{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,10]],"date-time":"2026-11-10T01:26:16Z","timestamp":1794273976403,"version":"4.9.0"},"reference-count":16,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2024,3,1]],"date-time":"2024-03-01T00:00:00Z","timestamp":1709251200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,3,1]],"date-time":"2024-03-01T00:00:00Z","timestamp":1709251200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,4,3]],"date-time":"2024-04-03T00:00:00Z","timestamp":1712102400000},"content-version":"vor","delay-in-days":33,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100000265","name":"MRC","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000265","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Clinical Medicine"],"published-print":{"date-parts":[[2024,3]]},"DOI":"10.1016\/j.clinme.2024.100200","type":"journal-article","created":{"date-parts":[[2024,4,6]],"date-time":"2024-04-06T17:46:59Z","timestamp":1712425619000},"page":"100200","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":14,"title":["Huntington's disease: A clinical primer for acute and general physicians"],"prefix":"10.1016","volume":"24","author":[{"given":"Thomas H.","family":"Massey","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Duncan J.","family":"McLauchlan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.clinme.2024.100200_bib0001","doi-asserted-by":"crossref","first-page":"15005","DOI":"10.1038\/nrdp.2015.5","article-title":"Huntington disease","volume":"1","author":"Bates","year":"2015","journal-title":"Nat Rev Dis Primers"},{"key":"10.1016\/j.clinme.2024.100200_bib0002","doi-asserted-by":"crossref","first-page":"77","DOI":"10.3233\/JHD-170270","article-title":"Age at death and causes of death in patients with huntington disease in Norway in 1986-2015","volume":"7","author":"Solberg","year":"2018","journal-title":"J Huntingtons Dis"},{"key":"10.1016\/j.clinme.2024.100200_bib0003","doi-asserted-by":"crossref","first-page":"1156","DOI":"10.1136\/jnnp-2012-304636","article-title":"Prevalence of adult Huntington's disease in the UK based on diagnoses recorded in general practice records","volume":"84","author":"Evans","year":"2013","journal-title":"J Neurol Neurosurg Psychiatry"},{"key":"10.1016\/j.clinme.2024.100200_bib0004","doi-asserted-by":"crossref","first-page":"971","DOI":"10.1016\/0092-8674(93)90585-E","article-title":"A novel gene containing a trinucleotide repeat that is expanded and unstable on Huntington's disease chromosomes. The Huntington's disease collaborative research group","volume":"72","year":"1993","journal-title":"Cell"},{"key":"10.1016\/j.clinme.2024.100200_bib0005","doi-asserted-by":"crossref","first-page":"e2395","DOI":"10.1212\/WNL.0000000000011893","article-title":"Timing and impact of psychiatric, cognitive, and motor abnormalities in huntington disease","volume":"96","author":"McAllister","year":"2021","journal-title":"Neurology"},{"key":"10.1016\/j.clinme.2024.100200_bib0006","doi-asserted-by":"crossref","first-page":"171","DOI":"10.3233\/JHD-180339","article-title":"Clinical presentation and features of juvenile-onset Huntington's disease: a systematic review","volume":"8","author":"Cronin","year":"2019","journal-title":"J Huntingtons Dis"},{"key":"10.1016\/j.clinme.2024.100200_bib0007","doi-asserted-by":"crossref","first-page":"1515","DOI":"10.1038\/ejhg.2016.81","article-title":"22 Years of predictive testing for Huntington's disease: the experience of the UK Huntington's Prediction Consortium","volume":"24","author":"Baig","year":"2016","journal-title":"Eur J Hum Genet"},{"key":"10.1016\/j.clinme.2024.100200_bib0008","doi-asserted-by":"crossref","DOI":"10.3390\/ijerph18105113","article-title":"Genetic and environmental contributors to neurodegeneration: an exploration of the effects of alcohol on clinical features of Huntington's disease using the enroll-HD global platform","volume":"18","author":"Symonds","year":"2021","journal-title":"Int J Environ Res Public Health"},{"key":"10.1016\/j.clinme.2024.100200_bib0009","doi-asserted-by":"crossref","first-page":"637","DOI":"10.1016\/S1474-4422(13)70088-7","article-title":"Predictors of phenotypic progression and disease onset in premanifest and early-stage Huntington's disease in the TRACK-HD study: analysis of 36-month observational data","volume":"12","author":"Tabrizi","year":"2013","journal-title":"Lancet Neurol"},{"key":"10.1016\/j.clinme.2024.100200_bib0015","doi-asserted-by":"crossref","first-page":"369","DOI":"10.1097\/00005072-199805000-00001","article-title":"Huntington disease","volume":"57","author":"Vonsattel","year":"1998","journal-title":"J Neuropathol Exp Neurol"},{"key":"10.1016\/j.clinme.2024.100200_bib0010","doi-asserted-by":"crossref","first-page":"710","DOI":"10.3389\/fneur.2019.00710","article-title":"International guidelines for the treatment of Huntington's disease","volume":"10","author":"Bachoud-L\u00e9vi","year":"2019","journal-title":"Front Neurol"},{"key":"10.1016\/j.clinme.2024.100200_bib0011","doi-asserted-by":"crossref","first-page":"366","DOI":"10.1212\/01.wnl.0000198586.85250.13","article-title":"Tetrabenazine as antichorea therapy in Huntington disease: a randomized controlled trial","volume":"66","year":"2006","journal-title":"Neurology"},{"key":"10.1016\/j.clinme.2024.100200_bib0012","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1016\/j.parkreldis.2022.06.013","article-title":"Physical activity and exercise outcomes in Huntington's disease (PACE-HD): results of a 12-month trial-within-cohort feasibility study of a physical activity intervention in people with Huntington's disease","volume":"101","author":"Quinn","year":"2022","journal-title":"Parkinsonism Relat Disord"},{"key":"10.1016\/j.clinme.2024.100200_bib0013","doi-asserted-by":"crossref","first-page":"517","DOI":"10.1212\/CPJ.0000000000001094","article-title":"Effects of percutaneous endoscopic gastrostomy in patients with huntington disease","volume":"11","author":"Frank","year":"2021","journal-title":"Neurol Clin Pract"},{"key":"10.1016\/j.clinme.2024.100200_bib0015a","doi-asserted-by":"crossref","first-page":"100038","DOI":"10.1016\/j.clinme.2024.100038","article-title":"An introduction to neuropalliative care: a growing need","volume":"24","author":"Wiblin","year":"2024","journal-title":"Clin Med"},{"key":"10.1016\/j.clinme.2024.100200_bib0016","doi-asserted-by":"crossref","first-page":"645","DOI":"10.1016\/S1474-4422(22)00121-1","article-title":"Potential disease-modifying therapies for Huntington's disease: lessons learned and future opportunities","volume":"21","author":"Tabrizi","year":"2022","journal-title":"Lancet Neurol"}],"container-title":["Clinical Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1470211824026721?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1470211824026721?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2024,5,8]],"date-time":"2024-05-08T09:12:50Z","timestamp":1715159570000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1470211824026721"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,3]]},"references-count":16,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2024,3]]}},"alternative-id":["S1470211824026721"],"URL":"https:\/\/doi.org\/10.1016\/j.clinme.2024.100200","relation":{},"ISSN":["1470-2118"],"issn-type":[{"value":"1470-2118","type":"print"}],"subject":[],"published":{"date-parts":[[2024,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Huntington's disease: A clinical primer for acute and general physicians","name":"articletitle","label":"Article Title"},{"value":"Clinical Medicine","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.clinme.2024.100200","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 The Authors. Published by Elsevier Ltd on behalf of Royal College of Physicians.","name":"copyright","label":"Copyright"}],"article-number":"100200"}}