{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,13]],"date-time":"2026-05-13T07:41:56Z","timestamp":1778658116453,"version":"3.51.4"},"reference-count":48,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2007,2,1]],"date-time":"2007-02-01T00:00:00Z","timestamp":1170288000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2007,2,1]],"date-time":"2007-02-01T00:00:00Z","timestamp":1170288000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Clinical Neurophysiology"],"published-print":{"date-parts":[[2007,2]]},"DOI":"10.1016\/j.clinph.2006.10.015","type":"journal-article","created":{"date-parts":[[2006,12,13]],"date-time":"2006-12-13T12:14:00Z","timestamp":1166012040000},"page":"427-437","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":17,"title":["Differential effect of supraspinal modulation on the nociceptive withdrawal reflex and pain sensation"],"prefix":"10.1016","volume":"118","author":[{"given":"Ruth","family":"Defrin","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Smadar","family":"Peleg","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Harold","family":"Weingarden","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rafi","family":"Heruti","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gideon","family":"Urca","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.clinph.2006.10.015_bib1","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1016\/0361-9230(95)02027-6","article-title":"The medullary dorsal reticular nucleus facilitates acute nociception in the rat","volume":"39","author":"Almeida","year":"1996","journal-title":"Brain Res Bull"},{"key":"10.1016\/j.clinph.2006.10.015_bib2","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1007\/s004210050026","article-title":"Facilitation of the withdrawal reflex by repeated transcutaneous electrical stimulation: an experimental study on central integration in humans","volume":"81","author":"Arendt-Nielsen","year":"2000","journal-title":"Eur J Appl Physiol"},{"key":"10.1016\/j.clinph.2006.10.015_bib3","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1016\/j.ejpain.2004.02.009","article-title":"Facilitation and inhibition of withdrawal reflexes following repetitive stimulation: electro and psychophysiological evidence for activation of noxious inhibitory controls in humans","volume":"9","author":"Bajaj","year":"2005","journal-title":"Eur J Pain"},{"key":"10.1016\/j.clinph.2006.10.015_bib4","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1016\/0304-3959(91)90126-I","article-title":"Study of experimental pain measures and nociceptive reflex in chronic pain patients and normal subjects","volume":"44","author":"Boureau","year":"1991","journal-title":"Pain"},{"key":"10.1016\/j.clinph.2006.10.015_bib5","first-page":"161","article-title":"Standardization of H reflex and diagnostic use in Sl radiculopathy","volume":"55","author":"Braddom","year":"1974","journal-title":"Arch Phys Med Rehabil"},{"key":"10.1016\/j.clinph.2006.10.015_bib6","doi-asserted-by":"crossref","first-page":"339","DOI":"10.1016\/0304-3959(80)90048-2","article-title":"Withdrawal reflex, skin resistance reaction and pain ratings due to electrical stimuli in man","volume":"9","author":"Bromm","year":"1980","journal-title":"Pain"},{"key":"10.1016\/j.clinph.2006.10.015_bib7","doi-asserted-by":"crossref","first-page":"417","DOI":"10.1093\/brain\/112.2.417","article-title":"The effects of voluntary contraction on the H reflex of human limb muscles","volume":"112","author":"Burke","year":"1989","journal-title":"Brain"},{"key":"10.1016\/j.clinph.2006.10.015_bib8","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1053\/eujp.1999.0158","article-title":"Descending facilitatory modulation of a behavioral nociceptive response by stimulation in the adult rat anterior cingulate cortex","volume":"4","author":"Calejesan","year":"2000","journal-title":"Eur J Pain"},{"key":"10.1016\/j.clinph.2006.10.015_bib9","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1016\/0304-3959(91)90050-8","article-title":"Comparison of human pain sensation and flexion withdrawal evoked by noxious radiant heat","volume":"45","author":"Campbell","year":"1991","journal-title":"Pain"},{"key":"10.1016\/j.clinph.2006.10.015_bib10","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1016\/0006-8993(89)91344-9","article-title":"Subjective pain sensation is linearly correlated with the flexion reflex in man","volume":"479","author":"Chan","year":"1989","journal-title":"Brain Res"},{"key":"10.1016\/j.clinph.2006.10.015_bib11","doi-asserted-by":"crossref","first-page":"361","DOI":"10.1016\/0304-3959(86)90064-3","article-title":"Measurement of pain and morphine hypalgesia in monkeys","volume":"26","author":"Cooper","year":"1986","journal-title":"Pain"},{"key":"10.1016\/j.clinph.2006.10.015_bib12","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1016\/S0304-3959(97)00208-X","article-title":"Different strategies of modulation can be operative during hypnotic analgesia: a neurophysiological study","volume":"75","author":"Danziger","year":"1998","journal-title":"Pain"},{"key":"10.1016\/j.clinph.2006.10.015_bib13","series-title":"Issues in Pain Measurement","first-page":"337","article-title":"The nociceptive reflex in humans: a specific and objective correlate of experimental pain","author":"DeBroucker","year":"1989"},{"key":"10.1016\/j.clinph.2006.10.015_bib14","first-page":"349","article-title":"Studies of spasticity in man. 3. Analysis of reflex activity evoked by noxious cutaneous stimulation","volume":"91","author":"Dimitrijevic\u2019","year":"1968","journal-title":"Brain"},{"key":"10.1016\/j.clinph.2006.10.015_bib15","first-page":"70","article-title":"The international standards booklet of neurological and functional classification of spinal cord injury","volume":"32","author":"Ditunno","year":"1994","journal-title":"Paraplegia"},{"key":"10.1016\/j.clinph.2006.10.015_bib16","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1016\/0304-3959(91)90051-X","article-title":"Spinal and supraspinal correlates of nociception in man","volume":"45","author":"Dowman","year":"1991","journal-title":"Pain"},{"key":"10.1016\/j.clinph.2006.10.015_bib17","doi-asserted-by":"crossref","first-page":"732","DOI":"10.1002\/(SICI)1097-4598(199806)21:6<732::AID-MUS4>3.0.CO;2-8","article-title":"The Hoffmann reflex of human plantar foot muscles","volume":"21","author":"Ellrich","year":"1998","journal-title":"Muscle Nerve"},{"key":"10.1016\/j.clinph.2006.10.015_bib18","series-title":"Textbook of Pain","first-page":"309","article-title":"Central nervous system mechanisms of pain modulation","author":"Fields","year":"1999"},{"key":"10.1016\/j.clinph.2006.10.015_bib19","doi-asserted-by":"crossref","first-page":"591","DOI":"10.1002\/(SICI)1097-4598(199805)21:5<591::AID-MUS5>3.0.CO;2-3","article-title":"Cutaneous withdrawal reflexes of the upper extremity","volume":"21","author":"Floeter","year":"1998","journal-title":"Muscle Nerve"},{"key":"10.1016\/j.clinph.2006.10.015_bib20","doi-asserted-by":"crossref","first-page":"358","DOI":"10.1016\/j.pain.2004.12.034","article-title":"The influence of acute anxiety on assessment of nociceptive flexion reflex thresholds in healthy young adults","volume":"114","author":"French","year":"2005","journal-title":"Pain"},{"key":"10.1016\/j.clinph.2006.10.015_bib21","doi-asserted-by":"crossref","first-page":"166","DOI":"10.1002\/(SICI)1097-4598(199802)21:2<166::AID-MUS3>3.0.CO;2-9","article-title":"Suppression of flexor reflex by transcutaneous electrical nerve stimulation in spinal cord injured patients","volume":"21","author":"Gregoric\u2019","year":"1998","journal-title":"Muscle Nerve"},{"key":"10.1016\/j.clinph.2006.10.015_bib22","doi-asserted-by":"crossref","first-page":"102","DOI":"10.1016\/0168-5597(92)90075-M","article-title":"Reinforcement of subliminal flexion reflexes by transcranial magnetic stimulation of motor cortex in subjects with spinal cord injury","volume":"85","author":"Hayes","year":"1992","journal-title":"Electroencephalo clin neurophysiol"},{"key":"10.1016\/j.clinph.2006.10.015_bib23","series-title":"New Developments in Electromyography and Clinical Neurophysiology","first-page":"713","article-title":"Exteroceptive reflexes to stimulation of the sural nerve in normal man","author":"Hugon","year":"1973"},{"key":"10.1016\/j.clinph.2006.10.015_bib24","doi-asserted-by":"crossref","first-page":"234","DOI":"10.1016\/S0006-8993(98)00379-5","article-title":"Influence of spinalization on spinal withdrawal reflex responses varies depending on the submodality of the test stimulus and the experimental pathophysiological condition in the rat","volume":"797","author":"Kauppilla","year":"1998","journal-title":"Brain Res"},{"key":"10.1016\/j.clinph.2006.10.015_bib25","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1016\/0304-3959(94)00134-Z","article-title":"Hypnotic analgesia reduces RIII nociceptive reflex: further evidence concerning the multifactorial nature of hypnotic analgesia","volume":"60","author":"Kiernan","year":"1995","journal-title":"Pain"},{"key":"10.1016\/j.clinph.2006.10.015_bib26","doi-asserted-by":"crossref","first-page":"1022","DOI":"10.1152\/jn.1990.63.5.1022","article-title":"Tonic descending influences on receptive-field properties of nociceptive dorsal horn neurones in sacral spinal cord of rat","volume":"63","author":"Laird","year":"1990","journal-title":"J Neurophysiol"},{"key":"10.1016\/j.clinph.2006.10.015_bib27","first-page":"1303","article-title":"Evocation of \u201cearly\u201d and \u201clate\u201d components of a cutaneous reflex by non-painful stimuli in man","volume":"14","author":"Nord","year":"1988","journal-title":"Soc Neurosci abs"},{"key":"10.1016\/j.clinph.2006.10.015_bib28","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1097\/00002508-198703010-00001","article-title":"Combined use of experimental pain and visual analogue scales in providing standardized measurement of clinical pain","volume":"3","author":"Price","year":"1987","journal-title":"Clin J Pain"},{"key":"10.1016\/j.clinph.2006.10.015_bib29","doi-asserted-by":"crossref","first-page":"707","DOI":"10.1093\/brain\/110.3.707","article-title":"Long-latency spinal reflex in man after flexor reflex afferent stimulation","volume":"110","author":"Roby-Brami","year":"1987","journal-title":"Brain"},{"key":"10.1016\/j.clinph.2006.10.015_bib30","doi-asserted-by":"crossref","first-page":"593","DOI":"10.1007\/BF02423509","article-title":"Effects of flexor reflex afferent stimulation on the soleus H reflex in patients with a complete spinal cord lesion: evidence for presynaptic inhibition of Ia transmission","volume":"81","author":"Roby-Brami","year":"1990","journal-title":"Exp Brain Res"},{"key":"10.1016\/j.clinph.2006.10.015_bib31","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1016\/0304-3959(94)00088-V","article-title":"Differential effects of spinalization on discharge patterns and discharge rates of simultaneously recorded nociceptive and non-nociceptive spinal dorsal horn neurons","volume":"60","author":"Sandk\u00fchler","year":"1995","journal-title":"Pain"},{"key":"10.1016\/j.clinph.2006.10.015_bib32","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1016\/S0304-3940(98)01000-3","article-title":"Differential effect of high doses of naloxon on spinal reflexes in normal subjects and chronic paraplegic patients","volume":"261","author":"Sandrini","year":"1999","journal-title":"Neurosci Lett"},{"key":"10.1016\/j.clinph.2006.10.015_bib33","doi-asserted-by":"crossref","first-page":"345","DOI":"10.1016\/0301-0082(87)90007-4","article-title":"The Hoffmann reflex: a means of assessing spinal reflex excitability and its descending control in man","volume":"28","author":"Schieppati","year":"1987","journal-title":"Prog Neurobiol"},{"key":"10.1016\/j.clinph.2006.10.015_bib34","doi-asserted-by":"crossref","first-page":"469","DOI":"10.1007\/BF00230929","article-title":"Functional organization of the nociceptive withdrawal reflexes: II. Changes of excitability and receptive fields after spinalization in the rat","volume":"90","author":"Schouenborg","year":"1992","journal-title":"Exp Brain Res"},{"key":"10.1016\/j.clinph.2006.10.015_bib35","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1113\/jphysiol.1910.sp001362","article-title":"Flexion-reflex of the limb, crossed extension-reflex and reflex stepping and standing","volume":"40","author":"Sherrington","year":"1910","journal-title":"J Physiol (Lond)"},{"key":"10.1016\/j.clinph.2006.10.015_bib36","doi-asserted-by":"crossref","first-page":"224","DOI":"10.1111\/j.1525-1594.2005.29040.x","article-title":"Repetitive painful stimulation produces an expansion of withdrawal reflex receptive fields in humans","volume":"29","author":"Spaich","year":"2005","journal-title":"Artif Organs"},{"key":"10.1016\/j.clinph.2006.10.015_bib37","doi-asserted-by":"crossref","first-page":"80","DOI":"10.1126\/science.133.3446.80","article-title":"To honor Fechner and repeal his law","volume":"133","author":"Stevens","year":"1961","journal-title":"Science"},{"key":"10.1016\/j.clinph.2006.10.015_bib38","doi-asserted-by":"crossref","first-page":"785","DOI":"10.1152\/jn.1986.56.3.785","article-title":"Effects of reversible spinalization on the visceral input to viscerosomatic neurons in the lower thoracic spinal cord of the cat","volume":"56","author":"Tattersall","year":"1986","journal-title":"J Neurophysiol"},{"key":"10.1016\/j.clinph.2006.10.015_bib39","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1046\/j.1365-201x.2001.00856.x","article-title":"Effects of heterotopic and segmental counter-stimulation on the nociceptive withdrawal reflex in humans","volume":"172","author":"Terkelsen","year":"2001","journal-title":"Acta Physiol Scand"},{"key":"10.1016\/j.clinph.2006.10.015_bib40","doi-asserted-by":"crossref","first-page":"405","DOI":"10.1111\/j.1365-201X.2004.01263.x","article-title":"Mental stree inhibits pain perception and heart rate variability but not a nociceptive withdrawal refelex","volume":"180","author":"Terkelsen","year":"2004","journal-title":"Acta Physiol Scand"},{"key":"10.1016\/j.clinph.2006.10.015_bib41","doi-asserted-by":"crossref","first-page":"731","DOI":"10.1152\/japplphysiol.00076.2004","article-title":"Neural control of muscle blood flow during exercise","volume":"97","author":"Thomas","year":"2004","journal-title":"J Appl Physiol"},{"key":"10.1016\/j.clinph.2006.10.015_bib42","doi-asserted-by":"crossref","first-page":"865","DOI":"10.1016\/S0022-3999(02)00429-4","article-title":"Hypothalamic\u2013pituitary\u2013adrenal axis, neroendocrine factors and stress","volume":"53","author":"Tsigos","year":"2002","journal-title":"J Psychosom Res"},{"key":"10.1016\/j.clinph.2006.10.015_bib43","doi-asserted-by":"crossref","first-page":"663","DOI":"10.1002\/mus.20011","article-title":"Different short-term modulation of cortical motor output to distal and proximal upper-limb muscles during painful sensory nerve stimulation","volume":"29","author":"Urban","year":"2004","journal-title":"Muscle Nerve"},{"key":"10.1016\/j.clinph.2006.10.015_bib44","doi-asserted-by":"crossref","first-page":"403","DOI":"10.1113\/jphysiol.1967.sp008146","article-title":"The laminar organization of dorsal horn and effects of descending pulses","volume":"188","author":"Wall","year":"1967","journal-title":"J Physiol (Lond)"},{"key":"10.1016\/j.clinph.2006.10.015_bib45","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1016\/0304-3959(77)90036-7","article-title":"Comparative study of perceived pain and nociceptive flexion reflex in man","volume":"3","author":"Willer","year":"1977","journal-title":"Pain"},{"key":"10.1016\/j.clinph.2006.10.015_bib46","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1016\/0006-8993(79)90489-X","article-title":"Supraspinal influences on nociceptive flexion reflex and pain sensation in man","volume":"179","author":"Willer","year":"1979","journal-title":"Brain Res"},{"key":"10.1016\/j.clinph.2006.10.015_bib47","doi-asserted-by":"crossref","first-page":"1095","DOI":"10.1093\/brain\/107.4.1095","article-title":"Psychophysical and electrophysiological approaches to the pain-relieving effects of heterotopic nociceptive stimuli","volume":"107","author":"Willer","year":"1984","journal-title":"Brain"},{"key":"10.1016\/j.clinph.2006.10.015_bib48","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1016\/0304-3959(90)91147-B","article-title":"Characterization of descending inhibition and facilitation from the nuclei reticularis gigantocellularis and gigantocellularis pars alpha in the rat","volume":"42","author":"Zhuo","year":"1990","journal-title":"Pain"}],"container-title":["Clinical Neurophysiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1388245706015082?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1388245706015082?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,25]],"date-time":"2025-10-25T10:34:47Z","timestamp":1761388487000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1388245706015082"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2007,2]]},"references-count":48,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2007,2]]}},"alternative-id":["S1388245706015082"],"URL":"https:\/\/doi.org\/10.1016\/j.clinph.2006.10.015","relation":{},"ISSN":["1388-2457"],"issn-type":[{"value":"1388-2457","type":"print"}],"subject":[],"published":{"date-parts":[[2007,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Differential effect of supraspinal modulation on the nociceptive withdrawal reflex and pain sensation","name":"articletitle","label":"Article Title"},{"value":"Clinical Neurophysiology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.clinph.2006.10.015","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2006 International Federation of Clinical Neurophysiology. Published by Elsevier Ireland Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}