{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,31]],"date-time":"2026-07-31T14:20:18Z","timestamp":1785507618724,"version":"3.56.0"},"reference-count":38,"publisher":"Elsevier BV","issue":"7","license":[{"start":{"date-parts":[[2006,7,1]],"date-time":"2006-07-01T00:00:00Z","timestamp":1151712000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2006,7,1]],"date-time":"2006-07-01T00:00:00Z","timestamp":1151712000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Clinical Neurophysiology"],"published-print":{"date-parts":[[2006,7]]},"DOI":"10.1016\/j.clinph.2006.03.028","type":"journal-article","created":{"date-parts":[[2006,6,6]],"date-time":"2006-06-06T23:34:33Z","timestamp":1149636873000},"page":"1434-1443","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":39,"title":["Neurophysiological and mitochondrial abnormalities in MuSK antibody seropositive myasthenia gravis compared to other immunological subtypes"],"prefix":"10.1016","volume":"117","author":[{"given":"A.","family":"Rostedt Punga","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K.","family":"Ahlqvist","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E.","family":"Bartoccioni","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"F.","family":"Scuderi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Marino","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Suomalainen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H.","family":"Kalimo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E.V.","family":"St\u00e5lberg","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.clinph.2006.03.028_bib1","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1212\/WNL.19.3.221","article-title":"The histographic analysis of human muscle biopsies with regard to fiber types","volume":"19","author":"Brooke","year":"1969","journal-title":"Neurology"},{"key":"10.1016\/j.clinph.2006.03.028_bib2","first-page":"1002","article-title":"Anti-MuSK myasthenia gravis presenting with purely ocular findings","volume":"6","author":"Caress","year":"2005","journal-title":"Arch Neurol"},{"key":"10.1016\/j.clinph.2006.03.028_bib3","series-title":"Muscle biopsy, a practical approach","author":"Dubowitz","year":"1985"},{"key":"10.1016\/j.clinph.2006.03.028_bib4","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1111\/j.1749-6632.1966.tb45464.x","article-title":"Muscle lesions in myasthenia gravis","volume":"135","author":"Engel","year":"1966","journal-title":"Ann NY Acad Sci"},{"key":"10.1016\/j.clinph.2006.03.028_bib5","doi-asserted-by":"crossref","first-page":"2304","DOI":"10.1093\/brain\/awg223","article-title":"Clinical correlates with anti-MuSK antibodies in generalized seronegative myasthenia gravis","volume":"126","author":"Evoli","year":"2003","journal-title":"Brain"},{"key":"10.1016\/j.clinph.2006.03.028_bib6","doi-asserted-by":"crossref","first-page":"568","DOI":"10.1002\/mus.20491","article-title":"Single-fiber electromyography in limb and facial muscles in muscle-specific kinase antibody and acetylcholine receptor antibody myasthenia gravis","volume":"33","author":"Farrugia","year":"2006","journal-title":"Muscle Nerve"},{"key":"10.1016\/j.clinph.2006.03.028_bib7","first-page":"151","article-title":"Single fiber EMG reference values: a collaborative effort","volume":"15","author":"Gilchrist","year":"1991","journal-title":"Muscle Nerve"},{"key":"10.1016\/j.clinph.2006.03.028_bib8","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1111\/j.1600-0404.1979.tb02942.x","article-title":"\u2018Semi-open\u2019 muscle biopsy technique. A simple outpatient procedure","volume":"59","author":"Henriksson","year":"1979","journal-title":"Acta Neurol Scand"},{"key":"10.1016\/j.clinph.2006.03.028_bib9","doi-asserted-by":"crossref","first-page":"365","DOI":"10.1038\/85520","article-title":"Auto-antibodies to the receptor tyrosine kinase MuSK in patients with myasthenia gravis without acetylcholine receptor antibodies","volume":"7","author":"Hoch","year":"2001","journal-title":"Nat Med"},{"key":"10.1016\/j.clinph.2006.03.028_bib10","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1212\/WNL.55.1.16","article-title":"Myasthenia gravis: recommendations for clinical research standards. Task Force of the Medical Scientific Advisory Board of the Myasthenia Gravis Foundation of America","volume":"55","author":"Jaretzki","year":"2000","journal-title":"Neurology"},{"key":"10.1016\/j.clinph.2006.03.028_bib11","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1002\/ana.410370106","article-title":"Late-onset mitochondrial myopathy","volume":"37","author":"Johnston","year":"1995","journal-title":"Ann Neurol"},{"key":"10.1016\/j.clinph.2006.03.028_bib12","doi-asserted-by":"crossref","first-page":"2821","DOI":"10.1093\/hmg\/9.19.2821","article-title":"Human mtDNA sublimons resemble rearranged mitochondrial genoms found in pathological states","volume":"9","author":"Kajander","year":"2000","journal-title":"Hum Mol Genet"},{"key":"10.1016\/j.clinph.2006.03.028_bib13","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1002\/mus.880100404","article-title":"Single fiber electromyography in chronic progressive external ophthalmoplegia","volume":"10","author":"Krendel","year":"1987","journal-title":"Muscle Nerve"},{"key":"10.1016\/j.clinph.2006.03.028_bib14","doi-asserted-by":"crossref","first-page":"394","DOI":"10.1136\/jnnp.41.5.394","article-title":"Determination of acetylcholine receptor antibodies in myasthenia gravis: clinical usefulness and pathogenetic implications","volume":"41","author":"Lefvert","year":"1978","journal-title":"J Neurol Neurosurg Psychiatry"},{"key":"10.1016\/j.clinph.2006.03.028_bib15","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1016\/0090-1229(77)90027-7","article-title":"An assay for antibodies to human acetylcholine receptor in serum from patients with myasthenia gravis","volume":"7","author":"Lindstrom","year":"1977","journal-title":"Clin Immunol Immunopathol"},{"key":"10.1016\/j.clinph.2006.03.028_bib16","doi-asserted-by":"crossref","first-page":"1054","DOI":"10.1212\/WNL.26.11.1054","article-title":"Antibody to acetylcholine receptor in myasthenia gravis: prevalence, clinical correlates, and diagnostic value","volume":"26","author":"Lindstrom","year":"1976","journal-title":"Neurology"},{"key":"10.1016\/j.clinph.2006.03.028_bib17","doi-asserted-by":"crossref","first-page":"1907","DOI":"10.1093\/hmg\/ddi196","article-title":"Functional defects due to spacer-region mutations of human mitochondrial DNA polymerase in a family with an ataxia\u2013myopathy syndrome","volume":"14","author":"Luoma","year":"2005","journal-title":"Hum Mol Genet"},{"key":"10.1016\/j.clinph.2006.03.028_bib18","doi-asserted-by":"crossref","first-page":"714","DOI":"10.1136\/jnnp.2004.043125","article-title":"Patterns and severity of neuromuscular transmission failure in seronegative myasthenia gravis","volume":"76","author":"Nemoto","year":"2005","journal-title":"J Neurol Neurosurg Psychiatry"},{"key":"10.1016\/j.clinph.2006.03.028_bib19","doi-asserted-by":"crossref","first-page":"2132","DOI":"10.1212\/01.WNL.0000129274.12702.92","article-title":"MuSK antibodies in AChR Ab-seropositive MG vs AChR Ab-seronegative MG","volume":"62","author":"Ohta","year":"2004","journal-title":"Neurology"},{"key":"10.1016\/j.clinph.2006.03.028_bib20","doi-asserted-by":"crossref","first-page":"1988","DOI":"10.1212\/01.wnl.0000188881.46043.44","article-title":"MuSK Ab described in seropositive MG sera found to be Ab to alkaline phosphatase","volume":"65","author":"Ohta","year":"2005","journal-title":"Neurology"},{"key":"10.1016\/j.clinph.2006.03.028_bib21","doi-asserted-by":"crossref","first-page":"581","DOI":"10.1097\/00005072-199507000-00012","article-title":"Mitochondrial DNA deletions in muscle fibers in inclusion body myositis","volume":"4","author":"Oldfors","year":"1995","journal-title":"J Neuropathol Exp Neurol"},{"key":"10.1016\/j.clinph.2006.03.028_bib22","doi-asserted-by":"crossref","unstructured":"Pesce V, Cormio A, Fracasso F, Vecchiet J, Felzani G, Lezza AM, Cantatore P, Gadaleta MN. Age-related mitochondrial genotypic and phenotypic alterations in human skeletal muscle. Free Radic Biol Med 2001;30:1223\u201333.","DOI":"10.1016\/S0891-5849(01)00517-2"},{"key":"10.1016\/j.clinph.2006.03.028_bib23","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1002\/mus.880080311","article-title":"Measurement of junctional acetylcholine receptors in myasthenia gravis: clinical correlates","volume":"8","author":"Pestronk","year":"1985","journal-title":"Muscle Nerve"},{"key":"10.1016\/j.clinph.2006.03.028_bib24","doi-asserted-by":"crossref","first-page":"1069","DOI":"10.1002\/(SICI)1097-4598(199609)19:9<1069::AID-MUS1>3.0.CO;2-Y","article-title":"AAEM minimograph #25: single-fiber electromyography","volume":"19","author":"Sanders","year":"1996","journal-title":"Muscle Nerve"},{"key":"10.1016\/j.clinph.2006.03.028_bib25","doi-asserted-by":"crossref","first-page":"1978","DOI":"10.1212\/01.WNL.0000065882.63904.53","article-title":"Clinical aspects of MuSK antibody positive seronegative MG","volume":"60","author":"Sanders","year":"2003","journal-title":"Neurology"},{"key":"10.1016\/j.clinph.2006.03.028_bib26","doi-asserted-by":"crossref","first-page":"1139","DOI":"10.1097\/01.LAB.0000028144.48023.9B","article-title":"Anti-p110 autoantibodies identify a subtype of \u2018seronegative\u2019 myasthenia gravis with prominent oculobulbar involvement","volume":"82","author":"Scuderi","year":"2002","journal-title":"Lab Invest"},{"key":"10.1016\/j.clinph.2006.03.028_bib27","doi-asserted-by":"crossref","first-page":"1945","DOI":"10.1212\/01.WNL.0000128048.23930.1D","article-title":"Are MuSK antibodies the primary cause of myasthenic symptoms?","volume":"62","author":"Selcen","year":"2004","journal-title":"Neurology"},{"key":"10.1016\/j.clinph.2006.03.028_bib28","doi-asserted-by":"crossref","first-page":"514","DOI":"10.1212\/WNL.38.4.514","article-title":"Seronegative myasthenia gravis","volume":"38","author":"Soliven","year":"1988","journal-title":"Neurology"},{"key":"10.1016\/j.clinph.2006.03.028_bib29","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1016\/0168-5597(93)90068-Z","article-title":"The ability of MUP parameters to discriminate between normal and neurogenic MUPs in concentric EMG: analysis of the MUP \u2018thickness\u2019 and the proposal of \u2018size index\u2019","volume":"89","author":"Sonoo","year":"1993","journal-title":"Electroencephalogr Clin Neurophysiol"},{"key":"10.1016\/j.clinph.2006.03.028_bib30","unstructured":"St\u00e5lberg E. Single fiber electromyography. In: Shahani M, editor. The motor system; Neurophysiological and muscle mechanisms. 1976. p. 79\u201392."},{"issue":"Suppl","key":"10.1016\/j.clinph.2006.03.028_bib31","first-page":"112","article-title":"Neuromuscular transmission studied with single fiber electromyography","author":"St\u00e5lberg","year":"1978","journal-title":"Acta Anaesthesiol Scand"},{"key":"10.1016\/j.clinph.2006.03.028_bib32","doi-asserted-by":"crossref","first-page":"622","DOI":"10.1136\/jnnp.43.7.622","article-title":"Clinical electrophysiology in myasthenia gravis","volume":"43","author":"St\u00e5lberg","year":"1980","journal-title":"J Neurol Neurosurg Psychiatry"},{"key":"10.1016\/j.clinph.2006.03.028_bib33","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1016\/0924-980X(95)00007-8","article-title":"Multi-MUP EMG analysis-a two year experience with a quantitative method in daily routine","volume":"97","author":"St\u00e5lberg","year":"1995","journal-title":"Electromyogr Clin Neurophysiol"},{"key":"10.1016\/j.clinph.2006.03.028_bib34","doi-asserted-by":"crossref","first-page":"2065","DOI":"10.1016\/j.clinph.2005.06.003","article-title":"MuSK-antibody positive myasthenia gravis: clinical and electrodiagnostic patterns","volume":"116","author":"Stickler","year":"2005","journal-title":"Clin Neurophysiol"},{"key":"10.1016\/j.clinph.2006.03.028_bib35","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1002\/ajmg.1379","article-title":"Diseases caused by nuclear genes affecting mtDNA stability","volume":"1","author":"Suomalainen","year":"2001","journal-title":"Am J Med Genet"},{"key":"10.1016\/j.clinph.2006.03.028_bib38","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1038\/90034","article-title":"Mutation of POLG is associated with progressive external ophthalmoplegia characterized by mtDNA deletions","volume":"28","author":"Van Goethem","year":"2001","journal-title":"Nat Genet"},{"key":"10.1016\/j.clinph.2006.03.028_bib36","doi-asserted-by":"crossref","first-page":"529","DOI":"10.1111\/j.1749-6632.1993.tb22936.x","article-title":"Seronegative myasthenia gravis. Evidence for plasma factor(s) interfering with acetylcholine receptor function","volume":"681","author":"Vincent","year":"1993","journal-title":"Ann NY Acad Sci"},{"key":"10.1016\/j.clinph.2006.03.028_bib37","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1002\/mus.20069","article-title":"Clinical comparison of muscle-specific tyrosine kinase (MuSK) antibody-positive and -negative myasthenic patients","volume":"30","author":"Zhou","year":"2004","journal-title":"Muscle Nerve"}],"container-title":["Clinical Neurophysiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1388245706001556?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1388245706001556?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,25]],"date-time":"2025-10-25T10:31:49Z","timestamp":1761388309000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1388245706001556"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2006,7]]},"references-count":38,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2006,7]]}},"alternative-id":["S1388245706001556"],"URL":"https:\/\/doi.org\/10.1016\/j.clinph.2006.03.028","relation":{},"ISSN":["1388-2457"],"issn-type":[{"value":"1388-2457","type":"print"}],"subject":[],"published":{"date-parts":[[2006,7]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Neurophysiological and mitochondrial abnormalities in MuSK antibody seropositive myasthenia gravis compared to other immunological subtypes","name":"articletitle","label":"Article Title"},{"value":"Clinical Neurophysiology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.clinph.2006.03.028","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2006 International Federation of Clinical Neurophysiology. Published by Elsevier Ireland Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}