{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,30]],"date-time":"2026-10-30T08:36:04Z","timestamp":1793349364653,"version":"4.5.0"},"reference-count":42,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2026,3,1]],"date-time":"2026-03-01T00:00:00Z","timestamp":1772323200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,3,1]],"date-time":"2026-03-01T00:00:00Z","timestamp":1772323200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,12,20]],"date-time":"2025-12-20T00:00:00Z","timestamp":1766188800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Clinical Medicine"],"published-print":{"date-parts":[[2026,3]]},"DOI":"10.1016\/j.clinme.2025.100548","type":"journal-article","created":{"date-parts":[[2026,1,5]],"date-time":"2026-01-05T07:37:33Z","timestamp":1767598653000},"page":"100548","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":3,"title":["Frailty and deconditioning on the acute take"],"prefix":"10.1016","volume":"26","author":[{"given":"Bhagya","family":"Arun","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0008-0745-7691","authenticated-orcid":false,"given":"Siobhan H.M.","family":"Lewis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.clinme.2025.100548_bib0001","doi-asserted-by":"crossref","first-page":"616","DOI":"10.1093\/pubmed\/fdt009","article-title":"Emergency hospital admissions for the elderly: insights from the Devon Predictive Model","volume":"35","author":"Chenore","year":"2013","journal-title":"J Public Health (UK)"},{"key":"10.1016\/j.clinme.2025.100548_bib0002","unstructured":"Royal College of Physicians. Don\u2019t stop moving: optimising safety while staying active in hospital - The 2024 National Audit of Inpatient Falls (NAIF) report on 2023 clincal data. 2024. https:\/\/www.rcp.ac.uk\/media\/igql3dbq\/naif_annual-report-2024.pdf. Accessed 7 October 2025."},{"key":"10.1016\/j.clinme.2025.100548_bib0003","first-page":"6","article-title":"Patient mobilisation: why the risk of falls should not be a barrier","volume":"34","author":"Dean","year":"2022","journal-title":"Nurs Older People"},{"key":"10.1016\/j.clinme.2025.100548_bib0004","unstructured":"National Institute for Health and Care Excellence. Hip fracture: management clinical guideline. 2011 www.nice.org.uk\/guidance\/cg124. Accessed 7 October 2025"},{"key":"10.1016\/j.clinme.2025.100548_bib0005","article-title":"Analgesia for older adults with abdominal or back pain in emergency department","author":"Mills","year":"2011","journal-title":"West J Emerg Med"},{"key":"10.1016\/j.clinme.2025.100548_bib0006","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1016\/j.annemergmed.2011.09.014","article-title":"Older US emergency department patients are less likely to receive pain medication than younger patients: results from a national survey","volume":"60","author":"Platts-Mills","year":"2012","journal-title":"Ann Emerg Med"},{"key":"10.1016\/j.clinme.2025.100548_bib0007","first-page":"53","article-title":"Understanding the association between pain and delirium in older hospital inpatients: systematic review and meta-analysis","author":"White","year":"2024","journal-title":"Age Ageing"},{"key":"10.1016\/j.clinme.2025.100548_bib0008","doi-asserted-by":"crossref","first-page":"351","DOI":"10.1111\/j.1365-2125.2010.03847.x","article-title":"Clinical pharmacology of analgesic medicines in older people: impact of frailty and cognitive impairment","volume":"71","author":"McLachlan","year":"2011","journal-title":"Br J Clin Pharmacol"},{"key":"10.1016\/j.clinme.2025.100548_bib0009","doi-asserted-by":"crossref","first-page":"284","DOI":"10.1016\/j.pnpbp.2019.04.006","article-title":"The silent epidemic of chronic pain in older adults","volume":"93","author":"Domenichiello","year":"2019","journal-title":"Prog Neuropsychopharmacol Biol Psychiatry"},{"key":"10.1016\/j.clinme.2025.100548_bib0010","first-page":"17","article-title":"Delirium is prevalent in older hospital inpatients and associated with adverse outcomes: results of a prospective multi-centre study on World Delirium Awareness Day","author":"Welch","year":"2019","journal-title":"BMC Med"},{"key":"10.1016\/j.clinme.2025.100548_bib0011","doi-asserted-by":"crossref","DOI":"10.1155\/2023\/1562773","article-title":"The Association between Delirium and In-Hospital Falls: a cross-sectional analysis of a delirium screening program","author":"Kalivas","year":"2023","journal-title":"J Aging Res"},{"key":"10.1016\/j.clinme.2025.100548_bib0012","doi-asserted-by":"crossref","DOI":"10.1016\/j.annemergmed.2025.02.003","article-title":"Outcomes of older adults with delirium discharged from the emergency department","author":"Howick","year":"2025","journal-title":"Ann Emerg Med"},{"key":"10.1016\/j.clinme.2025.100548_bib0013","doi-asserted-by":"crossref","first-page":"349","DOI":"10.1016\/j.ajem.2019.158454","article-title":"Recognition, prevention, and treatment of delirium in emergency department: an evidence-based narrative review","volume":"38","author":"Lee","year":"2020","journal-title":"Am J Emerg Med"},{"key":"10.1016\/j.clinme.2025.100548_bib0014","unstructured":"MacLullich A. 4AT User Guide. 2025. https:\/\/www.the4at.com\/userguide. Accessed 24 September 2025."},{"key":"10.1016\/j.clinme.2025.100548_bib0015","doi-asserted-by":"crossref","first-page":"196","DOI":"10.1016\/j.ajic.2003.08.007","article-title":"Inappropriate use of urinary catheters in elderly patients at a midwestern community teaching hospital","volume":"32","author":"Murthy Gokula","year":"2004","journal-title":"Am J Infect Control"},{"key":"10.1016\/j.clinme.2025.100548_bib0016","first-page":"5","article-title":"Absorbent incontinence pad use and the association with urinary tract infection and frailty: a retrospective cohort study","author":"Larsen","year":"2023","journal-title":"Int J Nurs Stud Adv"},{"key":"10.1016\/j.clinme.2025.100548_bib0017","unstructured":"Doshi M. Mouth Care Matters: A guide for hospital healthcare professionals. Health Education England. 2016. https:\/\/www.wyccn.org\/uploads\/6\/5\/1\/9\/65199375\/mcm-guide-2016_100pp_oct-16_v121.pdf. Accessed 7 October 2025."},{"key":"10.1016\/j.clinme.2025.100548_bib0018","first-page":"11","article-title":"Sleep quality and factors influencing self-reported sleep duration and quality in the general internal medicine inpatient population","author":"Dobing","year":"2016","journal-title":"PLoS One"},{"key":"10.1016\/j.clinme.2025.100548_bib0019","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1016\/j.sleep.2023.03.015","article-title":"Sleep loss the night before surgery and incidence of postoperative delirium in adults 65\u201395 years of age","volume":"105","author":"Leung","year":"2023","journal-title":"Sleep Med"},{"key":"10.1016\/j.clinme.2025.100548_bib0020","first-page":"9","article-title":"Circadian actin dynamics drive rhythmic fibroblast mobilization during wound healing","author":"Hoyle","year":"2017","journal-title":"Sci Transl Med"},{"key":"10.1016\/j.clinme.2025.100548_bib0021","doi-asserted-by":"crossref","first-page":"706","DOI":"10.1016\/j.bbi.2012.02.001","article-title":"Fatigue and sleep quality are associated with changes in inflammatory markers in breast cancer patients undergoing chemotherapy","author":"Liu","year":"2012","journal-title":"Brain Behav Immun"},{"key":"10.1016\/j.clinme.2025.100548_bib0022","doi-asserted-by":"crossref","first-page":"395","DOI":"10.5664\/jcsm.2032","article-title":"The impact of quality of sleep on recovery from fast-track abdominal hysterectomy","volume":"8","author":"Kj\u00f8lhede","year":"2012","journal-title":"J Clin Sleep Med"},{"key":"10.1016\/j.clinme.2025.100548_bib0023","first-page":"1667","article-title":"Pain sensitivity and recovery from mild chronic sleep loss","volume":"35","author":"Roehrs","year":"2012","journal-title":"Sleep"},{"key":"10.1016\/j.clinme.2025.100548_bib0024","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1016\/j.jointm.2022.11.002","article-title":"The impact of daylight and window views on length of stay among patients with heart disease: a retrospective study in a cardiac intensive care unit","volume":"3","author":"Jafarifiroozabadi","year":"2023","journal-title":"J Intensive Med"},{"key":"10.1016\/j.clinme.2025.100548_bib0025","doi-asserted-by":"crossref","DOI":"10.1136\/bmjquality.u207447.w4214","article-title":"Low stimulus environments: reducing noise levels in continuing care","volume":"5","author":"Brown","year":"2016","journal-title":"BMJ Qual Improv Rep"},{"key":"10.1016\/j.clinme.2025.100548_bib0026","unstructured":"Buxton P. How to choose flooring that will help rather than hinder dementia patients. RIBA J. 2015. https:\/\/www.ribaj.com\/products\/flooring-for-dementia-patients. Accessed 11 October 2025."},{"key":"10.1016\/j.clinme.2025.100548_bib0027","doi-asserted-by":"crossref","first-page":"1322","DOI":"10.1111\/j.1365-2648.2011.05842.x","article-title":"Cognitive stimulation during hospitalization improves global cognition of older Taiwanese undergoing elective total knee and hip replacement surgery","volume":"68","author":"Cheng","year":"2012","journal-title":"J Adv Nurs"},{"key":"10.1016\/j.clinme.2025.100548_bib0028","unstructured":"Leicester\u2019s Hospitals. Meaningful activities service in Leicester UHL NHS Trust. United Kingdom; 2024 https:\/\/www.youtube.com\/watch?v=HkgKzZWEBpM. Accessed 11 October 2025."},{"key":"10.1016\/j.clinme.2025.100548_bib0029","doi-asserted-by":"crossref","first-page":"6391","DOI":"10.1080\/09638288.2024.2335662","article-title":"Impact of the End PJ Paralysis interventions on patient health outcomes at the participating hospitals in Alberta, Canada","volume":"46","author":"James Wai","year":"2024","journal-title":"Disabil Rehabil"},{"key":"10.1016\/j.clinme.2025.100548_bib0030","unstructured":"British Geriatric Society. \u2018Sit up, get dressed and keep moving!\u2019 2020. https:\/\/www.bgs.org.uk\/%E2%80%98sit-up-get-dressed-and-keep-moving%E2%80%99. Accessed 24 September 2025."},{"key":"10.1016\/j.clinme.2025.100548_bib0031","doi-asserted-by":"crossref","first-page":"877","DOI":"10.2165\/00007256-200333120-00002","article-title":"Rate and mechanism of maximal oxygen consumption decline with aging: implications for exercise training","author":"Hawkins","year":"2003","journal-title":"Sports Med"},{"key":"10.1016\/j.clinme.2025.100548_bib0032","doi-asserted-by":"crossref","DOI":"10.1186\/s13054-022-04253-0","article-title":"The rate and assessment of muscle wasting during critical illness: a systematic review and meta-analysis","author":"Fazzini","year":"2023","journal-title":"Crit Care"},{"key":"10.1016\/j.clinme.2025.100548_bib0033","doi-asserted-by":"crossref","first-page":"449","DOI":"10.1016\/j.gerinurse.2024.12.032","article-title":"Acute muscle loss in elderly hospitalized patients: risk factors and adverse clinical outcomes","volume":"61","author":"Liu","year":"2025","journal-title":"Geriatr Nurs (Minneap)"},{"key":"10.1016\/j.clinme.2025.100548_bib0034","doi-asserted-by":"crossref","first-page":"E275","DOI":"10.7861\/clinmed.2020-1044","article-title":"Orthostatic hypotension in older people: considerations, diagnosis and management","author":"Dani","year":"2021","journal-title":"Clin Med"},{"key":"10.1016\/j.clinme.2025.100548_bib0035","article-title":"The aging lung: microenvironment, mechanisms, and diseases","author":"Wang","year":"2024","journal-title":"Front Immunol"},{"key":"10.1016\/j.clinme.2025.100548_bib0036","first-page":"25","article-title":"Exploring in-hospital mobility practices for geriatric patients: insights from a mixed-method study","author":"Johansen","year":"2025","journal-title":"BMC Geriatr"},{"key":"10.1016\/j.clinme.2025.100548_bib0037","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1016\/j.archger.2016.04.002","article-title":"Risk factors for functional decline in a population aged 75 years and older without total dependence: a one-year follow-up","volume":"65","author":"Arnau","year":"2016","journal-title":"Arch Gerontol Geriatr"},{"key":"10.1016\/j.clinme.2025.100548_bib0038","doi-asserted-by":"crossref","first-page":"27","DOI":"10.47102\/annals-acadmedsg.V35N1p27","article-title":"Factors causing delay in discharge of elderly patients in an acute care hospital","volume":"35","author":"Lim","year":"2006","journal-title":"Ann Acad Med Singap"},{"key":"10.1016\/j.clinme.2025.100548_bib0039","unstructured":"Arora A Recondition the nation. NHS England. 2023. https:\/\/www.england.nhs.uk\/blog\/recondition-the-nation\/. Accessed 11 October 2025."},{"key":"10.1016\/j.clinme.2025.100548_bib0040","doi-asserted-by":"crossref","DOI":"10.1016\/j.apnr.2019.151189","article-title":"How much do hospitalized adults move? A systematic review and meta-analysis","volume":"51","author":"Fazio","year":"2020","journal-title":"Appl Nurs Res"},{"key":"10.1016\/j.clinme.2025.100548_bib0041","doi-asserted-by":"crossref","first-page":"2171","DOI":"10.1111\/j.1532-5415.2008.02023.x","article-title":"Recovery of activities of daily living in older adults after hospitalization for acute medical illness","volume":"56","author":"Boyd","year":"2008","journal-title":"J Am Geriatr Soc"},{"key":"10.1016\/j.clinme.2025.100548_bib0042","unstructured":"British Geriatrics Society. End of life care in frailty: delirium. 2020. https:\/\/www.bgs.org.uk\/end-of-life-care-in-frailty-delirium. Accessed 24 September 2025."}],"container-title":["Clinical Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1470211825002660?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1470211825002660?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,4,13]],"date-time":"2026-04-13T10:36:07Z","timestamp":1776076567000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1470211825002660"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,3]]},"references-count":42,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2026,3]]}},"alternative-id":["S1470211825002660"],"URL":"https:\/\/doi.org\/10.1016\/j.clinme.2025.100548","relation":{},"ISSN":["1470-2118"],"issn-type":[{"value":"1470-2118","type":"print"}],"subject":[],"published":{"date-parts":[[2026,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Frailty and deconditioning on the acute take","name":"articletitle","label":"Article Title"},{"value":"Clinical Medicine","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.clinme.2025.100548","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 The Author(s). Published by Elsevier Ltd on behalf of Royal College of Physicians.","name":"copyright","label":"Copyright"}],"article-number":"100548"}}