{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T02:40:21Z","timestamp":1789958421593,"version":"4.0.1"},"reference-count":23,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2022,8,1]],"date-time":"2022-08-01T00:00:00Z","timestamp":1659312000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2022,8,1]],"date-time":"2022-08-01T00:00:00Z","timestamp":1659312000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2023,6,27]],"date-time":"2023-06-27T00:00:00Z","timestamp":1687824000000},"content-version":"am","delay-in-days":330,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Clinical Neurophysiology"],"published-print":{"date-parts":[[2022,8]]},"DOI":"10.1016\/j.clinph.2022.06.005","type":"journal-article","created":{"date-parts":[[2022,6,17]],"date-time":"2022-06-17T11:43:01Z","timestamp":1655466181000},"page":"136-144","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":27,"special_numbering":"C","title":["Early diagnosis of amyotrophic lateral sclerosis based on fasciculations in muscle ultrasonography: A machine learning approach"],"prefix":"10.1016","volume":"140","author":[{"given":"Koji","family":"Fukushima","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Naoko","family":"Takamatsu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuki","family":"Yamamoto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiroki","family":"Yamazaki","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takeshi","family":"Yoshida","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yusuke","family":"Osaki","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shotaro","family":"Haji","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Koji","family":"Fujita","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kazuma","family":"Sugie","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuishin","family":"Izumi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"3","key":"10.1016\/j.clinph.2022.06.005_b0005","doi-asserted-by":"crossref","first-page":"623","DOI":"10.1016\/j.clinph.2010.07.023","article-title":"Muscle changes in amyotrophic lateral sclerosis: a longitudinal ultrasonography study","volume":"122","author":"Arts","year":"2011","journal-title":"Clin Neurophysiol"},{"issue":"5","key":"10.1016\/j.clinph.2022.06.005_b0010","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1080\/146608200300079536","article-title":"World Federation of Neurology Research Group on Motor Neuron Diseases. El Escorial revisited: revised criteria for the diagnosis of amyotrophic lateral sclerosis","volume":"1","author":"Brooks","year":"2000","journal-title":"Amyotroph Lateral Scler Other Motor Neuron Disord"},{"key":"10.1016\/j.clinph.2022.06.005_b0015","doi-asserted-by":"crossref","first-page":"162","DOI":"10.1056\/NEJMra1603471","article-title":"Amyotrophic Lateral Sclerosis","volume":"377","author":"Brown","year":"2017","journal-title":"N Engl J Med"},{"issue":"1\u20132","key":"10.1016\/j.clinph.2022.06.005_b0020","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1016\/S0022-510X(99)00210-5","article-title":"The ALSFRS-R: a revised ALS functional rating scale that incorporates assessments of respiratory function. BDNF ALS Study Group (Phase III)","volume":"169","author":"Cedarbaum","year":"1999","journal-title":"J Neurol Sci"},{"issue":"3","key":"10.1016\/j.clinph.2022.06.005_b0025","doi-asserted-by":"crossref","first-page":"497","DOI":"10.1016\/j.clinph.2007.09.143","article-title":"Electrodiagnostic criteria for diagnosis of ALS","volume":"119","author":"de Carvalho","year":"2008","journal-title":"Clin Neurophysiol"},{"issue":"9","key":"10.1016\/j.clinph.2022.06.005_b0030","doi-asserted-by":"crossref","first-page":"963","DOI":"10.1136\/jnnp-2012-304545","article-title":"Fasciculation potentials and earliest changes in motor unit physiology in ALS","volume":"84","author":"de Carvalho","year":"2013","journal-title":"J Neurol Neurosurg Psychiatry"},{"issue":"7","key":"10.1016\/j.clinph.2022.06.005_b0035","doi-asserted-by":"crossref","first-page":"1662","DOI":"10.1016\/j.clinph.2020.03.014","article-title":"AANEM \u2013 IFCN glossary of terms in neuromuscular electrodiagnostic medicine and ultrasound","volume":"131","author":"Dengler","year":"2020","journal-title":"Clin Neurophysiol"},{"key":"10.1016\/j.clinph.2022.06.005_b0040","doi-asserted-by":"crossref","first-page":"116","DOI":"10.1590\/0100-3984.2019.0055","article-title":"Ultrasound versus electromyography for the detection of fasciculation in amyotrophic lateral sclerosis: systematic review and meta-analysis","volume":"53","author":"Duarte","year":"2020","journal-title":"Radiol Bras"},{"issue":"7","key":"10.1016\/j.clinph.2022.06.005_b0045","doi-asserted-by":"crossref","first-page":"2684","DOI":"10.1016\/j.clinph.2016.04.005","article-title":"Awaji criteria improves the diagnostic sensitivity in amyotrophic lateral sclerosis: A systematic review using individual patient data","volume":"127","author":"Geevasinga","year":"2016","journal-title":"Clin Neurophysiol"},{"issue":"4","key":"10.1016\/j.clinph.2022.06.005_b0050","doi-asserted-by":"crossref","first-page":"820","DOI":"10.1016\/j.clinph.2014.06.052","article-title":"Muscle ultrasonography as an additional diagnostic tool for the diagnosis of amyotrophic lateral sclerosis","volume":"126","author":"Grimm","year":"2015","journal-title":"Clin Neurophysiol"},{"issue":"11","key":"10.1016\/j.clinph.2022.06.005_b0055","doi-asserted-by":"crossref","first-page":"2250","DOI":"10.1016\/j.clinph.2017.08.031","article-title":"Fasciculations in nerve and muscle disorders \u2013 A prospective study of muscle ultrasound compared to electromyography","volume":"128","author":"Johansson","year":"2017","journal-title":"Clin Neurophysiol"},{"issue":"6","key":"10.1016\/j.clinph.2022.06.005_b0060","doi-asserted-by":"crossref","first-page":"458","DOI":"10.1080\/01616412.2020.1738100","article-title":"Muscle ultrasonography in the diagnosis of amyotrophic lateral sclerosis","volume":"42","author":"Juan","year":"2020","journal-title":"Neurol Res"},{"key":"10.1016\/j.clinph.2022.06.005_b0065","doi-asserted-by":"crossref","first-page":"451","DOI":"10.1136\/jnnp-2018-319294","article-title":"Ultra-high-dose methylcobalamin in amyotrophic lateral sclerosis: a long-term phase II\/III randomized controlled study","volume":"90","author":"Kaji","year":"2019","journal-title":"J Neurol Neurosurg Psychiatry"},{"issue":"1","key":"10.1016\/j.clinph.2022.06.005_b0070","doi-asserted-by":"crossref","DOI":"10.1186\/s12883-021-02473-5","article-title":"Fasciculation differences between ALS and non-ALS patients: an ultrasound study","volume":"21","author":"Liu","year":"2021","journal-title":"BMC Neurol"},{"issue":"11","key":"10.1016\/j.clinph.2022.06.005_b0075","doi-asserted-by":"crossref","first-page":"4657","DOI":"10.1007\/s10072-021-05166-6","article-title":"Fasciculation score: a sensitive biomarker in amyotrophic lateral sclerosis","volume":"42","author":"Ma","year":"2021","journal-title":"Neurol Sci"},{"issue":"16","key":"10.1016\/j.clinph.2022.06.005_b0080","doi-asserted-by":"crossref","first-page":"1532","DOI":"10.1212\/WNL.0b013e318233b36a","article-title":"Ultrasonographic detection of fasciculations markedly increases diagnostic sensitivity of ALS","volume":"77","author":"Misawa","year":"2011","journal-title":"Neurology"},{"issue":"6","key":"10.1016\/j.clinph.2022.06.005_b0085","doi-asserted-by":"crossref","first-page":"575","DOI":"10.1001\/jamaneurol.2022.0901","article-title":"Efficacy and safety of ultrahigh-dose methylcobalamin in early-stage amyotrophic lateral sclerosis: A randomized clinical trial","volume":"79","author":"Oki","year":"2022","journal-title":"JAMA Neurol"},{"key":"10.1016\/j.clinph.2022.06.005_b0090","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1016\/j.neuron.2011.09.010","article-title":"A hexanucleotide repeat expansion in C9ORF72 is the cause of chromosome 9p21-linked ALS-FTD","volume":"72","author":"Renton","year":"2011","journal-title":"Neuron"},{"key":"10.1016\/j.clinph.2022.06.005_b0095","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1111\/jon19977123","article-title":"Ultrasonographic assessment of the prevalence of fasciculations in lesions of the peripheral nervous system","volume":"7","author":"Scheel","year":"1997","journal-title":"J Neuroimaging"},{"issue":"8","key":"10.1016\/j.clinph.2022.06.005_b0100","doi-asserted-by":"crossref","first-page":"1975","DOI":"10.1016\/j.clinph.2020.04.005","article-title":"A Proposal for New Diagnostic Criteria for ALS","volume":"131","author":"Shefner","year":"2020","journal-title":"Clin Neurophysiol"},{"issue":"1","key":"10.1016\/j.clinph.2022.06.005_b0105","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1002\/mus.21196","article-title":"Utility of trapezius EMG for diagnosis of amyotrophic lateral sclerosis","volume":"39","author":"Sonoo","year":"2009","journal-title":"Muscle Nerve"},{"issue":"12","key":"10.1016\/j.clinph.2022.06.005_b0110","doi-asserted-by":"crossref","first-page":"2804","DOI":"10.1016\/j.clinph.2020.08.021","article-title":"Difference in distribution of fasciculations between multifocal motor neuropathy and amyotrophic lateral sclerosis","volume":"131","author":"Tsuji","year":"2020","journal-title":"Clin Neurophysiol"},{"issue":"6","key":"10.1016\/j.clinph.2022.06.005_b0115","doi-asserted-by":"crossref","first-page":"1069","DOI":"10.1016\/j.clinph.2017.02.015","article-title":"A muscle ultrasound score in the diagnosis of amyotrophic lateral sclerosis","volume":"128","author":"Tsuji","year":"2017","journal-title":"Clin Neurophysiol"}],"container-title":["Clinical Neurophysiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S138824572200298X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S138824572200298X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,25]],"date-time":"2025-10-25T12:08:55Z","timestamp":1761394135000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S138824572200298X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,8]]},"references-count":23,"alternative-id":["S138824572200298X"],"URL":"https:\/\/doi.org\/10.1016\/j.clinph.2022.06.005","relation":{},"ISSN":["1388-2457"],"issn-type":[{"value":"1388-2457","type":"print"}],"subject":[],"published":{"date-parts":[[2022,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Early diagnosis of amyotrophic lateral sclerosis based on fasciculations in muscle ultrasonography: A machine learning approach","name":"articletitle","label":"Article Title"},{"value":"Clinical Neurophysiology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.clinph.2022.06.005","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2022 International Federation of Clinical Neurophysiology. Published by Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}]}}