{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,19]],"date-time":"2026-10-19T09:12:40Z","timestamp":1792401160608,"version":"4.4.0"},"reference-count":46,"publisher":"Elsevier BV","issue":"9","license":[{"start":{"date-parts":[[2015,9,1]],"date-time":"2015-09-01T00:00:00Z","timestamp":1441065600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2015,9,1]],"date-time":"2015-09-01T00:00:00Z","timestamp":1441065600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/501100004543","name":"China Scholarship Council","doi-asserted-by":"publisher","award":["2011607033"],"award-info":[{"award-number":["2011607033"]}],"id":[{"id":"10.13039\/501100004543","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012166","name":"National Key Research and Development Program of China","doi-asserted-by":"publisher","award":["2012CB517901"],"award-info":[{"award-number":["2012CB517901"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012226","name":"Fundamental Research Funds for the Central Universities","doi-asserted-by":"publisher","award":["ZYGX2013Z004"],"award-info":[{"award-number":["ZYGX2013Z004"]}],"id":[{"id":"10.13039\/501100012226","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100013286","name":"Specialized Research Fund for the Doctoral Program of Higher Education of China","doi-asserted-by":"publisher","award":["20120185110028"],"award-info":[{"award-number":["20120185110028"]}],"id":[{"id":"10.13039\/501100013286","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002338","name":"Ministry of Education of the People's Republic of China","doi-asserted-by":"publisher","award":["A03003023901010"],"award-info":[{"award-number":["A03003023901010"]}],"id":[{"id":"10.13039\/501100002338","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["31400901"],"award-info":[{"award-number":["31400901"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["61035006"],"award-info":[{"award-number":["61035006"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["61125304"],"award-info":[{"award-number":["61125304"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81171406"],"award-info":[{"award-number":["81171406"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Clinical Neurophysiology"],"published-print":{"date-parts":[[2015,9]]},"DOI":"10.1016\/j.clinph.2014.11.014","type":"journal-article","created":{"date-parts":[[2014,11,29]],"date-time":"2014-11-29T05:26:57Z","timestamp":1417238817000},"page":"1711-1716","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":119,"title":["Disrupted cortical hubs in functional brain networks in social anxiety disorder"],"prefix":"10.1016","volume":"126","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2733-8602","authenticated-orcid":false,"given":"Feng","family":"Liu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chunyan","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yifeng","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenbin","family":"Guo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Meiling","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenqin","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhiliang","family":"Long","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yajing","family":"Meng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qian","family":"Cui","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ling","family":"Zeng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qiyong","family":"Gong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huafu","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.clinph.2014.11.014_b0005","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1523\/JNEUROSCI.3874-05.2006","article-title":"A resilient, low-frequency, small-world human brain functional network with highly connected association cortical hubs","volume":"26","author":"Achard","year":"2006","journal-title":"J Neurosci"},{"key":"10.1016\/j.clinph.2014.11.014_b0010","series-title":"Diagnostic and statistical manual of mental disorders: DSM-IV","author":"APA","year":"1994"},{"key":"10.1016\/j.clinph.2014.11.014_b0015","doi-asserted-by":"crossref","first-page":"512","DOI":"10.1177\/1073858406293182","article-title":"Small-world brain networks","volume":"12","author":"Bassett","year":"2006","journal-title":"Neuroscientist"},{"key":"10.1016\/j.clinph.2014.11.014_b9000","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1212\/WNL.58.1.71","article-title":"Lesions of the fusiform face area impair perception of facial configuration in prosopagnosia","volume":"58","author":"Barton","year":"2002","journal-title":"Neurol"},{"key":"10.1016\/j.clinph.2014.11.014_b0020","doi-asserted-by":"crossref","first-page":"1860","DOI":"10.1523\/JNEUROSCI.5062-08.2009","article-title":"Cortical hubs revealed by intrinsic functional connectivity: mapping, assessment of stability, and relation to Alzheimer\u2019s disease","volume":"29","author":"Buckner","year":"2009","journal-title":"J Neurosci"},{"key":"10.1016\/j.clinph.2014.11.014_b0025","doi-asserted-by":"crossref","first-page":"186","DOI":"10.1038\/nrn2575","article-title":"Complex brain networks: graph theoretical analysis of structural and functional systems","volume":"10","author":"Bullmore","year":"2009","journal-title":"Nat Rev Neurosci"},{"key":"10.1016\/j.clinph.2014.11.014_b0030","doi-asserted-by":"crossref","first-page":"455","DOI":"10.1016\/j.biopsych.2006.09.017","article-title":"Time-varying amygdala response to emotional faces in generalized social phobia","volume":"62","author":"Campbell","year":"2007","journal-title":"Biol Psychiatry"},{"key":"10.1016\/j.clinph.2014.11.014_b0035","doi-asserted-by":"crossref","first-page":"564","DOI":"10.1093\/brain\/awl004","article-title":"The precuneus: a review of its functional anatomy and behavioural correlates","volume":"129","author":"Cavanna","year":"2006","journal-title":"Brain"},{"key":"10.1016\/j.clinph.2014.11.014_b0040","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1016\/j.jad.2012.05.025","article-title":"Early and late onset, first-episode, treatment-naive depression: same clinical symptoms, different regional neural activities","volume":"143","author":"Chen","year":"2012","journal-title":"J Affect Disord"},{"key":"10.1016\/j.clinph.2014.11.014_b0045","doi-asserted-by":"crossref","first-page":"3057","DOI":"10.1016\/j.neuroimage.2009.10.090","article-title":"Topological FDR for neuroimaging","volume":"49","author":"Chumbley","year":"2010","journal-title":"Neuroimage"},{"key":"10.1016\/j.clinph.2014.11.014_b0050","doi-asserted-by":"crossref","first-page":"3132","DOI":"10.1016\/j.neuroimage.2009.11.001","article-title":"Identifying the brain\u2019s most globally connected regions","volume":"49","author":"Cole","year":"2010","journal-title":"Neuroimage"},{"key":"10.1016\/j.clinph.2014.11.014_b0055","doi-asserted-by":"crossref","first-page":"1476","DOI":"10.1176\/appi.ajp.2007.07030504","article-title":"Functional neuroimaging of anxiety: a meta-analysis of emotional processing in PTSD, social anxiety disorder, and specific phobia","volume":"164","author":"Etkin","year":"2007","journal-title":"Am J Psychiatry"},{"key":"10.1016\/j.clinph.2014.11.014_b0060","doi-asserted-by":"crossref","first-page":"9673","DOI":"10.1073\/pnas.0504136102","article-title":"The human brain is intrinsically organized into dynamic, anticorrelated functional networks","volume":"102","author":"Fox","year":"2005","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.clinph.2014.11.014_b0065","doi-asserted-by":"crossref","first-page":"3270","DOI":"10.1152\/jn.90777.2008","article-title":"The global signal and observed anticorrelated resting state brain networks","volume":"101","author":"Fox","year":"2009","journal-title":"J Neurophysiol"},{"key":"10.1016\/j.clinph.2014.11.014_b0070","doi-asserted-by":"crossref","first-page":"565","DOI":"10.1016\/j.pnpbp.2010.02.028","article-title":"Neuroimaging in social anxiety disorder: a systematic review of the literature","volume":"34","author":"Freitas-Ferrari","year":"2010","journal-title":"Prog Neuropsychopharmacol Biol Psychiatry"},{"key":"10.1016\/j.clinph.2014.11.014_b0075","doi-asserted-by":"crossref","first-page":"e312","DOI":"10.1038\/tp.2013.85","article-title":"Altered fusiform connectivity during processing of fearful faces in social anxiety disorder","volume":"3","author":"Frick","year":"2013","journal-title":"Transl Psychiatry"},{"key":"10.1016\/j.clinph.2014.11.014_b0080","doi-asserted-by":"crossref","first-page":"424","DOI":"10.1097\/WCO.0b013e328306f2c5","article-title":"Resting-state functional connectivity in neuropsychiatric disorders","volume":"21","author":"Greicius","year":"2008","journal-title":"Curr Opin Neurol"},{"key":"10.1016\/j.clinph.2014.11.014_b0085","doi-asserted-by":"crossref","first-page":"326","DOI":"10.1016\/j.jad.2011.06.048","article-title":"Abnormal neural activities in first-episode, treatment-naive, short-illness-duration, and treatment-response patients with major depressive disorder: a resting-state fMRI study","volume":"135","author":"Guo","year":"2011","journal-title":"J Affect Disord"},{"key":"10.1016\/j.clinph.2014.11.014_b0090","doi-asserted-by":"crossref","first-page":"e159","DOI":"10.1371\/journal.pbio.0060159","article-title":"Mapping the structural core of human cerebral cortex","volume":"6","author":"Hagmann","year":"2008","journal-title":"PLoS Biol"},{"key":"10.1016\/j.clinph.2014.11.014_b0095","doi-asserted-by":"crossref","first-page":"881","DOI":"10.1016\/j.neuroimage.2011.02.064","article-title":"Reduced resting-state functional connectivity between amygdala and orbitofrontal cortex in social anxiety disorder","volume":"56","author":"Hahn","year":"2011","journal-title":"Neuroimage"},{"key":"10.1016\/j.clinph.2014.11.014_b0100","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1016\/S1364-6613(00)01482-0","article-title":"The distributed human neural system for face perception","volume":"4","author":"Haxby","year":"2000","journal-title":"Trends Cogn Sci"},{"key":"10.1016\/j.clinph.2014.11.014_b0105","doi-asserted-by":"crossref","first-page":"e5226","DOI":"10.1371\/journal.pone.0005226","article-title":"Uncovering intrinsic modular organization of spontaneous brain activity in humans","volume":"4","author":"He","year":"2009","journal-title":"PLoS ONE"},{"key":"10.1016\/j.clinph.2014.11.014_b9005","doi-asserted-by":"crossref","first-page":"4302","DOI":"10.1523\/JNEUROSCI.17-11-04302.1997","article-title":"The fusiform face area: a module in human extrastriate cortex specialized for face perception","volume":"17","author":"Kanwisher","year":"1997","journal-title":"J Neurosci"},{"key":"10.1016\/j.clinph.2014.11.014_b9010","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1097\/00001756-199901180-00035","article-title":"The fusiform face area is selective for faces not animals","volume":"10","author":"Kanwisher","year":"1999","journal-title":"Neuroreport"},{"key":"10.1016\/j.clinph.2014.11.014_b0110","doi-asserted-by":"crossref","first-page":"593","DOI":"10.1001\/archpsyc.62.6.593","article-title":"Lifetime prevalence and age-of-onset distributions of DSM-IV disorders in the National Comorbidity Survey Replication","volume":"62","author":"Kessler","year":"2005","journal-title":"Arch Gen Psychiatry"},{"key":"10.1016\/j.clinph.2014.11.014_b0115","doi-asserted-by":"crossref","first-page":"617","DOI":"10.1001\/archpsyc.62.6.617","article-title":"Prevalence, severity, and comorbidity of 12-month DSM-IV disorders in the National Comorbidity Survey Replication","volume":"62","author":"Kessler","year":"2005","journal-title":"Arch Gen Psychiatry"},{"key":"10.1016\/j.clinph.2014.11.014_b0120","doi-asserted-by":"crossref","first-page":"1929","DOI":"10.1073\/pnas.1214900110","article-title":"Coupling of functional connectivity and regional cerebral blood flow reveals a physiological basis for network hubs of the human brain","volume":"110","author":"Liang","year":"2013","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.clinph.2014.11.014_b0125","doi-asserted-by":"crossref","first-page":"1549","DOI":"10.1016\/j.neuroimage.2010.05.010","article-title":"Selective aberrant functional connectivity of resting state networks in social anxiety disorder","volume":"52","author":"Liao","year":"2010","journal-title":"Neuroimage"},{"key":"10.1016\/j.clinph.2014.11.014_b0130","article-title":"Multivariate classification of social anxiety disorder using whole brain functional connectivity","author":"Liu","year":"2013","journal-title":"Brain Struct Funct"},{"key":"10.1016\/j.clinph.2014.11.014_b0135","doi-asserted-by":"crossref","first-page":"401","DOI":"10.1016\/j.jad.2012.10.001","article-title":"Abnormal amplitude low-frequency oscillations in medication-naive, first-episode patients with major depressive disorder: a resting-state fMRI study","volume":"146","author":"Liu","year":"2013","journal-title":"J Affect Disord"},{"key":"10.1016\/j.clinph.2014.11.014_b0140","doi-asserted-by":"crossref","first-page":"326","DOI":"10.1016\/j.pnpbp.2012.07.004","article-title":"Abnormal regional spontaneous neural activity in first-episode, treatment-naive patients with late-life depression: a resting-state fMRI study","volume":"39","author":"Liu","year":"2012","journal-title":"Prog Neuropsychopharmacol Biol Psychiatry"},{"key":"10.1016\/j.clinph.2014.11.014_b0145","article-title":"Characterization of post-traumatic stress disorder using resting-state fMRI with a multi-level parametric classification approach","author":"Liu","year":"2014","journal-title":"Brain Topogr"},{"key":"10.1016\/j.clinph.2014.11.014_b0150","doi-asserted-by":"crossref","first-page":"893","DOI":"10.1016\/j.neuroimage.2008.09.036","article-title":"The impact of global signal regression on resting state correlations: are anti-correlated networks introduced?","volume":"44","author":"Murphy","year":"2009","journal-title":"Neuroimage"},{"key":"10.1016\/j.clinph.2014.11.014_b9015","doi-asserted-by":"crossref","first-page":"1568","DOI":"10.1016\/j.cub.2007.07.063","article-title":"TMS evidence for the involvement of the right occipital face area in early face processing","volume":"17","author":"Pitcher","year":"2007","journal-title":"Curr Biol"},{"key":"10.1016\/j.clinph.2014.11.014_b0155","doi-asserted-by":"crossref","first-page":"1177","DOI":"10.1017\/S003329170800500X","article-title":"Influence of the fusiform gyrus on amygdala response to emotional faces in the non-clinical range of social anxiety","volume":"39","author":"Pujol","year":"2009","journal-title":"Psychol Med"},{"key":"10.1016\/j.clinph.2014.11.014_b0160","doi-asserted-by":"crossref","first-page":"676","DOI":"10.1073\/pnas.98.2.676","article-title":"A default mode of brain function","volume":"98","author":"Raichle","year":"2001","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.clinph.2014.11.014_b0165","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1089\/brain.2012.0080","article-title":"Trouble at rest: how correlation patterns and group differences become distorted after global signal regression","volume":"2","author":"Saad","year":"2012","journal-title":"Brain Connect"},{"key":"10.1016\/j.clinph.2014.11.014_b0170","doi-asserted-by":"crossref","first-page":"921","DOI":"10.1016\/j.biopsych.2004.09.024","article-title":"Effect of task conditions on brain responses to threatening faces in social phobics: an event-related functional magnetic resonance imaging study","volume":"56","author":"Straube","year":"2004","journal-title":"Biol Psychiatry"},{"key":"10.1016\/j.clinph.2014.11.014_b0175","doi-asserted-by":"crossref","first-page":"e99273","DOI":"10.1371\/journal.pone.0099273","article-title":"Dissociation of regional activity in default mode network in medication-naive, first-episode somatization disorder","volume":"9","author":"Su","year":"2014","journal-title":"PLoS ONE"},{"key":"10.1016\/j.clinph.2014.11.014_b0180","doi-asserted-by":"crossref","first-page":"932","DOI":"10.1523\/JNEUROSCI.4227-13.2014","article-title":"Precuneus is a functional core of the default-mode network","volume":"34","author":"Utevsky","year":"2014","journal-title":"J Neurosci"},{"key":"10.1016\/j.clinph.2014.11.014_b0185","doi-asserted-by":"crossref","first-page":"683","DOI":"10.1016\/j.tics.2013.09.012","article-title":"Network hubs in the human brain","volume":"17","author":"van den Heuvel","year":"2013","journal-title":"Trends Cogn Sci"},{"key":"10.1016\/j.clinph.2014.11.014_b0190","doi-asserted-by":"crossref","first-page":"431","DOI":"10.1016\/j.neuroimage.2011.07.044","article-title":"The influence of head motion on intrinsic functional connectivity MRI","volume":"59","author":"Van Dijk","year":"2012","journal-title":"Neuroimage"},{"key":"10.1016\/j.clinph.2014.11.014_b0195","doi-asserted-by":"crossref","first-page":"1154","DOI":"10.1002\/hbm.22241","article-title":"Overlapping and segregated resting-state functional connectivity in patients with major depressive disorder with and without childhood neglect","volume":"35","author":"Wang","year":"2014","journal-title":"Hum Brain Mapp"},{"key":"10.1016\/j.clinph.2014.11.014_b0200","series-title":"Social network analysis: methods and applications","author":"Wasserman","year":"1994"},{"key":"10.1016\/j.clinph.2014.11.014_b0205","first-page":"13","article-title":"DPARSF: A MATLAB toolbox for \u201cpipeline\u201d data analysis of resting-state fMRI","volume":"4","author":"Yan","year":"2010","journal-title":"Front Syst Neurosci"},{"key":"10.1016\/j.clinph.2014.11.014_b0210","doi-asserted-by":"crossref","first-page":"1862","DOI":"10.1093\/cercor\/bhr269","article-title":"Network centrality in the human functional connectome","volume":"22","author":"Zuo","year":"2012","journal-title":"Cereb Cortex"}],"container-title":["Clinical Neurophysiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1388245714008062?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1388245714008062?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,25]],"date-time":"2025-10-25T11:28:20Z","timestamp":1761391700000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1388245714008062"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,9]]},"references-count":46,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2015,9]]}},"alternative-id":["S1388245714008062"],"URL":"https:\/\/doi.org\/10.1016\/j.clinph.2014.11.014","relation":{},"ISSN":["1388-2457"],"issn-type":[{"value":"1388-2457","type":"print"}],"subject":[],"published":{"date-parts":[[2015,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Disrupted cortical hubs in functional brain networks in social anxiety disorder","name":"articletitle","label":"Article Title"},{"value":"Clinical Neurophysiology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.clinph.2014.11.014","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2014 International Federation of Clinical Neurophysiology. Published by Elsevier Ireland Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}