{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T20:32:09Z","timestamp":1790886729935,"version":"4.1.0"},"reference-count":25,"publisher":"Elsevier BV","issue":"6-7","license":[{"start":{"date-parts":[[2011,6,1]],"date-time":"2011-06-01T00:00:00Z","timestamp":1306886400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2011,6,1]],"date-time":"2011-06-01T00:00:00Z","timestamp":1306886400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","em-consulte.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Clinics and Research in Hepatology and Gastroenterology"],"published-print":{"date-parts":[[2011,6]]},"DOI":"10.1016\/j.clinre.2011.02.009","type":"journal-article","created":{"date-parts":[[2011,4,15]],"date-time":"2011-04-15T18:19:52Z","timestamp":1302891592000},"page":"494-499","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":23,"title":["Efficacy of a simethicone, activated charcoal and magnesium oxide combination (Carbosymag\u00ae) in functional dyspepsia: Results of a general practice-based randomized trial"],"prefix":"10.1016","volume":"35","author":[{"given":"Benoit","family":"Coffin","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claude","family":"Bortolloti","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Odile","family":"Bourgeois","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luc","family":"Denicourt","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.clinre.2011.02.009_bib0005","first-page":"785","article-title":"Descriptive study of digestive functional symptoms in the French general population","volume":"22","author":"Frexinos","year":"1988","journal-title":"Gastroenterol Clin Biol"},{"issue":"Suppl 7","key":"10.1016\/j.clinre.2011.02.009_bib0010","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1111\/j.1365-2036.2004.02183.x","article-title":"Review article: epidemiology and quality of life in functional gastro-intestinal disorders","volume":"20","author":"Chang","year":"2004","journal-title":"Aliment Pharmacol Ther"},{"key":"10.1016\/j.clinre.2011.02.009_bib0015","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1111\/j.1365-2036.2009.04047.x","article-title":"Systematic review: frequency and reasons for consultation for gastro-oesophageal reflux disease and dyspepsia","volume":"30","author":"Hungin","year":"2009","journal-title":"Aliment Pharmacol Ther"},{"key":"10.1016\/j.clinre.2011.02.009_bib0020","doi-asserted-by":"crossref","first-page":"1466","DOI":"10.1053\/j.gastro.2005.11.059","article-title":"Functional gastroduodenal disorders","volume":"130","author":"Tack","year":"2006","journal-title":"Gastroenterology"},{"key":"10.1016\/j.clinre.2011.02.009_bib0025","doi-asserted-by":"crossref","unstructured":"Delaney B, Ford AC, Forman D, Moayyedi P, Qume M. Initial management strategies for dyspepsia. Cochrane Database Syst Rev 2005;CD001961.","DOI":"10.1002\/14651858.CD001961.pub2"},{"key":"10.1016\/j.clinre.2011.02.009_bib0030","doi-asserted-by":"crossref","unstructured":"Ford AC, Marwaha A, Lim A, Moayyedi P. What is the prevalence of clinically significant endoscopic findings in subjects with dyspepsia? Systematic review and meta-analysis. Clin Gastroenterol Hepatol 2010;8:830\u20137.","DOI":"10.1016\/j.cgh.2010.05.031"},{"key":"10.1016\/j.clinre.2011.02.009_bib0035","doi-asserted-by":"crossref","first-page":"238","DOI":"10.1093\/fampra\/cmh304","article-title":"Empirical treatment followed by a test-and-treat strategy is more cost-effective in comparison with prompt endoscopy or radiography in patients with dyspeptic symptoms: a randomized trial in a primary care setting","volume":"21","author":"Laheij","year":"2004","journal-title":"Fam Pract"},{"key":"10.1016\/j.clinre.2011.02.009_bib0040","doi-asserted-by":"crossref","unstructured":"Moayyedi P, Soo S, Deeks J, Delaney B, Innes M, Forman D. Pharmacological interventions for non-ulcer dyspepsia. Cochrane Database Syst Rev 2006;CD001960.","DOI":"10.1002\/14651858.CD001960.pub3"},{"key":"10.1016\/j.clinre.2011.02.009_bib0045","doi-asserted-by":"crossref","first-page":"7","DOI":"10.3109\/00365528809093840","article-title":"Treatment with cimetidine, antacid, or placebo in patients with dyspepsia of unknown origin","volume":"23","author":"Gotthard","year":"1988","journal-title":"Scand J Gastroenterol"},{"key":"10.1016\/j.clinre.2011.02.009_bib0050","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1016\/S0140-6736(09)60070-2","article-title":"Effect and cost-effectiveness of step-up versus step-down treatment with antacids. H2-receptor antagonists, and proton pump inhibitors in patients with new onset dyspepsia (DIAMOND study): a primary-care-based randomised controlled trial","volume":"373","author":"van Marrewijk","year":"2009","journal-title":"Lancet"},{"key":"10.1016\/j.clinre.2011.02.009_bib0055","doi-asserted-by":"crossref","first-page":"478","DOI":"10.1016\/j.gcb.2008.09.021","article-title":"Efficacy of an activated charcoal-simethicone combination in dyspeptic syndrome: results of a randomized prospective study in general practice","volume":"33","author":"Lecuyer","year":"2009","journal-title":"Gastroenterol Clin Biol"},{"key":"10.1016\/j.clinre.2011.02.009_bib0060","doi-asserted-by":"crossref","first-page":"1538","DOI":"10.1053\/j.gastro.2005.11.058","article-title":"Design of treatment trials for functional gastro-intestinal disorders","volume":"130","author":"Irvine","year":"2006","journal-title":"Gastroenterology"},{"key":"10.1016\/j.clinre.2011.02.009_bib0065","doi-asserted-by":"crossref","first-page":"1135","DOI":"10.1111\/j.1365-2036.2005.02445.x","article-title":"Managing dyspepsia without alarm signs in primary care: new national guidance for England and Wales","volume":"21","author":"Mason","year":"2005","journal-title":"Aliment Pharmacol Ther"},{"key":"10.1016\/j.clinre.2011.02.009_bib0070","doi-asserted-by":"crossref","first-page":"871","DOI":"10.1111\/j.1365-2036.2009.03935.x","article-title":"Adherence to best practice guidelines in dyspepsia: a survey comparing dyspepsia experts, community gastroenterologists and primary-care providers","volume":"29","author":"Spiegel","year":"2009","journal-title":"Aliment Pharmacol Ther"},{"key":"10.1016\/j.clinre.2011.02.009_bib0075","doi-asserted-by":"crossref","first-page":"401","DOI":"10.1016\/j.cgh.2009.07.020","article-title":"Systematic review and meta-analysis of the prevalence of irritable bowel syndrome in individuals with dyspepsia","volume":"8","author":"Ford","year":"2010","journal-title":"Clin Gastroenterol Hepatol"},{"key":"10.1016\/j.clinre.2011.02.009_bib0080","doi-asserted-by":"crossref","first-page":"903","DOI":"10.1053\/gast.2003.50155","article-title":"Heterogeneity of symptom pattern, psychosocial factors, and pathophysiological mechanisms in severe functional dyspepsia","volume":"124","author":"Fischler","year":"2003","journal-title":"Gastroenterology"},{"key":"10.1016\/j.clinre.2011.02.009_bib0085","doi-asserted-by":"crossref","first-page":"832","DOI":"10.1056\/NEJMoa052639","article-title":"A placebo-controlled trial of itopride in functional dyspepsia","volume":"354","author":"Holtmann","year":"2006","journal-title":"N Engl J Med"},{"key":"10.1016\/j.clinre.2011.02.009_bib0090","doi-asserted-by":"crossref","first-page":"740","DOI":"10.1136\/gut.2007.132449","article-title":"Itopride in functional dyspepsia: results of two phase\u00a0III multicentre, randomised, double-blind, placebo-controlled trials","volume":"57","author":"Talley","year":"2008","journal-title":"Gut"},{"key":"10.1016\/j.clinre.2011.02.009_bib0095","doi-asserted-by":"crossref","first-page":"1370","DOI":"10.1136\/gut.2004.053355","article-title":"Prevalence of acid reflux in functional dyspepsia and its association with symptom profile","volume":"54","author":"Tack","year":"2005","journal-title":"Gut"},{"key":"10.1016\/j.clinre.2011.02.009_bib0100","unstructured":"Haute Autorit\u00e9 de Sant\u00e9. Bon usage du m\u00e9dicament: les inhibiteurs de la pompe \u00e0 protons chez l\u2019adulte, juin 2009. www.has-sante.fr."},{"key":"10.1016\/j.clinre.2011.02.009_bib0105","doi-asserted-by":"crossref","first-page":"1641","DOI":"10.1046\/j.1365-2036.2002.01322.x","article-title":"A randomized placebo-controlled trial of simethicone and cisapride for the treatment of patients with functional dyspepsia","volume":"16","author":"Holtmann","year":"2002","journal-title":"Aliment Pharmacol Ther"},{"key":"10.1016\/j.clinre.2011.02.009_bib0110","doi-asserted-by":"crossref","first-page":"1459","DOI":"10.1046\/j.1365-2036.1999.00644.x","article-title":"Randomised double-blind comparison of simethicone with cisapride in functional dyspepsia","volume":"13","author":"Holtmann","year":"1999","journal-title":"Aliment Pharmacol Ther"},{"key":"10.1016\/j.clinre.2011.02.009_bib0115","doi-asserted-by":"crossref","first-page":"554","DOI":"10.1177\/014107689008300907","article-title":"Comparison of a dimethicone\/antacid (Asilone gel) with an alginate\/antacid (Gaviscon liquid) in the management of reflux oesophagitis","volume":"83","author":"Smart","year":"1990","journal-title":"J R Soc Med"},{"key":"10.1016\/j.clinre.2011.02.009_bib0120","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1093\/jac\/37.1.45","article-title":"Susceptibility of Helicobacter pylori to simethicone and other non-antibiotic drugs","volume":"37","author":"Ansorg","year":"1996","journal-title":"J Antimicrob Chemother"},{"key":"10.1016\/j.clinre.2011.02.009_bib0125","doi-asserted-by":"crossref","first-page":"1060","DOI":"10.1053\/j.gastro.2005.06.062","article-title":"Abdominal bloating","volume":"129","author":"Azpiroz","year":"2005","journal-title":"Gastroenterology"}],"container-title":["Clinics and Research in Hepatology and Gastroenterology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2210740111000702?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2210740111000702?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,31]],"date-time":"2025-10-31T07:12:03Z","timestamp":1761894723000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2210740111000702"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011,6]]},"references-count":25,"journal-issue":{"issue":"6-7","published-print":{"date-parts":[[2011,6]]}},"alternative-id":["S2210740111000702"],"URL":"https:\/\/doi.org\/10.1016\/j.clinre.2011.02.009","relation":{},"ISSN":["2210-7401"],"issn-type":[{"value":"2210-7401","type":"print"}],"subject":[],"published":{"date-parts":[[2011,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Efficacy of a simethicone, activated charcoal and magnesium oxide combination (Carbosymag\u00ae) in functional dyspepsia: Results of a general practice-based randomized trial","name":"articletitle","label":"Article Title"},{"value":"Clinics and Research in Hepatology and Gastroenterology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.clinre.2011.02.009","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2011 Elsevier Masson SAS. All rights reserved.","name":"copyright","label":"Copyright"}]}}