{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T21:36:34Z","timestamp":1792791394185,"version":"4.5.0"},"reference-count":34,"publisher":"Elsevier BV","issue":"6","license":[{"start":{"date-parts":[[2021,6,1]],"date-time":"2021-06-01T00:00:00Z","timestamp":1622505600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2021,6,1]],"date-time":"2021-06-01T00:00:00Z","timestamp":1622505600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Clinical Neurophysiology"],"published-print":{"date-parts":[[2021,6]]},"DOI":"10.1016\/j.clinph.2021.02.392","type":"journal-article","created":{"date-parts":[[2021,3,31]],"date-time":"2021-03-31T13:40:12Z","timestamp":1617198012000},"page":"1203-1208","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":8,"title":["Valproate but not levetiracetam slows the EEG alpha peak frequency \u2013 A pharmaco-EEG study"],"prefix":"10.1016","volume":"132","author":[{"given":"Johann Philipp","family":"Z\u00f6llner","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adam","family":"Strzelczyk","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Felix","family":"Rosenow","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2328-3413","authenticated-orcid":false,"given":"Ricardo","family":"Kienitz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.clinph.2021.02.392_b0005","doi-asserted-by":"crossref","first-page":"152","DOI":"10.1212\/WNL.28.2.152","article-title":"Sodium valproate in the treatment of intractable seizure disorders: a clinical and electroencephalographic study","volume":"28","author":"Adams","year":"1978","journal-title":"Neurology"},{"key":"10.1016\/j.clinph.2021.02.392_b0010","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1159\/000118168","article-title":"Spectral analysis of the EEG in children during the introduction of antiepileptic therapy with valproic acid","volume":"13","author":"Benninger","year":"1985","journal-title":"Neuropsychobiology"},{"key":"10.1016\/j.clinph.2021.02.392_b0015","series-title":"Valproins\u00e4ure","first-page":"121","article-title":"EEG-Ver\u00e4nderungen unter Valproins\u00e4ure","author":"Besser","year":"2002"},{"key":"10.1016\/j.clinph.2021.02.392_b0020","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1212\/WNL.30.1.42","article-title":"Clinical efficacy and long-term effects of valproic acid therapy on spike-and-wave discharges","volume":"30","author":"Bruni","year":"1980","journal-title":"Neurology"},{"key":"10.1016\/j.clinph.2021.02.392_b0025","doi-asserted-by":"crossref","first-page":"883","DOI":"10.1016\/j.clinph.2011.09.012","article-title":"Effect of levetiracetam monotherapy on background EEG activity and cognition in drug-naive epilepsy patients","volume":"123","author":"Cho","year":"2012","journal-title":"Clin Neurophysiol"},{"key":"10.1016\/j.clinph.2021.02.392_b0030","doi-asserted-by":"crossref","first-page":"190","DOI":"10.1016\/j.eplepsyres.2006.05.003","article-title":"Quantitative EEG effects of carbamazepine, oxcarbazepine, valproate, lamotrigine, and possible clinical relevance of the findings","volume":"70","author":"Clemens","year":"2006","journal-title":"Epilepsy Res"},{"key":"10.1016\/j.clinph.2021.02.392_b0035","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1111\/j.1528-1157.1987.tb04216.x","article-title":"Antiepileptic drugs and the electroencephalogram","volume":"28","author":"Duncan","year":"1987","journal-title":"Epilepsia"},{"key":"10.1016\/j.clinph.2021.02.392_b0040","doi-asserted-by":"crossref","first-page":"590","DOI":"10.1111\/j.1528-1157.1989.tb05477.x","article-title":"Effects of the removal of phenytoin, carbamazepine, and valproate on the electroencephalogram","volume":"30","author":"Duncan","year":"1989","journal-title":"Epilepsia"},{"key":"10.1016\/j.clinph.2021.02.392_b0045","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1016\/j.seizure.2016.07.001","article-title":"Guideline conform initial monotherapy increases in patients with focal epilepsy: A population-based study on German health insurance data","volume":"41","author":"Ertl","year":"2016","journal-title":"Seizure"},{"key":"10.1016\/j.clinph.2021.02.392_b0050","doi-asserted-by":"crossref","first-page":"522","DOI":"10.1111\/epi.13670","article-title":"Operational classification of seizure types by the International League Against Epilepsy: Position Paper of the ILAE Commission for Classification and Terminology","volume":"58","author":"Fisher","year":"2017","journal-title":"Epilepsia"},{"key":"10.1016\/j.clinph.2021.02.392_b0055","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1016\/j.neuroimage.2014.01.049","article-title":"Inter- and intra-individual variability in alpha peak frequency","volume":"92","author":"Haegens","year":"2014","journal-title":"Neuroimage"},{"key":"10.1016\/j.clinph.2021.02.392_b0060","doi-asserted-by":"crossref","first-page":"230","DOI":"10.1212\/WNL.54.1.230","article-title":"Valproate-induced hyperammonemic encephalopathy in the presence of topiramate","volume":"54","author":"Hamer","year":"2000","journal-title":"Neurology"},{"key":"10.1016\/j.clinph.2021.02.392_b0065","doi-asserted-by":"crossref","first-page":"210","DOI":"10.1097\/00004691-199304000-00008","article-title":"Effects of antiepileptic drug treatment on the background frequency of EEGs in epileptic patients","volume":"10","author":"Herkes","year":"1993","journal-title":"J Clin Neurophysiol"},{"key":"10.1016\/j.clinph.2021.02.392_b0070","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1177\/155005949502600209","article-title":"Effects of antiepileptic drugs on EEG background activity in children with epilepsy: initial phase of therapy","volume":"26","author":"Konishi","year":"1995","journal-title":"Clin Electroencephalogr"},{"key":"10.1016\/j.clinph.2021.02.392_b0075","doi-asserted-by":"crossref","first-page":"1006","DOI":"10.1111\/j.1528-1157.1998.tb01452.x","article-title":"Semiological seizure classification","volume":"39","author":"Luders","year":"1998","journal-title":"Epilepsia"},{"key":"10.1016\/j.clinph.2021.02.392_b0080","doi-asserted-by":"crossref","first-page":"708","DOI":"10.1016\/j.yebeh.2005.08.015","article-title":"EpiTrack: tracking cognitive side effects of medication on attention and executive functions in patients with epilepsy","volume":"7","author":"Lutz","year":"2005","journal-title":"Epilepsy Behav"},{"key":"10.1016\/j.clinph.2021.02.392_b0085","doi-asserted-by":"crossref","first-page":"146","DOI":"10.1016\/j.neuroscience.2017.07.037","article-title":"State-dependent alpha peak frequency shifts: Experimental evidence, potential mechanisms and functional implications","volume":"360","author":"Mierau","year":"2017","journal-title":"Neuroscience"},{"key":"10.1016\/j.clinph.2021.02.392_b0090","article-title":"Modifications \u00e9lectroenc\u00e9phalographiques chez des enfants \u00e9pileptiques trait\u00e9s par le D\u00e9pak\u00e8ne","volume":"313\u201320","author":"Miribel","year":"1968","journal-title":"Rev Neurol (Paris)"},{"key":"10.1016\/j.clinph.2021.02.392_b0095","first-page":"21","article-title":"A glossary of terms most commonly used by clinical electroencephalographers and proposal for the report form for the EEG findings. The International Federation of Clinical Neurophysiology","volume":"52","author":"Noachtar","year":"1999","journal-title":"Electroencephalogr Clin Neurophysiol Suppl"},{"key":"10.1016\/j.clinph.2021.02.392_b0100","doi-asserted-by":"crossref","DOI":"10.1155\/2011\/156869","article-title":"FieldTrip: Open source software for advanced analysis of MEG, EEG, and invasive electrophysiological data","volume":"2011","author":"Oostenveld","year":"2011","journal-title":"Comput Intell Neurosci"},{"key":"10.1016\/j.clinph.2021.02.392_b0105","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1016\/j.seizure.2020.02.018","article-title":"Could the 2017 ILAE and the four-dimensional epilepsy classifications be merged to a new \u201cIntegrated Epilepsy Classification\u201d?","volume":"78","author":"Rosenow","year":"2020","journal-title":"Seizure"},{"key":"10.1016\/j.clinph.2021.02.392_b0110","doi-asserted-by":"crossref","first-page":"1215","DOI":"10.1111\/epi.13449","article-title":"Revised version of quality guidelines for presurgical epilepsy evaluation and surgical epilepsy therapy issued by the Austrian, German, and Swiss working group on presurgical epilepsy diagnosis and operative epilepsy treatment","volume":"57","author":"Rosenow","year":"2016","journal-title":"Epilepsia"},{"key":"10.1016\/j.clinph.2021.02.392_b0115","series-title":"Advances in Epileptology: Xth Epilepsy International Symposium","article-title":"The effect of valproic acid on the EEG background","author":"Sackellares","year":"1980"},{"key":"10.1016\/j.clinph.2021.02.392_b0120","doi-asserted-by":"crossref","first-page":"697","DOI":"10.1111\/j.1528-1157.1979.tb04853.x","article-title":"Stupor following administration of valproic acid to patients receiving other antiepileptic drugs","volume":"20","author":"Sackellares","year":"1979","journal-title":"Epilepsia"},{"key":"10.1016\/j.clinph.2021.02.392_b0125","doi-asserted-by":"crossref","first-page":"186","DOI":"10.1016\/0013-4694(94)90090-6","article-title":"Intraindividual analysis of antiepileptic drug effects on EEG background rhythms","volume":"90","author":"Salinsky","year":"1994","journal-title":"Electroencephalogr Clin Neurophysiol"},{"key":"10.1016\/j.clinph.2021.02.392_b0130","doi-asserted-by":"crossref","first-page":"1042","DOI":"10.1046\/j.1528-1157.2003.60602.x","article-title":"Assessment of CNS effects of antiepileptic drugs by using quantitative EEG measures","volume":"44","author":"Salinsky","year":"2003","journal-title":"Epilepsia"},{"key":"10.1016\/j.clinph.2021.02.392_b0135","doi-asserted-by":"crossref","first-page":"512","DOI":"10.1111\/epi.13709","article-title":"ILAE classification of the epilepsies: Position paper of the ILAE Commission for Classification and Terminology","volume":"58","author":"Scheffer","year":"2017","journal-title":"Epilepsia"},{"key":"10.1016\/j.clinph.2021.02.392_b0140","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1111\/j.1600-0404.2006.00655.x","article-title":"Valproate-induced hyperammonemic encephalopathy","volume":"114","author":"Segura-Bruna","year":"2006","journal-title":"Acta Neurol Scand"},{"key":"10.1016\/j.clinph.2021.02.392_b0145","doi-asserted-by":"crossref","first-page":"392","DOI":"10.1016\/j.seizure.2009.02.001","article-title":"Impact of levetiracetam add-on therapy on different EEG occipital frequencies in epileptic patients","volume":"18","author":"Veauthier","year":"2009","journal-title":"Seizure"},{"key":"10.1016\/j.clinph.2021.02.392_b0150","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1016\/j.seizure.2015.07.004","article-title":"The adverse event profile of levetiracetam: A meta-analysis on children and adults","volume":"31","author":"Verrotti","year":"2015","journal-title":"Seizure"},{"key":"10.1016\/j.clinph.2021.02.392_b0155","doi-asserted-by":"crossref","first-page":"886","DOI":"10.1212\/WNL.28.9.886","article-title":"Effect of valproic acid on spike and wave discharges in patients with absence seizures","volume":"28","author":"Villarreal","year":"1978","journal-title":"Neurology"},{"key":"10.1016\/j.clinph.2021.02.392_b0160","doi-asserted-by":"crossref","first-page":"376","DOI":"10.1016\/j.seizure.2009.01.006","article-title":"Levetiracetam accumulation in renal failure causing myoclonic encephalopathy with triphasic waves","volume":"18","author":"Vulliemoz","year":"2009","journal-title":"Seizure"},{"key":"10.1016\/j.clinph.2021.02.392_b0165","doi-asserted-by":"crossref","first-page":"1353","DOI":"10.1111\/epi.16052","article-title":"Rapid discontinuation of sodium channel-blocking antiseizure drugs evokes focal edema in the splenium corporis callosi: A matched case-control study","volume":"60","author":"Zollner","year":"2019","journal-title":"Epilepsia"},{"key":"10.1016\/j.clinph.2021.02.392_b0170","series-title":"Klinische Elektroenzephalographie","first-page":"313","article-title":"EEG bei diffusen Erkrankungen des Gehirns","author":"Zschocke","year":"2012"}],"container-title":["Clinical Neurophysiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1388245721004867?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1388245721004867?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,25]],"date-time":"2025-10-25T12:01:54Z","timestamp":1761393714000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1388245721004867"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,6]]},"references-count":34,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2021,6]]}},"alternative-id":["S1388245721004867"],"URL":"https:\/\/doi.org\/10.1016\/j.clinph.2021.02.392","relation":{},"ISSN":["1388-2457"],"issn-type":[{"value":"1388-2457","type":"print"}],"subject":[],"published":{"date-parts":[[2021,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Valproate but not levetiracetam slows the EEG alpha peak frequency \u2013 A pharmaco-EEG study","name":"articletitle","label":"Article Title"},{"value":"Clinical Neurophysiology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.clinph.2021.02.392","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2021 International Federation of Clinical Neurophysiology. Published by Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}]}}