{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T23:49:38Z","timestamp":1790466578330,"version":"4.1.0"},"reference-count":41,"publisher":"Elsevier BV","issue":"11","license":[{"start":{"date-parts":[[2021,11,1]],"date-time":"2021-11-01T00:00:00Z","timestamp":1635724800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2021,11,1]],"date-time":"2021-11-01T00:00:00Z","timestamp":1635724800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Clinical Neurophysiology"],"published-print":{"date-parts":[[2021,11]]},"DOI":"10.1016\/j.clinph.2021.05.027","type":"journal-article","created":{"date-parts":[[2021,6,28]],"date-time":"2021-06-28T01:48:52Z","timestamp":1624844932000},"page":"2896-2906","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":8,"title":["Early nociceptive evoked potentials (NEPs) recorded from the scalp"],"prefix":"10.1016","volume":"132","author":[{"given":"Massimo","family":"Leandri","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giulia","family":"Di Stefano","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrea","family":"Truini","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lucio","family":"Marinelli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.clinph.2021.05.027_b0005","doi-asserted-by":"crossref","first-page":"1407","DOI":"10.1136\/jnnp.49.12.1407","article-title":"Somatosensory evoked potentials in syringomyelia","volume":"49","author":"Anderson","year":"1986","journal-title":"J Neurol Neurosurg Psychiatry"},{"key":"10.1016\/j.clinph.2021.05.027_b0010","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1016\/0168-5597(93)90002-7","article-title":"Variability of laser-evoked potentials: attention, arousal and lateralized differences","volume":"88","author":"Beydoun","year":"1993","journal-title":"Electroencephalogr Clin Neurophysiol Potentials Sect"},{"key":"10.1016\/j.clinph.2021.05.027_b0015","doi-asserted-by":"crossref","first-page":"541","DOI":"10.1113\/jphysiol.1967.sp008227","article-title":"Myelinated afferent fibres responding specifically to noxious stimulation of the skin","volume":"190","author":"Burgess","year":"1967","journal-title":"J Physiol"},{"key":"10.1016\/j.clinph.2021.05.027_b0020","doi-asserted-by":"crossref","first-page":"1705","DOI":"10.1016\/j.clinph.2008.03.016","article-title":"Recommendations for the clinical use of somatosensory-evoked potentials","volume":"119","author":"Cruccu","year":"2008","journal-title":"Clin Neurophysiol"},{"key":"10.1016\/j.clinph.2021.05.027_b0025","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1111\/j.1468-1331.2004.00791.x","article-title":"EFNS guidelines on neuropathic pain assessment","volume":"11","author":"Cruccu","year":"2004","journal-title":"Eur J Neurol"},{"key":"10.1016\/j.clinph.2021.05.027_b0030","doi-asserted-by":"crossref","first-page":"956","DOI":"10.1002\/ejp.1545","article-title":"The new micropatterned interdigitated electrode for selective assessment of the nociceptive system","volume":"24","author":"Di Stefano","year":"2020","journal-title":"Eur J Pain"},{"key":"10.1016\/j.clinph.2021.05.027_b0035","doi-asserted-by":"crossref","first-page":"5486","DOI":"10.1002\/hbm.22565","article-title":"Processing of nociceptive input from posterior to anterior insula in humans: nociceptive Input Processing in the Insula","volume":"35","author":"Frot","year":"2014","journal-title":"Hum Brain Mapp"},{"key":"10.1016\/j.clinph.2021.05.027_b0040","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1136\/jnnp.26.3.211","article-title":"Cerebral evoked potentials in patients with dissociated sensory loss","volume":"26","author":"Halliday","year":"1963","journal-title":"J Neurol Neurosurg Psychiatry"},{"key":"10.1016\/j.clinph.2021.05.027_b0045","doi-asserted-by":"crossref","first-page":"383","DOI":"10.1016\/j.neuroimage.2013.08.057","article-title":"The primary somatosensory cortex contributes to the latest part of the cortical response elicited by nociceptive somatosensory stimuli in humans","volume":"84","author":"Hu","year":"2014","journal-title":"NeuroImage"},{"key":"10.1016\/j.clinph.2021.05.027_b0050","unstructured":"International Association for the Study of Pain. Classification of chronic pain. Descriptions of chronic pain syndromes and definitions. 2nd ed. Seattle: IASP Press; 1994."},{"key":"10.1016\/j.clinph.2021.05.027_b0055","doi-asserted-by":"crossref","first-page":"551","DOI":"10.1136\/jnnp-2011-301484","article-title":"Pain perception in humans: use of intraepidermal electrical stimulation: Figure 1","volume":"83","author":"Inui","year":"2012","journal-title":"J Neurol Neurosurg Psychiatry"},{"key":"10.1016\/j.clinph.2021.05.027_b0060","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1016\/S0304-3959(01)00453-5","article-title":"Preferential stimulation of Adelta fibers by intra-epidermal needle electrode in humans","volume":"96","author":"Inui","year":"2002","journal-title":"Pain"},{"key":"10.1016\/j.clinph.2021.05.027_b0065","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1016\/0168-5597(90)90066-M","article-title":"Somatosensory evoked potentials and magnetic resonance imaging in syringomyelia","volume":"77","author":"Jabbari","year":"1990","journal-title":"Electroencephalogr Clin Neurophysiol Potentials Sect"},{"key":"10.1016\/j.clinph.2021.05.027_b0070","doi-asserted-by":"crossref","first-page":"945","DOI":"10.1002\/ana.25231","article-title":"Tuning in C-nociceptors to reveal mechanisms in chronic neuropathic pain","volume":"83","author":"Jonas","year":"2018","journal-title":"Ann Neurol"},{"key":"10.1016\/j.clinph.2021.05.027_b0075","doi-asserted-by":"crossref","first-page":"1511","DOI":"10.1111\/j.1526-4610.2006.00446.x","article-title":"A novel method of eliciting pain-related potentials by transcutaneous electrical stimulation","volume":"46","author":"Katsarava","year":"2006","journal-title":"Headache J Head Face Pain"},{"key":"10.1016\/j.clinph.2021.05.027_b0080","doi-asserted-by":"crossref","first-page":"413","DOI":"10.1016\/S1388-2457(99)00295-3","article-title":"A new method to increase nociception specificity of the human blink reflex","volume":"111","author":"Kaube","year":"2000","journal-title":"Clin Neurophysiol"},{"key":"10.1016\/j.clinph.2021.05.027_b0085","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1002\/ejp.1112","article-title":"Skin denervation does not alter cortical potentials to surface concentric electrode stimulation: a comparison with laser evoked potentials and contact heat evoked potentials","volume":"22","author":"La Cesa","year":"2018","journal-title":"Eur J Pain"},{"key":"10.1016\/j.clinph.2021.05.027_b0090","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1113\/eph8702350","article-title":"Phenotype and function of somatic primary afferent nociceptive neurones with C-, A\u03b4- or A\u03b1\/\u03b2-fibres","volume":"87","author":"Lawson","year":"2002","journal-title":"Exp Physiol"},{"key":"10.1016\/j.clinph.2021.05.027_b0095","doi-asserted-by":"crossref","first-page":"244","DOI":"10.3171\/jns.1991.75.2.0244","article-title":"Diagnostic relevance of trigeminal evoked potentials following infraorbital nerve stimulation","volume":"75","author":"Leandri","year":"1991","journal-title":"J Neurosurg"},{"key":"10.1016\/j.clinph.2021.05.027_b0100","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1016\/j.jneumeth.2017.08.032","article-title":"Micropatterned surface electrode for massive selective stimulation of intraepidermal nociceptive fibres","volume":"293","author":"Leandri","year":"2018","journal-title":"J Neurosci Methods"},{"key":"10.1016\/j.clinph.2021.05.027_b0105","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1016\/0168-5597(85)90021-8","article-title":"Early evoked potentials detected from the scalp of man following infraorbital nerve stimulation","volume":"62","author":"Leandri","year":"1985","journal-title":"Electroencephalogr Clin Neurophysiol Potentials Sect"},{"key":"10.1016\/j.clinph.2021.05.027_b0110","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1016\/0013-4694(87)90074-5","article-title":"Subcortical and cortical responses following infraorbital nerve stimulation in man","volume":"66","author":"Leandri","year":"1987","journal-title":"Electroencephalogr Clin Neurophysiol"},{"key":"10.1016\/j.clinph.2021.05.027_b0115","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1016\/j.neucli.2006.08.004","article-title":"Measurement of skin temperature after infrared laser stimulation","volume":"36","author":"Leandri","year":"2006","journal-title":"Neurophysiol Clin Neurophysiol"},{"key":"10.1016\/j.clinph.2021.05.027_b0120","doi-asserted-by":"crossref","unstructured":"Lefaucheur J-P. Clinical neurophysiology of pain. Handb. Clin. Neurol., vol. 161, Elsevier; 2019, p. 121\u201348. https:\/\/doi.org\/10.1016\/B978-0-444-64142-7.00045-X.","DOI":"10.1016\/B978-0-444-64142-7.00045-X"},{"key":"10.1016\/j.clinph.2021.05.027_b0125","doi-asserted-by":"crossref","first-page":"827","DOI":"10.1002\/j.1532-2149.2011.00063.x","article-title":"Differences in perception and brain activation following stimulation by large versus small area cutaneous surface electrodes","volume":"16","author":"Lelic","year":"2012","journal-title":"Eur J Pain"},{"key":"10.1016\/j.clinph.2021.05.027_b0130","doi-asserted-by":"crossref","first-page":"459","DOI":"10.3389\/fnhum.2019.00459","article-title":"Contact heat evoked potentials are responsive to peripheral sensitization: requisite stimulation parameters","volume":"13","author":"Linde","year":"2020","journal-title":"Front Hum Neurosci"},{"key":"10.1016\/j.clinph.2021.05.027_b0135","doi-asserted-by":"crossref","first-page":"3258","DOI":"10.1152\/jn.91181.2008","article-title":"Nociceptive laser-evoked brain potentials do not reflect nociceptive-specific neural activity","volume":"101","author":"Mouraux","year":"2009","journal-title":"J Neurophysiol"},{"key":"10.1016\/j.clinph.2021.05.027_b0140","doi-asserted-by":"crossref","unstructured":"Muzyka IM, Estephan B. Chapter 35 - Somatosensory evoked potentials. In: Levin KH, Chauvel P, editors. Handb. Clin. Neurol., vol. 160, Elsevier; 2019, p. 523\u201340. https:\/\/doi.org\/10.1016\/B978-0-444-64032-1.00035-7.","DOI":"10.1016\/B978-0-444-64032-1.00035-7"},{"key":"10.1016\/j.clinph.2021.05.027_b0145","doi-asserted-by":"crossref","first-page":"eaaw1297","DOI":"10.1126\/sciadv.aaw1297","article-title":"An ultrafast system for signaling mechanical pain in human skin","volume":"5","author":"Nagi","year":"2019","journal-title":"Sci Adv"},{"key":"10.1016\/j.clinph.2021.05.027_b0150","doi-asserted-by":"crossref","first-page":"1244","DOI":"10.1016\/j.pain.2012.03.004","article-title":"Do we activate specifically somatosensory thin fibres with the concentric planar electrode? A scalp and intracranial EEG study","volume":"153","author":"Perchet","year":"2012","journal-title":"Pain"},{"key":"10.1016\/j.clinph.2021.05.027_b0155","doi-asserted-by":"crossref","first-page":"1336","DOI":"10.1006\/nimg.2002.1315","article-title":"Role of Operculoinsular cortices in human pain processing: converging evidence from PET, fMRI, dipole modeling, and intracerebral recordings of evoked potentials","volume":"17","author":"Peyron","year":"2002","journal-title":"NeuroImage"},{"key":"10.1016\/j.clinph.2021.05.027_b0160","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1016\/j.neulet.2003.09.003","article-title":"Microneurographic study of C fiber discharges induced by CO2 laser stimulation in humans","volume":"353","author":"Qiu","year":"2003","journal-title":"Neurosci Lett"},{"key":"10.1016\/j.clinph.2021.05.027_b0165","doi-asserted-by":"crossref","first-page":"1976","DOI":"10.1097\/j.pain.0000000000001939","article-title":"The revised International Association for the Study of Pain definition of pain: concepts, challenges, and compromises","volume":"161","author":"Raja","year":"2020","journal-title":"Pain"},{"key":"10.1016\/j.clinph.2021.05.027_b0170","doi-asserted-by":"crossref","unstructured":"Rice FL, Albrecth PJ. Cutaneous mechanisms of tactile sensation: morphological and chemical organization of the innervation of the skin. In: Masland RH, Albrigth TH, Dallos P, Firestein S, Bushnell MC, Kaas JH, et al., editors. Senses Compr. Ref., Elsevier; 2008, p. 1\u20133. https:\/\/doi.org\/10.1016\/B978-012370880-9.00135-3.","DOI":"10.1016\/B978-012370880-9.00340-6"},{"key":"10.1016\/j.clinph.2021.05.027_b0175","doi-asserted-by":"crossref","unstructured":"Tavee J. Nerve conduction studies: Basic concepts. Handb. Clin. Neurol., vol. 160, Elsevier; 2019, p. 217\u201324.","DOI":"10.1016\/B978-0-444-64032-1.00014-X"},{"key":"10.1016\/j.clinph.2021.05.027_b0180","doi-asserted-by":"crossref","unstructured":"Treede RD. The adequate stimulus. In: Masland RH, Albrigth TH, Dallos P, Firestein S, Bushnell MC, Kaas JH, et al., editors. Senses Compr. Ref., Elsevier; 2008, p. 1\u20133. https:\/\/doi.org\/10.1016\/B978-012370880-9.00135-3.","DOI":"10.1016\/B978-012370880-9.00135-3"},{"key":"10.1016\/j.clinph.2021.05.027_b0185","first-page":"669","article-title":"Nociceptive processing in the cerebral cortex","author":"Treede","year":"2008","journal-title":"Pain"},{"key":"10.1016\/j.clinph.2021.05.027_b0190","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1097\/00004691-199505010-00007","article-title":"Middle-latency somatosensory evoked potentials after stimulation of the radial and median nerves: component structure and scalp topography","volume":"12","author":"Treede","year":"1995","journal-title":"J Clin Neurophysiol"},{"key":"10.1016\/j.clinph.2021.05.027_b0195","doi-asserted-by":"crossref","first-page":"1082","DOI":"10.1152\/jn.1998.80.3.1082","article-title":"Myelinated mechanically insensitive afferents from monkey hairy skin: heat-response properties","volume":"80","author":"Treede","year":"1998","journal-title":"J Neurophysiol"},{"key":"10.1016\/j.clinph.2021.05.027_b0200","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1016\/S1388-2457(03)00287-6","article-title":"Different neuronal contribution to N20 somatosensory evoked potential and to CO2 laser evoked potentials: an intracerebral recording study","volume":"115","author":"Valeriani","year":"2004","journal-title":"Clin Neurophysiol"},{"key":"10.1016\/j.clinph.2021.05.027_b0210","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1016\/0006-8993(93)90968-S","article-title":"A system of unmyelinated afferents for innocuous mechanoreception in the human skin","volume":"628","author":"Vallbo","year":"1993","journal-title":"Brain Res"}],"container-title":["Clinical Neurophysiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1388245721006209?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1388245721006209?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,25]],"date-time":"2025-10-25T12:05:32Z","timestamp":1761393932000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1388245721006209"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,11]]},"references-count":41,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2021,11]]}},"alternative-id":["S1388245721006209"],"URL":"https:\/\/doi.org\/10.1016\/j.clinph.2021.05.027","relation":{},"ISSN":["1388-2457"],"issn-type":[{"value":"1388-2457","type":"print"}],"subject":[],"published":{"date-parts":[[2021,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Early nociceptive evoked potentials (NEPs) recorded from the scalp","name":"articletitle","label":"Article Title"},{"value":"Clinical Neurophysiology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.clinph.2021.05.027","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2021 International Federation of Clinical Neurophysiology. Published by Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}]}}