clinimag.2012.02.017_bb0025","doi-asserted-by":"crossref","first-page":"1450","DOI":"10.1016\/0006-291X(84)91253-1","article-title":"Partial purification and characterization of hepatocyte growth factor from serum of hepatectomized rats","volume":"122","author":"Nakamura","year":"1984","journal-title":"Biochem Biophys Res Commun"},{"key":"10.1016\/j.clinimag.2012.02.017_bb0030","doi-asserted-by":"crossref","first-page":"639","DOI":"10.1006\/bbrc.1997.7517","article-title":"Hepatocyte growth factor (HGF) as a tissue organizer for organogenesis and regeneration","volume":"239","author":"Matsumoto","year":"1997","journal-title":"Biochem Biophys Res Commun"},{"key":"10.1016\/j.clinimag.2012.02.017_bb0035","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1016\/S0140-6736(95)90279-1","article-title":"Hepatocyte growth factor: a multi functional cytokine","volume":"345","author":"Boros","year":"1995","journal-title":"Lancet"},{"key":"10.1016\/j.clinimag.2012.02.017_bb0040","doi-asserted-by":"crossref","first-page":"6205","DOI":"10.1002\/j.1460-2075.1996.tb01009.x","article-title":"HGF receptor associates with anti-apoptotic protein BAG-1 and prevents cell death","volume":"15","author":"Bardelli","year":"1996","journal-title":"EMBO J"},{"key":"10.1016\/j.clinimag.2012.02.017_bb0045","doi-asserted-by":"crossref","first-page":"4357","DOI":"10.1073\/pnas.91.10.4357","article-title":"Hepatocyte growth factor prevents acute renal failure and accelerates renal regeneration in mice","volume":"91","author":"Kawaida","year":"1994","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1016\/j.clinimag.2012.02.017_bb0050","doi-asserted-by":"crossref","first-page":"226","DOI":"10.1038\/5593","article-title":"Hepatocyte growth factor gene therapy of liver cirrhosis in rats","volume":"5","author":"Ueki","year":"1999","journal-title":"Nat Med"},{"key":"10.1016\/j.clinimag.2012.02.017_bb0055","doi-asserted-by":"crossref","first-page":"374","DOI":"10.1016\/j.surg.2008.04.011","article-title":"Hepatocyte growth factor improves survival after partial hepatectomy in cirrhotic rats suppressing apoptosis of hepatocytes","volume":"144","author":"Nishino","year":"2008","journal-title":"J Surg"},{"key":"10.1016\/j.clinimag.2012.02.017_bb0060","doi-asserted-by":"crossref","first-page":"563","DOI":"10.1016\/j.surg.2005.10.003","article-title":"Combination gene therapy of HGF and truncated type II TGF-beta receptor for rat liver cirrhosis after partial hepatectomy","volume":"139","author":"Ozawa","year":"2006","journal-title":"Surgery"},{"key":"10.1016\/j.clinimag.2012.02.017_bb0065","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1016\/j.jconrel.2008.07.021","article-title":"Effect of hepatocyte growth factor encapsulated in targeted liposomes on liver cirrhosis","volume":"131","author":"Li","year":"2008","journal-title":"J Control Release"},{"key":"10.1016\/j.clinimag.2012.02.017_bb0070","doi-asserted-by":"crossref","first-page":"372","DOI":"10.1038\/sj.gt.3301678","article-title":"Development of safe and efficient novel nonviral gene transfer using ultrasound: enhancement of transfection efficiency of naked plasmid DNA in skeletal muscle","volume":"9","author":"Taniyama","year":"2002","journal-title":"Gene Ther"},{"key":"10.1016\/j.clinimag.2012.02.017_bb0075","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1590\/S0100-879X2010007500132","article-title":"The effect of down-regulation of Smad3 by RNAi on hepatic stellate cells and a carbon tetrachloride-induced rat model of hepatic fibrosis","volume":"44","author":"Wang","year":"2011","journal-title":"Braz J Med Biol Res"},{"key":"10.1016\/j.clinimag.2012.02.017_bb0080","doi-asserted-by":"crossref","first-page":"312","DOI":"10.1016\/j.biopha.2007.10.020","article-title":"Attenuation of hepatic fibrosis through captopril and enalapril in the livers of bile duct ligated rats","volume":"62","author":"Karimian","year":"2008","journal-title":"Biomed Pharmacother"},{"key":"10.1016\/j.clinimag.2012.02.017_bb0085","doi-asserted-by":"crossref","first-page":"3569","DOI":"10.3748\/wjg.14.3569","article-title":"Preventive effect of Qianggan-Rongxian decoction on rat liver fibrosis","volume":"14","author":"Li","year":"2008","journal-title":"World J Gastroenterol"},{"key":"10.1016\/j.clinimag.2012.02.017_bb0090","doi-asserted-by":"crossref","first-page":"4753","DOI":"10.3748\/wjg.15.4753","article-title":"Emodin protects rat liver from CCl4-induced fibrogenesis via inhibition of hepatic stellate cells activation","volume":"15","author":"Dong","year":"2009","journal-title":"World J Gastroenterol"},{"key":"10.1016\/j.clinimag.2012.02.017_bb0095","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1016\/S1386-6346(99)00085-6","article-title":"An assessment of the clinical utility of serum ALT and AST in chronic hepatitis C","volume":"18","author":"Anderson","year":"2000","journal-title":"Hepatol Res"},{"key":"10.1016\/j.clinimag.2012.02.017_bb0100","doi-asserted-by":"crossref","first-page":"1376","DOI":"10.1002\/hep.20717","article-title":"Comparison and validation of simple noninvasive tests for prediction of fibrosis in chronic hepatitis C","volume":"41","author":"Lackner","year":"2005","journal-title":"Hepatology"},{"key":"10.1016\/j.clinimag.2012.02.017_bb0105","doi-asserted-by":"crossref","first-page":"454","DOI":"10.1016\/j.clinimag.2009.07.001","article-title":"The treatment of liver fibrosis induced by hepatocyte growth factor-directed, ultrasound-targeted microbubble destruction in rats","volume":"33","author":"Wang","year":"2009","journal-title":"Clin Imaging"},{"key":"10.1016\/j.clinimag.2012.02.017_bb0110","doi-asserted-by":"crossref","first-page":"395","DOI":"10.1016\/j.clinimag.2004.04.003","article-title":"Ultrasound-mediated microbubble destruction enhances VEGF gene delivery to the infracted myocardium in rats","volume":"28","author":"Zhigang","year":"2004","journal-title":"Clin Imaging"},{"key":"10.1016\/j.clinimag.2012.02.017_bb0115","doi-asserted-by":"crossref","first-page":"1286","DOI":"10.1056\/NEJM199411103311907","article-title":"Transforming growth factor beta in tissue fibrosis","volume":"331","author":"Border","year":"1994","journal-title":"N Engl J Med"},{"key":"10.1016\/j.clinimag.2012.02.017_bb0120","doi-asserted-by":"crossref","first-page":"1017","DOI":"10.1016\/S0002-9440(10)62323-1","article-title":"Growth inhibition and apoptosis in liver myofibroblasts promoted by hepatocyte growth factor leads to resolution from liver cirrhosis","volume":"166","author":"Kim","year":"2005","journal-title":"Am J Pathol"},{"key":"10.1016\/j.clinimag.2012.02.017_bb0125","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1016\/S0168-8278(01)00245-8","article-title":"Hepatocyte growth factor induces collagenase (matrix metalloproteinase-1) via the transcription factor Ets-1 in human hepatic stellate cell line","volume":"36","author":"Ozaki","year":"2002","journal-title":"J Hepatol"},{"key":"10.1016\/j.clinimag.2012.02.017_bb0130","doi-asserted-by":"crossref","first-page":"701","DOI":"10.1073\/pnas.94.2.701","article-title":"Diverse tumorigenesis associated with aberrant development in mice overexpressing hepatocyte growth factor\/scatter factor","volume":"94","author":"Takayama","year":"1997","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1016\/j.clinimag.2012.02.017_bb0135","doi-asserted-by":"crossref","first-page":"268","DOI":"10.1016\/j.canlet.2008.03.064","article-title":"A novel and effective hepatocyte growth factor kringle 1 domain and p53 cocktail viral gene therapy for the treatment of hepatocellular carcinoma","volume":"272","author":"Shen","year":"2008","journal-title":"Cancer Lett"}],"container-title":["Clinical Imaging"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0899707112000952?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0899707112000952?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2019,6,29]],"date-time":"2019-06-29T11:51:49Z","timestamp":1561809109000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0899707112000952"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,1]]},"references-count":27,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2013,1]]}},"alternative-id":["S0899707112000952"],"URL":"https:\/\/doi.org\/10.1016\/j.clinimag.2012.02.017","relation":{},"ISSN":["0899-7071"],"issn-type":[{"value":"0899-7071","type":"print"}],"subject":[],"published":{"date-parts":[[2013,1]]}}}