{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,23]],"date-time":"2026-04-23T07:54:04Z","timestamp":1776930844794,"version":"3.51.2"},"reference-count":50,"publisher":"Elsevier BV","issue":"6","license":[{"start":{"date-parts":[[2017,6,1]],"date-time":"2017-06-01T00:00:00Z","timestamp":1496275200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2017,6,1]],"date-time":"2017-06-01T00:00:00Z","timestamp":1496275200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/501100004731","name":"Natural Science Foundation of Zhejiang Province","doi-asserted-by":"publisher","award":["LY16H090009"],"award-info":[{"award-number":["LY16H090009"]}],"id":[{"id":"10.13039\/501100004731","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Clinical Neurophysiology"],"published-print":{"date-parts":[[2017,6]]},"DOI":"10.1016\/j.clinph.2017.02.004","type":"journal-article","created":{"date-parts":[[2017,2,21]],"date-time":"2017-02-21T01:17:13Z","timestamp":1487639833000},"page":"867-874","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":10,"title":["Altered effective brain connectivity at early response of antipsychotics in first-episode schizophrenia with auditory hallucinations"],"prefix":"10.1016","volume":"128","author":[{"given":"Leilei","family":"Zheng","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Weibo","family":"Liu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wei","family":"He","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shaohua","family":"Yu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Guodong","family":"Zhong","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.clinph.2017.02.004_b0005","doi-asserted-by":"crossref","unstructured":"American Psychiatric Association. The diagnostic and statistical manual of mental disorders, 5th ed. (DSM-5); 2013.","DOI":"10.1176\/appi.books.9780890425596"},{"key":"10.1016\/j.clinph.2017.02.004_b0010","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1093\/oxfordjournals.schbul.a033321","article-title":"\u201cCognitive dysmetria\u201d as an integrative theory of schizophrenia: a dysfunction in cortical-subcortical-cerebellar circuitry?","volume":"24","author":"Andreasen","year":"1998","journal-title":"Schizophr Bull"},{"key":"10.1016\/j.clinph.2017.02.004_b0015","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1038\/nrn2044","article-title":"Synaptic mechanisms of synchronized gamma oscillations in inhibitory interneuron networks","volume":"8","author":"Bartos","year":"2007","journal-title":"Nat Rev Neurosci"},{"key":"10.1016\/j.clinph.2017.02.004_b0020","doi-asserted-by":"crossref","first-page":"695","DOI":"10.1016\/j.neuron.2012.10.038","article-title":"Canonical microcircuits for predictive coding","volume":"76","author":"Bastos","year":"2012","journal-title":"Neuron"},{"key":"10.1016\/j.clinph.2017.02.004_b0025","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1177\/1073858406298391","article-title":"Cerebral disconnectivity: an early event in schizophrenia","volume":"14","author":"Begre","year":"2008","journal-title":"Neuroscientist"},{"key":"10.1016\/j.clinph.2017.02.004_b0030","doi-asserted-by":"crossref","first-page":"1667","DOI":"10.1093\/brain\/awv093","article-title":"The relative phases of basal ganglia activities dynamically shape effective connectivity in Parkinson's disease","volume":"138","author":"Cagnan","year":"2015","journal-title":"Brain"},{"key":"10.1016\/j.clinph.2017.02.004_b0035","doi-asserted-by":"crossref","first-page":"4129","DOI":"10.1002\/hbm.20834","article-title":"Superior temporal lobe dysfunction and frontotemporal dysconnectivity in subjects at risk of psychosis and in first-episode psychosis","volume":"30","author":"Crossley","year":"2009","journal-title":"Hum Brain Mapp"},{"key":"10.1016\/j.clinph.2017.02.004_b0040","doi-asserted-by":"crossref","first-page":"1050","DOI":"10.1093\/schbul\/sbr018","article-title":"Associations of cortical thickness and cognition in patients with schizophrenia and healthy controls","volume":"38","author":"Ehrlich","year":"2012","journal-title":"Schizophr Bull"},{"key":"10.1016\/j.clinph.2017.02.004_b0045","doi-asserted-by":"crossref","first-page":"704","DOI":"10.1038\/35094565","article-title":"Dynamic predictions: oscillations and synchrony in top-down processing","volume":"2","author":"Engel","year":"2001","journal-title":"Nat Rev Neurosci"},{"key":"10.1016\/j.clinph.2017.02.004_b0050","doi-asserted-by":"crossref","first-page":"474","DOI":"10.1016\/j.tics.2005.08.011","article-title":"A mechanism for cognitive dynamics: neuronal communication through neuronal coherence","volume":"9","author":"Fries","year":"2005","journal-title":"Trends Cogn Sci"},{"key":"10.1016\/j.clinph.2017.02.004_b0055","doi-asserted-by":"crossref","first-page":"971","DOI":"10.1016\/j.neuroimage.2013.08.065","article-title":"Bayesian model selection for group studies \u2013 revisited","volume":"84","author":"Rigoux","year":"2014","journal-title":"Neuroimage"},{"key":"10.1016\/j.clinph.2017.02.004_b0060","doi-asserted-by":"crossref","first-page":"439","DOI":"10.1016\/j.neuroimage.2011.07.048","article-title":"DCM for complex valued data: cross-spectra, coherence and phase-delays","volume":"59","author":"Friston","year":"2012","journal-title":"Neuroimage"},{"key":"10.1016\/j.clinph.2017.02.004_b0065","doi-asserted-by":"crossref","first-page":"796","DOI":"10.1016\/j.neuroimage.2014.06.062","article-title":"Granger causality revisited","volume":"101","author":"Friston","year":"2014","journal-title":"Neuroimage"},{"key":"10.1016\/j.clinph.2017.02.004_b0070","first-page":"89","article-title":"Schizophrenia: a disconnection syndrome?","volume":"3","author":"Friston","year":"1995","journal-title":"Clin Neurosci"},{"key":"10.1016\/j.clinph.2017.02.004_b0075","doi-asserted-by":"crossref","first-page":"1104","DOI":"10.1016\/j.neuroimage.2007.09.048","article-title":"Multiple sparse priors for the M\/EEG inverse problem","volume":"39","author":"Friston","year":"2008","journal-title":"Neuroimage"},{"key":"10.1016\/j.clinph.2017.02.004_b0080","doi-asserted-by":"crossref","first-page":"1273","DOI":"10.1016\/S1053-8119(03)00202-7","article-title":"Dynamic causal modelling","volume":"19","author":"Friston","year":"2003","journal-title":"Neuroimage"},{"key":"10.1016\/j.clinph.2017.02.004_b0085","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1111\/j.1600-0447.1999.tb05985.x","article-title":"Schizophrenia and the disconnection hypothesis","volume":"395","author":"Friston","year":"1999","journal-title":"Acta Psychiat Scand Suppl"},{"key":"10.1016\/j.clinph.2017.02.004_b0090","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1016\/0959-4388(95)80030-1","article-title":"Cognitive deficits and the neurobiology of schizophrenia","volume":"5","author":"Gold","year":"1995","journal-title":"Curr Opin Neurobiol"},{"key":"10.1016\/j.clinph.2017.02.004_b0095","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1192\/bjp.bp.110.086835","article-title":"Time course of regional brain activity accompanying auditory verbal hallucinations in schizophrenia","volume":"198","author":"Hoffman","year":"2011","journal-title":"Brit J Psychiat"},{"key":"10.1016\/j.clinph.2017.02.004_b0100","doi-asserted-by":"crossref","first-page":"1893","DOI":"10.1016\/j.jpsychires.2013.09.009","article-title":"Resting state EEG power and coherence abnormalities in bipolar disorder and schizophrenia","volume":"47","author":"Kam","year":"2013","journal-title":"J Psychiat Res"},{"key":"10.1016\/j.clinph.2017.02.004_b0105","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1093\/schbul\/13.2.261","article-title":"The positive and negative syndrome scale (PANSS) for schizophrenia","volume":"13","author":"Kay","year":"1987","journal-title":"Schizophr Bull"},{"key":"10.1016\/j.clinph.2017.02.004_b0110","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1093\/schbul\/sbm034","article-title":"Disturbed structural connectivity in schizophrenia primary factor in pathology or epiphenomenon?","volume":"34","author":"Konrad","year":"2008","journal-title":"Schizophr Bull"},{"key":"10.1016\/j.clinph.2017.02.004_b0115","doi-asserted-by":"crossref","first-page":"1543","DOI":"10.1016\/j.biopsych.2005.02.023","article-title":"Early-onset hypothesis of antipsychotic drug action: a hypothesis tested, confirmed and extended","volume":"57","author":"Leucht","year":"2005","journal-title":"Biol Psychiat"},{"key":"10.1016\/j.clinph.2017.02.004_b0120","doi-asserted-by":"crossref","first-page":"168","DOI":"10.1016\/j.schres.2012.08.030","article-title":"Early symptom response to antipsychotic medication as a marker of subsequent symptom change: an eighteen-month follow-up study of recent episode schizophrenia","volume":"141","author":"Levine","year":"2012","journal-title":"Schizophr Res"},{"key":"10.1016\/j.clinph.2017.02.004_b0125","doi-asserted-by":"crossref","first-page":"1396","DOI":"10.1176\/appi.ajp.160.8.1396","article-title":"HGDH Study Group. Comparative efficacy and safety of atypical and conventional antipsychotic drugs in first-episode psychosis: a randomized, double-blind trial of olanzapine versus haloperidol","volume":"160","author":"Lieberman","year":"2003","journal-title":"Am J Psychiatry"},{"key":"10.1016\/j.clinph.2017.02.004_b0130","doi-asserted-by":"crossref","first-page":"537","DOI":"10.1016\/j.conb.2011.10.018","article-title":"Excitation, inhibition, local oscillations, or large-scale loops: what causes the symptoms of schizophrenia?","volume":"22","author":"Lisman","year":"2012","journal-title":"Curr Opin Neurobiol"},{"key":"10.1016\/j.clinph.2017.02.004_b0135","doi-asserted-by":"crossref","first-page":"2878","DOI":"10.1016\/j.cub.2014.10.017","article-title":"GABAergic modulation of visual gamma and alpha oscillations and its consequences for working memory performance","volume":"24","author":"Lozano-Soldevilla","year":"2014","journal-title":"Curr Biol"},{"key":"10.1016\/j.clinph.2017.02.004_b0140","doi-asserted-by":"crossref","first-page":"783","DOI":"10.1001\/archgenpsychiatry.2010.84","article-title":"Short-term effects of antipsychotic treatment on cerebral function in drug-na\u00efve first-episode schizophrenia revealed by \u201cresting state\u201d functional magnetic resonance imaging","volume":"67","author":"Lui","year":"2010","journal-title":"Arch Gen Psychiat"},{"key":"10.1016\/j.clinph.2017.02.004_b0145","doi-asserted-by":"crossref","first-page":"108","DOI":"10.1093\/schbul\/sbp010","article-title":"Presynaptic regulation of dopamine transmission in schizophrenia","volume":"37","author":"Lyon","year":"2011","journal-title":"Schizophr Bull"},{"key":"10.1016\/j.clinph.2017.02.004_b0150","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1016\/j.neuroimage.2008.04.239","article-title":"Population dynamics: variance and the sigmoid activation function","volume":"42","author":"Marreiros","year":"2008","journal-title":"Neuroimage"},{"key":"10.1016\/j.clinph.2017.02.004_b0155","doi-asserted-by":"crossref","first-page":"753","DOI":"10.1016\/j.neuroimage.2005.10.037","article-title":"Meg source localization under multiple constraints: an extended Bayesian framework","volume":"30","author":"Mattout","year":"2006","journal-title":"Neuroimage"},{"key":"10.1016\/j.clinph.2017.02.004_b0160","doi-asserted-by":"crossref","first-page":"1320","DOI":"10.1016\/j.cub.2011.06.053","article-title":"An in vivo assay of synaptic function mediating human cognition","volume":"21","author":"Moran","year":"2011","journal-title":"Curr Biol"},{"key":"10.1016\/j.clinph.2017.02.004_b0165","doi-asserted-by":"crossref","first-page":"796","DOI":"10.1016\/j.neuroimage.2008.09.048","article-title":"Dynamic causal models of steady-state responses","volume":"44","author":"Moran","year":"2009","journal-title":"Neuroimage"},{"key":"10.1016\/j.clinph.2017.02.004_b0170","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1017\/S003329170003381X","article-title":"The auditory hallucination: a phenomenological survey","volume":"26","author":"Nayani","year":"1996","journal-title":"Psychol Med"},{"key":"10.1016\/j.clinph.2017.02.004_b0175","doi-asserted-by":"crossref","first-page":"484","DOI":"10.1093\/schbul\/sbr028","article-title":"Adolescent onset of cortical disinhibition in schizophrenia: insights from animal models","volume":"37","author":"O'Donnell","year":"2011","journal-title":"Schizophr Bull"},{"key":"10.1016\/j.clinph.2017.02.004_b0180","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1016\/j.jneumeth.2009.06.029","article-title":"Dynamic causal models for phase coupling","volume":"183","author":"Penny","year":"2009","journal-title":"J Neurosci Meth"},{"key":"10.1016\/j.clinph.2017.02.004_b0185","doi-asserted-by":"crossref","first-page":"997","DOI":"10.1016\/j.neuroimage.2004.10.030","article-title":"An empirical Bayesian solution to the source reconstruction problem in EEG","volume":"24","author":"Phillips","year":"2005","journal-title":"Neuroimage"},{"key":"10.1016\/j.clinph.2017.02.004_b0190","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1016\/S0006-3223(02)01435-X","article-title":"Prefrontal-posterior parietal networks in schizophrenia: primary dysfunctions and secondary compensations","volume":"53","author":"Quintana","year":"2003","journal-title":"Biol Psychiat"},{"key":"10.1016\/j.clinph.2017.02.004_b0195","doi-asserted-by":"crossref","first-page":"904","DOI":"10.1038\/npp.2009.192","article-title":"Treatment with olanzapine is associated with modulation of the default mode network in patients with Schizophrenia","volume":"35","author":"Sambataro","year":"2010","journal-title":"Neuropsychopharmacol"},{"key":"10.1016\/j.clinph.2017.02.004_b0200","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1176\/ajp.156.1.79","article-title":"Olanzapine versus haloperidol treatment in first-episode psychosis","volume":"156","author":"Sanger","year":"1999","journal-title":"Am J Psychiat"},{"key":"10.1016\/j.clinph.2017.02.004_b0205","doi-asserted-by":"crossref","first-page":"2394","DOI":"10.1093\/cercor\/bhs238","article-title":"Modeling ketamine effects on synaptic plasticity during the mismatch negativity","volume":"23","author":"Schmidt","year":"2013","journal-title":"Cereb Cortex"},{"key":"10.1016\/j.clinph.2017.02.004_b0210","doi-asserted-by":"crossref","first-page":"947","DOI":"10.1176\/appi.ajp.162.5.947","article-title":"Risperidone and haloperidol in first-episode psychosis: a long-term randomized trial","volume":"162","author":"Schooler","year":"2005","journal-title":"Am J Psychiat"},{"issue":"49\u201365","key":"10.1016\/j.clinph.2017.02.004_b0215","first-page":"111","article-title":"Neuronal synchrony: a versatile code for the definition of relations?","volume":"24","author":"Singer","year":"1999","journal-title":"Neuron"},{"key":"10.1016\/j.clinph.2017.02.004_b0220","doi-asserted-by":"crossref","first-page":"698","DOI":"10.1038\/nature07991","article-title":"Parvalbumin neurons and gamma rhythms enhance cortical circuit performance","volume":"459","author":"Sohal","year":"2009","journal-title":"Nature"},{"key":"10.1016\/j.clinph.2017.02.004_b0225","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1007\/s12038-007-0012-5","article-title":"Dynamic causal models of neural system dynamics: current state and future extensions","volume":"32","author":"Stephan","year":"2007","journal-title":"J Biosci"},{"key":"10.1016\/j.clinph.2017.02.004_b0230","doi-asserted-by":"crossref","first-page":"929","DOI":"10.1016\/j.biopsych.2005.10.005","article-title":"Synaptic plasticity and disconnection in schizophrenia","volume":"59","author":"Stephan","year":"2006","journal-title":"Biol Psychiat"},{"key":"10.1016\/j.clinph.2017.02.004_b0235","doi-asserted-by":"crossref","first-page":"1004","DOI":"10.1016\/j.neuroimage.2009.03.025","article-title":"Bayesian model selection for group studies","volume":"46","author":"Stephan","year":"2009","journal-title":"Neuroimage"},{"key":"10.1016\/j.clinph.2017.02.004_b0240","doi-asserted-by":"crossref","first-page":"789","DOI":"10.1093\/schbul\/sbn009","article-title":"Cortical dopamine D2\/D3 receptors are a common site of action for antipsychotic drugs- an original patient data meta-analysis of the SPECT and PET in vivo receptor imaging literature","volume":"35","author":"Stone","year":"2009","journal-title":"Schizophr Bull"},{"key":"10.1016\/j.clinph.2017.02.004_b0245","doi-asserted-by":"crossref","first-page":"1288","DOI":"10.1093\/schbul\/sbs122","article-title":"Insight in schizophrenia: involvement of self-reflection networks?","volume":"39","author":"van der Meer","year":"2013","journal-title":"Schizophr Bull"},{"key":"10.1016\/j.clinph.2017.02.004_b0250","series-title":"The ICD-10 classification of mental and behavioural disorders: clinical descriptions and diagnostic guidelines","author":"World Health Organization","year":"1992"}],"container-title":["Clinical Neurophysiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1388245717300585?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1388245717300585?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,25]],"date-time":"2025-10-25T11:42:16Z","timestamp":1761392536000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1388245717300585"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,6]]},"references-count":50,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2017,6]]}},"alternative-id":["S1388245717300585"],"URL":"https:\/\/doi.org\/10.1016\/j.clinph.2017.02.004","relation":{},"ISSN":["1388-2457"],"issn-type":[{"value":"1388-2457","type":"print"}],"subject":[],"published":{"date-parts":[[2017,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Altered effective brain connectivity at early response of antipsychotics in first-episode schizophrenia with auditory hallucinations","name":"articletitle","label":"Article Title"},{"value":"Clinical Neurophysiology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.clinph.2017.02.004","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2017 International Federation of Clinical Neurophysiology. Published by Elsevier Ireland Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}