{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,4]],"date-time":"2026-06-04T05:45:28Z","timestamp":1780551928969,"version":"3.54.1"},"reference-count":25,"publisher":"Elsevier BV","issue":"12","license":[{"start":{"date-parts":[[2019,12,1]],"date-time":"2019-12-01T00:00:00Z","timestamp":1575158400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2019,12,1]],"date-time":"2019-12-01T00:00:00Z","timestamp":1575158400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Clinical Neurophysiology"],"published-print":{"date-parts":[[2019,12]]},"DOI":"10.1016\/j.clinph.2019.08.031","type":"journal-article","created":{"date-parts":[[2019,10,24]],"date-time":"2019-10-24T12:21:34Z","timestamp":1571919694000},"page":"2231-2237","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":4,"title":["Connectivity measures suggest a sub-cortical generator of myoclonus in Angelman syndrome"],"prefix":"10.1016","volume":"130","author":[{"given":"Edoardo","family":"Ferlazzo","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Silvana","family":"Franceschetti","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sara","family":"Gasparini","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maurizio","family":"Elia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laura","family":"Canafoglia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chiara","family":"Pantaleoni","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michele","family":"Ascoli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tiziana","family":"D'Agostino","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chiara","family":"Sueri","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giulia","family":"Ferrigno","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ferruccio","family":"Panzica","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vittoria","family":"Cianci","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Umberto","family":"Aguglia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.clinph.2019.08.031_b0005","doi-asserted-by":"crossref","first-page":"93","DOI":"10.2147\/TACG.S57386","article-title":"Angelman syndrome: review of clinical and molecular aspects","volume":"16","author":"Bird","year":"2014","journal-title":"Appl Clin Genet"},{"key":"10.1016\/j.clinph.2019.08.031_b0010","series-title":"Time series analysis","author":"Box","year":"1970"},{"key":"10.1016\/j.clinph.2019.08.031_b0015","doi-asserted-by":"crossref","first-page":"461","DOI":"10.1093\/brain\/122.3.461","article-title":"Coherent cortical and muscle discharge in cortical myoclonus","volume":"122","author":"Brown","year":"1999","journal-title":"Brain"},{"key":"10.1016\/j.clinph.2019.08.031_b0025","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0115012","article-title":"Alpha band cortico-muscular coherence occurs in healthy individuals during mechanically-induced tremor","volume":"9","author":"Budini","year":"2014","journal-title":"PLoS One"},{"key":"10.1016\/j.clinph.2019.08.031_b0030","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1016\/j.eplepsyres.2017.01.007","article-title":"Movement-activated cortical myoclonus in Dravet syndrome","volume":"130","author":"Canafoglia","year":"2017","journal-title":"Epilepsy Res"},{"key":"10.1016\/j.clinph.2019.08.031_b0035","unstructured":"Da Silva FH L, Mars NJI. Parametric methods in EEG analysis. In: Niedermeyer E, da Silva FH L, editors. Electroencephalography: basic principles, clinical application and related fields. Baltimore. Urban & Schwarzenberg 1987; p. 871\u201396."},{"issue":"Suppl. 5","key":"10.1016\/j.clinph.2019.08.031_b0040","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1111\/j.1528-1167.2009.02119.x","article-title":"Myoclonic status in non-progressive encephalopathies: an update","volume":"50","author":"Elia","year":"2009","journal-title":"Epilepsia"},{"key":"10.1016\/j.clinph.2019.08.031_b0045","doi-asserted-by":"crossref","first-page":"214","DOI":"10.1186\/s12883-016-0738-5","article-title":"The network sustaining action myoclonus: a MEG-EMG study in patients with EPM1","volume":"16","author":"Franceschetti","year":"2016","journal-title":"BMC Neurol"},{"key":"10.1016\/j.clinph.2019.08.031_b0050","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1684\/j.1950-6945.2005.tb00095.x","article-title":"Analysis of the characteristics of epilepsy in 37 patients with the molecular diagnosis of Angelman syndrome","volume":"7","author":"Galvan-Manso","year":"2005","journal-title":"Epileptic Disord"},{"key":"10.1016\/j.clinph.2019.08.031_b0055","doi-asserted-by":"crossref","first-page":"216","DOI":"10.1016\/j.braindev.2014.04.005","article-title":"Episodic tremors representing cortical myoclonus are characteristic in Angelman syndrome due to UBE3A mutations","volume":"37","author":"Goto","year":"2015","journal-title":"Brain Dev"},{"key":"10.1016\/j.clinph.2019.08.031_b0060","doi-asserted-by":"crossref","first-page":"326","DOI":"10.1093\/brain\/awg043","article-title":"Abnormal corticomuscular and intermuscular coupling in high-frequency rhythmic myoclonus","volume":"126","author":"Grosse","year":"2003","journal-title":"Brain"},{"key":"10.1016\/j.clinph.2019.08.031_b0065","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1002\/ana.410400109","article-title":"Cortical myoclonus in Angelman syndrome","volume":"40","author":"Guerrini","year":"1996","journal-title":"Ann Neurol"},{"key":"10.1016\/j.clinph.2019.08.031_b0070","doi-asserted-by":"crossref","first-page":"647","DOI":"10.2165\/00148581-200305100-00001","article-title":"Angelman syndrome: etiology, clinical features, diagnosis, and management of symptoms","volume":"5","author":"Guerrini","year":"2003","journal-title":"Paediatr Drugs"},{"key":"10.1016\/j.clinph.2019.08.031_b0075","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1016\/S0079-6107(96)00009-0","article-title":"A framework for the analysis of mixed time series\/point process data \u2013 theory and application to the study of physiological tremor, single motor unit discharges and electromyograms","volume":"64","author":"Halliday","year":"1995","journal-title":"Prog Biophys Mol Biol"},{"key":"10.1016\/j.clinph.2019.08.031_b0080","series-title":"Spectral analysis and its applications","author":"Jenkins","year":"1968"},{"key":"10.1016\/j.clinph.2019.08.031_b0085","doi-asserted-by":"crossref","first-page":"501","DOI":"10.1097\/00004691-199911000-00002","article-title":"Corticomuscular coherence: a review","volume":"16","author":"Mima","year":"1999","journal-title":"J Clin Neurophysiol"},{"key":"10.1016\/j.clinph.2019.08.031_b0090","doi-asserted-by":"crossref","first-page":"1041","DOI":"10.1016\/S1388-2457(03)00066-X","article-title":"Movement-activated myoclonus in genetically defined progressive myoclonic epilepsies: EEG-EMG relationship estimated using autoregressive models","volume":"114","author":"Panzica","year":"2003","journal-title":"Clin Neurophysiol"},{"key":"10.1016\/j.clinph.2019.08.031_b0095","doi-asserted-by":"crossref","first-page":"1803","DOI":"10.1016\/j.clinph.2014.01.005","article-title":"EEG-EMG information flow in movement-activated myoclonus in patients with Unverricht-Lundborg disease","volume":"125","author":"Panzica","year":"2014","journal-title":"Clin Neurophysiol"},{"key":"10.1016\/j.clinph.2019.08.031_b0100","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.pneurobio.2005.10.003","article-title":"Nonlinear multivariate analysis of neurophysiological signals","volume":"77","author":"Pereda","year":"2005","journal-title":"Prog Neurobiol"},{"key":"10.1016\/j.clinph.2019.08.031_b0105","doi-asserted-by":"crossref","first-page":"184","DOI":"10.1016\/0013-4694(89)90180-6","article-title":"Spherical splines for scalp potential and current density mapping","volume":"72","author":"Perrin","year":"1989","journal-title":"Electroencephalogr Clin Neurophysiol"},{"key":"10.1016\/j.clinph.2019.08.031_b0110","doi-asserted-by":"crossref","first-page":"170","DOI":"10.1016\/j.yebeh.2018.02.006","article-title":"Myoclonus in Angelman syndrome","volume":"82","author":"Pollack","year":"2018","journal-title":"Epilepsy Behav"},{"key":"10.1016\/j.clinph.2019.08.031_b0115","doi-asserted-by":"crossref","first-page":"1327","DOI":"10.1002\/ajmg.a.38694","article-title":"Angelman syndrome in adolescence and adulthood: A retrospective chart review of 53 cases","volume":"176","author":"Prasad","year":"2018","journal-title":"Am J Med Genet A"},{"key":"10.1016\/j.clinph.2019.08.031_b0120","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1016\/S0303-8467(03)00005-2","article-title":"Reserpine responsive myoclonus and hyperpyrexia in a patient with Angelman syndrome","volume":"105","author":"Stecker","year":"2003","journal-title":"Clin Neurol Neurosurg"},{"key":"10.1016\/j.clinph.2019.08.031_b0125","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1016\/j.yebeh.2017.07.041","article-title":"Epilepsy and sleep disorders improve in adolescents and adults with Angelman syndrome: A multicenter study on 46 patients","volume":"75","author":"Sueri","year":"2017","journal-title":"Epilepsy Behav"},{"key":"10.1016\/j.clinph.2019.08.031_b0130","doi-asserted-by":"crossref","first-page":"413","DOI":"10.1002\/ajmg.a.31074","article-title":"Angelman syndrome 2005: updated consensus for diagnostic criteria","volume":"140","author":"Williams","year":"2006","journal-title":"Am J Med Genet A"}],"container-title":["Clinical Neurophysiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1388245719312386?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1388245719312386?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,25]],"date-time":"2025-10-25T11:53:42Z","timestamp":1761393222000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1388245719312386"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,12]]},"references-count":25,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2019,12]]}},"alternative-id":["S1388245719312386"],"URL":"https:\/\/doi.org\/10.1016\/j.clinph.2019.08.031","relation":{},"ISSN":["1388-2457"],"issn-type":[{"value":"1388-2457","type":"print"}],"subject":[],"published":{"date-parts":[[2019,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Connectivity measures suggest a sub-cortical generator of myoclonus in Angelman syndrome","name":"articletitle","label":"Article Title"},{"value":"Clinical Neurophysiology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.clinph.2019.08.031","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2019 International Federation of Clinical Neurophysiology. Published by Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}]}}