{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,13]],"date-time":"2026-03-13T02:38:28Z","timestamp":1773369508301,"version":"3.50.1"},"reference-count":63,"publisher":"Elsevier BV","issue":"5","license":[{"start":{"date-parts":[[2025,9,1]],"date-time":"2025-09-01T00:00:00Z","timestamp":1756684800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,9,1]],"date-time":"2025-09-01T00:00:00Z","timestamp":1756684800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,7,9]],"date-time":"2025-07-09T00:00:00Z","timestamp":1752019200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Clinical Medicine"],"published-print":{"date-parts":[[2025,9]]},"DOI":"10.1016\/j.clinme.2025.100488","type":"journal-article","created":{"date-parts":[[2025,7,29]],"date-time":"2025-07-29T23:40:36Z","timestamp":1753832436000},"page":"100488","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":1,"title":["Pituitary disorders in pregnancy"],"prefix":"10.1016","volume":"25","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4745-9922","authenticated-orcid":false,"given":"Darran Mc","family":"Donald","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2562-5210","authenticated-orcid":false,"given":"Maria","family":"Tomkins","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9108-9105","authenticated-orcid":false,"given":"Michael W.","family":"O\u2019Reilly","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mark","family":"Sherlock","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"issue":"6","key":"10.1016\/j.clinme.2025.100488_bib0001","doi-asserted-by":"crossref","first-page":"897","DOI":"10.1016\/j.beem.2011.07.006","article-title":"Pregnancy and other pituitary disorders (including GH deficiency)","volume":"25","author":"Karaca","year":"2011","journal-title":"Best Pract Res Clin Endocrinol Metab"},{"issue":"3","key":"10.1016\/j.clinme.2025.100488_bib0002","doi-asserted-by":"crossref","first-page":"e53","DOI":"10.1210\/clinem\/dgz112","article-title":"Fertility and pregnancy in women with hypopituitarism: a systematic literature review","volume":"105","author":"Vila","year":"2019","journal-title":"J Clin Endocrinol Metabol"},{"issue":"1","key":"10.1016\/j.clinme.2025.100488_bib0003","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1111\/j.1365-2265.2006.02550.x","article-title":"Fertility outcomes in women with hypopituitarism","volume":"65","author":"Hall","year":"2006","journal-title":"Clin Endocrinol (Oxf)"},{"issue":"4","key":"10.1016\/j.clinme.2025.100488_bib0004","doi-asserted-by":"crossref","first-page":"365","DOI":"10.1055\/a-0794-7587","article-title":"Pituitary disease in pregnancy: special aspects of diagnosis and treatment?","volume":"79","author":"Petersenn","year":"2019","journal-title":"Geburtshilfe Frauenheilkd"},{"issue":"3","key":"10.1016\/j.clinme.2025.100488_bib0005","doi-asserted-by":"crossref","first-page":"453","DOI":"10.1530\/EJE-09-0923","article-title":"Pregnancy and pituitary disorders","volume":"162","author":"Karaca","year":"2010","journal-title":"Eur J Endocrinol"},{"issue":"6","key":"10.1016\/j.clinme.2025.100488_bib0006","doi-asserted-by":"crossref","first-page":"735","DOI":"10.1046\/j.1365-2265.2001.01406.x","article-title":"Prevalence and incidence of hypopituitarism in an adult Caucasian population in northwestern Spain","volume":"55","author":"Regal","year":"2001","journal-title":"Clin Endocrinol (Oxf)"},{"issue":"3","key":"10.1016\/j.clinme.2025.100488_bib0007","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1210\/er.2009-0033","article-title":"Mortality in patients with pituitary disease","volume":"31","author":"Sherlock","year":"2010","journal-title":"Endocr Rev"},{"issue":"12","key":"10.1016\/j.clinme.2025.100488_bib0008","doi-asserted-by":"crossref","first-page":"4769","DOI":"10.1210\/jc.2006-1668","article-title":"High prevalence of pituitary adenomas: a cross-sectional study in the province of Liege, Belgium","volume":"91","author":"Daly","year":"2006","journal-title":"J Clin Endocrinol Metab"},{"issue":"6","key":"10.1016\/j.clinme.2025.100488_bib0009","doi-asserted-by":"crossref","first-page":"683","DOI":"10.1111\/cen.15216","article-title":"Systematic review and meta-analysis on the prevalence of radiotherapy-induced hypopituitarism in adults with primary non-pituitary brain tumours","volume":"102","author":"Donald","year":"2025","journal-title":"Clin Endocrinol (Oxf)"},{"issue":"3","key":"10.1016\/j.clinme.2025.100488_bib0010","doi-asserted-by":"crossref","first-page":"1020","DOI":"10.1210\/clinem\/dgz022","article-title":"Opioids and their endocrine effects: a systematic review and meta-analysis","volume":"105","author":"de Vries","year":"2020","journal-title":"J Clin Endocrinol Metab"},{"issue":"3","key":"10.1016\/j.clinme.2025.100488_bib0011","doi-asserted-by":"crossref","DOI":"10.1210\/clinem\/dgz112","article-title":"Fertility and pregnancy in women with hypopituitarism: a systematic literature review","volume":"105","author":"Vila","year":"2020","journal-title":"J Clin Endocrinol Metab"},{"issue":"3","key":"10.1016\/j.clinme.2025.100488_bib0012","doi-asserted-by":"crossref","first-page":"467","DOI":"10.1007\/s11154-023-09863-9","article-title":"Fertility issues in hypopituitarism","volume":"25","author":"Chen","year":"2024","journal-title":"Rev Endocr Metab Disord"},{"issue":"6","key":"10.1016\/j.clinme.2025.100488_bib0013","doi-asserted-by":"crossref","first-page":"1464","DOI":"10.1093\/humrep\/17.6.1464","article-title":"High risk pregnancies in hypopituitary women","volume":"17","author":"Overton","year":"2002","journal-title":"Hum Reprod"},{"issue":"10","key":"10.1016\/j.clinme.2025.100488_bib0014","doi-asserted-by":"crossref","first-page":"1322","DOI":"10.1210\/js.2017-00005","article-title":"Successful pregnancies after adequate hormonal replacement in patients with combined pituitary hormone deficiencies","volume":"1","author":"Correa","year":"2017","journal-title":"J Endocr Soc"},{"issue":"5","key":"10.1016\/j.clinme.2025.100488_bib0015","doi-asserted-by":"crossref","first-page":"1210","DOI":"10.1016\/j.fertnstert.2015.07.1132","article-title":"Pregnancy outcomes in women with growth hormone deficiency","volume":"104","author":"Vila","year":"2015","journal-title":"Fertil Steril"},{"issue":"2","key":"10.1016\/j.clinme.2025.100488_bib0016","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1007\/s11102-021-01196-7","article-title":"Hypopituitarism and pregnancy: clinical characteristics, management and pregnancy outcome","volume":"25","author":"Aulinas","year":"2022","journal-title":"Pituitary"},{"issue":"1","key":"10.1016\/j.clinme.2025.100488_bib0017","doi-asserted-by":"crossref","first-page":"R10","DOI":"10.1093\/ejendo\/lvae005","article-title":"Extensive expertise in endocrinology: adrenal crisis in assisted reproduction and pregnancy","volume":"190","author":"Feldt-Rasmussen","year":"2024","journal-title":"Eur J Endocrinol"},{"issue":"11","key":"10.1016\/j.clinme.2025.100488_bib0018","doi-asserted-by":"crossref","first-page":"3888","DOI":"10.1210\/jc.2016-2118","article-title":"Hormonal replacement in hypopituitarism in adults: an Endocrine Society clinical practice guideline","volume":"101","author":"Fleseriu","year":"2016","journal-title":"J Clin Endocrinol Metabol"},{"issue":"3","key":"10.1016\/j.clinme.2025.100488_bib0019","doi-asserted-by":"crossref","first-page":"G1","DOI":"10.1530\/EJE-21-0462","article-title":"ESE Clinical Practice Guideline on functioning and nonfunctioning pituitary adenomas in pregnancy","volume":"185","author":"Luger","year":"2021","journal-title":"Eur J Endocrinol"},{"issue":"4","key":"10.1016\/j.clinme.2025.100488_bib0020","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1038\/s41574-023-00929-x","article-title":"Iatrogenic adrenal insufficiency in adults","volume":"20","author":"Martin-Grace","year":"2024","journal-title":"Nat Rev Endocrinol"},{"issue":"3","key":"10.1016\/j.clinme.2025.100488_bib0021","first-page":"184","article-title":"Update on adrenal insufficiency: diagnosis and management in pregnancy. Current Opinion in endocrinology","volume":"24","author":"Langlois","year":"2017","journal-title":"Diabetes Obes"},{"issue":"5","key":"10.1016\/j.clinme.2025.100488_bib0022","doi-asserted-by":"crossref","first-page":"654","DOI":"10.1111\/anae.14963","article-title":"Guidelines for the management of glucocorticoids during the peri-operative period for patients with adrenal insufficiency: guidelines from the Association of Anaesthetists, the Royal College of Physicians and the Society for Endocrinology UK","volume":"75","author":"Woodcock","year":"2020","journal-title":"Anaesthesia"},{"issue":"2","key":"10.1016\/j.clinme.2025.100488_bib0023","doi-asserted-by":"crossref","first-page":"R45","DOI":"10.1530\/EJE-17-0975","article-title":"Management of endocrine disease: fertility, pregnancy and lactation in women with adrenal insufficiency","volume":"178","author":"Anand","year":"2018","journal-title":"Eur J Endocrinol"},{"issue":"5","key":"10.1016\/j.clinme.2025.100488_bib0024","doi-asserted-by":"crossref","first-page":"560","DOI":"10.1111\/j.1365-2265.2005.02382.x","article-title":"Maternal hypothyroidism in early and late gestation: effects on neonatal and obstetric outcome","volume":"63","author":"Idris","year":"2005","journal-title":"Clin Endocrinol (Oxf)"},{"issue":"1","key":"10.1016\/j.clinme.2025.100488_bib0025","doi-asserted-by":"crossref","first-page":"9","DOI":"10.3109\/09513590.2015.1104296","article-title":"The impact of maternal hypothyroidism during pregnancy on neonatal outcomes: a systematic review and meta-analysis","volume":"32","author":"Hou","year":"2016","journal-title":"Gynecol Endocrinol"},{"issue":"8","key":"10.1016\/j.clinme.2025.100488_bib0026","doi-asserted-by":"crossref","first-page":"549","DOI":"10.1056\/NEJM199908193410801","article-title":"Maternal thyroid deficiency during pregnancy and subsequent neuropsychological development of the child","volume":"341","author":"Haddow","year":"1999","journal-title":"N Engl J Med"},{"issue":"3","key":"10.1016\/j.clinme.2025.100488_bib0027","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1089\/thy.2016.0457","article-title":"2017 Guidelines of the American Thyroid Association for the Diagnosis and management of Thyroid disease during pregnancy and the postpartum","volume":"27","author":"Alexander","year":"2017","journal-title":"Thyroid"},{"issue":"11","key":"10.1016\/j.clinme.2025.100488_bib0028","doi-asserted-by":"crossref","first-page":"3888","DOI":"10.1210\/jc.2016-2118","article-title":"Hormonal replacement in hypopituitarism in adults: an Endocrine Society clinical practice guideline","volume":"101","author":"Fleseriu","year":"2016","journal-title":"J Clin Endocrinol Metab"},{"issue":"4","key":"10.1016\/j.clinme.2025.100488_bib0029","doi-asserted-by":"crossref","first-page":"611","DOI":"10.1007\/s11102-021-01138-3","article-title":"Pregnancy outcomes in women receiving growth hormone replacement therapy enrolled in the NordiNet\u00ae International Outcome Study (IOS) and the American Norditropin\u00ae Studies: Web-Enabled Research (ANSWER) Program","volume":"24","author":"Biller","year":"2021","journal-title":"Pituitary"},{"issue":"6","key":"10.1016\/j.clinme.2025.100488_bib0030","doi-asserted-by":"crossref","first-page":"743","DOI":"10.1046\/j.1365-2265.2003.01916.x","article-title":"Acquired prolactin deficiency indicates severe hypopituitarism in patients with disease of the hypothalamic-pituitary axis","volume":"59","author":"Mukherjee","year":"2003","journal-title":"Clin Endocrinol (Oxf)"},{"issue":"2","key":"10.1016\/j.clinme.2025.100488_bib0031","doi-asserted-by":"crossref","first-page":"e359","DOI":"10.1542\/peds.2010-1627","article-title":"Effects of recombinant human prolactin on breast milk composition","volume":"127","author":"Powe","year":"2011","journal-title":"Pediatrics"},{"issue":"10","key":"10.1016\/j.clinme.2025.100488_bib0032","doi-asserted-by":"crossref","first-page":"2701","DOI":"10.1210\/clinem\/dgac381","article-title":"Diagnosis and management of Central diabetes Insipidus in adults","volume":"107","author":"Tomkins","year":"2022","journal-title":"J Clin Endocrinol Metab"},{"issue":"8","key":"10.1016\/j.clinme.2025.100488_bib0033","doi-asserted-by":"crossref","first-page":"487","DOI":"10.1038\/s41574-024-00985-x","article-title":"Arginine vasopressin deficiency: diagnosis, management and the relevance of oxytocin deficiency","volume":"20","author":"Atila","year":"2024","journal-title":"Nat Rev Endocrinol"},{"issue":"10","key":"10.1016\/j.clinme.2025.100488_bib0034","doi-asserted-by":"crossref","first-page":"650","DOI":"10.1097\/00006254-200010000-00025","article-title":"Mechanism of parturition and preterm labor","volume":"55","author":"Challis","year":"2000","journal-title":"Obstet Gynecol Surv"},{"key":"10.1016\/j.clinme.2025.100488_bib0035","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1016\/j.ejogrb.2015.11.028","article-title":"Questioning the role of pituitary oxytocin in parturition: spontaneous onset of labor in women with panhypopituitarism \u2013 a case series","volume":"197","author":"Shinar","year":"2016","journal-title":"Eur J Obstet Gynecol Reprod Biol"},{"issue":"3","key":"10.1016\/j.clinme.2025.100488_bib0036","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1177\/1088868310363594","article-title":"Oxytocin and human social behavior","volume":"14","author":"Campbell","year":"2010","journal-title":"Pers Soc Psychol Rev"},{"issue":"8","key":"10.1016\/j.clinme.2025.100488_bib0037","doi-asserted-by":"crossref","first-page":"995","DOI":"10.1515\/jpem-2015-0445","article-title":"Parent observed neuro-behavioral and pro-social improvements with oxytocin following surgical resection of craniopharyngioma","volume":"29","author":"Cook","year":"2016","journal-title":"J Pediatr Endocrinol Metab"},{"issue":"8","key":"10.1016\/j.clinme.2025.100488_bib0038","doi-asserted-by":"crossref","first-page":"2729","DOI":"10.1210\/jc.2009-0177","article-title":"Estimated age and sex-specific incidence and prevalence of dopamine agonist-treated hyperprolactinemia","volume":"94","author":"Kars","year":"2009","journal-title":"J Clin Endocrinol Metab"},{"issue":"4","key":"10.1016\/j.clinme.2025.100488_bib0039","doi-asserted-by":"crossref","first-page":"200","DOI":"10.1038\/ncpendmet0160","article-title":"Drug insight: cabergoline and bromocriptine in the treatment of hyperprolactinemia in men and women","volume":"2","author":"Colao","year":"2006","journal-title":"Nat Clin Pract Endocrinol Metab"},{"issue":"12","key":"10.1016\/j.clinme.2025.100488_bib0040","doi-asserted-by":"crossref","first-page":"722","DOI":"10.1038\/s41574-023-00886-5","article-title":"Diagnosis and management of prolactin-secreting pituitary adenomas: a Pituitary Society international consensus statement","volume":"19","author":"Petersenn","year":"2023","journal-title":"Nat Rev Endocrinol"},{"issue":"3","key":"10.1016\/j.clinme.2025.100488_bib0041","doi-asserted-by":"crossref","first-page":"569","DOI":"10.1016\/j.ecl.2019.05.004","article-title":"Pituitary tumors in pregnancy","volume":"48","author":"Huang","year":"2019","journal-title":"Endocrinol Metab Clin North Am"},{"issue":"5","key":"10.1016\/j.clinme.2025.100488_bib0042","doi-asserted-by":"crossref","first-page":"R205","DOI":"10.1530\/EJE-14-0848","article-title":"Endocrinology in pregnancy: management of the pregnant patient with a prolactinoma","volume":"172","author":"Molitch","year":"2015","journal-title":"Eur J Endocrinol"},{"issue":"2","key":"10.1016\/j.clinme.2025.100488_bib0043","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1210\/jc.2010-1692","article-title":"Diagnosis and treatment of hyperprolactinemia: an Endocrine Society clinical practice guideline","volume":"96","author":"Melmed","year":"2011","journal-title":"J Clin Endocrinol Metab"},{"issue":"3","key":"10.1016\/j.clinme.2025.100488_bib0044","doi-asserted-by":"crossref","first-page":"325","DOI":"10.1111\/j.1365-2265.1986.tb01698.x","article-title":"Failure of prophylactic surgery to avert massive pituitary expansion in pregnancy","volume":"25","author":"Belchetz","year":"1986","journal-title":"Clin Endocrinol (Oxf)"},{"issue":"1","key":"10.1016\/j.clinme.2025.100488_bib0045","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1007\/s11102-005-5083-4","article-title":"Prolactinomas and pregnancy","volume":"8","author":"Bronstein","year":"2005","journal-title":"Pituitary"},{"issue":"1","key":"10.1016\/j.clinme.2025.100488_bib0046","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1007\/s11102-019-00989-1","article-title":"Dopamine agonists in prolactinomas: when to withdraw?","volume":"23","author":"Souteiro","year":"2020","journal-title":"Pituitary"},{"issue":"5","key":"10.1016\/j.clinme.2025.100488_bib0047","doi-asserted-by":"crossref","first-page":"642","DOI":"10.1111\/cen.12370","article-title":"Outcome of prolactinoma after pregnancy and lactation: a study on 73 patients","volume":"80","author":"Domingue","year":"2014","journal-title":"Clin Endocrinol (Oxf)"},{"issue":"4","key":"10.1016\/j.clinme.2025.100488_bib0048","doi-asserted-by":"crossref","first-page":"1170","DOI":"10.1210\/clinem\/dgab839","article-title":"Outcomes of initial management strategies in patients with autoimmune lymphocytic hypophysitis: a systematic review and meta-analysis","volume":"107","author":"Donegan","year":"2022","journal-title":"J Clin Endocrinol Metab"},{"issue":"2","key":"10.1016\/j.clinme.2025.100488_bib0049","doi-asserted-by":"crossref","DOI":"10.1093\/ejendo\/lvad003","article-title":"Pregnancy-related hypophysitis revisited","volume":"188","author":"Honegger","year":"2023","journal-title":"Eur J Endocrinol"},{"issue":"5","key":"10.1016\/j.clinme.2025.100488_bib0050","doi-asserted-by":"crossref","first-page":"339","DOI":"10.1007\/BF03343733","article-title":"Lymphocytic hypophysitis and autoimmune thyroid disease","volume":"23","author":"Barbaro","year":"2000","journal-title":"J Endocrinol Invest"},{"issue":"4","key":"10.1016\/j.clinme.2025.100488_bib0051","doi-asserted-by":"crossref","first-page":"240","DOI":"10.1097\/00005792-198907000-00006","article-title":"Lymphocytic hypophysitis. Report of 3 new cases and review of the literature","volume":"68","author":"Cosman","year":"1989","journal-title":"Med (Baltimore)"},{"issue":"9356","key":"10.1016\/j.clinme.2025.100488_bib0052","doi-asserted-by":"crossref","first-page":"520","DOI":"10.1016\/S0140-6736(03)12490-7","article-title":"Sheehan syndrome","volume":"361","author":"Kovacs","year":"2003","journal-title":"Lancet"},{"issue":"2","key":"10.1016\/j.clinme.2025.100488_bib0053","doi-asserted-by":"crossref","first-page":"523","DOI":"10.1016\/j.fertnstert.2005.02.022","article-title":"Epidemiologic aspects of postpartum pituitary hypofunction (Sheehan's syndrome)","volume":"84","author":"Zargar","year":"2005","journal-title":"Fertil Steril"},{"issue":"6","key":"10.1016\/j.clinme.2025.100488_bib0054","doi-asserted-by":"crossref","first-page":"622","DOI":"10.1210\/er.2015-1042","volume":"36","author":"Briet","year":"2015","journal-title":"Pituitary Apoplexy Endocr Rev."},{"issue":"2","key":"10.1016\/j.clinme.2025.100488_bib0055","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1210\/jcem-71-2-323","article-title":"Improvement of pituitary function after surgical decompression for pituitary tumor apoplexy","volume":"71","author":"Arafah","year":"1990","journal-title":"J Clin Endocrinol Metab"},{"issue":"6","key":"10.1016\/j.clinme.2025.100488_bib0056","doi-asserted-by":"crossref","first-page":"747","DOI":"10.1111\/j.1365-2265.2004.02162.x","article-title":"Acute management of pituitary apoplexy\u2013surgery or conservative management?","volume":"61","author":"Ayuk","year":"2004","journal-title":"Clin Endocrinol (Oxf)"},{"issue":"2","key":"10.1016\/j.clinme.2025.100488_bib0057","doi-asserted-by":"crossref","first-page":"555","DOI":"10.1007\/s12020-016-1117-0","article-title":"Cushing's syndrome and pregnancy outcomes: a systematic review of published cases","volume":"55","author":"Caimari","year":"2017","journal-title":"Endocrine"},{"issue":"2","key":"10.1016\/j.clinme.2025.100488_bib0058","doi-asserted-by":"crossref","first-page":"R85","DOI":"10.1530\/EJE-14-1130","article-title":"Management of endocrine disease: management of pregnant patients with Cushing's syndrome","volume":"173","author":"Bronstein","year":"2015","journal-title":"Eur J Endocrinol"},{"issue":"9","key":"10.1016\/j.clinme.2025.100488_bib0059","doi-asserted-by":"crossref","first-page":"601","DOI":"10.1056\/NEJM199508313330918","article-title":"Maternal\u2013fetal transfer of octreotide","volume":"333","author":"Caron","year":"1995","journal-title":"N Engl J Med"},{"issue":"10","key":"10.1016\/j.clinme.2025.100488_bib0060","doi-asserted-by":"crossref","first-page":"4680","DOI":"10.1210\/jc.2009-2331","article-title":"Acromegaly and pregnancy: a retrospective multicenter study of 59 pregnancies in 46 women","volume":"95","author":"Caron","year":"2010","journal-title":"J Clin Endocrinol Metab"},{"issue":"4","key":"10.1016\/j.clinme.2025.100488_bib0061","doi-asserted-by":"crossref","first-page":"K21","DOI":"10.1530\/EJE-18-0688","article-title":"Pregnancy in acromegaly is safe and is associated with improvements in IGF-1 concentrations","volume":"180","author":"Hannon","year":"2019","journal-title":"Eur J Endocrinol"},{"issue":"1","key":"10.1016\/j.clinme.2025.100488_bib0062","doi-asserted-by":"crossref","first-page":"R1","DOI":"10.1530\/EJE-16-1059","article-title":"Management of endocrine disease: acromegaly and pregnancy: a contemporary review","volume":"177","author":"Abucham","year":"2017","journal-title":"Eur J Endocrinol"},{"issue":"5","key":"10.1016\/j.clinme.2025.100488_bib0063","doi-asserted-by":"crossref","first-page":"554","DOI":"10.1111\/j.1365-2265.2005.02257.x","article-title":"Ghrelin and its relationship to growth hormones during normal pregnancy","volume":"62","author":"Fuglsang","year":"2005","journal-title":"Clin Endocrinol (Oxf)"}],"container-title":["Clinical Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1470211825002064?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1470211825002064?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,4]],"date-time":"2025-11-04T16:11:30Z","timestamp":1762272690000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1470211825002064"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,9]]},"references-count":63,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2025,9]]}},"alternative-id":["S1470211825002064"],"URL":"https:\/\/doi.org\/10.1016\/j.clinme.2025.100488","relation":{},"ISSN":["1470-2118"],"issn-type":[{"value":"1470-2118","type":"print"}],"subject":[],"published":{"date-parts":[[2025,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Pituitary disorders in pregnancy","name":"articletitle","label":"Article Title"},{"value":"Clinical Medicine","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.clinme.2025.100488","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 Published by Elsevier Ltd on behalf of Royal College of Physicians.","name":"copyright","label":"Copyright"}],"article-number":"100488"}}