{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,3]],"date-time":"2026-08-03T13:16:16Z","timestamp":1785762976413,"version":"3.56.0"},"reference-count":41,"publisher":"Elsevier BV","issue":"4","license":[{"start":{"date-parts":[[2025,7,1]],"date-time":"2025-07-01T00:00:00Z","timestamp":1751328000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,7,1]],"date-time":"2025-07-01T00:00:00Z","timestamp":1751328000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,5,21]],"date-time":"2025-05-21T00:00:00Z","timestamp":1747785600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Clinical Medicine"],"published-print":{"date-parts":[[2025,7]]},"DOI":"10.1016\/j.clinme.2025.100333","type":"journal-article","created":{"date-parts":[[2025,6,16]],"date-time":"2025-06-16T12:27:33Z","timestamp":1750076853000},"page":"100333","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":1,"title":["Fertility treatments in patients with medical conditions"],"prefix":"10.1016","volume":"25","author":[{"ORCID":"https:\/\/orcid.org\/0009-0006-0144-8458","authenticated-orcid":false,"given":"Paramjit","family":"Uppal","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Edward","family":"Coats","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7650-5780","authenticated-orcid":false,"given":"Charlotte","family":"Frise","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.clinme.2025.100333_bib0001","series-title":"Infertility","year":"2024"},{"issue":"5","key":"10.1016\/j.clinme.2025.100333_bib0002","doi-asserted-by":"crossref","first-page":"1144","DOI":"10.1093\/humrep\/deh870","article-title":"Definition and prevalence of subfertility and infertility","volume":"20","author":"Gnoth","year":"2005","journal-title":"Human Reproduct"},{"issue":"9","key":"10.1016\/j.clinme.2025.100333_bib0003","doi-asserted-by":"crossref","first-page":"2063","DOI":"10.1007\/s10815-023-02888-8","article-title":"Dual trigger improves the pregnancy rate in fresh in vitro fertilization (IVF) cycles compared with the human chorionic gonadotropin (hCG) trigger: a systematic review and meta-analysis of randomized trials","volume":"40","author":"Hsia","year":"2023","journal-title":"J Assist Reprod Genet"},{"issue":"1","key":"10.1016\/j.clinme.2025.100333_bib0004","doi-asserted-by":"crossref","first-page":"4456","DOI":"10.1038\/s41598-022-08400-z","article-title":"Conventional GnRH antagonist protocols versus long GnRH agonist protocol in IVF\/ICSI cycles of polycystic ovary syndrome women: a systematic review and meta-analysis","volume":"12","author":"Kadoura","year":"2022","journal-title":"Sci Rep"},{"key":"10.1016\/j.clinme.2025.100333_bib0005","doi-asserted-by":"crossref","first-page":"2027","DOI":"10.1007\/s12325-020-01612-7","article-title":"Comparison of the long-acting GnRH agonist follicular protocol with the GnRH antagonist protocol in women undergoing In vitro fertilization: a systematic review and meta-analysis","volume":"38","author":"Yang","year":"2021","journal-title":"Adv Ther"},{"issue":"Supplement_1","key":"10.1016\/j.clinme.2025.100333_bib0006","doi-asserted-by":"crossref","DOI":"10.1093\/humrep\/deac104.009","article-title":"Controlled Ovarian Stimulation (COS) protocols for assisted reproduction: a Cochrane systematic review and network meta-analysis","volume":"37","author":"Melo","year":"2022","journal-title":"Hum Reprod"},{"key":"10.1016\/j.clinme.2025.100333_bib0007","article-title":"Live birth rate of gonadotropin-releasing hormone antagonist versus luteal phase gonadotropin-releasing hormone agonist protocol in IVF\/ICSI: a systematic review and meta-analysis","volume":"26","author":"Liu","year":"2024"},{"key":"10.1016\/j.clinme.2025.100333_bib0008","first-page":"2593","article-title":"Blockeel C. An OHSS-Free Clinic by segmentation of IVF treatment","volume":"26","author":"Devroey","year":"2011"},{"issue":"3","key":"10.1016\/j.clinme.2025.100333_bib0009","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1111\/tog.12504","article-title":"Complications of assisted reproductive technology treatment and the factors influencing reproductive outcome","volume":"20","author":"Bhandari","year":"2018","journal-title":"Obstetric Gynaecol"},{"key":"10.1016\/j.clinme.2025.100333_bib0010","series-title":"Cleavage-stage versus blastocyst-stage embryo transfer in assisted reproductive technology. 2022, Cochrane Database of Systematic Reviews","author":"Glujovsky","year":"2022"},{"key":"10.1016\/j.clinme.2025.100333_bib0011","unstructured":"Human Fertilisation & Embryology Authority. Embryo Freezing. [cited 14 Aug 2024]. Available from: https:\/\/www.hfea.gov.uk\/treatments\/fertility-preservation\/embryo-freezing\/."},{"issue":"3","key":"10.1016\/j.clinme.2025.100333_bib0012","doi-asserted-by":"crossref","first-page":"586","DOI":"10.1093\/humrep\/deab267","article-title":"Pre-eclampsia in pregnancies resulting from oocyte donation, natural conception or IVF: a systematic review and meta-analysis","volume":"37","author":"Keukens","year":"2022","journal-title":"Human Reproduct"},{"key":"10.1016\/j.clinme.2025.100333_bib0013","unstructured":"Genetic Alliance UK. Pre-implantation genetic testing [Internet]. [cited 14 Aug 2024]. Available from: https:\/\/geneticalliance.org.uk\/preimplantation-genetic-testing\/."},{"key":"10.1016\/j.clinme.2025.100333_bib0014","unstructured":"Human Fertilisation & Embryology Authority. Pre-implantation genetic testing for monogenic disorders (PGT-M) and Pre-implantation genetic testing for chromosomal structural rearrangements (PGT-SR) [Internet]. [cited 14 Aug 2024]. Available from: https:\/\/www.hfea.gov.uk\/treatments\/embryo-testing-and-treatments-for-disease\/pre-implantation-genetic-testing-for-monogenic-disorders-pgt-m-and-pre-implantation-genetic-testing-for-chromosomal-structural-rearrangements-pgt-sr\/."},{"key":"10.1016\/j.clinme.2025.100333_bib0015","unstructured":"Human Fertilisation & Embryology Authority. Pre-implantation genetic testing for aneuploidy (PGT-A). [cited 14 Aug 2024]. available from: https:\/\/www.hfea.gov.uk\/treatments\/treatment-add-ons\/pre-implantation-genetic-testing-for-aneuploidy-pgt-a\/."},{"key":"10.1016\/j.clinme.2025.100333_bib0016","series-title":"Fertility problems: Assessment and Treatment Clinical guideline","year":"2013"},{"key":"10.1016\/j.clinme.2025.100333_bib0017","first-page":"81","article-title":"Pregnancy outcomes following oocyte donation","volume":"70","author":"Berntsen","year":"2021"},{"issue":"SUPPL. 3","key":"10.1016\/j.clinme.2025.100333_bib0018","doi-asserted-by":"crossref","first-page":"S8","DOI":"10.1016\/S0049-3848(09)70127-6","article-title":"Prophylaxis of VTE in women - during assisted reproductive techniques","volume":"123","author":"Nelson","year":"2009","journal-title":"Thromb Res"},{"issue":"3","key":"10.1016\/j.clinme.2025.100333_bib0019","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1111\/tog.12504","article-title":"Complications of assisted reproductive technology treatment and the factors influencing reproductive outcome","volume":"20","author":"Bhandari","year":"2018","journal-title":"Obstetric Gynaecol"},{"issue":"3","key":"10.1016\/j.clinme.2025.100333_bib0020","first-page":"248","article-title":"Ovarian Hyperstimulation Syndrome: A narrative review of its pathophysiology, risk factors, prevention, Classification, and management","volume":"43","author":"Namavar Jahromi","year":"2018","journal-title":"Iran J Med Sci"},{"key":"10.1016\/j.clinme.2025.100333_bib0021","article-title":"Fresh versus frozen embryo transfers in assisted reproduction","volume":"2021","author":"Zaat","year":"2021"},{"issue":"4","key":"10.1016\/j.clinme.2025.100333_bib0022","first-page":"806","article-title":"Maternal cardiac function in twin pregnancy","volume":"102","author":"Kametas","year":"2003","journal-title":"Obstetr Gynecol"},{"issue":"11","key":"10.1016\/j.clinme.2025.100333_bib0023","doi-asserted-by":"crossref","first-page":"1254","DOI":"10.1161\/CIRCULATIONAHA.113.003904","article-title":"Chronic hypertension in pregnancy","volume":"129","author":"Seely","year":"2014","journal-title":"Circulation"},{"issue":"9","key":"10.1016\/j.clinme.2025.100333_bib0024","article-title":"Spontaneous coronary artery dissection associated with infertility treatment","volume":"14","author":"Iyasere","year":"2022","journal-title":"Cureus"},{"key":"10.1016\/j.clinme.2025.100333_bib0025","author":"Knight"},{"key":"10.1016\/j.clinme.2025.100333_bib0026","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1016\/j.ejogrb.2020.01.033","article-title":"Acute cardiovascular changes in women undergoing in vitro fertilisation (IVF), a systematic review and meta-analysis","volume":"248","author":"Fujitake","year":"2020","journal-title":"Eur J Obstetr Gynecol Reproduct Biol"},{"key":"10.1016\/j.clinme.2025.100333_bib0027","doi-asserted-by":"crossref","first-page":"1959","DOI":"10.1016\/j.cjca.2021.09.002","article-title":"Infertility, Infertility treatment, and cardiovascular disease: an overview","volume":"37","author":"Smith","year":"2021","journal-title":"Cndn J Cardiol"},{"key":"10.1016\/j.clinme.2025.100333_bib0028","doi-asserted-by":"crossref","first-page":"3165","DOI":"10.1093\/eurheartj\/ehy340","article-title":"2018 ESC Guidelines for the management of cardiovascular diseases during pregnancy","volume":"39","author":"Regitz-Zagrosek","year":"2018","journal-title":"Eur Heart J"},{"key":"10.1016\/j.clinme.2025.100333_bib0029","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1111\/joim.13136","article-title":"Cardiovascular problems associated with IVF therapy","volume":"289","author":"Henriksson","year":"2021","journal-title":"J Intern Med"},{"key":"10.1016\/j.clinme.2025.100333_bib0030","doi-asserted-by":"crossref","first-page":"1","DOI":"10.5402\/2011\/928592","article-title":"Evaluating the Association between assisted Conception and the severity of preeclampsia","volume":"2011","author":"Calhoun","year":"2011","journal-title":"ISRN Obstet Gynecol"},{"key":"10.1016\/j.clinme.2025.100333_bib0031","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1186\/s12884-019-2291-x","article-title":"Assisted reproductive technology and the risk of preeclampsia: an updated systematic review and meta-analysis","volume":"19","author":"Almasi-Hashiani","year":"2019","journal-title":"BMC Pregnancy Childbirth"},{"issue":"3","key":"10.1016\/j.clinme.2025.100333_bib0032","doi-asserted-by":"crossref","first-page":"586","DOI":"10.1093\/humrep\/deab267","article-title":"Pre-eclampsia in pregnancies resulting from oocyte donation, natural conception or IVF: A systematic review and meta-analysis","volume":"37","author":"Keukens","year":"2022","journal-title":"Human Reproduct"},{"issue":"3","key":"10.1016\/j.clinme.2025.100333_bib0033","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1055\/s-0042-1760255","article-title":"Venous thromboembolism associated with assisted reproductive technology: a systematic review and meta-analysis","volume":"123","author":"Goualou","year":"2023","journal-title":"Thromb Haemost"},{"key":"10.1016\/j.clinme.2025.100333_bib0034","doi-asserted-by":"crossref","first-page":"193","DOI":"10.4103\/jhrs.JHRS_58_17","article-title":"Assisted reproductive techniques in a patient with history of venous thromboembolism: a case report and review of literature","volume":"11","author":"Gurunath","year":"2018","journal-title":"J Hum Reprod Sci"},{"key":"10.1016\/j.clinme.2025.100333_bib0035","doi-asserted-by":"crossref","first-page":"1045","DOI":"10.1111\/aogs.13147","article-title":"Thromboembolism and in vitro fertilization \u2013 a systematic review","volume":"96","author":"Sennstr\u00f6m","year":"2017","journal-title":"Acta Obstet Gynecol Scand"},{"key":"10.1016\/j.clinme.2025.100333_bib0036","article-title":"Status of the coagulation and fibrinolytic systems hyperstimulation syndrome","volume":"66","author":"Kodama","year":"1996"},{"issue":"8","key":"10.1016\/j.clinme.2025.100333_bib0037","doi-asserted-by":"crossref","first-page":"1965","DOI":"10.1111\/jth.14840","article-title":"Incidence of pulmonary and venous thromboembolism in pregnancies after in vitro fertilization with fresh respectively frozen-thawed embryo transfer: nationwide cohort study","volume":"18","author":"Olausson","year":"2020","journal-title":"J Thrombos Haemostas"},{"issue":"4","key":"10.1016\/j.clinme.2025.100333_bib0039","doi-asserted-by":"crossref","first-page":"330","DOI":"10.1055\/s-0042-1758062","article-title":"The ART of thromboprophylaxis in the prevention of gestational venous thromboembolism","volume":"49","author":"Grandone","year":"2023","journal-title":"Semin Thromb Hemost"},{"issue":"5","key":"10.1016\/j.clinme.2025.100333_bib0040","doi-asserted-by":"crossref","first-page":"1239","DOI":"10.1007\/s40620-023-01670-4","article-title":"Chronic kidney disease, female infertility, and medically assisted reproduction: a best practice position statement by the Kidney and Pregnancy Group of the Italian Society of Nephrology","volume":"36","author":"Attini","year":"2023","journal-title":"J Nephrol"},{"key":"10.1016\/j.clinme.2025.100333_bib0041","doi-asserted-by":"crossref","first-page":"2227","DOI":"10.1007\/s40620-022-01510-x","article-title":"Systematic review of pregnancy and renal outcomes for women with chronic kidney disease receiving assisted reproductive therapy","volume":"35","author":"Bhaduri","year":"2022","journal-title":"J Nephrol"},{"issue":"4","key":"10.1016\/j.clinme.2025.100333_bib0042","doi-asserted-by":"crossref","first-page":"1089","DOI":"10.1016\/j.transproceed.2019.01.105","article-title":"Vitro fertilization after renal transplantation: a single-center experience","volume":"51","author":"Yaprak","year":"2019","journal-title":"Transplant Proc."}],"container-title":["Clinical Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S147021182500051X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S147021182500051X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,8,8]],"date-time":"2025-08-08T05:41:14Z","timestamp":1754631674000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S147021182500051X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,7]]},"references-count":41,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2025,7]]}},"alternative-id":["S147021182500051X"],"URL":"https:\/\/doi.org\/10.1016\/j.clinme.2025.100333","relation":{},"ISSN":["1470-2118"],"issn-type":[{"value":"1470-2118","type":"print"}],"subject":[],"published":{"date-parts":[[2025,7]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Fertility treatments in patients with medical conditions","name":"articletitle","label":"Article Title"},{"value":"Clinical Medicine","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.clinme.2025.100333","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 The Author(s). Published by Elsevier Ltd on behalf of Royal College of Physicians.","name":"copyright","label":"Copyright"}],"article-number":"100333"}}