{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,22]],"date-time":"2026-06-22T16:01:20Z","timestamp":1782144080007,"version":"3.54.5"},"reference-count":39,"publisher":"Elsevier BV","issue":"10","license":[{"start":{"date-parts":[[2021,10,1]],"date-time":"2021-10-01T00:00:00Z","timestamp":1633046400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2021,10,1]],"date-time":"2021-10-01T00:00:00Z","timestamp":1633046400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Clinical Neurophysiology"],"published-print":{"date-parts":[[2021,10]]},"DOI":"10.1016\/j.clinph.2021.05.034","type":"journal-article","created":{"date-parts":[[2021,7,14]],"date-time":"2021-07-14T04:59:54Z","timestamp":1626238794000},"page":"2722-2728","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":8,"title":["A model incorporating ultrasound to predict the probability of fast disease progression in amyotrophic lateral sclerosis"],"prefix":"10.1016","volume":"132","author":[{"given":"Tsun-Haw","family":"Toh","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nur Adilah","family":"Abdul-Aziz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohd Azly","family":"Yahya","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Khean-Jin","family":"Goh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ee-Chin","family":"Loh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David Paul","family":"Capelle","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nortina","family":"Shahrizaila","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"1-2","key":"10.1016\/j.clinph.2021.05.034_b0005","doi-asserted-by":"crossref","first-page":"108","DOI":"10.1080\/21678421.2020.1832121","article-title":"Natural history and clinical features of ALS in Malaysia","volume":"22","author":"Abdul Aziz","year":"2021","journal-title":"Amyotroph Lateral Scler Frontotemporal Degener"},{"issue":"3","key":"10.1016\/j.clinph.2021.05.034_b0010","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1016\/j.tjem.2018.08.001","article-title":"User's guide to correlation coefficients","volume":"18","author":"Akoglu","year":"2018","journal-title":"Turk J Emerg Med"},{"key":"10.1016\/j.clinph.2021.05.034_b0015","doi-asserted-by":"crossref","first-page":"204","DOI":"10.1002\/mus.27125","article-title":"Fasciculation frequency at the biceps brachii and brachialis muscles is associated with amyotrophic lateral sclerosis disease burden and activity","volume":"63","author":"Avidan","year":"2021","journal-title":"Muscle Nerve"},{"issue":"7","key":"10.1016\/j.clinph.2021.05.034_b0020","doi-asserted-by":"crossref","first-page":"1564","DOI":"10.1016\/j.clinph.2021.02.394","article-title":"Neurophysiological indices in amyotrophic lateral sclerosis correlate with functional outcome measures, staging and disease progression","volume":"132","author":"Barp","year":"2021","journal-title":"Clin Neurophysiol"},{"key":"10.1016\/j.clinph.2021.05.034_b0025","first-page":"89","article-title":"Clinical and research applications of neuromuscular ultrasound in amyotrophic lateral sclerosis","volume":"9","author":"Barnes","year":"2019","journal-title":"Degener Neurol Neuromuscul Dis"},{"issue":"2","key":"10.1016\/j.clinph.2021.05.034_b0030","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1002\/mus.24979","article-title":"ALS biomarkers for therapy development: state of the field and future directions","volume":"53","author":"Benatar","year":"2016","journal-title":"Muscle Nerve"},{"issue":"5","key":"10.1016\/j.clinph.2021.05.034_b0035","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1080\/146608200300079536","article-title":"World Federation of Neurology Research Group on Motor Neuron D. El Escorial revisited: revised criteria for the diagnosis of amyotrophic lateral sclerosis","volume":"1","author":"Brooks","year":"2000","journal-title":"Amyotroph Lateral Scler Other Motor Neuron Disor"},{"issue":"2","key":"10.1016\/j.clinph.2021.05.034_b0040","doi-asserted-by":"crossref","first-page":"162","DOI":"10.1056\/NEJMra1603471","article-title":"Amyotrophic lateral sclerosis","volume":"377","author":"Brown","year":"2017","journal-title":"N Engl J Med"},{"issue":"3","key":"10.1016\/j.clinph.2021.05.034_b0045","doi-asserted-by":"crossref","first-page":"346","DOI":"10.1002\/mus.22035","article-title":"Peripheral nerve and muscle ultrasound in amyotrophic lateral sclerosis","volume":"44","author":"Cartwright","year":"2011","journal-title":"Muscle Nerve"},{"issue":"4","key":"10.1016\/j.clinph.2021.05.034_b0050","doi-asserted-by":"crossref","first-page":"557","DOI":"10.1001\/archneur.63.4.557","article-title":"Can selection of rapidly progressing patients shorten clinical trials in amyotrophic lateral sclerosis?","volume":"63","author":"de Carvalho","year":"2006","journal-title":"Arch Neurol"},{"issue":"3","key":"10.1016\/j.clinph.2021.05.034_b0055","doi-asserted-by":"crossref","first-page":"497","DOI":"10.1016\/j.clinph.2007.09.143","article-title":"Electrodiagnostic criteria for diagnosis of ALS","volume":"119","author":"de Carvalho","year":"2008","journal-title":"Clin Neurophysiol"},{"issue":"1-2","key":"10.1016\/j.clinph.2021.05.034_b0060","doi-asserted-by":"crossref","first-page":"119","DOI":"10.3109\/21678421.2013.838970","article-title":"Pooled Resource Open-Access ALS Clinical Trials Consortium. Amyotrophic lateral sclerosis disease progression model","volume":"15","author":"Gomeni","year":"2014","journal-title":"Amyotroph Lateral Scler Frontotemporal Degener"},{"issue":"10","key":"10.1016\/j.clinph.2021.05.034_b0065","doi-asserted-by":"crossref","first-page":"1713","DOI":"10.1007\/s00415-010-5609-1","article-title":"Progression in ALS is not linear but is curvilinear","volume":"257","author":"Gordon","year":"2010","journal-title":"J Neurol"},{"issue":"2","key":"10.1016\/j.clinph.2021.05.034_b0070","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1212\/01.wnl.0000194316.91908.8a","article-title":"Progression rate of ALSFRS-R at time of diagnosis predicts survival time in ALS","volume":"66","author":"Kimura","year":"2006","journal-title":"Neurology"},{"issue":"12","key":"10.1016\/j.clinph.2021.05.034_b0075","doi-asserted-by":"crossref","first-page":"1361","DOI":"10.1136\/jnnp-2015-312908","article-title":"A clinical tool for predicting survival in ALS","volume":"87","author":"Knibb","year":"2016","journal-title":"J Neurol Neurosurg Psychiatry"},{"issue":"6","key":"10.1016\/j.clinph.2021.05.034_b0080","doi-asserted-by":"crossref","first-page":"628","DOI":"10.1136\/jnnp-2015-310998","article-title":"Rate of disease progression: a prognostic biomarker in ALS","volume":"87","author":"Labra","year":"2016","journal-title":"J Neurol Neurosurg Psychiatry"},{"issue":"5","key":"10.1016\/j.clinph.2021.05.034_b0085","doi-asserted-by":"crossref","first-page":"814","DOI":"10.1002\/mus.21779","article-title":"Muscle ultrasound quantifies the rate of reduction of muscle thickness in amyotrophic lateral sclerosis","volume":"42","author":"Lee","year":"2010","journal-title":"Muscle Nerve"},{"issue":"4","key":"10.1016\/j.clinph.2021.05.034_b0090","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1080\/17482960600947648","article-title":"Amyotrophic lateral sclerosis: prognostic indicators of survival","volume":"7","author":"Mandrioli","year":"2006","journal-title":"Amyotroph Lat Scler"},{"issue":"1","key":"10.1016\/j.clinph.2021.05.034_b0095","doi-asserted-by":"crossref","first-page":"102","DOI":"10.1016\/j.ultrasmedbio.2017.09.013","article-title":"Monitoring progression of amyotrophic lateral sclerosis using ultrasound morpho-textural muscle biomarkers: a pilot study","volume":"44","author":"Mart\u00ednez-Pay\u00e1","year":"2018","journal-title":"Ultrasound Med Biol"},{"issue":"16","key":"10.1016\/j.clinph.2021.05.034_b0100","doi-asserted-by":"crossref","first-page":"1532","DOI":"10.1212\/WNL.0b013e318233b36a","article-title":"Ultrasonographic detection of fasciculations markedly increases diagnostic sensitivity of ALS","volume":"77","author":"Misawa","year":"2011","journal-title":"Neurology"},{"issue":"1.2","key":"10.1016\/j.clinph.2021.05.034_b0105","doi-asserted-by":"crossref","first-page":"54","DOI":"10.2152\/jmi.63.54","article-title":"Sonographic evaluation of cervical nerve roots in ALS and its clinical subtypes","volume":"63","author":"Mori","year":"2016","journal-title":"J Med Invest"},{"issue":"9","key":"10.1016\/j.clinph.2021.05.034_b0110","doi-asserted-by":"crossref","first-page":"1906","DOI":"10.1016\/j.clinph.2014.01.033","article-title":"Thinning of cervical nerve roots and peripheral nerves in ALS as measured by sonography","volume":"125","author":"Nodera","year":"2014","journal-title":"Clin Neurophysiol"},{"issue":"6","key":"10.1016\/j.clinph.2021.05.034_b0115","doi-asserted-by":"crossref","first-page":"777","DOI":"10.1002\/mus.26301","article-title":"Comparison of cross-sectional areas and distal\u2013proximal nerve ratios in amyotrophic lateral sclerosis","volume":"58","author":"Noto","year":"2018","journal-title":"Muscle Nerve"},{"issue":"6","key":"10.1016\/j.clinph.2021.05.034_bib196","doi-asserted-by":"crossref","first-page":"1068","DOI":"10.1002\/mus.25607","article-title":"Detection of fasciculations in amyotrophic lateral sclerosis: The optimal ultrasound scan time","volume":"56","author":"Noto","year":"2017","journal-title":"Muscle Nerve"},{"issue":"2","key":"10.1016\/j.clinph.2021.05.034_b0120","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1002\/mus.26360","article-title":"A pilot study of neuromuscular ultrasound as a biomarker for amyotrophic lateral sclerosis","volume":"59","author":"Pathak","year":"2019","journal-title":"Muscle Nerve"},{"key":"10.1016\/j.clinph.2021.05.034_b0125","doi-asserted-by":"crossref","first-page":"1652","DOI":"10.1016\/j.clinph.2015.06.030","article-title":"Serial peripheral nerve ultrasound in Guillain-Barre syndrome","volume":"127","author":"Razali","year":"2016","journal-title":"Clin Neurophysiol"},{"issue":"5","key":"10.1016\/j.clinph.2021.05.034_b0130","doi-asserted-by":"crossref","first-page":"381","DOI":"10.1136\/jnnp-2016-314661","article-title":"What does the ALSFRS-R really measure? A longitudinal and survival analysis of functional dimension subscores in amyotrophic lateral sclerosis","volume":"88","author":"Rooney","year":"2017","journal-title":"J Neurol Neurosurg Psychiatry"},{"issue":"3","key":"10.1016\/j.clinph.2021.05.034_b0135","doi-asserted-by":"crossref","first-page":"391","DOI":"10.1002\/mus.25066","article-title":"Quantifying disease progression in amyotrophic lateral sclerosis using peripheral nerve sonography","volume":"54","author":"Schreiber","year":"2016","journal-title":"Muscle Nerve"},{"key":"10.1016\/j.clinph.2021.05.034_b0140","doi-asserted-by":"crossref","unstructured":"Schreiber S, Schreiber F, Garz C, Debska-Vielhaber G, Assmann A, Perosa V, et al. Toward in vivo determination of peripheral nervous system immune activity in amyotrophic lateral sclerosis. Muscle Nerve 2019;59:567\u201376.","DOI":"10.1002\/mus.26444"},{"issue":"9","key":"10.1016\/j.clinph.2021.05.034_b0150","doi-asserted-by":"crossref","first-page":"2315","DOI":"10.1016\/j.clinph.2020.03.026","article-title":"Peripheral nerve imaging in amyotrophic lateral sclerosis","volume":"131","author":"Schreiber","year":"2020","journal-title":"Clin Neurophysiol"},{"issue":"1","key":"10.1016\/j.clinph.2021.05.034_b0155","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1016\/j.clinph.2016.11.010","article-title":"Quantitative muscle ultrasound as a biomarker in Charcot-Marie-Tooth neuropathy","volume":"128","author":"Shahrizaila","year":"2017","journal-title":"Clin Neurophysiol"},{"issue":"1.2","key":"10.1016\/j.clinph.2021.05.034_b0160","doi-asserted-by":"crossref","first-page":"49","DOI":"10.2152\/jmi.63.49","article-title":"Which muscle shows fasciculations by ultrasound in patients with ALS?","volume":"63","author":"Takamatsu","year":"2016","journal-title":"J Med Invest"},{"issue":"6","key":"10.1016\/j.clinph.2021.05.034_b0165","doi-asserted-by":"crossref","first-page":"937","DOI":"10.1002\/mus.26042","article-title":"Pooled Resource Open-Access ALS Clinical Trials Consortium. Trajectories of impairment in amyotrophic lateral sclerosis: Insights from the Pooled Resource Open-Access ALS Clinical Trials cohort","volume":"57","author":"Thakore","year":"2018","journal-title":"Muscle Nerve"},{"issue":"0","key":"10.1016\/j.clinph.2021.05.034_b0170","first-page":"0","article-title":"Count of Fasciculation in Ultrasound Can Predict the Prognosis of Amyotrophic Lateral Sclerosis","volume":"0","author":"Todo","year":"2019","journal-title":"Ann Indian Acad Neurol"},{"issue":"10","key":"10.1016\/j.clinph.2021.05.034_b0175","doi-asserted-by":"crossref","first-page":"2149","DOI":"10.1016\/j.clinph.2018.07.015","article-title":"Fasciculation intensity and disease progression in amyotrophic lateral sclerosis","volume":"129","author":"Tsugawa","year":"2018","journal-title":"Clin Neurophysiol"},{"issue":"6","key":"10.1016\/j.clinph.2021.05.034_b0180","doi-asserted-by":"crossref","first-page":"1069","DOI":"10.1016\/j.clinph.2017.02.015","article-title":"A muscle ultrasound score in the diagnosis of amyotrophic lateral sclerosis","volume":"128","author":"Tsuji","year":"2017","journal-title":"Clin Neurophysiol"},{"issue":"1","key":"10.1016\/j.clinph.2021.05.034_b0185","doi-asserted-by":"crossref","first-page":"94","DOI":"10.1016\/S1474-4422(08)70293-X","article-title":"Biomarkers in amyotrophic lateral sclerosis","volume":"8","author":"Turner","year":"2009","journal-title":"Lancet Neurol"},{"issue":"12","key":"10.1016\/j.clinph.2021.05.034_b0190","doi-asserted-by":"crossref","first-page":"2650","DOI":"10.1016\/j.clinph.2018.09.014","article-title":"New insights into the pathophysiology of fasciculations in amyotrophic lateral sclerosis: an ultrasound study","volume":"129","author":"V\u00e1zquez-Costa","year":"2018","journal-title":"Clin Neurophysiol"},{"issue":"5","key":"10.1016\/j.clinph.2021.05.034_b0195","doi-asserted-by":"crossref","first-page":"423","DOI":"10.1016\/S1474-4422(18)30089-9","article-title":"Prognosis for patients with amyotrophic lateral sclerosis: development and validation of a personalised prediction model","volume":"17","author":"Westeneng","year":"2018","journal-title":"Lancet Neurol"}],"container-title":["Clinical Neurophysiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1388245721006465?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1388245721006465?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,25]],"date-time":"2025-10-25T12:04:21Z","timestamp":1761393861000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1388245721006465"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,10]]},"references-count":39,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2021,10]]}},"alternative-id":["S1388245721006465"],"URL":"https:\/\/doi.org\/10.1016\/j.clinph.2021.05.034","relation":{},"ISSN":["1388-2457"],"issn-type":[{"value":"1388-2457","type":"print"}],"subject":[],"published":{"date-parts":[[2021,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"A model incorporating ultrasound to predict the probability of fast disease progression in amyotrophic lateral sclerosis","name":"articletitle","label":"Article Title"},{"value":"Clinical Neurophysiology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.clinph.2021.05.034","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2021 International Federation of Clinical Neurophysiology. Published by Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}]}}