{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,19]],"date-time":"2026-01-19T04:01:13Z","timestamp":1768795273933,"version":"3.49.0"},"reference-count":35,"publisher":"Elsevier BV","issue":"7","license":[{"start":{"date-parts":[[2021,7,1]],"date-time":"2021-07-01T00:00:00Z","timestamp":1625097600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2021,7,1]],"date-time":"2021-07-01T00:00:00Z","timestamp":1625097600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/100009091","name":"Justus Liebig Universitat Giessen","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100009091","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Clinical Neurophysiology"],"published-print":{"date-parts":[[2021,7]]},"DOI":"10.1016\/j.clinph.2021.04.012","type":"journal-article","created":{"date-parts":[[2021,5,8]],"date-time":"2021-05-08T02:10:36Z","timestamp":1620439836000},"page":"1537-1542","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":3,"title":["Increased muscle sympathetic nerve activity and impaired baroreflex control in isolated REM-sleep behavior disorder"],"prefix":"10.1016","volume":"132","author":[{"given":"Ana Luiza C.","family":"Sayegh","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Annette","family":"Janzen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Isabella","family":"Strzedulla","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Frank","family":"Birklein","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gothje","family":"Lautenschl\u00e4ger","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wolfgang H.","family":"Oertel","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Heidrun H.","family":"Kr\u00e4mer","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christoph","family":"Best","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"issue":"4","key":"10.1016\/j.clinph.2021.04.012_b0005","doi-asserted-by":"crossref","first-page":"622","DOI":"10.1002\/mds.1120","article-title":"Association of REM sleep behavior disorder and neurodegenerative disease may reflect an underlying synucleinopathy","volume":"16","author":"Boeve","year":"2001","journal-title":"Mov Disord"},{"issue":"5","key":"10.1016\/j.clinph.2021.04.012_b0010","doi-asserted-by":"crossref","first-page":"517","DOI":"10.1007\/s00702-002-0808-2","article-title":"Idiopathic Parkinson's disease: possible routes by which vulnerable neuronal types may be subject to neuroinvasion by an unknown pathogen","volume":"110","author":"Braak","year":"2003","journal-title":"J Neural Transm"},{"key":"10.1016\/j.clinph.2021.04.012_b0015","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1016\/j.expneurol.2019.04.015","article-title":"Monoaminergic regulation of nociceptive circuitry in a Parkinson's disease rat model","volume":"318","author":"Campos","year":"2019","journal-title":"Exp Neurol"},{"issue":"1\u20132","key":"10.1016\/j.clinph.2021.04.012_b0020","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1016\/0304-3940(92)90755-V","article-title":"Inhibition by locus coeruleus on the baroreceptor reflex response in the rat","volume":"144","author":"Chan","year":"1992","journal-title":"Neurosci Lett"},{"issue":"8","key":"10.1016\/j.clinph.2021.04.012_b0025","doi-asserted-by":"crossref","first-page":"655","DOI":"10.1038\/nrn894","article-title":"How do you feel? Interoception: the sense of the physiological condition of the body","volume":"3","author":"Craig","year":"2002","journal-title":"Nat Rev Neurosci"},{"issue":"3","key":"10.1016\/j.clinph.2021.04.012_b0030","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1046\/j.1365-201X.2003.01070.x","article-title":"Medullary and supramedullary mechanisms regulating sympathetic vasomotor tone","volume":"177","author":"Dampney","year":"2003","journal-title":"Acta Physiol Scand"},{"issue":"4\u20135","key":"10.1016\/j.clinph.2021.04.012_b0035","doi-asserted-by":"crossref","first-page":"597","DOI":"10.1023\/A:1025080314925","article-title":"Functional organization of brain pathways subserving the baroreceptor reflex: studies in conscious animals using immediate early gene expression","volume":"23","author":"Dampney","year":"2003","journal-title":"Cell Mol Neurobiol"},{"key":"10.1016\/j.clinph.2021.04.012_b0040","series-title":"American academy of sleep medicine international classification of sleep disorders","author":"Darien","year":"2014"},{"issue":"8","key":"10.1016\/j.clinph.2021.04.012_b0045","doi-asserted-by":"crossref","first-page":"725","DOI":"10.1212\/WNL.0b013e3182825127","article-title":"Skin sympathetic fiber alpha-synuclein deposits: a potential biomarker for pure autonomic failure","volume":"80","author":"Donadio","year":"2013","journal-title":"Neurology"},{"issue":"4","key":"10.1016\/j.clinph.2021.04.012_b0050","doi-asserted-by":"crossref","first-page":"535","DOI":"10.1007\/s00401-017-1684-z","article-title":"Dermal phospho-alpha-synuclein deposits confirm REM sleep behaviour disorder as prodromal Parkinson's disease","volume":"133","author":"Doppler","year":"2017","journal-title":"Acta Neuropathol"},{"issue":"5","key":"10.1016\/j.clinph.2021.04.012_b0055","doi-asserted-by":"crossref","first-page":"367","DOI":"10.1093\/sleep\/19.5.367","article-title":"Cardiac autonomic activity during wakefulness and sleep in REM sleep behavior disorder","volume":"19","author":"Ferini-Strambi","year":"1996","journal-title":"Sleep"},{"issue":"4","key":"10.1016\/j.clinph.2021.04.012_b0060","first-page":"S1","article-title":"Myogenic mechanisms in the control of systemic resistance. Introduction and historical background","volume":"7","author":"Folkow","year":"1989","journal-title":"J Hypertens Suppl"},{"issue":"2","key":"10.1016\/j.clinph.2021.04.012_b0065","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1007\/s10286-011-0119-5","article-title":"Consensus statement on the definition of orthostatic hypotension, neurally mediated syncope and the postural tachycardia syndrome","volume":"21","author":"Freeman","year":"2011","journal-title":"Clin Auton Res"},{"issue":"Pt 7","key":"10.1016\/j.clinph.2021.04.012_b0070","doi-asserted-by":"crossref","first-page":"2120","DOI":"10.1093\/brain\/awt152","article-title":"The coeruleus\/subcoeruleus complex in rapid eye movement sleep behaviour disorders in Parkinson's disease","volume":"136","author":"Garcia-Lorenzo","year":"2013","journal-title":"Brain"},{"issue":"2","key":"10.1016\/j.clinph.2021.04.012_b0075","doi-asserted-by":"crossref","first-page":"443","DOI":"10.1152\/japplphysiol.00069.2011","article-title":"Lower vascular tone and larger plasma volume in Parkinson's disease with orthostatic hypotension","volume":"111","author":"Groothuis","year":"2011","journal-title":"J Appl Physiol (1985)"},{"issue":"1","key":"10.1016\/j.clinph.2021.04.012_b0080","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1111\/j.1748-1716.1977.tb10347.x","article-title":"Local reflex in microcirculation in human skeletal muscle","volume":"99","author":"Henriksen","year":"1977","journal-title":"Acta Physiol Scand"},{"key":"10.1016\/j.clinph.2021.04.012_b0085","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1016\/j.neuroimage.2012.12.047","article-title":"Real-time imaging of cortical and subcortical control of muscle sympathetic nerve activity in awake human subjects","volume":"70","author":"James","year":"2013","journal-title":"Neuroimage"},{"issue":"2","key":"10.1016\/j.clinph.2021.04.012_b0090","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1007\/s11517-011-0853-9","article-title":"ECG signal analysis for the assessment of sleep-disordered breathing and sleep pattern","volume":"50","author":"Kesper","year":"2012","journal-title":"Med Biol Eng Comput"},{"issue":"4","key":"10.1016\/j.clinph.2021.04.012_b0095","doi-asserted-by":"crossref","first-page":"623","DOI":"10.1111\/ejn.12437","article-title":"Central correlation of muscle sympathetic nerve activation during baroreflex unloading - a microneurography-positron emission tomography study","volume":"39","author":"Kramer","year":"2014","journal-title":"Eur J Neurosci"},{"issue":"12","key":"10.1016\/j.clinph.2021.04.012_b0100","doi-asserted-by":"crossref","DOI":"10.1002\/brb3.1463","article-title":"Reduced central sympathetic activity in Parkinson's disease","volume":"9","author":"Kramer","year":"2019","journal-title":"Brain Behav"},{"issue":"4","key":"10.1016\/j.clinph.2021.04.012_b0105","doi-asserted-by":"crossref","first-page":"539","DOI":"10.1002\/hbm.20885","article-title":"Real-time imaging of the medullary circuitry involved in the generation of spontaneous muscle sympathetic nerve activity in awake subjects","volume":"31","author":"Macefield","year":"2010","journal-title":"Hum Brain Mapp"},{"issue":"3","key":"10.1016\/j.clinph.2021.04.012_b0110","doi-asserted-by":"crossref","first-page":"1199","DOI":"10.1152\/jn.00783.2015","article-title":"\u201cReal-time\u201d imaging of cortical and subcortical sites of cardiovascular control: concurrent recordings of sympathetic nerve activity and fMRI in awake subjects","volume":"116","author":"Macefield","year":"2016","journal-title":"J Neurophysiol"},{"issue":"12","key":"10.1016\/j.clinph.2021.04.012_b0115","doi-asserted-by":"crossref","first-page":"2236","DOI":"10.1212\/01.wnl.0000249313.25627.2e","article-title":"Reduced cardiac 123I-MIBG scintigraphy in idiopathic REM sleep behavior disorder","volume":"67","author":"Miyamoto","year":"2006","journal-title":"Neurology"},{"issue":"12","key":"10.1016\/j.clinph.2021.04.012_b0120","doi-asserted-by":"crossref","first-page":"2220","DOI":"10.1002\/mds.23825","article-title":"Pain sensitivity and clinical progression in Parkinson's disease","volume":"26","author":"Mylius","year":"2011","journal-title":"Mov Disord"},{"issue":"4","key":"10.1016\/j.clinph.2021.04.012_b0125","doi-asserted-by":"crossref","first-page":"409","DOI":"10.1016\/j.parkreldis.2014.01.003","article-title":"Role of cardiac sympathetic nerves in preventing orthostatic hypotension in Parkinson's disease","volume":"20","author":"Nakamura","year":"2014","journal-title":"Parkinsonism Relat Disord"},{"issue":"Suppl 1","key":"10.1016\/j.clinph.2021.04.012_b0130","doi-asserted-by":"crossref","first-page":"S94","DOI":"10.1016\/S1353-8020(13)70024-5","article-title":"Autonomic disorders predicting Parkinson's disease","volume":"20","author":"Palma","year":"2014","journal-title":"Parkinsonism Relat Disord"},{"issue":"14","key":"10.1016\/j.clinph.2021.04.012_b0135","doi-asserted-by":"crossref","first-page":"2304","DOI":"10.1002\/mds.23347","article-title":"Cardiac autonomic dysfunction in idiopathic REM sleep behavior disorder","volume":"25","author":"Postuma","year":"2010","journal-title":"Mov Disord"},{"issue":"11","key":"10.1016\/j.clinph.2021.04.012_b0140","doi-asserted-by":"crossref","first-page":"1419","DOI":"10.1002\/mds.20580","article-title":"Analysis of the relationship between muscle sympathetic nerve activity and cardiac 123I-metaiodobenzylguanidine uptake in patients with Parkinson's disease","volume":"20","author":"Shindo","year":"2005","journal-title":"Mov Disord"},{"issue":"8","key":"10.1016\/j.clinph.2021.04.012_b0145","doi-asserted-by":"crossref","first-page":"980","DOI":"10.1007\/s00115-010-3010-z","article-title":"Non-motor Symptoms Questionnaire and Scale for Parkinson's disease. Cross-cultural adaptation into the German language","volume":"81","author":"Storch","year":"2010","journal-title":"Nervenarzt"},{"issue":"8","key":"10.1016\/j.clinph.2021.04.012_b0150","doi-asserted-by":"crossref","first-page":"659","DOI":"10.1177\/0269881113490326","article-title":"Functional neuroanatomy of the central noradrenergic system","volume":"27","author":"Szabadi","year":"2013","journal-title":"J Psychopharmacol"},{"issue":"1","key":"10.1016\/j.clinph.2021.04.012_b0155","first-page":"71","article-title":"Cardiac sympathetic denervation from the early stage of Parkinson's disease: clinical and experimental studies with radiolabeled MIBG","volume":"41","author":"Takatsu","year":"2000","journal-title":"J Nucl Med"},{"issue":"4","key":"10.1016\/j.clinph.2021.04.012_b0160","doi-asserted-by":"crossref","first-page":"1262","DOI":"10.1152\/japplphysiol.00470.2003","article-title":"Microneurography: how the technique developed and its role in the investigation of the sympathetic nervous system","volume":"96","author":"Vallbo","year":"2004","journal-title":"J Appl Physiol"},{"issue":"4","key":"10.1016\/j.clinph.2021.04.012_b0165","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1111\/j.1748-1716.2007.01730.x","article-title":"Interindividual differences in muscle sympathetic nerve activity: a key to new insight into cardiovascular regulation?","volume":"190","author":"Wallin","year":"2007","journal-title":"Acta Physiol (Oxf)"},{"issue":"5","key":"10.1016\/j.clinph.2021.04.012_b0170","doi-asserted-by":"crossref","first-page":"595","DOI":"10.1002\/mus.20831","article-title":"Sympathetic neural control of integrated cardiovascular function: insights from measurement of human sympathetic nerve activity","volume":"36","author":"Wallin","year":"2007","journal-title":"Muscle Nerve"},{"issue":"Suppl 2","key":"10.1016\/j.clinph.2021.04.012_b0175","doi-asserted-by":"crossref","first-page":"S54","DOI":"10.1016\/j.sleep.2011.10.012","article-title":"REM behaviour disorder and neurodegenerative diseases","volume":"12","author":"Zanigni","year":"2011","journal-title":"Sleep Med"}],"container-title":["Clinical Neurophysiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1388245721005563?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1388245721005563?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,25]],"date-time":"2025-10-25T12:03:38Z","timestamp":1761393818000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1388245721005563"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,7]]},"references-count":35,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2021,7]]}},"alternative-id":["S1388245721005563"],"URL":"https:\/\/doi.org\/10.1016\/j.clinph.2021.04.012","relation":{},"ISSN":["1388-2457"],"issn-type":[{"value":"1388-2457","type":"print"}],"subject":[],"published":{"date-parts":[[2021,7]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Increased muscle sympathetic nerve activity and impaired baroreflex control in isolated REM-sleep behavior disorder","name":"articletitle","label":"Article Title"},{"value":"Clinical Neurophysiology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.clinph.2021.04.012","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2021 International Federation of Clinical Neurophysiology. Published by Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}]}}