{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,14]],"date-time":"2026-04-14T19:55:26Z","timestamp":1776196526148,"version":"3.50.1"},"reference-count":48,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/501100007129","name":"Natural Science Foundation of Shandong Province","doi-asserted-by":"publisher","award":["ZR2024QH384"],"award-info":[{"award-number":["ZR2024QH384"]}],"id":[{"id":"10.13039\/501100007129","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82501509"],"award-info":[{"award-number":["82501509"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Clinical Neurophysiology"],"published-print":{"date-parts":[[2026,6]]},"DOI":"10.1016\/j.clinph.2026.2111859","type":"journal-article","created":{"date-parts":[[2026,3,22]],"date-time":"2026-03-22T15:52:22Z","timestamp":1774194742000},"page":"2111859","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["Depression in Parkinson\u2019s disease: prevalence and impact on oculomotor features"],"prefix":"10.1016","volume":"186","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3255-9736","authenticated-orcid":false,"given":"Lingyan","family":"Zhou","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Meng","family":"Guan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bo","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cheng","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhanfang","family":"Sun","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Weiqi","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuanyuan","family":"Xiang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiao","family":"Man","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.clinph.2026.2111859_b0005","doi-asserted-by":"crossref","DOI":"10.1016\/j.arr.2022.101840","article-title":"Neurobiology of depression in Parkinson's disease: insights into epidemiology, molecular mechanisms and treatment strategies","volume":"85","author":"Ahmad","year":"2023","journal-title":"Ageing Res. Rev."},{"issue":"4","key":"10.1016\/j.clinph.2026.2111859_b0010","doi-asserted-by":"crossref","first-page":"715","DOI":"10.3233\/JPD-150686","article-title":"Oculo-visual dysfunction in Parkinson's disease","volume":"5","author":"Armstrong","year":"2015","journal-title":"J. Parkinsons Dis."},{"issue":"2","key":"10.1016\/j.clinph.2026.2111859_b0015","doi-asserted-by":"crossref","first-page":"448","DOI":"10.1111\/j.1460-9568.2005.04215.x","article-title":"Activity of substantia nigra pars reticulata neurons during smooth pursuit eye movements in monkeys","volume":"22","author":"Basso","year":"2005","journal-title":"Eur. J. Neurosci."},{"issue":"8","key":"10.1016\/j.clinph.2026.2111859_b0020","doi-asserted-by":"crossref","first-page":"2603","DOI":"10.1007\/s00429-019-01932-7","article-title":"Functional neuroanatomy of the human eye movement network: a review and atlas","volume":"224","author":"Coiner","year":"2019","journal-title":"Brain Struct. Funct."},{"key":"10.1016\/j.clinph.2026.2111859_b0025","doi-asserted-by":"crossref","DOI":"10.1136\/bmj-2023-074819","article-title":"Evaluation of clinical prediction models (part 1): from development to external validation","volume":"384","author":"Collins","year":"2024","journal-title":"BMJ"},{"issue":"1","key":"10.1016\/j.clinph.2026.2111859_b0030","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1093\/brain\/awac026","article-title":"Peripheral neuropathy in Parkinson's disease: prevalence and functional impact on gait and balance","volume":"146","author":"Corra","year":"2023","journal-title":"Brain"},{"issue":"5","key":"10.1016\/j.clinph.2026.2111859_b0035","doi-asserted-by":"crossref","first-page":"2678","DOI":"10.1152\/jn.00501.2002","article-title":"Pursuit subregion of the frontal eye field projects to the caudate nucleus in monkeys","volume":"89","author":"Cui","year":"2003","journal-title":"J. Neurophysiol."},{"issue":"3","key":"10.1016\/j.clinph.2026.2111859_b0040","doi-asserted-by":"crossref","first-page":"609","DOI":"10.1111\/j.0953-816X.2003.03137.x","article-title":"Single-neuron evidence for a contribution of the dorsal pontine nuclei to both types of target-directed eye movements, saccades and smooth-pursuit","volume":"19","author":"Dicke","year":"2004","journal-title":"Eur. J. Neurosci."},{"issue":"3","key":"10.1016\/j.clinph.2026.2111859_b0045","doi-asserted-by":"crossref","first-page":"774","DOI":"10.1016\/j.neuroimage.2007.03.023","article-title":"An effect of context on saccade-related behavior and brain activity","volume":"36","author":"Dyckman","year":"2007","journal-title":"Neuroimage"},{"issue":"5","key":"10.1016\/j.clinph.2026.2111859_b0050","doi-asserted-by":"crossref","first-page":"1309","DOI":"10.1007\/s00221-017-4916-5","article-title":"Clinical application of eye movement tasks as an aid to understanding Parkinson's disease pathophysiology","volume":"235","author":"Fukushima","year":"2017","journal-title":"Exp. Brain Res."},{"issue":"1","key":"10.1016\/j.clinph.2026.2111859_b0055","first-page":"2","article-title":"Using eye-tracking technology in Neuromarketing","volume":"67","author":"Gheorghe","year":"2023","journal-title":"Rom J Ophthalmol"},{"issue":"4","key":"10.1016\/j.clinph.2026.2111859_b0060","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1016\/j.pneurobio.2005.11.001","article-title":"From brainstem to cortex: computational models of saccade generation circuitry","volume":"77","author":"Girard","year":"2005","journal-title":"Prog. Neurobiol."},{"issue":"9","key":"10.1016\/j.clinph.2026.2111859_b0065","doi-asserted-by":"crossref","first-page":"1390","DOI":"10.1002\/mds.27454","article-title":"Oculo-visual abnormalities in Parkinson's disease: possible value as biomarkers","volume":"33","author":"Guo","year":"2018","journal-title":"Mov. Disord."},{"issue":"5","key":"10.1016\/j.clinph.2026.2111859_b0070","doi-asserted-by":"crossref","first-page":"427","DOI":"10.1212\/WNL.17.5.427","article-title":"Parkinsonism: onset, progression and mortality","volume":"17","author":"Hoehn","year":"1967","journal-title":"Neurology"},{"issue":"s2","key":"10.1016\/j.clinph.2026.2111859_b0075","doi-asserted-by":"crossref","first-page":"S297","DOI":"10.3233\/JPD-230419","article-title":"Approaches to early Parkinson's disease subtyping","volume":"14","author":"Hu","year":"2024","journal-title":"J. Parkinsons Dis."},{"issue":"3","key":"10.1016\/j.clinph.2026.2111859_b0080","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1016\/j.bandc.2008.08.021","article-title":"Cognitive control of saccadic eye movements","volume":"68","author":"Hutton","year":"2008","journal-title":"Brain Cogn."},{"key":"10.1016\/j.clinph.2026.2111859_b0085","doi-asserted-by":"crossref","unstructured":"Jost, S. T., Kaldenbach, M. A., Antonini, A., Martinez-Martin, P., Timmermann, L., Odin, P., Katzenschlager, R., Borgohain, R., Fasano, A., Stocchi, F., Hattori, N., Kukkle, P. L., Rodriguez-Violante, M., Falup-Pecurariu, C., Schade, S., Petry-Schmelzer, J. N., Metta, V., Weintraub, D., Deuschl, G., Espay, A. J., Tan, E. K., Bhidayasiri, R., Fung, V. S. C., Cardoso, F., Trenkwalder, C., Jenner, P., Ray Chaudhuri, K., Dafsari, H. S., International, P., & Movement Disorders Society Non-Motor Parkinson Disease Study, G. (2023). Levodopa Dose Equivalency in Parkinson's Disease: Updated Systematic Review and Proposals. Mov Disord, 38(7), 1236-1252. https:\/\/doi.org\/10.1002\/mds.29410.","DOI":"10.1002\/mds.29410"},{"issue":"5\u20136","key":"10.1016\/j.clinph.2026.2111859_b0090","doi-asserted-by":"crossref","first-page":"601","DOI":"10.1007\/s00702-021-02456-3","article-title":"Parkinson and depression: review and outlook","volume":"129","author":"Laux","year":"2022","journal-title":"J. Neural Transm. (Vienna)"},{"issue":"6","key":"10.1016\/j.clinph.2026.2111859_b0095","first-page":"326","article-title":"Eye movement indices in the study of depressive disorder","volume":"28","author":"Li","year":"2016","journal-title":"Shanghai Arch. Psychiatry"},{"issue":"2","key":"10.1016\/j.clinph.2026.2111859_b0100","doi-asserted-by":"crossref","first-page":"1089","DOI":"10.1002\/alz.13517","article-title":"A detection model of cognitive impairment via the integrated gait and eye movement analysis from a large Chinese community cohort","volume":"20","author":"Lin","year":"2024","journal-title":"Alzheimers Dement."},{"key":"10.1016\/j.clinph.2026.2111859_b0105","article-title":"Identifying depression with mixed features: the potential value of eye-tracking features","volume":"16","author":"Liu","year":"2025","journal-title":"Front. Neurol."},{"issue":"1","key":"10.1016\/j.clinph.2026.2111859_b0110","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1176\/jnp.6.1.36","article-title":"Smooth pursuit eye movement abnormality in severe major depression: effects of ECT and clinical recovery","volume":"6","author":"Malaspina","year":"1994","journal-title":"J. Neuropsychiatry Clin. Neurosci."},{"issue":"1","key":"10.1016\/j.clinph.2026.2111859_b0115","doi-asserted-by":"crossref","first-page":"228","DOI":"10.1007\/s00415-012-6624-1","article-title":"Expanded and independent validation of the movement disorder society-unified Parkinson's disease rating scale (MDS-UPDRS)","volume":"260","author":"Martinez-Martin","year":"2013","journal-title":"J. Neurol."},{"issue":"4","key":"10.1016\/j.clinph.2026.2111859_b0120","doi-asserted-by":"crossref","first-page":"2308","DOI":"10.1007\/s00415-023-11582-9","article-title":"Sequential alterations in diffusion metrics as correlates of disease severity in amyotrophic lateral sclerosis","volume":"270","author":"Muller","year":"2023","journal-title":"J. Neurol."},{"issue":"10","key":"10.1016\/j.clinph.2026.2111859_b0125","doi-asserted-by":"crossref","first-page":"1291","DOI":"10.1007\/s00702-023-02658-x","article-title":"Sex- and age-specific prevalence and risk factors of depressive symptoms in Parkinson's disease","volume":"130","author":"Niu","year":"2023","journal-title":"J. Neural Transm. (Vienna)"},{"key":"10.1016\/j.clinph.2026.2111859_b0130","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1196\/annals.1325.023","article-title":"The role of the human dorsolateral prefrontal cortex in ocular motor behavior","volume":"1039","author":"Pierrot-Deseilligny","year":"2005","journal-title":"Ann. N. Y. Acad. Sci."},{"issue":"12","key":"10.1016\/j.clinph.2026.2111859_b0135","doi-asserted-by":"crossref","first-page":"1591","DOI":"10.1002\/mds.26424","article-title":"MDS clinical diagnostic criteria for Parkinson's disease","volume":"30","author":"Postuma","year":"2015","journal-title":"Mov. Disord."},{"key":"10.1016\/j.clinph.2026.2111859_b0140","doi-asserted-by":"crossref","first-page":"349","DOI":"10.1016\/j.jad.2025.01.080","article-title":"Apathy in Alzheimer's disease: eye movements characteristics and neurostructural basis","volume":"375","author":"Qi","year":"2025","journal-title":"J. Affect. Disord."},{"issue":"3","key":"10.1016\/j.clinph.2026.2111859_b0145","doi-asserted-by":"crossref","first-page":"236","DOI":"10.1007\/s00415-025-12973-w","article-title":"Reflexive and voluntary saccades as a proxy for bradykinesia and apathy in Parkinson's disease","volume":"272","author":"Rey","year":"2025","journal-title":"J. Neurol."},{"issue":"7","key":"10.1016\/j.clinph.2026.2111859_b0150","doi-asserted-by":"crossref","first-page":"435","DOI":"10.1038\/nrn.2017.62","article-title":"Non-motor features of Parkinson disease","volume":"18","author":"Schapira","year":"2017","journal-title":"Nat. Rev. Neurosci."},{"issue":"4","key":"10.1016\/j.clinph.2026.2111859_b0155","doi-asserted-by":"crossref","first-page":"439","DOI":"10.1007\/s00221-001-0912-9","article-title":"The brainstem burst generator for saccadic eye movements: a modern synthesis","volume":"142","author":"Scudder","year":"2002","journal-title":"Exp. Brain Res."},{"key":"10.1016\/j.clinph.2026.2111859_b0160","doi-asserted-by":"crossref","first-page":"3","DOI":"10.2147\/EB.S384769","article-title":"Detecting abnormal eye movements in patients with neurodegenerative diseases - current insights","volume":"16","author":"Sekar","year":"2024","journal-title":"Eye Brain"},{"issue":"6","key":"10.1016\/j.clinph.2026.2111859_b0165","doi-asserted-by":"crossref","first-page":"360","DOI":"10.1001\/archneur.1979.00500420070009","article-title":"Oculomotor abnormalities in Parkinson's disease","volume":"36","author":"Shibasaki","year":"1979","journal-title":"Arch. Neurol."},{"key":"10.1016\/j.clinph.2026.2111859_b0170","doi-asserted-by":"crossref","DOI":"10.1016\/j.clineuro.2021.106523","article-title":"Correlation between depression and quality of life in patients with Parkinson's disease","volume":"202","author":"Su","year":"2021","journal-title":"Clin. Neurol. Neurosurg."},{"issue":"8","key":"10.1016\/j.clinph.2026.2111859_b0175","doi-asserted-by":"crossref","first-page":"584","DOI":"10.1016\/S0006-3223(97)00485-X","article-title":"Prefrontal and cerebellar abnormalities in major depression: evidence from oculomotor studies","volume":"43","author":"Sweeney","year":"1998","journal-title":"Biol. Psychiatry"},{"key":"10.1016\/j.clinph.2026.2111859_b0180","article-title":"Eye movement abnormalities in major depressive disorder","volume":"12","author":"Takahashi","year":"2021","journal-title":"Front. Psych."},{"issue":"25","key":"10.1016\/j.clinph.2026.2111859_b0185","doi-asserted-by":"crossref","first-page":"5866","DOI":"10.1523\/JNEUROSCI.0676-05.2005","article-title":"Involvement of the central thalamus in the control of smooth pursuit eye movements","volume":"25","author":"Tanaka","year":"2005","journal-title":"J. Neurosci."},{"issue":"10","key":"10.1016\/j.clinph.2026.2111859_b0190","doi-asserted-by":"crossref","first-page":"772","DOI":"10.2183\/pjab.93.049","article-title":"What do eye movements tell us about patients with neurological disorders? - An introduction to saccade recording in the clinical setting","volume":"93","author":"Terao","year":"2017","journal-title":"Proc. Jpn. Acad. Ser. B Phys. Biol. Sci."},{"issue":"2","key":"10.1016\/j.clinph.2026.2111859_b0195","doi-asserted-by":"crossref","first-page":"936","DOI":"10.1152\/jn.1998.80.2.936","article-title":"Visualization of the information flow through human oculomotor cortical regions by transcranial magnetic stimulation","volume":"80","author":"Terao","year":"1998","journal-title":"J. Neurophysiol."},{"issue":"6","key":"10.1016\/j.clinph.2026.2111859_b0200","doi-asserted-by":"crossref","first-page":"645","DOI":"10.1016\/j.conb.2005.10.013","article-title":"The neural basis of smooth-pursuit eye movements","volume":"15","author":"Thier","year":"2005","journal-title":"Curr. Opin. Neurobiol."},{"key":"10.1016\/j.clinph.2026.2111859_b0205","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1016\/j.parkreldis.2018.03.013","article-title":"Eye movement parameters and cognitive functions in Parkinson's disease patients without dementia","volume":"52","author":"Wong","year":"2018","journal-title":"Parkinsonism Relat. Disord."},{"issue":"5\u20136","key":"10.1016\/j.clinph.2026.2111859_b0210","doi-asserted-by":"crossref","first-page":"563","DOI":"10.1007\/s00702-021-02437-6","article-title":"Cognition, motor symptoms, and glycolipid metabolism in Parkinson's disease with depressive symptoms","volume":"129","author":"Yao","year":"2022","journal-title":"J. Neural Transm. (Vienna)"},{"issue":"2","key":"10.1016\/j.clinph.2026.2111859_b0215","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1097\/WNR.0b013e32831af055","article-title":"Neuronal activity in the primate globus pallidus during smooth pursuit eye movements","volume":"20","author":"Yoshida","year":"2009","journal-title":"Neuroreport"},{"issue":"2","key":"10.1016\/j.clinph.2026.2111859_b0220","doi-asserted-by":"crossref","first-page":"194","DOI":"10.3988\/jcn.2022.0413","article-title":"Smooth pursuit and reflexive saccade in discriminating multiple-system atrophy with predominant parkinsonism from Parkinson's disease","volume":"20","author":"Yu","year":"2024","journal-title":"J Clin Neurol"},{"key":"10.1016\/j.clinph.2026.2111859_b0225","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1016\/j.jad.2022.03.077","article-title":"Effective differentiation between depressed patients and controls using discriminative eye movement features","volume":"307","author":"Zhang","year":"2022","journal-title":"J. Affect. Disord."},{"issue":"1","key":"10.1016\/j.clinph.2026.2111859_b0230","doi-asserted-by":"crossref","first-page":"246","DOI":"10.1186\/s12906-025-04991-y","article-title":"Efficacy and safety of Wuling capsule for the treatment of mild depression in patients with early Parkinson's disease in China: a randomized clinical trial","volume":"25","author":"Zhao","year":"2025","journal-title":"BMC Complement Med Ther"},{"issue":"5","key":"10.1016\/j.clinph.2026.2111859_b0235","doi-asserted-by":"crossref","first-page":"e3510","DOI":"10.1002\/brb3.3510","article-title":"Clinical value of video oculomotor evaluation in the differential diagnosis of multiple system atrophy and Parkinson's disease","volume":"14","author":"Zhou","year":"2024","journal-title":"Brain Behav."},{"issue":"1","key":"10.1016\/j.clinph.2026.2111859_b0240","doi-asserted-by":"crossref","first-page":"37","DOI":"10.3988\/jcn.2023.0037","article-title":"Abnormal ocular movement in the early stage of multiple-system atrophy with predominant parkinsonism distinct from Parkinson's Disease","volume":"20","author":"Zhou","year":"2024","journal-title":"J Clin Neurol"}],"container-title":["Clinical Neurophysiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1388245726003585?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1388245726003585?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,4,14]],"date-time":"2026-04-14T19:01:32Z","timestamp":1776193292000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1388245726003585"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,6]]},"references-count":48,"alternative-id":["S1388245726003585"],"URL":"https:\/\/doi.org\/10.1016\/j.clinph.2026.2111859","relation":{},"ISSN":["1388-2457"],"issn-type":[{"value":"1388-2457","type":"print"}],"subject":[],"published":{"date-parts":[[2026,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Depression in Parkinson\u2019s disease: prevalence and impact on oculomotor features","name":"articletitle","label":"Article Title"},{"value":"Clinical Neurophysiology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.clinph.2026.2111859","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 International Federation of Clinical Neurophysiology. Published by Elsevier B.V. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"2111859"}}