{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,18]],"date-time":"2026-03-18T21:16:56Z","timestamp":1773868616930,"version":"3.50.1"},"reference-count":46,"publisher":"Elsevier BV","issue":"5","license":[{"start":{"date-parts":[[2011,5,1]],"date-time":"2011-05-01T00:00:00Z","timestamp":1304208000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2011,5,1]],"date-time":"2011-05-01T00:00:00Z","timestamp":1304208000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Clinical Neurophysiology"],"published-print":{"date-parts":[[2011,5]]},"DOI":"10.1016\/j.clinph.2010.07.029","type":"journal-article","created":{"date-parts":[[2010,9,28]],"date-time":"2010-09-28T05:44:39Z","timestamp":1285652679000},"page":"1005-1010","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":17,"title":["Heightened flexor withdrawal responses following ACL rupture are enhanced by passive tibial translation"],"prefix":"10.1016","volume":"122","author":[{"given":"Carol A.","family":"Courtney","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Reuben K.","family":"Durr","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alicia J.","family":"Emerson-Kavchak","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eric O.","family":"Witte","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marcio J.","family":"Santos","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.clinph.2010.07.029_b0005","doi-asserted-by":"crossref","first-page":"1117","DOI":"10.1007\/s00167-009-0846-5","article-title":"Knee laxity measurements after anterior cruciate ligament reconstruction, using either bone-patellar-tendon-bone or hamstring tendon autografts, with special emphasis on comparison over time","volume":"17","author":"Ahlden","year":"2009","journal-title":"Knee Surg Sports Traumatol Arthrosc"},{"key":"10.1016\/j.clinph.2010.07.029_b0010","doi-asserted-by":"crossref","first-page":"434","DOI":"10.1007\/s00221-003-1550-1","article-title":"Foot-sole reflex receptive fields for human withdrawal reflexes in symmetrical standing position","volume":"152","author":"Andersen","year":"2003","journal-title":"Exp Brain Res"},{"key":"10.1016\/j.clinph.2010.07.029_b0015","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1007\/s004210050026","article-title":"Facilitation of the withdrawal reflex by repeated transcutaneous electrical stimulation: an experimental study on central integration in humans","volume":"81","author":"Arendt-Nielsen","year":"2000","journal-title":"Eur J Appl Physiol"},{"key":"10.1016\/j.clinph.2010.07.029_b0020","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1007\/BF00231718","article-title":"Directional specificity of postural muscles in feed-forward postural reactions during fast voluntary arm movements","volume":"103","author":"Aruin","year":"1995","journal-title":"Exp Brain Res"},{"key":"10.1016\/j.clinph.2010.07.029_b0025","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1016\/j.ejpain.2004.02.009","article-title":"Facilitation and inhibition of withdrawal reflexes following repetitive stimulation: electro- and psychophysiological evidence for activation of noxious inhibitory controls in humans","volume":"9","author":"Bajaj","year":"2005","journal-title":"Eur J Pain"},{"key":"10.1016\/j.clinph.2010.07.029_b0030","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1016\/j.pain.2003.05.001","article-title":"Evidence for spinal cord hypersensitivity in chronic pain after whiplash injury and in fibromyalgia","volume":"107","author":"Banic","year":"2004","journal-title":"Pain"},{"key":"10.1016\/j.clinph.2010.07.029_b0035","doi-asserted-by":"crossref","first-page":"871","DOI":"10.2106\/00004623-199072060-00012","article-title":"Gait adaptations by patients who have a deficient anterior cruciate ligament","volume":"72","author":"Berchuck","year":"1990","journal-title":"J Bone Joint Surg Am"},{"key":"10.1016\/j.clinph.2010.07.029_b0040","doi-asserted-by":"crossref","first-page":"567","DOI":"10.1007\/s00421-008-0729-3","article-title":"Loss of neuromuscular control related to motion in the acutely ACL-injured knee: an experimental study","volume":"104","author":"Bonsfills","year":"2008","journal-title":"Eur J Appl Physiol"},{"key":"10.1016\/j.clinph.2010.07.029_b0045","doi-asserted-by":"crossref","first-page":"445","DOI":"10.1113\/jphysiol.1991.sp018393","article-title":"Task-dependent changes in the responses to low-threshold cutaneous afferent volleys in the human lower limb","volume":"432","author":"Burke","year":"1991","journal-title":"J Physiol"},{"key":"10.1016\/j.clinph.2010.07.029_b0050","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1249\/mss.0b013e31815cbb0e","article-title":"Knee kinematics, cartilage morphology, and osteoarthritis after ACL injury","volume":"40","author":"Chaudhari","year":"2008","journal-title":"Med Sci Sports Exerc"},{"key":"10.1016\/j.clinph.2010.07.029_b0055","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1016\/S0966-6362(01)00202-8","article-title":"Changes in weight-bearing following injury or surgical reconstruction of the ACL: relationship to quadriceps strength and function","volume":"16","author":"Chmielewski","year":"2002","journal-title":"Gait Posture"},{"key":"10.1016\/j.clinph.2010.07.029_b0060","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1016\/j.jelekin.2004.07.003","article-title":"Elucidation of a potentially destabilizing control strategy in ACL deficient non-copers","volume":"15","author":"Chmielewski","year":"2005","journal-title":"J Electromyogr Kinesiol"},{"key":"10.1016\/j.clinph.2010.07.029_b0065","doi-asserted-by":"crossref","first-page":"545","DOI":"10.1111\/j.1469-7793.2001.0545i.x","article-title":"Transcranial magnetic stimulation and stretch reflexes in the tibialis anterior muscle during human walking","volume":"531","author":"Christensen","year":"2001","journal-title":"J Physiol"},{"key":"10.1016\/j.clinph.2010.07.029_b0070","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1016\/j.gaitpost.2004.07.002","article-title":"Central somatosensory changes and altered muscle synergies in subjects with anterior cruciate ligament deficiency","volume":"22","author":"Courtney","year":"2005","journal-title":"Gait Posture"},{"key":"10.1016\/j.clinph.2010.07.029_b0080","doi-asserted-by":"crossref","first-page":"190","DOI":"10.1016\/j.gaitpost.2005.08.006","article-title":"Central somatosensory changes associated with improved dynamic balance in subjects with anterior cruciate ligament deficiency","volume":"24","author":"Courtney","year":"2006","journal-title":"Gait Posture"},{"key":"10.1016\/j.clinph.2010.07.029_b0075","doi-asserted-by":"crossref","first-page":"1242","DOI":"10.1016\/j.jpain.2009.05.004","article-title":"Heightened flexor withdrawal responses in subjects with knee osteoarthritis","volume":"10","author":"Courtney","year":"2009","journal-title":"J Pain"},{"issue":"2","key":"10.1016\/j.clinph.2010.07.029_b0085","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1016\/j.jpain.2009.07.005","article-title":"Heightened flexor withdrawal response in individuals with knee osteoarthritis is modulated by joint compression and joint mobilization","volume":"11","author":"Courtney","year":"2010","journal-title":"J Pain"},{"key":"10.1016\/j.clinph.2010.07.029_b0090","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1007\/BF00229271","article-title":"Effect of knee joint laxity on long-loop postural reflexes: evidence for a human capsular-hamstring reflex","volume":"90","author":"Di Fabio","year":"1992","journal-title":"Exp Brain Res"},{"key":"10.1016\/j.clinph.2010.07.029_b0095","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1016\/0304-3959(92)90142-X","article-title":"Possible startle response contamination of the spinal nociceptive withdrawal reflex","volume":"49","author":"Dowman","year":"1992","journal-title":"Pain"},{"key":"10.1016\/j.clinph.2010.07.029_b0100","doi-asserted-by":"crossref","first-page":"2191","DOI":"10.1152\/jappl.2000.89.6.2191","article-title":"Muscular reflexes elicited by electrical stimulation of the anterior cruciate ligament in humans","volume":"89","author":"Dyhre-Poulsen","year":"2000","journal-title":"J Appl Physiol"},{"key":"10.1016\/j.clinph.2010.07.029_b0105","doi-asserted-by":"crossref","first-page":"210","DOI":"10.1097\/00005768-199902000-00002","article-title":"Laxity, instability, and functional outcome after ACL injury: copers versus noncopers","volume":"31","author":"Eastlack","year":"1999","journal-title":"Med Sci Sports Exerc"},{"key":"10.1016\/j.clinph.2010.07.029_b0110","doi-asserted-by":"crossref","first-page":"1707","DOI":"10.1002\/art.23495","article-title":"Decreased lubricin concentrations and markers of joint inflammation in the synovial fluid of patients with anterior cruciate ligament injury","volume":"58","author":"Elsaid","year":"2008","journal-title":"Arthritis Rheum"},{"key":"10.1016\/j.clinph.2010.07.029_b0115","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1113\/expphysiol.1988.sp003127","article-title":"The effect of acute joint inflammation on flexion reflex excitability in the decerebrate, low-spinal cat","volume":"73","author":"Ferrell","year":"1988","journal-title":"Q J Exp Physiol"},{"key":"10.1016\/j.clinph.2010.07.029_b0120","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1080\/17453670710014743","article-title":"Insufficient recovery of neuromuscular activity around the knee after experimental anterior cruciate ligament reconstruction","volume":"79","author":"Gomez-Barrena","year":"2008","journal-title":"Acta Orthop"},{"key":"10.1016\/j.clinph.2010.07.029_b0125","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1123\/jsr.17.1.60","article-title":"The relationship between grading and instrumented measurements of anterior knee joint laxity","volume":"17","author":"Hurley","year":"2008","journal-title":"J Sport Rehabil"},{"key":"10.1016\/j.clinph.2010.07.029_b0130","doi-asserted-by":"crossref","first-page":"1132","DOI":"10.2106\/00004623-199808000-00006","article-title":"Development of a patient-reported measure of function of the knee","volume":"80","author":"Irrgang","year":"1998","journal-title":"J Bone Joint Surg Am"},{"key":"10.1016\/j.clinph.2010.07.029_b0135","doi-asserted-by":"crossref","first-page":"696","DOI":"10.1016\/j.tins.2003.09.017","article-title":"Central sensitization and LTP: do pain and memory share similar mechanisms?","volume":"26","author":"Ji","year":"2003","journal-title":"Trends Neurosci"},{"key":"10.1016\/j.clinph.2010.07.029_b0140","doi-asserted-by":"crossref","first-page":"709","DOI":"10.1113\/jphysiol.1971.sp009684","article-title":"Observations on the control of stepping and hopping movements in man","volume":"219","author":"Jones","year":"1971","journal-title":"J Physiol"},{"key":"10.1016\/j.clinph.2010.07.029_b0145","doi-asserted-by":"crossref","first-page":"1061","DOI":"10.1001\/archneur.1993.00540100056015","article-title":"Decreased nociceptive flexion reflex threshold in chronic tension-type headache","volume":"50","author":"Langemark","year":"1993","journal-title":"Arch Neurol"},{"key":"10.1016\/j.clinph.2010.07.029_b0150","article-title":"Osteoarthritis in patients with anterior cruciate ligament rupture: a review of risk factors","author":"Louboutin","year":"2008","journal-title":"Knee"},{"key":"10.1016\/j.clinph.2010.07.029_b0155","doi-asserted-by":"crossref","first-page":"114","DOI":"10.1016\/j.joca.2005.08.005","article-title":"Early post-traumatic osteoarthritis-like changes in human articular cartilage following rupture of the anterior cruciate ligament","volume":"14","author":"Nelson","year":"2006","journal-title":"Osteoarthritis Cartilage"},{"key":"10.1016\/j.clinph.2010.07.029_b0160","doi-asserted-by":"crossref","first-page":"360","DOI":"10.1038\/384360a0","article-title":"Inflammatory pain hypersensitivity mediated by phenotypic switch in myelinated primary sensory neurons","volume":"384","author":"Neumann","year":"1996","journal-title":"Nature"},{"key":"10.1016\/j.clinph.2010.07.029_b0165","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1111\/j.1600-0838.1999.tb00202.x","article-title":"Motor performance in different dynamic tests in knee rehabilitation","volume":"9","author":"Pfeifer","year":"1999","journal-title":"Scand J Med Sci Sports"},{"key":"10.1016\/j.clinph.2010.07.029_b0170","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1016\/0304-3959(83)90126-4","article-title":"The validation of visual analogue scales as ratio scale measures for chronic and experimental pain","volume":"17","author":"Price","year":"1983","journal-title":"Pain"},{"key":"10.1016\/j.clinph.2010.07.029_b0175","doi-asserted-by":"crossref","first-page":"1320","DOI":"10.1016\/j.arthro.2007.07.003","article-title":"A meta-analysis of the incidence of anterior cruciate ligament tears as a function of gender, sport, and a knee injury-reduction regimen","volume":"23","author":"Prodromos","year":"2007","journal-title":"Arthroscopy"},{"issue":"Pt. 2","key":"10.1016\/j.clinph.2010.07.029_b0180","doi-asserted-by":"crossref","first-page":"521","DOI":"10.1113\/jphysiol.1994.sp020460","article-title":"Flexibility of lower limb reflex responses to painful cutaneous stimulation in standing humans: evidence of load-dependent modulation","volume":"481","author":"Rossi","year":"1994","journal-title":"J Physiol"},{"key":"10.1016\/j.clinph.2010.07.029_b0185","doi-asserted-by":"crossref","first-page":"353","DOI":"10.1016\/j.pneurobio.2005.11.003","article-title":"The lower limb flexion reflex in humans","volume":"77","author":"Sandrini","year":"2005","journal-title":"Prog Neurobiol"},{"key":"10.1016\/j.clinph.2010.07.029_b0190","doi-asserted-by":"crossref","first-page":"589","DOI":"10.1016\/j.gaitpost.2007.08.001","article-title":"Unloading reactions in functional ankle instability","volume":"27","author":"Santos","year":"2008","journal-title":"Gait Posture"},{"key":"10.1016\/j.clinph.2010.07.029_b0195","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1016\/S0304-3959(03)00320-8","article-title":"Joint manipulation reduces hyperalgesia by activation of monoamine receptors but not opioid or GABA receptors in the spinal cord","volume":"106","author":"Skyba","year":"2003","journal-title":"Pain"},{"key":"10.1016\/j.clinph.2010.07.029_b0200","doi-asserted-by":"crossref","first-page":"555","DOI":"10.2106\/00004623-199404000-00010","article-title":"Reflex inhibition of the quadriceps femoris muscle after injury or reconstruction of the anterior cruciate ligament","volume":"76","author":"Snyder-Mackler","year":"1994","journal-title":"J Bone Joint Surg Am"},{"key":"10.1016\/j.clinph.2010.07.029_b0205","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1177\/036354658701500302","article-title":"The synergistic action of the anterior cruciate ligament and thigh muscles in maintaining joint stability","volume":"15","author":"Solomonow","year":"1987","journal-title":"Am J Sports Med"},{"key":"10.1016\/j.clinph.2010.07.029_b0210","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1034\/j.1600-0838.2001.011002064.x","article-title":"Sensorimotor control of knee stability. A review","volume":"11","author":"Solomonow","year":"2001","journal-title":"Scand J Med Sci Sports"},{"key":"10.1016\/j.clinph.2010.07.029_b0215","doi-asserted-by":"crossref","first-page":"124","DOI":"10.1097\/AJP.0b013e31815ca293","article-title":"Psychologic factors are related to some sensory pain thresholds but not nociceptive flexion reflex threshold in chronic whiplash","volume":"24","author":"Sterling","year":"2008","journal-title":"Clin J Pain"},{"key":"10.1016\/j.clinph.2010.07.029_b0220","doi-asserted-by":"crossref","first-page":"497","DOI":"10.1007\/s00167-003-0453-9","article-title":"Distribution of substance-P nerve fibers in intact and ruptured human anterior cruciate ligament: a semi-quantitative immunohistochemical assessment","volume":"12","author":"Witonski","year":"2004","journal-title":"Knee Surg Sports Traumatol Arthrosc"},{"key":"10.1016\/j.clinph.2010.07.029_b0225","doi-asserted-by":"crossref","first-page":"1433","DOI":"10.1523\/JNEUROSCI.06-05-01433.1986","article-title":"Relative effectiveness of C primary afferent fibers of different origins in evoking a prolonged facilitation of the flexor reflex in the rat","volume":"6","author":"Woolf","year":"1986","journal-title":"J Neurosci"},{"key":"10.1016\/j.clinph.2010.07.029_b0230","doi-asserted-by":"crossref","first-page":"1967","DOI":"10.1177\/0363546509335000","article-title":"Identification of athletes at future risk of anterior cruciate ligament ruptures by neuromuscular screening","volume":"37","author":"Zebis","year":"2009","journal-title":"Am J Sports Med"}],"container-title":["Clinical Neurophysiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1388245710006620?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1388245710006620?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,25]],"date-time":"2025-10-25T11:01:13Z","timestamp":1761390073000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1388245710006620"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011,5]]},"references-count":46,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2011,5]]}},"alternative-id":["S1388245710006620"],"URL":"https:\/\/doi.org\/10.1016\/j.clinph.2010.07.029","relation":{},"ISSN":["1388-2457"],"issn-type":[{"value":"1388-2457","type":"print"}],"subject":[],"published":{"date-parts":[[2011,5]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Heightened flexor withdrawal responses following ACL rupture are enhanced by passive tibial translation","name":"articletitle","label":"Article Title"},{"value":"Clinical Neurophysiology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.clinph.2010.07.029","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2010 International Federation of Clinical Neurophysiology. Published by Elsevier Ireland Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}