{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,21]],"date-time":"2026-10-21T21:46:37Z","timestamp":1792619197526,"version":"4.5.0"},"reference-count":133,"publisher":"Stanford University Press","license":[{"start":{"date-parts":[[2019,9,1]],"date-time":"2019-09-01T00:00:00Z","timestamp":1567296000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2019,9,1]],"date-time":"2019-09-01T00:00:00Z","timestamp":1567296000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2021,9,1]],"date-time":"2021-09-01T00:00:00Z","timestamp":1630454400000},"content-version":"vor","delay-in-days":731,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/501100001665","name":"Agence Nationale de la Recherche","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001665","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Clinical Mass Spectrometry"],"published-print":{"date-parts":[[2019,9]]},"DOI":"10.1016\/j.clinms.2019.06.001","type":"journal-article","created":{"date-parts":[[2019,6,4]],"date-time":"2019-06-04T03:00:12Z","timestamp":1559617212000},"page":"18-30","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":67,"special_numbering":"PA","title":["Metaproteomics of the human gut microbiota: Challenges and contributions to other OMICS"],"prefix":"10.21627","volume":"14","author":[{"given":"Ngom","family":"Issa Isaac","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Decloquement","family":"Philippe","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Armstrong","family":"Nicholas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Didier","family":"Raoult","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chabri\u00e8re","family":"Eric","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"4811","reference":[{"issue":"1","key":"10.1016\/j.clinms.2019.06.001_b0005","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1146\/annurev-genom-090711-163814","article-title":"The human microbiome: our second genome","volume":"13","author":"Grice","year":"2012","journal-title":"Annu. Rev. Genom. Hum. Genet."},{"issue":"7402","key":"10.1016\/j.clinms.2019.06.001_b0010","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1038\/nature11234","article-title":"Structure, function and diversity of the healthy human microbiome","volume":"486","author":"Human Microbiome Project Consortium","year":"2012","journal-title":"Nature"},{"key":"10.1016\/j.clinms.2019.06.001_b0015","doi-asserted-by":"crossref","first-page":"478","DOI":"10.1038\/nri1373","article-title":"Interactions between commensal intestinal bacteria and the immune system","volume":"4","author":"Macpherson","year":"2004","journal-title":"Nat. Rev. Immunol."},{"key":"10.1016\/j.clinms.2019.06.001_b0020","doi-asserted-by":"crossref","first-page":"804","DOI":"10.1038\/nature06244","article-title":"The human microbiome project: exploring the microbial part of ourselves in a changing world","volume":"449","author":"Turnbaugh","year":"2007","journal-title":"Nature"},{"issue":"2","key":"10.1016\/j.clinms.2019.06.001_b0025","doi-asserted-by":"crossref","first-page":"E215","DOI":"10.3390\/nu11020215","article-title":"Dietary advanced glycation end products: digestion, metabolism and modulation of gut microbial ecology","volume":"11","author":"Snelson","year":"2019","journal-title":"Nutrients"},{"issue":"6","key":"10.1016\/j.clinms.2019.06.001_b0030","doi-asserted-by":"crossref","first-page":"807","DOI":"10.4239\/wjd.v6.i6.807","article-title":"Gut-brain connection: the neuroprotective effects of the anti-diabetic drug liraglutide","volume":"6","author":"Candeias","year":"2015","journal-title":"World J. Diabetes"},{"issue":"Suppl 1","key":"10.1016\/j.clinms.2019.06.001_b0035","doi-asserted-by":"crossref","first-page":"S45","DOI":"10.1111\/j.1753-4887.2012.00505.x","article-title":"Role of the intestinal microbiome in health and disease: from correlation to causation","volume":"70","author":"de Vos","year":"2012","journal-title":"Nutr Rev."},{"issue":"1","key":"10.1016\/j.clinms.2019.06.001_b0040","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1111\/j.1462-2920.2012.02845.x","article-title":"Microbiota from the distal guts of lean and obese adolescents exhibit partial functional redundancy besides clear differences in community structure","volume":"15","author":"Ferrer","year":"2013","journal-title":"Environ. Microbiol."},{"issue":"1","key":"10.1016\/j.clinms.2019.06.001_b0045","doi-asserted-by":"crossref","first-page":"3","DOI":"10.3920\/BM2017.0066","article-title":"Our gut microbiota: a long walk to homeostasis","volume":"9","author":"Dicks","year":"2018","journal-title":"Benef Microbes"},{"issue":"1","key":"10.1016\/j.clinms.2019.06.001_b0050","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1186\/s13073-015-0157-z","article-title":"The gut microbiome incardio-metabolic health","volume":"7","author":"Hansen","year":"2015","journal-title":"Genome Med."},{"issue":"5728","key":"10.1016\/j.clinms.2019.06.001_b0055","doi-asserted-by":"crossref","first-page":"1635","DOI":"10.1126\/science.1110591","article-title":"Diversity of the human intestinal microbial flora","volume":"308","author":"Eckburg","year":"2005","journal-title":"Science"},{"issue":"3","key":"10.1016\/j.clinms.2019.06.001_b0060","doi-asserted-by":"crossref","first-page":"148","DOI":"10.1016\/j.gpb.2015.02.005","article-title":"Metagenomic surveys of gut microbiota","volume":"13","author":"Mandal","year":"2015","journal-title":"Genom. Proteom. Bioinform."},{"issue":"7","key":"10.1016\/j.clinms.2019.06.001_b0065","first-page":"459","article-title":"Characterization of the gut microbiome using 16S or shotgun metagenomics","volume":"20","author":"Jovel","year":"2016","journal-title":"Front. Microbiol."},{"issue":"3","key":"10.1016\/j.clinms.2019.06.001_b0070","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0017447","article-title":"Metatranscriptomic approach to analyze the functional human gut microbiota","volume":"6","author":"Gosalbes","year":"2011","journal-title":"PLoS One"},{"issue":"1","key":"10.1016\/j.clinms.2019.06.001_b0075","doi-asserted-by":"crossref","first-page":"16203","DOI":"10.1038\/nmicrobiol.2016.203","article-title":"Culture of previously uncultured members of the human gut microbiota by culturomics","volume":"7","author":"Lagier","year":"2016","journal-title":"Nat. Microbiol."},{"issue":"4","key":"10.1016\/j.clinms.2019.06.001_b0080","doi-asserted-by":"crossref","first-page":"785","DOI":"10.1002\/pmic.200900450","article-title":"Environmental proteomics: analysis of structure and function of microbial communities","volume":"10","author":"Schneider","year":"2010","journal-title":"Proteomics"},{"issue":"5","key":"10.1016\/j.clinms.2019.06.001_b0085","first-page":"4","article-title":"Metaproteomics as a complementary approach to gut microbiota in health and disease","volume":"26","author":"Petriz","year":"2017","journal-title":"Front. Chem."},{"issue":"97","key":"10.1016\/j.clinms.2019.06.001_b0090","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1016\/j.jprot.2013.05.018","article-title":"Metaproteomics of our microbiome \u2013 developing insight in function and activity in man and model systems","volume":"31","author":"Kolmeder","year":"2014","journal-title":"J. Proteomics."},{"issue":"1","key":"10.1016\/j.clinms.2019.06.001_b0095","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1186\/s12929-017-0342-z","article-title":"Metaproteomic analysis of human gutmicrobiota: where are we heading?","volume":"24","author":"Lee","year":"2017","journal-title":"J. Biomed. Sci."},{"issue":"180","key":"10.1016\/j.clinms.2019.06.001_b0100","doi-asserted-by":"crossref","first-page":"120","DOI":"10.1016\/j.jprot.2017.07.001","article-title":"Assessing the impact ofprotein extraction methods for human gut metaproteomics","volume":"30","author":"Zhang","year":"2018","journal-title":"J. Proteom."},{"issue":"6","key":"10.1016\/j.clinms.2019.06.001_b0105","doi-asserted-by":"crossref","first-page":"535","DOI":"10.1080\/14789450.2016.1190652","article-title":"Proteomic interrogation of the gut microbiota: potential clinical impact","volume":"13","author":"Haange","year":"2016","journal-title":"Expert. Rev. Proteom."},{"key":"10.1016\/j.clinms.2019.06.001_b0110","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1016\/j.chroma.2007.01.045","article-title":"Trends in sample preparation for classical and second generation proteomics","volume":"1153","author":"Ca\u00f1as","year":"2007","journal-title":"J. Chromatogr. A."},{"key":"10.1016\/j.clinms.2019.06.001_b0115","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1016\/j.mimet.2016.02.001","article-title":"Assessing the impact of long term frozen storage of faecal samples on protein concentration and protease activity","volume":"123","author":"Morris","year":"2016","journal-title":"J. Microbiol. Methods"},{"issue":"2","key":"10.1016\/j.clinms.2019.06.001_b0120","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1038\/ismej.2008.108","article-title":"Shotgun metaproteomics of the human distal gut microbiota","volume":"3","author":"Verberkmoes","year":"2009","journal-title":"ISME J."},{"issue":"20","key":"10.1016\/j.clinms.2019.06.001_b0125","doi-asserted-by":"crossref","first-page":"3474","DOI":"10.1002\/pmic.201400573","article-title":"Enrichment or depletion? The impact of stool pretreatment on metaproteomic characterization of the human gutmicrobiota","volume":"15","author":"Tanca","year":"2015","journal-title":"Proteomics"},{"issue":"5","key":"10.1016\/j.clinms.2019.06.001_b0130","doi-asserted-by":"crossref","first-page":"359","DOI":"10.1038\/nmeth.1322","article-title":"Universal sample preparationmethod for proteome analysis","volume":"6","author":"Wi\u015bniewski","year":"2009","journal-title":"Nat Methods"},{"issue":"20","key":"10.1016\/j.clinms.2019.06.001_b0135","doi-asserted-by":"crossref","first-page":"3590","DOI":"10.1002\/pmic.201400556","article-title":"Catching the tip of the iceberg \u2013 evaluation of samplepreparation protocols for metaproteomic studies of the rumen microbiota","volume":"15","author":"Deusch","year":"2015","journal-title":"Proteomics"},{"issue":"12","key":"10.1016\/j.clinms.2019.06.001_b0140","doi-asserted-by":"crossref","first-page":"6615","DOI":"10.1021\/pr100787q","article-title":"Direct cellular lysis\/protein extraction protocol for soil metaproteomics","volume":"9","author":"Chourey","year":"2010","journal-title":"J. Proteome Res."},{"issue":"1","key":"10.1016\/j.clinms.2019.06.001_b0145","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1186\/s40168-014-0049-2","article-title":"A straightforward and efficient analytical pipeline formetaproteome characterization","volume":"2","author":"Tanca","year":"2014","journal-title":"Microbiome"},{"issue":"1","key":"10.1016\/j.clinms.2019.06.001_b0150","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1186\/s40168-016-0176-z","article-title":"MetaPro-IQ: a universal metaproteomicapproach to studying human and mouse gut microbiota","volume":"4","author":"Zhang","year":"2016","journal-title":"Microbiome"},{"issue":"2","key":"10.1016\/j.clinms.2019.06.001_b0155","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1016\/j.ab.2009.07.026","article-title":"Comparative analyses of cell disruption methods for mitochondrial isolation in high-throughput proteomics study","volume":"394","author":"Chaiyarit","year":"2009","journal-title":"Anal Biochem."},{"issue":"4","key":"10.1016\/j.clinms.2019.06.001_b0160","doi-asserted-by":"crossref","first-page":"1454","DOI":"10.1016\/j.jprot.2011.11.016","article-title":"Systematic and quantitative comparison of digest efficiency and specificity reveals the impact of trypsin quality on MS-based proteomics","volume":"75","author":"Burkhart","year":"2012","journal-title":"J. Proteom."},{"issue":"5","key":"10.1016\/j.clinms.2019.06.001_b0165","doi-asserted-by":"crossref","first-page":"993","DOI":"10.1038\/nprot.2016.057","article-title":"Six alternative proteases for mass spectrometry-based proteomics beyond trypsin","volume":"11","author":"Giansanti","year":"2016","journal-title":"Nat. Protoc."},{"key":"10.1016\/j.clinms.2019.06.001_b0170","doi-asserted-by":"crossref","DOI":"10.1002\/0471140864.ps0612s69","article-title":"Removal of detergents from proteins and peptides in a spin-column format Chapter 6: Unit 6.12","author":"Antharavally","year":"2012","journal-title":"Curr. Protoc. Protein Sci."},{"key":"10.1016\/j.clinms.2019.06.001_b0175","doi-asserted-by":"crossref","first-page":"911","DOI":"10.1111\/j.1462-2920.2004.00687.x","article-title":"The application of two-dimensional polyacrylamide gel electrophoresis and downstream analyses to a mixed community of prokaryotic microorganisms","volume":"6","author":"Wilmes","year":"2004","journal-title":"Environ. Microbiol."},{"key":"10.1016\/j.clinms.2019.06.001_b0180","doi-asserted-by":"crossref","first-page":"1388","DOI":"10.1128\/AEM.01921-06","article-title":"Metaproteomics approach to study the functionality of the microbiota in the human infant gastrointestinal tract","volume":"73","author":"Klaassens","year":"2007","journal-title":"Appl. Environ. Microbiol."},{"key":"10.1016\/j.clinms.2019.06.001_b0185","doi-asserted-by":"crossref","first-page":"9390","DOI":"10.1073\/pnas.160270797","article-title":"Evaluation of two-dimensional gel electrophoresis-based proteome analysis technology","volume":"97","author":"Gygi","year":"2000","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.clinms.2019.06.001_b0190","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1007\/978-1-61779-319-6_4","article-title":"Three-dimensional peptide fractionation for highly sensitive nanoscale LC-based shotgun proteomic analysis of complex protein mixtures","volume":"790","author":"Bandhakavi","year":"2011","journal-title":"Methods Mol. Biol."},{"key":"10.1016\/j.clinms.2019.06.001_b0195","doi-asserted-by":"crossref","DOI":"10.1002\/0471140864.ps0807s61","article-title":"Reversed-phase high performance liquid chromatography of proteins","author":"Josic","year":"2010","journal-title":"Curr. Protoc. Protein Sci."},{"key":"10.1016\/j.clinms.2019.06.001_b0200","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1007\/978-1-61779-319-6_9","article-title":"Nano LC-MS\/MS: a robust setup for proteomic analysis","volume":"790","author":"Gaspari","year":"2011","journal-title":"Methods Mol. Biol."},{"issue":"11","key":"10.1016\/j.clinms.2019.06.001_b0205","doi-asserted-by":"crossref","first-page":"1329","DOI":"10.4155\/bio.13.31","article-title":"Micro-LC-MS\/MS: the future of bioanalysis","volume":"5","author":"Arnold","year":"2013","journal-title":"Bioanalysis"},{"key":"10.1016\/j.clinms.2019.06.001_b0210","doi-asserted-by":"crossref","DOI":"10.1016\/j.trac.2014.07.016","article-title":"Recent innovations in UHPLC columns and instrumentation","author":"Walter","year":"2014","journal-title":"TrAC Trends Anal. Chem."},{"key":"10.1016\/j.clinms.2019.06.001_b0215","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1586\/14789450.1.1.37","article-title":"2D-LC\/MS techniques for the identification of proteins in highly complex mixtures","volume":"1","author":"N\u00e4gele","year":"2004","journal-title":"Expert Rev. Proteom."},{"issue":"11","key":"10.1016\/j.clinms.2019.06.001_b0220","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0027173","article-title":"Strategies for metagenomic-guided whole-community proteomics of complex microbial environments","volume":"6","author":"Cantarel","year":"2011","journal-title":"PLoS One"},{"issue":"10","key":"10.1016\/j.clinms.2019.06.001_b0225","doi-asserted-by":"crossref","first-page":"2019","DOI":"10.1002\/pmic.201000722","article-title":"Reversed-phase chromatography with multiple fraction concatenation strategy for proteome profiling of human MCF10A cells","volume":"11","author":"Yang","year":"2011","journal-title":"Proteomics"},{"key":"10.1016\/j.clinms.2019.06.001_b0230","doi-asserted-by":"crossref","first-page":"6426","DOI":"10.1021\/ac050923i","article-title":"Orthogonality of separation in two-dimensional liquid chromatography","volume":"77","author":"Gilar","year":"2005","journal-title":"Anal. Chem."},{"key":"10.1016\/j.clinms.2019.06.001_b0235","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1002\/elps.200406189","article-title":"Prefractionation techniques in proteome analysis: the mining tools of the third millennium","volume":"26","author":"Righetti","year":"2005","journal-title":"Electrophoresis"},{"key":"10.1016\/j.clinms.2019.06.001_b0240","doi-asserted-by":"crossref","first-page":"280","DOI":"10.1016\/0076-6879(90)93420-P","article-title":"Mass spectrometry of peptides and proteins by matrix-assisted ultraviolet laser desorption\/ionization","volume":"193","author":"Hillenkamp","year":"1990","journal-title":"Methods Enzymol."},{"issue":"11","key":"10.1016\/j.clinms.2019.06.001_b0245","doi-asserted-by":"crossref","first-page":"5317","DOI":"10.1021\/pr900557k","article-title":"The benefit of combining nLC-MALDI-Orbitrap MS data withnLC-MALDI-TOF\/TOF data for proteomic analyses employing elastase","volume":"8","author":"Rietschel","year":"2009","journal-title":"J. Proteome Res."},{"key":"10.1016\/j.clinms.2019.06.001_b0250","doi-asserted-by":"crossref","first-page":"2113","DOI":"10.1021\/ac0518811","article-title":"Performance evaluation of a hybrid linear ion trap\/orbitrap mass spectrometer","volume":"78","author":"Makarov","year":"2006","journal-title":"Anal. Chem."},{"key":"10.1016\/j.clinms.2019.06.001_b0255","doi-asserted-by":"crossref","first-page":"430","DOI":"10.1002\/jms.856","article-title":"The Orbitrap: a new mass spectrometer","volume":"40","author":"Hu","year":"2005","journal-title":"J. Mass Spectrom."},{"key":"10.1016\/j.clinms.2019.06.001_b0260","doi-asserted-by":"crossref","first-page":"17","DOI":"10.4161\/bbug.2.1.14413","article-title":"Proteomics in the microbial sciences","volume":"2","author":"Graham","year":"2011","journal-title":"Bioeng. Bugs."},{"key":"10.1016\/j.clinms.2019.06.001_b0265","doi-asserted-by":"crossref","first-page":"138","DOI":"10.1016\/j.cbpa.2017.12.005","article-title":"Advances in mass spectrometry imaging coupled to ion mobility spectrometry for enhanced imaging of biological tissues","volume":"42","author":"Sans","year":"2018","journal-title":"Curr. Opin. Chem. Biol."},{"issue":"12","key":"10.1016\/j.clinms.2019.06.001_b0270","doi-asserted-by":"crossref","first-page":"2534","DOI":"10.1074\/mcp.TIR118.000900","article-title":"Online parallel accumulation-serial fragmentation (PASEF) with a novel trapped ion mobility mass spectrometer","volume":"17","author":"Meier","year":"2018","journal-title":"Mol. Cell Proteom."},{"issue":"6","key":"10.1016\/j.clinms.2019.06.001_b0275","doi-asserted-by":"crossref","DOI":"10.1074\/mcp.O111.016717","article-title":"Targeted data extraction of the MS\/MS spectra generated by data-independent acquisition: a new concept for consistent and accurate proteome analysis","volume":"11","author":"Gillet","year":"2012","journal-title":"Mol. Cell Proteom."},{"issue":"1","key":"10.1016\/j.clinms.2019.06.001_b0280","doi-asserted-by":"crossref","first-page":"86","DOI":"10.1021\/acs.analchem.7b04340","article-title":"Proteomic and metaproteomic approaches to understand host\u2013microbe interactions","volume":"90","author":"Starr","year":"2018","journal-title":"Anal. Chem."},{"issue":"6","key":"10.1016\/j.clinms.2019.06.001_b0285","doi-asserted-by":"crossref","first-page":"1683","DOI":"10.1002\/pmic.200800562","article-title":"The detection, correlation, and comparison of peptide precursor and product ions from data independent LC-MS with data dependant LC-MS\/MS","volume":"9","author":"Geromanos","year":"2009","journal-title":"Proteomics"},{"issue":"8","key":"10.1016\/j.clinms.2019.06.001_b0290","doi-asserted-by":"crossref","first-page":"1352","DOI":"10.1002\/pmic.201200352","article-title":"A two-step database search method improves sensitivity in peptide sequence matches for metaproteomics and proteogenomics studies","volume":"13","author":"Jagtap","year":"2013","journal-title":"Proteomics"},{"issue":"1","key":"10.1016\/j.clinms.2019.06.001_b0295","doi-asserted-by":"crossref","first-page":"642","DOI":"10.1186\/s12864-016-2855-3","article-title":"A comprehensive and scalable database search system for metaproteomics","volume":"17","author":"Chatterjee","year":"2016","journal-title":"BMC Genom."},{"key":"10.1016\/j.clinms.2019.06.001_b0300","doi-asserted-by":"crossref","first-page":"1082","DOI":"10.1021\/pr049946o","article-title":"Potential for false positive identifications from large databases through tandem mass spectrometry","volume":"3","author":"Cargile","year":"2004","journal-title":"J. Proteome Res."},{"issue":"1","key":"10.1016\/j.clinms.2019.06.001_b0305","doi-asserted-by":"crossref","first-page":"146","DOI":"10.1021\/ac801664q","article-title":"Decoy methods for assessingfalse positives and false discovery rates in shotgun proteomics","volume":"81","author":"Wang","year":"2009","journal-title":"Anal. Chem."},{"key":"10.1016\/j.clinms.2019.06.001_b0310","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1038\/nmeth1019","article-title":"Target-decoy search strategy for increased confidence in large-scale protein identifications by mass spectrometry","volume":"4","author":"Elias","year":"2007","journal-title":"Nat. Methods"},{"key":"10.1016\/j.clinms.2019.06.001_b0315","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1007\/978-1-60761-444-9_5","article-title":"Target-decoy search strategy for mass spectrometry-based proteomics","volume":"604","author":"Elias","year":"2010","journal-title":"Methods Mol. Biol."},{"key":"10.1016\/j.clinms.2019.06.001_b0320","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pcbi.1000667","article-title":"A primer on metagenomics","volume":"6","author":"Wooley","year":"2010","journal-title":"PLoS Comput. Biol."},{"key":"10.1016\/j.clinms.2019.06.001_b0325","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1002\/rcm.1741","article-title":"Average peptide score: a useful parameter for identification of proteins derived from database searches of liquid chromatography\/tandem mass spectrometry data","volume":"19","author":"Chepanoske","year":"2005","journal-title":"Rapid Commun. Mass Spectr."},{"key":"10.1016\/j.clinms.2019.06.001_b0330","doi-asserted-by":"crossref","first-page":"3551","DOI":"10.1002\/(SICI)1522-2683(19991201)20:18<3551::AID-ELPS3551>3.0.CO;2-2","article-title":"Probability-based protein identification by searching sequence databases using mass spectrometry data","volume":"20","author":"Perkins","year":"1999","journal-title":"Electrophoresis"},{"key":"10.1016\/j.clinms.2019.06.001_b0335","doi-asserted-by":"crossref","first-page":"958","DOI":"10.1021\/pr0499491","article-title":"Open mass spectrometry search algorithm","volume":"3","author":"Geer","year":"2004","journal-title":"J. Proteome Res."},{"key":"10.1016\/j.clinms.2019.06.001_b0340","doi-asserted-by":"crossref","first-page":"1466","DOI":"10.1093\/bioinformatics\/bth092","article-title":"TANDEM: matching proteins with tandem mass spectra","volume":"20","author":"Craig","year":"2004","journal-title":"Bioinformatics"},{"issue":"13","key":"10.1016\/j.clinms.2019.06.001_b0345","doi-asserted-by":"crossref","first-page":"288","DOI":"10.1186\/1471-2105-13-288","article-title":"PAnalyzer: a software tool for protein inference in shotgun proteomics","volume":"5","author":"Prieto","year":"2012","journal-title":"BMC Bioinform."},{"key":"10.1016\/j.clinms.2019.06.001_b0350","doi-asserted-by":"crossref","first-page":"577","DOI":"10.1038\/nrm1683","article-title":"Scoring proteomes with proteotypic peptide probes","volume":"6","author":"Kuster","year":"2005","journal-title":"Nat. Rev. Mole. Cell Biol."},{"issue":"6","key":"10.1016\/j.clinms.2019.06.001_b0355","doi-asserted-by":"crossref","first-page":"1052","DOI":"10.1074\/mcp.M116.061721","article-title":"Typing and characterization of bacteria using bottom-up tandem mass spectrometry proteomics","volume":"16","author":"Boulund","year":"2017","journal-title":"Mol. Cell Proteom."},{"issue":"11","key":"10.1016\/j.clinms.2019.06.001_b0360","doi-asserted-by":"crossref","first-page":"1746","DOI":"10.1093\/bioinformatics\/btw039","article-title":"Unipept web services for metaproteomics analysis","volume":"32","author":"Mesuere","year":"2016","journal-title":"Bioinformatics"},{"key":"10.1016\/j.clinms.2019.06.001_b0365","doi-asserted-by":"crossref","first-page":"377","DOI":"10.1101\/gr.5969107","article-title":"MEGAN analysis of metagenomic data","volume":"17","author":"Huson","year":"2007","journal-title":"Genome Res."},{"issue":"4","key":"10.1016\/j.clinms.2019.06.001_b0370","doi-asserted-by":"crossref","first-page":"1596","DOI":"10.1021\/acs.jproteome.7b00894","article-title":"Metagenomic taxonomy-guided database-searching strategy for improving metaproteomic analysis","volume":"17","author":"Xiao","year":"2018","journal-title":"J. Proteome Res."},{"issue":"7","key":"10.1016\/j.clinms.2019.06.001_b0375","doi-asserted-by":"crossref","first-page":"992","DOI":"10.1002\/pmic.201100503","article-title":"Deep metaproteomic analysis of human salivary supernatant","volume":"12","author":"Jagtap","year":"2012","journal-title":"Proteomics"},{"issue":"2","key":"10.1016\/j.clinms.2019.06.001_b0380","doi-asserted-by":"crossref","DOI":"10.1074\/mcp.O111.014902","article-title":"novo sequencing and homology searching","volume":"11","author":"Ma","year":"2012","journal-title":"Mol. Cell Proteom."},{"issue":"8","key":"10.1016\/j.clinms.2019.06.001_b0385","doi-asserted-by":"crossref","first-page":"757","DOI":"10.1080\/14789450.2016.1209418","article-title":"Metaproteomic data analysis at a glance: advances in computational microbial community proteomics","volume":"13","author":"Muth","year":"2016","journal-title":"Expert Rev. Proteom."},{"key":"10.1016\/j.clinms.2019.06.001_b0390","doi-asserted-by":"crossref","first-page":"2337","DOI":"10.1002\/rcm.1196","article-title":"PEAKS: powerful software for peptide de novo sequencing by tandem mass spectrometry","volume":"17","author":"Ma","year":"2003","journal-title":"Rapid Commun. Mass Spectrom."},{"key":"10.1016\/j.clinms.2019.06.001_b0395","doi-asserted-by":"crossref","first-page":"964","DOI":"10.1021\/ac048788h","article-title":"PepNovo: de novo peptide sequencing via probabilistic network modeling","volume":"77","author":"Frank","year":"2005","journal-title":"Anal. Chem."},{"issue":"11","key":"10.1016\/j.clinms.2019.06.001_b0400","doi-asserted-by":"crossref","first-page":"1885","DOI":"10.1007\/s13361-015-1204-0","article-title":"Novor: real-time peptide de novo sequencing software","volume":"26","author":"Ma","year":"2015","journal-title":"J. Am. Soc. Mass Spectrom."},{"key":"10.1016\/j.clinms.2019.06.001_b0405","doi-asserted-by":"crossref","first-page":"7265","DOI":"10.1021\/ac0508853","article-title":"NovoHMM: a hidden markov model for de novo peptide sequencing","volume":"77","author":"Fischer","year":"2005","journal-title":"Anal. Chem."},{"issue":"16","key":"10.1016\/j.clinms.2019.06.001_b0410","doi-asserted-by":"crossref","first-page":"1953","DOI":"10.1093\/bioinformatics\/btt338","article-title":"UniNovo: a universal tool for de novo peptide sequencing","volume":"29","author":"Jeong","year":"2013","journal-title":"Bioinformatics"},{"key":"10.1016\/j.clinms.2019.06.001_b0415","doi-asserted-by":"crossref","first-page":"4870","DOI":"10.1021\/ac070039n","article-title":"MSNovo: a dynamic programming algorithm for de novo peptide sequencing via tandem mass spectrometry","volume":"79","author":"Mo","year":"2007","journal-title":"Anal. Chem."},{"key":"10.1016\/j.clinms.2019.06.001_b0420","doi-asserted-by":"crossref","first-page":"1917","DOI":"10.1021\/ac0013709","article-title":"Charting the proteomes of organisms with unsequenced genomes by MALDI-quadrupole time-of-flight mass spectrometry and BLAST homology searching","volume":"73","author":"Shevchenko","year":"2001","journal-title":"Anal. Chem."},{"issue":"20","key":"10.1016\/j.clinms.2019.06.001_b0425","doi-asserted-by":"crossref","first-page":"3463","DOI":"10.1002\/pmic.201400563","article-title":"Metaproteomics reveals functional shifts in microbial and human proteins during a preterm infant gut colonization case","volume":"15","author":"Young","year":"2015","journal-title":"Proteomics"},{"issue":"1","key":"10.1016\/j.clinms.2019.06.001_b0430","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0029913","article-title":"Comparative metaproteomics and diversity analysis of human intestinal microbiota testifies for its temporal stability and expression of core functions","volume":"7","author":"Kolmeder","year":"2012","journal-title":"PLoS One"},{"issue":"2","key":"10.1016\/j.clinms.2019.06.001_b0435","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1007\/s11920-012-0337-0","article-title":"The gut microbiome: a new frontier in autism research","volume":"15","author":"Mulle","year":"2013","journal-title":"Curr. Psychiatry Rep."},{"issue":"5\u20136","key":"10.1016\/j.clinms.2019.06.001_b0440","doi-asserted-by":"crossref","first-page":"1142","DOI":"10.1002\/pmic.201400329","article-title":"Symbiosis, dysbiosis, and rebiosis-the value of metaproteomics in human microbiome monitoring","volume":"15","author":"Mao","year":"2015","journal-title":"Proteomics"},{"issue":"15","key":"10.1016\/j.clinms.2019.06.001_b0445","doi-asserted-by":"crossref","first-page":"108","DOI":"10.1186\/s12944-016-0278-4","article-title":"The role of gut microbiota in the development of obesity and diabetes","volume":"18","author":"Baothman","year":"2016","journal-title":"Lipids Health Dis."},{"issue":"8","key":"10.1016\/j.clinms.2019.06.001_b0450","doi-asserted-by":"crossref","first-page":"3077","DOI":"10.1007\/s00253-017-8215-7","article-title":"Metaproteomic strategies and applications for gut microbial research","volume":"101","author":"Xiao","year":"2017","journal-title":"Appl. Microbiol. Biotechnol."},{"issue":"1","key":"10.1016\/j.clinms.2019.06.001_b0455","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1111\/j.1462-2920.2012.02845.x","article-title":"Microbiota from the distal guts of lean and obese adolescents exhibit partial functional redundancy besides clear differences in community structure","volume":"15","author":"Wilmes","year":"2013","journal-title":"Environ. Microbiol."},{"issue":"17","key":"10.1016\/j.clinms.2019.06.001_b0460","doi-asserted-by":"crossref","first-page":"9407","DOI":"10.1021\/acs.analchem.7b02224","article-title":"Deep metaproteomics approach for the study of human microbiomes","volume":"89","author":"Zhang","year":"2017","journal-title":"Anal. Chem."},{"issue":"1","key":"10.1016\/j.clinms.2019.06.001_b0465","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1111\/j.1462-2920.2012.02811.x","article-title":"Microbiology and proteomics, getting the best of both worlds","volume":"15","author":"Armengaud","year":"2013","journal-title":"Environ. Microbiol."},{"issue":"13","key":"10.1016\/j.clinms.2019.06.001_b0470","doi-asserted-by":"crossref","first-page":"1692","DOI":"10.1002\/elps.201700476","article-title":"Multi-omics approach to elucidate the gut microbiota activity: metaproteomics and metagenomics connection","volume":"39","author":"Guirro","year":"2018","journal-title":"Electrophoresis"},{"issue":"11","key":"10.1016\/j.clinms.2019.06.001_b0475","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0049138","article-title":"Integrated metagenomics\/metaproteomics reveals human host-microbiota signatures of Crohn's disease","volume":"7","author":"Erickson","year":"2012","journal-title":"PLoS One"},{"issue":"3","key":"10.1016\/j.clinms.2019.06.001_b0480","doi-asserted-by":"crossref","first-page":"409","DOI":"10.1002\/ibd.21793","article-title":"Host-microbe relationships in inflammatory bowel disease detected by bacterial and metaproteomic analysis of the mucosal-luminal interface","volume":"18","author":"Presley","year":"2012","journal-title":"Inflamm. Bowel Dis."},{"issue":"2","key":"10.1016\/j.clinms.2019.06.001_b0485","doi-asserted-by":"crossref","first-page":"242","DOI":"10.1016\/j.jcf.2015.08.003","article-title":"Faecal proteomics: A tool to investigate dysbiosis and inflammation in patients with cystic fibrosis","volume":"15","author":"Debyser","year":"2016","journal-title":"J. Cyst Fibros."},{"key":"10.1016\/j.clinms.2019.06.001_b0490","doi-asserted-by":"crossref","DOI":"10.1038\/s41564-018-0337-x","article-title":"The neuroactive potential of the human gut microbiota in quality of life and depression","author":"Valles-Colomer","year":"2019","journal-title":"Nat. Microbiol."},{"issue":"6","key":"10.1016\/j.clinms.2019.06.001_b0495","first-page":"1543","article-title":"Antibiotics and the human gut microbiome: dysbioses and accumulation of resistances","volume":"12","author":"Francino","year":"2016","journal-title":"Front. Microbiol."},{"key":"10.1016\/j.clinms.2019.06.001_b0500","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1038\/ismej.2007.3","article-title":"Long-term ecological impacts of antibiotic administration on the human intestinal microbiota","volume":"1","author":"Jernberg","year":"2007","journal-title":"ISME J."},{"issue":"11","key":"10.1016\/j.clinms.2019.06.001_b0505","doi-asserted-by":"crossref","first-page":"1591","DOI":"10.1136\/gutjnl-2012-303184","article-title":"Gut microbiota disturbance during antibiotic therapy: a multi-omic approach","volume":"62","author":"P\u00e9rez-Cobas","year":"2013","journal-title":"Gut"},{"issue":"1","key":"10.1016\/j.clinms.2019.06.001_b0510","doi-asserted-by":"crossref","first-page":"E2","DOI":"10.3390\/proteomes7010002","article-title":"Challenges in clinical metaproteomics highlighted by the analysis of acute leukemia patients with gut colonization by multidrug-resistant enterobacteriaceae","volume":"7","author":"Rechenberger","year":"2019","journal-title":"Proteomes"},{"issue":"2","key":"10.1016\/j.clinms.2019.06.001_b0515","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1210\/er.2017-00192","article-title":"Evaluating causality of gut microbiota in obesity and diabetes in humans","volume":"39","author":"Meijnikman","year":"2018","journal-title":"Endocr. Rev."},{"issue":"10","key":"10.1016\/j.clinms.2019.06.001_b0520","doi-asserted-by":"crossref","first-page":"2178","DOI":"10.2337\/dc18-0777","article-title":"Intestinal metaproteomics reveals host-microbiota interactions in subjects at risk for Type 1 diabetes","volume":"41","author":"Gavin","year":"2018","journal-title":"Diabetes Care"},{"issue":"1","key":"10.1016\/j.clinms.2019.06.001_b0525","doi-asserted-by":"crossref","DOI":"10.1186\/s12876-016-0534-0","article-title":"Cirrhosis related functionality characteristic of the fecal microbiota as revealed by a metaproteomic approach","volume":"16","author":"Wei","year":"2016","journal-title":"BMC Gastroenterol."},{"key":"10.1016\/j.clinms.2019.06.001_b0530","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1016\/j.phrs.2017.12.009","article-title":"The long way between preclinical studies and clinical evidence","volume":"129","author":"Mancuso","year":"2018","journal-title":"Pharmacol. Res."},{"issue":"3","key":"10.1016\/j.clinms.2019.06.001_b0535","doi-asserted-by":"crossref","first-page":"E56","DOI":"10.3390\/diseases6030056","article-title":"Gut microbiome and cardiovascular diseases","volume":"6","author":"Yoshida","year":"2018","journal-title":"Diseases"},{"key":"10.1016\/j.clinms.2019.06.001_b0540","doi-asserted-by":"crossref","DOI":"10.1155\/2008\/613979","article-title":"Conceptualizing human microbiota: from multicelled organ to ecological community","volume":"2008","author":"Foxman","year":"2008","journal-title":"Interdiscip Perspect Infect. Dis."},{"issue":"2","key":"10.1016\/j.clinms.2019.06.001_b0545","doi-asserted-by":"crossref","first-page":"16180","DOI":"10.1038\/nmicrobiol.2016.180","article-title":"Integrated multi-omics of the human gut microbiome in a case study of familial type 1 diabetes","volume":"10","author":"Heintz-Buschart","year":"2016","journal-title":"Nat. Microbiol."},{"issue":"5","key":"10.1016\/j.clinms.2019.06.001_b0550","doi-asserted-by":"crossref","first-page":"358","DOI":"10.1111\/nmo.12134","article-title":"Beyond phylotyping: understanding the impact of gutmicrobiota on host biology","volume":"25","author":"Reigstad","year":"2013","journal-title":"Neurogastroenterol. Motil."},{"issue":"1","key":"10.1016\/j.clinms.2019.06.001_b0555","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1186\/s40168-017-0293-3","article-title":"Potential and active functions in the gut microbiota of a healthy human cohort","volume":"5","author":"Tanca","year":"2017","journal-title":"Microbiome"},{"issue":"1","key":"10.1016\/j.clinms.2019.06.001_b0560","doi-asserted-by":"crossref","first-page":"684","DOI":"10.3390\/ijms15010684","article-title":"Meta-omic platforms to assist in the understanding of NAFLD gut microbiota alterations: tools and applications","volume":"15","author":"Del Chierico","year":"2014","journal-title":"Int. J. Mol. Sci."},{"issue":"261","key":"10.1016\/j.clinms.2019.06.001_b0565","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1016\/j.jbiotec.2017.06.1201","article-title":"Challenges and perspectives of metaproteomic data analysis","volume":"10","author":"Heyer","year":"2017","journal-title":"J. Biotechnol."},{"issue":"3\u20134","key":"10.1016\/j.clinms.2019.06.001_b0570","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1002\/prca.201400117","article-title":"Using data-independent, high-resolution mass spectrometry in protein biomarker research: perspectives and clinical applications","volume":"9","author":"Sajic","year":"2015","journal-title":"Proteom. Clin. Appl."},{"key":"10.1016\/j.clinms.2019.06.001_b0575","doi-asserted-by":"crossref","first-page":"3418","DOI":"10.1002\/pmic.201500104","article-title":"Improving the quality of genome, protein sequence, and taxonomy databases: a prerequisite for microbiome meta-omics 2.0","volume":"15","author":"Pible","year":"2015","journal-title":"Proteomics"},{"key":"10.1016\/j.clinms.2019.06.001_b0580","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1186\/s40168-016-0196-8","article-title":"The impact of sequence database choice on metaproteomic results in gut microbiota studies","volume":"4","author":"Tanca","year":"2016","journal-title":"Microbiome"},{"issue":"17","key":"10.1016\/j.clinms.2019.06.001_b0585","doi-asserted-by":"crossref","first-page":"2313","DOI":"10.1002\/pmic.201600023","article-title":"The unique peptidome: Taxon-specific tryptic peptides as biomarkers for targeted metaproteomics","volume":"16","author":"Mesuere","year":"2016","journal-title":"Proteomics"},{"issue":"11","key":"10.1016\/j.clinms.2019.06.001_b0590","doi-asserted-by":"crossref","first-page":"1733","DOI":"10.2217\/fmb.10.127","article-title":"MALDI-TOF-mass spectrometry applications in clinical microbiology","volume":"5","author":"Seng","year":"2010","journal-title":"Future Microbiol."},{"issue":"2","key":"10.1016\/j.clinms.2019.06.001_b0595","doi-asserted-by":"crossref","first-page":"1014","DOI":"10.1021\/acs.jproteome.6b00938","article-title":"Quantitative metaproteomics and activity-based probe enrichment reveals significant alterations in protein expression from a mouse model of inflammatory bowel disease","volume":"16","author":"Mayers","year":"2017","journal-title":"J. Proteome Res."},{"issue":"2","key":"10.1016\/j.clinms.2019.06.001_b0600","doi-asserted-by":"crossref","DOI":"10.1128\/AEM.01955-16","article-title":"Quantitative metaproteomics highlight the metabolic contributions of uncultured phylotypes in a thermophilic anaerobic digester","volume":"83","author":"Hagen","year":"2017","journal-title":"Appl. Environ. Microbiol."},{"issue":"12","key":"10.1016\/j.clinms.2019.06.001_b0605","doi-asserted-by":"crossref","first-page":"1185","DOI":"10.1111\/1469-0691.12023","article-title":"Microbial culturomics: paradigm shift in the human gut microbiome study","volume":"18","author":"Lagier","year":"2012","journal-title":"Clin. Microbiol. Infect."},{"issue":"1","key":"10.1016\/j.clinms.2019.06.001_b0610","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1128\/CMR.00014-14","article-title":"The rebirth of culture in microbiology through the example of culturomics to study human gut microbiota","volume":"28","author":"Lagier","year":"2015","journal-title":"Clin. Microbiol. Rev."},{"key":"10.1016\/j.clinms.2019.06.001_b0615","doi-asserted-by":"crossref","first-page":"540","DOI":"10.1038\/s41579-018-0041-0","article-title":"Culturing the human microbiota and culturomics","volume":"1","author":"Lagier","year":"2018","journal-title":"Nat. Rev. Microbiol."},{"issue":"1","key":"10.1016\/j.clinms.2019.06.001_b0620","doi-asserted-by":"crossref","first-page":"154","DOI":"10.1021\/acs.jproteome.7b00461","article-title":"Evaluating in vitro culture medium of gut microbiome with orthogonal experimental design and a metaproteomics approach","volume":"17","author":"Li","year":"2018","journal-title":"J. Proteome Res."},{"issue":"6","key":"10.1016\/j.clinms.2019.06.001_b0625","article-title":"An iterative workflow for mining the human intestinal metaproteome","volume":"12","author":"Rooijers","year":"2011","journal-title":"BMC Genom."},{"issue":"10","key":"10.1016\/j.clinms.2019.06.001_b0630","doi-asserted-by":"crossref","first-page":"1566","DOI":"10.1136\/gutjnl-2012-303786","article-title":"Bacterial protein signals are associated with Crohn's disease","volume":"63","author":"Juste","year":"2014","journal-title":"Gut."},{"issue":"12","key":"10.1016\/j.clinms.2019.06.001_b0635","doi-asserted-by":"crossref","first-page":"1855","DOI":"10.1016\/j.mayocp.2017.10.004","article-title":"Microbiome at the frontier of personalized medicine","volume":"92","author":"Kashyap","year":"2017","journal-title":"Mayo Clin. Proc."},{"issue":"1","key":"10.1016\/j.clinms.2019.06.001_b0640","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1021\/pr500936p","article-title":"Development of an enhanced metaproteomic approach for deepening the microbiome characterization of the human infant gut","volume":"14","author":"Xiong","year":"2015","journal-title":"J. Proteome Res."},{"issue":"20","key":"10.1016\/j.clinms.2019.06.001_b0645","doi-asserted-by":"crossref","first-page":"3544","DOI":"10.1002\/pmic.201500049","article-title":"Colonic metaproteomic signatures of active bacteria and the host in obesity","volume":"15","author":"Kolmeder","year":"2015","journal-title":"Proteomics"},{"issue":"12","key":"10.1016\/j.clinms.2019.06.001_b0650","doi-asserted-by":"crossref","first-page":"6120","DOI":"10.1021\/acs.analchem.6b01412","article-title":"In vitro metabolic labeling of intestinal microbiota for quantitative metaproteomics","volume":"88","author":"Zhang","year":"2016","journal-title":"Anal. Chem."},{"issue":"4","key":"10.1016\/j.clinms.2019.06.001_b0655","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0153294","article-title":"Faecal metaproteomic analysis reveals a personalized and stable functional microbiome and limited effects of a probiotic intervention in adults","volume":"11","author":"Kolmeder","year":"2016","journal-title":"PLoS One"},{"issue":"11","key":"10.1016\/j.clinms.2019.06.001_b0660","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0026542","article-title":"A metaproteomic approach to study human-microbial ecosystems at the mucosal luminal interface","volume":"6","author":"Li","year":"2011","journal-title":"PLoS One"},{"issue":"4926","key":"10.1016\/j.clinms.2019.06.001_b0665","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1126\/science.2675315","article-title":"Electrospray ionization for mass spectrometry of large biomolecules","volume":"246","author":"Fenn","year":"1989","journal-title":"Science"}],"container-title":["Clinical Mass Spectrometry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2376999819300133?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2376999819300133?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,2,5]],"date-time":"2026-02-05T03:47:38Z","timestamp":1770263258000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2376999819300133"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,9]]},"references-count":133,"alternative-id":["S2376999819300133"],"URL":"https:\/\/doi.org\/10.1016\/j.clinms.2019.06.001","relation":{},"ISSN":["2376-9998"],"issn-type":[{"value":"2376-9998","type":"print"}],"subject":[],"published":{"date-parts":[[2019,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Metaproteomics of the human gut microbiota: Challenges and contributions to other OMICS","name":"articletitle","label":"Article Title"},{"value":"Clinical Mass Spectrometry","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.clinms.2019.06.001","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2019 The Association for Mass Spectrometry: Applications to the Clinical Lab (MSACL). Published by Elsevier B.V.","name":"copyright","label":"Copyright"}]}}