{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T13:35:08Z","timestamp":1791898508494,"version":"4.3.4"},"reference-count":61,"publisher":"Elsevier BV","issue":"11","license":[{"start":{"date-parts":[[2004,11,1]],"date-time":"2004-11-01T00:00:00Z","timestamp":1099267200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2004,11,1]],"date-time":"2004-11-01T00:00:00Z","timestamp":1099267200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Clinical Neurophysiology"],"published-print":{"date-parts":[[2004,11]]},"DOI":"10.1016\/j.clinph.2004.05.022","type":"journal-article","created":{"date-parts":[[2004,7,6]],"date-time":"2004-07-06T19:35:45Z","timestamp":1089142545000},"page":"2650-2658","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":23,"title":["Comparison of pupil responses to luminance and colour in severe optic neuritis"],"prefix":"10.1016","volume":"115","author":[{"given":"J.L.","family":"Barbur","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.","family":"Moro","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.A.","family":"Harlow","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"B.L.","family":"Lam","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.clinph.2004.05.022_BIB1","series-title":"The pupil","author":"Alexandridis","year":"1995"},{"key":"10.1016\/j.clinph.2004.05.022_BIB2","first-page":"223","article-title":"Methods of studying the behaviour of the pupil","volume":"5","author":"Alexandridis","year":"1992","journal-title":"J Psychophysiol"},{"key":"10.1016\/j.clinph.2004.05.022_BIB11","series-title":"A statistical analysis of pupillary responses in human vision","author":"Barbur","year":"1990"},{"key":"10.1016\/j.clinph.2004.05.022_BIB3","first-page":"259","article-title":"Pupillary responses to grating stimuli","volume":"5","author":"Barbur","year":"1991","journal-title":"J Psychophysiol"},{"key":"10.1016\/j.clinph.2004.05.022_BIB4","first-page":"641","article-title":"Learning from the pupil: studies of basic mechanisms and clinical applications","volume":"vol. 1","author":"Barbur","year":"2004"},{"key":"10.1016\/j.clinph.2004.05.022_BIB9","first-page":"131","article-title":"A new system for the simultaneous measurement of pupil size and two-dimensional eye movements","volume":"2","author":"Barbur","year":"1987","journal-title":"Clin Vis Sci"},{"key":"10.1016\/j.clinph.2004.05.022_BIB5","first-page":"74","article-title":"The pupil colour response (evidence for involvement of central mechanisms)","volume":"21","author":"Barbur","year":"1992","journal-title":"Perception"},{"key":"10.1016\/j.clinph.2004.05.022_BIB7","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1111\/j.1475-1313.1992.tb00276.x","article-title":"Pupillary responses to stimulus structure, colour and movement","volume":"12","author":"Barbur","year":"1992","journal-title":"Ophthalmic Physiol Opt"},{"key":"10.1016\/j.clinph.2004.05.022_BIB8","series-title":"Responses to chromatic stimuli in the absence of VI: pupillometric and psychophysical studies","volume":"vol. 2","author":"Barbur","year":"1994"},{"key":"10.1016\/j.clinph.2004.05.022_BIB6","series-title":"Chromatic discrimination in subjects with both congenital and acquired colour vision deficiencies","volume":"vol. 28","author":"Barbur","year":"1997"},{"key":"10.1016\/j.clinph.2004.05.022_BIB10","doi-asserted-by":"crossref","first-page":"2321","DOI":"10.1098\/rspb.1998.0578","article-title":"Visual processing levels revealed by response latencies to changes in different visual attributes","volume":"265","author":"Barbur","year":"1998","journal-title":"Proc R Soc Lond B Biol Sci"},{"key":"10.1016\/j.clinph.2004.05.022_BIB13","doi-asserted-by":"crossref","first-page":"944","DOI":"10.1001\/archopht.121.7.944","article-title":"High- and low-risk profiles for the development of multiple sclerosis within 10 years after optic neuritis: experience of the optic neuritis treatment trial","volume":"121","author":"Beck","year":"2003","journal-title":"Arch Ophthalmology"},{"key":"10.1016\/j.clinph.2004.05.022_BIB12","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1016\/S0002-9394(03)00862-6","article-title":"Visual function more than 10 years after optic neuritis: experience of the optic neuritis treatment trial","volume":"137","author":"Beck","year":"2004","journal-title":"Am J Ophthalmol"},{"key":"10.1016\/j.clinph.2004.05.022_BIB14","doi-asserted-by":"crossref","first-page":"607","DOI":"10.1364\/JOSAA.17.000607","article-title":"Functional consequences of the relative numbers of L and M cones","volume":"17","author":"Brainard","year":"2000","journal-title":"J Opt Soc Am A"},{"key":"10.1016\/j.clinph.2004.05.022_BIB15","doi-asserted-by":"crossref","first-page":"468","DOI":"10.1093\/brain\/124.3.468","article-title":"Long-term remyelination after optic neuritis: A 2-year visual evoked potential and psychophysical serial study","volume":"124","author":"Brusa","year":"2001","journal-title":"Brain"},{"key":"10.1016\/j.clinph.2004.05.022_BIB16","doi-asserted-by":"crossref","first-page":"1471","DOI":"10.1093\/brain\/123.7.1471","article-title":"Correlation of MRI lesions with visual psychophysical deficit in secondary progressive multiple sclerosis","volume":"123","author":"Caruana","year":"2000","journal-title":"Brain"},{"key":"10.1016\/j.clinph.2004.05.022_BIB17","doi-asserted-by":"crossref","first-page":"224","DOI":"10.1007\/BF00236527","article-title":"Luminance and darkness detectors in the loivary and posterior pretectal nuclei and their relationship to the pupillary light reflex in the rat","volume":"57","author":"Clarke","year":"1985","journal-title":"Exp Brain Res"},{"key":"10.1016\/j.clinph.2004.05.022_BIB18","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1097\/00055735-199512000-00002","article-title":"Optic neuritis and demyelination","volume":"6","author":"Cornblath","year":"1995","journal-title":"Curr Opin Ophthalmol"},{"key":"10.1016\/j.clinph.2004.05.022_BIB19","series-title":"Colour vision","first-page":"181","article-title":"Functional architecture of cone signal pathways in the primate retina","author":"Dacey","year":"1999"},{"key":"10.1016\/j.clinph.2004.05.022_BIB20","doi-asserted-by":"crossref","first-page":"1813","DOI":"10.1093\/brain\/124.9.1813","article-title":"Size-selective neuronal changes in the anterior optic pathways suggest a differential susceptibility to injury in multiple sclerosis","volume":"124","author":"Evangelou","year":"2001","journal-title":"Brain"},{"key":"10.1016\/j.clinph.2004.05.022_BIB21","first-page":"415","article-title":"The pupillary light reflex pathway of the primate","volume":"66","author":"Gamlin","year":"1995","journal-title":"J Am Optom Assoc"},{"key":"10.1016\/j.clinph.2004.05.022_BIB22","first-page":"676","article-title":"Physiology and morphology of retinal ganglion cells projecting to the pretectal olivary nucleus in the rhesus monkey","volume":"42","author":"Gamlin","year":"2001","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"10.1016\/j.clinph.2004.05.022_BIB23","doi-asserted-by":"crossref","first-page":"527","DOI":"10.1364\/JOSAA.17.000527","article-title":"Cone pigment gene expression in individual photoreceptors and the chromatic topography of the retina","volume":"17","author":"Hagstrom","year":"2000","journal-title":"J Opt Soc Am A"},{"key":"10.1016\/j.clinph.2004.05.022_BIB24","series-title":"Optic neuritis","author":"Hess","year":"1986"},{"key":"10.1016\/j.clinph.2004.05.022_BIB25","series-title":"Statistical methods for psychology","author":"Howell","year":"2002"},{"key":"10.1016\/j.clinph.2004.05.022_BIB26","series-title":"Clinical neuroophthalmology","article-title":"Anatomy and physiology of the pupil","author":"Kardon","year":"1998"},{"key":"10.1016\/j.clinph.2004.05.022_BIB27","doi-asserted-by":"crossref","first-page":"351","DOI":"10.1016\/S0002-9394(14)73587-1","article-title":"The relationship between static perimetry and the relative afferent pupillary defect","volume":"115","author":"Kardon","year":"1993","journal-title":"Am J Ophthalmol"},{"key":"10.1016\/j.clinph.2004.05.022_BIB28","doi-asserted-by":"crossref","first-page":"897","DOI":"10.1016\/0042-6989(94)00188-R","article-title":"Nature of the pupillary responses evoked by chromatic flashes on a white background","volume":"35","author":"Kimura","year":"1995","journal-title":"Vis Res"},{"key":"10.1016\/j.clinph.2004.05.022_BIB29","series-title":"The pupil: anatomy, physiology, and clinical applications","author":"Loewenfeld","year":"1999"},{"key":"10.1016\/j.clinph.2004.05.022_BIB30","series-title":"An introduction to the analysis and processing of signals","author":"Lynn","year":"1982"},{"key":"10.1016\/j.clinph.2004.05.022_BIB31","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1364\/JOSA.32.000247","article-title":"Visual sensitivities to color differences in daylight","volume":"32","author":"MacAdam","year":"1942","journal-title":"J Opt Soc Am A"},{"key":"10.1016\/j.clinph.2004.05.022_BIB32","doi-asserted-by":"crossref","first-page":"467","DOI":"10.1016\/S0959-4388(96)80051-1","article-title":"Processing and encoding of visual information in the retina","volume":"6","author":"Masland","year":"1996","journal-title":"Curr Opin Neurobiol"},{"key":"10.1016\/j.clinph.2004.05.022_BIB33","doi-asserted-by":"crossref","first-page":"1403","DOI":"10.1093\/brain\/124.7.1403","article-title":"Spontaneous remyelination following extensive demyelination is associated with improved neurological function in a viral model of multiple sclerosis","volume":"124","author":"Murray","year":"2001","journal-title":"Brain"},{"key":"10.1016\/j.clinph.2004.05.022_BIB34","doi-asserted-by":"crossref","first-page":"1125","DOI":"10.1016\/0306-4522(84)90007-1","article-title":"Retinal ganglion cells that project to the superior colliculus and pretectum in the macaque monkey","volume":"12","author":"Perry","year":"1984","journal-title":"Neuroscience"},{"key":"10.1016\/j.clinph.2004.05.022_BIB35","doi-asserted-by":"crossref","first-page":"1101","DOI":"10.1016\/0306-4522(84)90006-X","article-title":"Retinal ganglion cells that project to the dorsal lateral geniculate nucleus in the macaque monkey","volume":"12","author":"Perry","year":"1984","journal-title":"Neuroscience"},{"key":"10.1016\/j.clinph.2004.05.022_BIB36","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1002\/cne.901580202","article-title":"Anatomical analysis of pupillary reflex pathways in the Rhesus Monkey","volume":"158","author":"Pierson","year":"1974","journal-title":"J Comp Neurol"},{"key":"10.1016\/j.clinph.2004.05.022_BIB37","series-title":"Inherited and acquired colour vision deficiencies: fundamental aspects and clinical studies","first-page":"173","article-title":"Disorders of colour vision in diseases of the nervous system","author":"Plant","year":"1991"},{"key":"10.1016\/j.clinph.2004.05.022_BIB38","series-title":"Numerical recipes in C: the art of scientific computing","author":"Press","year":"1992"},{"key":"10.1016\/j.clinph.2004.05.022_BIB39","doi-asserted-by":"crossref","first-page":"350","DOI":"10.1038\/331350a0","article-title":"Segregation of functionally distinct axons in the monkey's optic tract","volume":"331","author":"Reese","year":"1988","journal-title":"Nature"},{"key":"10.1016\/j.clinph.2004.05.022_BIB40","doi-asserted-by":"crossref","first-page":"563","DOI":"10.1093\/brain\/100.3.563","article-title":"Visual acuity and contrast sensitivity in multiple sclerosis: hidden visual loss","volume":"100","author":"Regan","year":"1977","journal-title":"Brain"},{"key":"10.1016\/j.clinph.2004.05.022_BIB41","doi-asserted-by":"crossref","first-page":"1129","DOI":"10.1093\/brain\/114.3.1129","article-title":"Recognition of motion-defined shapes in patients with multiple sclerosis and optic neuritis","volume":"114","author":"Regan","year":"1991","journal-title":"Brain"},{"key":"10.1016\/j.clinph.2004.05.022_BIB42","doi-asserted-by":"crossref","first-page":"1668","DOI":"10.1001\/archopht.1991.01080120052024","article-title":"Optic neuritis and ischemic optic neuropathy. Overlapping clinical profiles","volume":"109","author":"Rizzo","year":"1991","journal-title":"Arch Ophthalmol"},{"key":"10.1016\/j.clinph.2004.05.022_BIB43","series-title":"The primate retina","author":"Rodieck","year":"1988"},{"key":"10.1016\/j.clinph.2004.05.022_BIB44","series-title":"Contrast sensitivity","first-page":"117","article-title":"The origin of parallel visual pathways","author":"Rodieck","year":"1993"},{"key":"10.1016\/j.clinph.2004.05.022_BIB45","doi-asserted-by":"crossref","first-page":"2419","DOI":"10.1093\/brain\/114.6.2419","article-title":"The visual defect in multiple sclerosis and optic neuritis","volume":"114","author":"Russell","year":"1991","journal-title":"Brain"},{"key":"10.1016\/j.clinph.2004.05.022_BIB46","doi-asserted-by":"crossref","first-page":"353","DOI":"10.3109\/01658108609016475","article-title":"The neuroanatomy of the human visual system. Part I. retinal projections to the LGN and PT as demonstrated with a new stain","volume":"6","author":"Sadum","year":"1986","journal-title":"Neuro-ophthalmology"},{"key":"10.1016\/j.clinph.2004.05.022_BIB47","doi-asserted-by":"crossref","first-page":"583","DOI":"10.1097\/00004691-200111000-00010","article-title":"Equiluminant red-green and blueyellow VEPs in multiple sclerosis","volume":"18","author":"Sartucci","year":"2001","journal-title":"J Clin Neurophysiol"},{"key":"10.1016\/j.clinph.2004.05.022_BIB48","first-page":"2278","article-title":"Colour vision defect type and spatial vision in the optic neuritis treatment trial","volume":"38","author":"Schneck","year":"1997","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"10.1016\/j.clinph.2004.05.022_BIB49","series-title":"Colour vision deficiencies XIII","first-page":"179","article-title":"Spatio-chromatic VEPS in recovered optic neuritis and multiple sclerosis","author":"Schneck","year":"1997"},{"key":"10.1016\/j.clinph.2004.05.022_BIB50","doi-asserted-by":"crossref","first-page":"635","DOI":"10.1146\/annurev.ps.41.020190.003223","article-title":"Visual sensitivity and parallel retinocortical channels","volume":"41","author":"Shapley","year":"1990","journal-title":"Annu Rev Psychol"},{"key":"10.1016\/j.clinph.2004.05.022_BIB51","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1016\/S0002-9394(14)72261-5","article-title":"Visual recovery in patients with optic neuritis and visual loss to no light perception","volume":"111","author":"Slamovits","year":"1991","journal-title":"Am J Ophthalmol"},{"key":"10.1016\/j.clinph.2004.05.022_BIB52","doi-asserted-by":"crossref","first-page":"681","DOI":"10.1016\/0002-9394(82)90460-3","article-title":"The relationship between visual acuity, pupillary defect and visual field loss","volume":"93","author":"Thompson","year":"1982","journal-title":"Am J Ophthalmol"},{"key":"10.1016\/j.clinph.2004.05.022_BIB53","doi-asserted-by":"crossref","first-page":"547","DOI":"10.1016\/S0002-9394(14)75429-7","article-title":"Contrast sensitivity and other vision tests in the optic neuritis treatment trial","volume":"121","author":"Trobe","year":"1996","journal-title":"Am J Ophthalmol"},{"key":"10.1016\/j.clinph.2004.05.022_BIB54","doi-asserted-by":"crossref","first-page":"2203","DOI":"10.1098\/rspb.2001.1775","article-title":"A linear chromatic mechanism drives the pupillary response","volume":"268","author":"Tsujimura","year":"2001","journal-title":"Proc R Soc Lond B"},{"key":"10.1016\/j.clinph.2004.05.022_BIB55","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1002\/1520-6378(2001)26:1+<::AID-COL9>3.0.CO;2-S","article-title":"Measurements of chromatic sensitivity in the mesopic range","volume":"26","author":"Walkey","year":"2001","journal-title":"Colour Res Appl"},{"key":"10.1016\/j.clinph.2004.05.022_BIB56","doi-asserted-by":"crossref","first-page":"1408","DOI":"10.1001\/archopht.1997.01100160578009","article-title":"Does optic disc appearance distinguish ischemic optic neuropathy from optic neuritis?","volume":"115","author":"Warner","year":"1997","journal-title":"Arch Ophthalmol"},{"key":"10.1016\/j.clinph.2004.05.022_BIB57","doi-asserted-by":"crossref","first-page":"2296","DOI":"10.1093\/brain\/awf232","article-title":"Pupil response components: studies in patients with Parinaud's syndrome","volume":"125","author":"Wilhelm","year":"2002","journal-title":"Brain"},{"key":"10.1016\/j.clinph.2004.05.022_BIB58","first-page":"S45","article-title":"Pupil latencies to sinusoidally modulated stimulus attributes","volume":"40","author":"Wolf","year":"1999","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"10.1016\/j.clinph.2004.05.022_BIB59","series-title":"Color science: concepts and methods","author":"Wyszecki","year":"1982"},{"key":"10.1016\/j.clinph.2004.05.022_BIB61","doi-asserted-by":"crossref","first-page":"2048","DOI":"10.1364\/JOSAA.8.002048","article-title":"Determination of lights that are isoluminant for both scotopic and photopic vision","volume":"8","author":"Young","year":"1991","journal-title":"J Opt Soc Am"},{"key":"10.1016\/j.clinph.2004.05.022_BIB62","doi-asserted-by":"crossref","first-page":"1721","DOI":"10.1093\/brain\/113.6.1721","article-title":"A century of cerebral achromatopsia","volume":"113","author":"Zeki","year":"1990","journal-title":"Brain"}],"container-title":["Clinical Neurophysiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S138824570400207X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S138824570400207X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,25]],"date-time":"2025-10-25T10:26:47Z","timestamp":1761388007000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S138824570400207X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2004,11]]},"references-count":61,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2004,11]]}},"alternative-id":["S138824570400207X"],"URL":"https:\/\/doi.org\/10.1016\/j.clinph.2004.05.022","relation":{},"ISSN":["1388-2457"],"issn-type":[{"value":"1388-2457","type":"print"}],"subject":[],"published":{"date-parts":[[2004,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Comparison of pupil responses to luminance and colour in severe optic neuritis","name":"articletitle","label":"Article Title"},{"value":"Clinical Neurophysiology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.clinph.2004.05.022","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"converted-article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2004 International Federation of Clinical Neurophysiology. Published by Elsevier Ireland Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}